G L Reed

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets
    S H Chung
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, MA 02115, USA
    J Biol Chem 275:25286-91. 2000
  2. ncbi request reprint Chimerism reveals a role for the streptokinase Beta -domain in nonproteolytic active site formation, substrate, and inhibitor interactions
    Inna P Gladysheva
    Cardiovascular Biology Laboratory, Harvard School of Public Health II 127, 677 Huntington Avenue, Boston, MA 02114, USA
    J Biol Chem 277:26846-51. 2002
  3. ncbi request reprint Development of platelet secretory granules
    Sarah M King
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Bldg II 127, 677 Huntington Ave, Boston, MA 02115, USA
    Semin Cell Dev Biol 13:293-302. 2002
  4. ncbi request reprint Comparative biochemical and ultrastructural studies of P-selectin in rabbit platelets
    G L Reed
    Massachusetts General Hospital, Boston, USA
    Comp Biochem Physiol B Biochem Mol Biol 119:729-38. 1998
  5. ncbi request reprint The contribution of activated factor XIII to fibrinolytic resistance in experimental pulmonary embolism
    G L Reed
    Harvard School of Public Health, Harvard Medical School, and Massachusetts General Hospital, Boston, MA, USA
    Circulation 99:299-304. 1999
  6. ncbi request reprint Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion
    G L Reed
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Cardiac Unit, Massachusetts General Hospital, Boston, MA, USA
    Blood 93:2617-26. 1999
  7. pmc A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator
    G L Reed
    Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:8879-83. 1999
  8. ncbi request reprint Platelet secretory mechanisms
    Guy L Reed
    Harvard University, School of Public Health, Boston, Massachusetts 02115, USA
    Semin Thromb Hemost 30:441-50. 2004
  9. ncbi request reprint The mechanism of a bacterial plasminogen activator intermediate between streptokinase and staphylokinase
    I Y Sazonova
    Cardiovascular Biology Laboratory, Harvard School of Public Health and the Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 276:12609-13. 2001
  10. pmc Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution
    M L Fitzgerald
    Cardiovascular Biology Laboratory, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Biochem J 342:353-60. 1999

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human platelets
    S H Chung
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, MA 02115, USA
    J Biol Chem 275:25286-91. 2000
    ..These results provide evidence that extracellular activation can be coupled through intracellular PKC signaling so as to modulate SNARE protein interactions involved in platelet exocytosis...
  2. ncbi request reprint Chimerism reveals a role for the streptokinase Beta -domain in nonproteolytic active site formation, substrate, and inhibitor interactions
    Inna P Gladysheva
    Cardiovascular Biology Laboratory, Harvard School of Public Health II 127, 677 Huntington Avenue, Boston, MA 02114, USA
    J Biol Chem 277:26846-51. 2002
    ....
  3. ncbi request reprint Development of platelet secretory granules
    Sarah M King
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Bldg II 127, 677 Huntington Ave, Boston, MA 02115, USA
    Semin Cell Dev Biol 13:293-302. 2002
    ....
  4. ncbi request reprint Comparative biochemical and ultrastructural studies of P-selectin in rabbit platelets
    G L Reed
    Massachusetts General Hospital, Boston, USA
    Comp Biochem Physiol B Biochem Mol Biol 119:729-38. 1998
    ..This suggests that studies of P-selectin in thrombosis in rabbits are likely to provide useful insights into the role of this molecule in human thrombotic vascular disease and related conditions...
  5. ncbi request reprint The contribution of activated factor XIII to fibrinolytic resistance in experimental pulmonary embolism
    G L Reed
    Harvard School of Public Health, Harvard Medical School, and Massachusetts General Hospital, Boston, MA, USA
    Circulation 99:299-304. 1999
    ..This study examines the contribution of activated factor XIII (factor XIIIa) to fibrinolytic resistance in experimental pulmonary embolism...
  6. ncbi request reprint Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion
    G L Reed
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Cardiac Unit, Massachusetts General Hospital, Boston, MA, USA
    Blood 93:2617-26. 1999
    ....
  7. pmc A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activator
    G L Reed
    Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 96:8879-83. 1999
    ..Because deletion of the NH(2) terminus alters SK's mechanism of action and targets Pg activation to fibrin, there is the potential to improve SK's therapeutic efficacy...
