Research Topics
Genomes and GenesSpecies | G L ReedSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Protein kinase C phosphorylation of syntaxin 4 in thrombin-activated human plateletsS H Chung
Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, MA 02115, USA
J Biol Chem 275:25286-91. 2000..These results provide evidence that extracellular activation can be coupled through intracellular PKC signaling so as to modulate SNARE protein interactions involved in platelet exocytosis...- Chimerism reveals a role for the streptokinase Beta -domain in nonproteolytic active site formation, substrate, and inhibitor interactionsInna P Gladysheva
Cardiovascular Biology Laboratory, Harvard School of Public Health II 127, 677 Huntington Avenue, Boston, MA 02114, USA
J Biol Chem 277:26846-51. 2002.... - Development of platelet secretory granulesSarah M King
Cardiovascular Biology Laboratory, Harvard School of Public Health, Bldg. II-127, 677 Huntington Ave, Boston, MA 02115, USA
Semin Cell Dev Biol 13:293-302. 2002.... - Comparative biochemical and ultrastructural studies of P-selectin in rabbit plateletsG L Reed
Massachusetts General Hospital, Boston, USA
Comp Biochem Physiol B Biochem Mol Biol 119:729-38. 1998..This suggests that studies of P-selectin in thrombosis in rabbits are likely to provide useful insights into the role of this molecule in human thrombotic vascular disease and related conditions... - The contribution of activated factor XIII to fibrinolytic resistance in experimental pulmonary embolismG L Reed
Harvard School of Public Health, Harvard Medical School, and Massachusetts General Hospital, Boston, MA, USA
Circulation 99:299-304. 1999..This study examines the contribution of activated factor XIII (factor XIIIa) to fibrinolytic resistance in experimental pulmonary embolism... - Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretionG L Reed
Cardiovascular Biology Laboratory, Harvard School of Public Health, Cardiac Unit, Massachusetts General Hospital, Boston, MA, USA
Blood 93:2617-26. 1999.... 
A catalytic switch and the conversion of streptokinase to a fibrin-targeted plasminogen activatorG L Reed
Harvard School of Public Health, Harvard University, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 96:8879-83. 1999..Because deletion of the NH(2) terminus alters SK's mechanism of action and targets Pg activation to fibrin, there is the potential to improve SK's therapeutic efficacy...- Platelet secretory mechanismsGuy L Reed
Harvard University, School of Public Health, Boston, Massachusetts 02115, USA
Semin Thromb Hemost 30:441-50. 2004..A convergence of new insights from several different organisms has begun to illuminate the molecular mechanisms responsible for the platelet secretory process, from granule development through membrane fusion and exocytosis... - The mechanism of a bacterial plasminogen activator intermediate between streptokinase and staphylokinaseI Y Sazonova
Cardiovascular Biology Laboratory, Harvard School of Public Health and the Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biol Chem 276:12609-13. 2001..However, the streptokinase gamma-domain enhances the rates of active site formation in b-plasminogen and this enhancing effect may be required for efficient activation of plasminogen from other species... - Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distributionM L Fitzgerald
Cardiovascular Biology Laboratory, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Biochem J 342:353-60. 1999..We suggest that PKC phosphorylation may be an important mechanism through which Rab functional interactions in vesicle trafficking and secretion can be altered in response to an external stimulus... - Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated plateletsA K Houng
Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, MA 02115, USA
Eur J Biochem 243:209-18. 1997.... - Novel factor XIII probes for blood coagulation imagingChing-Hsuan Tung
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Chembiochem 4:897-9. 2003 - Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretionJanos Polgar
Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, MA 02115, USA
Blood 100:1081-3. 2002..In contrast, rVAMP-2, which formed SNARE complexes in vitro, had no effect on platelet exocytosis. We conclude that VAMP-3 and VAMP-8 form SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion... - Platelet dense-granule secretion plays a critical role in thrombosis and subsequent vascular remodeling in atherosclerotic miceSarah M King
Cardiovascular Biology, Harvard School of Public Health, Boston, Mass, USA
Circulation 120:785-91. 2009..Therefore, we examined the hypothesis that platelet dense-granule secretion modulates thrombosis, inflammation, and atherosclerotic vascular remodeling after injury... - Munc18-syntaxin complexes and exocytosis in human plateletsAiilyan Houng
Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Biol Chem 278:19627-33. 2003..Acute inhibition of the SM-syntaxin complex promotes Ca2+-induced exocytosis, suggesting that complex formation per se has a regulatory effect on triggered secretion... - Phosphorylation of SNAP-23 in activated human plateletsJanos Polgar
Cardiovascular Biology Laboratory, Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Biol Chem 278:44369-76. 2003..Because mutants that mimic SNAP-23 phosphorylation affect syntaxin 4 interactions, we hypothesize that SNAP-23 phosphorylation may be important for modulating SNARE-complex interactions during membrane trafficking and fusion... - Molecular imaging of factor XIIIa activity in thrombosis using a novel, near-infrared fluorescent contrast agent that covalently links to thrombiFarouc A Jaffer
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
Circulation 110:170-6. 2004..In vivo imaging of FXIIIa activity could further elucidate the role of this molecule in thrombosis and other biological processes and aid in the clinical detection of acute thrombi... - Stimulated platelets use serotonin to enhance their retention of procoagulant proteins on the cell surfaceGeorge L Dale
W K Warren Medical Research Institute and Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA
Nature 415:175-9. 2002..These data indicate that COAT-platelets use serotonin conjugation to augment the retention of procoagulant proteins on their cell surface through an as yet unidentified serotonin receptor... - The CREB leucine zipper regulates CREB phosphorylation, cardiomyopathy, and lethality in a transgenic model of heart failureGordon S Huggins
Molecular Cardiology Research Institute, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
Am J Physiol Heart Circ Physiol 293:H1877-82. 2007.... - Factor XIII deficiency causes cardiac rupture, impairs wound healing, and aggravates cardiac remodeling in mice with myocardial infarctionMatthias Nahrendorf
Medizinische Klinik und Poliklinik I, Universitat Wurzburg, Wurzburg, Germany
Circulation 113:1196-202. 2006..We hypothesized that clotting factor XIII (FXIII), a transglutaminase involved in wound healing, may play an important role in MI given prior clinical and mouse model data... - Coevolutionary patterns in plasminogen activationInna P Gladysheva
Cardiovascular Biology Laboratory, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 100:9168-72. 2003.... - Good breeding matters: in-bred rodents provide genetic insights into platelet secretionGuy L Reed
Thromb Haemost 89:951-2. 2003 - Structural elements that govern the substrate specificity of the clot-dissolving enzyme plasminRyan B Turner
Cardiovascular Biology Laboratory, Harvard School of Public Health and the Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Biol Chem 277:33068-74. 2002..Because modification of these regions affected substrate and inhibitor interactions, loop chimerization may hold promise for improving the clot dissolving properties of this enzyme...