  8. ncbi request reprint Platelet secretory mechanisms
    Guy L Reed
    Harvard University, School of Public Health, Boston, Massachusetts 02115, USA
    Semin Thromb Hemost 30:441-50. 2004
    ..A convergence of new insights from several different organisms has begun to illuminate the molecular mechanisms responsible for the platelet secretory process, from granule development through membrane fusion and exocytosis...
  9. ncbi request reprint The mechanism of a bacterial plasminogen activator intermediate between streptokinase and staphylokinase
    I Y Sazonova
    Cardiovascular Biology Laboratory, Harvard School of Public Health and the Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 276:12609-13. 2001
    ..However, the streptokinase gamma-domain enhances the rates of active site formation in b-plasminogen and this enhancing effect may be required for efficient activation of plasminogen from other species...
  10. pmc Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution
    M L Fitzgerald
    Cardiovascular Biology Laboratory, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Biochem J 342:353-60. 1999
    ..We suggest that PKC phosphorylation may be an important mechanism through which Rab functional interactions in vesicle trafficking and secretion can be altered in response to an external stimulus...
  11. ncbi request reprint Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets
    A K Houng
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, MA 02115, USA
    Eur J Biochem 243:209-18. 1997
    ....
  12. ncbi request reprint Novel factor XIII probes for blood coagulation imaging
    Ching Hsuan Tung
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Chembiochem 4:897-9. 2003
  13. ncbi request reprint Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion
    Janos Polgar
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, MA 02115, USA
    Blood 100:1081-3. 2002
    ..In contrast, rVAMP-2, which formed SNARE complexes in vitro, had no effect on platelet exocytosis. We conclude that VAMP-3 and VAMP-8 form SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion...
  14. pmc Platelet dense-granule secretion plays a critical role in thrombosis and subsequent vascular remodeling in atherosclerotic mice
    Sarah M King
    Cardiovascular Biology, Harvard School of Public Health, Boston, Mass, USA
    Circulation 120:785-91. 2009
    ..Therefore, we examined the hypothesis that platelet dense-granule secretion modulates thrombosis, inflammation, and atherosclerotic vascular remodeling after injury...
  15. ncbi request reprint Munc18-syntaxin complexes and exocytosis in human platelets
    Aiilyan Houng
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 278:19627-33. 2003
    ..Acute inhibition of the SM-syntaxin complex promotes Ca2+-induced exocytosis, suggesting that complex formation per se has a regulatory effect on triggered secretion...
  16. ncbi request reprint Phosphorylation of SNAP-23 in activated human platelets
    Janos Polgar
    Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Biol Chem 278:44369-76. 2003
    ..Because mutants that mimic SNAP-23 phosphorylation affect syntaxin 4 interactions, we hypothesize that SNAP-23 phosphorylation may be important for modulating SNARE-complex interactions during membrane trafficking and fusion...
  17. ncbi request reprint Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombi
    Farouc A Jaffer
    Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Circulation 110:170-6. 2004
    ..In vivo imaging of FXIIIa activity could further elucidate the role of this molecule in thrombosis and other biological processes and aid in the clinical detection of acute thrombi...
  18. ncbi request reprint Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surface
    George L Dale
    W K Warren Medical Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
    Nature 415:175-9. 2002
    ..These data indicate that COAT-platelets use serotonin conjugation to augment the retention of procoagulant proteins on their cell surface through an as yet unidentified serotonin receptor...
  19. pmc The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failure
    Gordon S Huggins
    Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Am J Physiol Heart Circ Physiol 293:H1877-82. 2007
    ....
  20. pmc Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarction
    Matthias Nahrendorf
    Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Wurzburg, Germany
    Circulation 113:1196-202. 2006
    ..We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved in wound healing, may play an important role in MI given prior clinical and mouse model data...
  21. pmc Coevolutionary patterns in plasminogen activation
    Inna P Gladysheva
    Cardiovascular Biology Laboratory, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:9168-72. 2003
    ....
  22. ncbi request reprint Good breeding matters: in-bred rodents provide genetic insights into platelet secretion
    Guy L Reed
    Thromb Haemost 89:951-2. 2003
  23. ncbi request reprint Structural elements that govern the substrate specificity of the clot-dissolving enzyme plasmin
    Ryan B Turner
    Cardiovascular Biology Laboratory, Harvard School of Public Health and the Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Biol Chem 277:33068-74. 2002
    ..Because modification of these regions affected substrate and inhibitor interactions, loop chimerization may hold promise for improving the clot dissolving properties of this enzyme...