F Re

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 277:23427-32. 2002
  2. ncbi Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 171:5272-6. 2003
  3. ncbi Heterogeneity of TLR-induced responses in dendritic cells: from innate to adaptive immunity
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunobiology 209:191-8. 2004
  4. ncbi IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 173:7548-55. 2004
  5. ncbi Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin
    Athmane Teghanemt
    Department of Internal Medicine and The Inflammation Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Biol Chem 283:1257-66. 2008
  6. ncbi Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
    F Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 276:37692-9. 2001
  7. ncbi Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain
    Polonca Prohinar
    Inflammation Program, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 282:1010-7. 2007
  8. ncbi Cell activation by Toll-like receptors: role of LBP and CD14
    Robert W Finberg
    Department of Medicine, University of Massachusetts Medical School, 264 Plantation Street, Worcester, Massachusetts 01605, USA
    J Endotoxin Res 10:413-8. 2004
  9. pmc HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes
    Fred Chang
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Biol Cell 15:1793-801. 2004
  10. pmc Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling
    Frantisek Sandor
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605 2324, USA
    J Cell Biol 162:1099-110. 2003

Collaborators

Detail Information

Publications13

  1. ncbi Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 277:23427-32. 2002
    ..Remarkably, although the majority of recombinant MD-2 exists in multimeric form, monomeric MD-2 was found to preferentially bind TLR4 and to confer LPS responsiveness more efficiently than MD-2 multimers...
  2. ncbi Separate functional domains of human MD-2 mediate Toll-like receptor 4-binding and lipopolysaccharide responsiveness
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 171:5272-6. 2003
    ..Either of the two functional domains of MD-2 can be disrupted to impair LPS responses and therefore represent attractive targets for therapeutic interventions...
  3. ncbi Heterogeneity of TLR-induced responses in dendritic cells: from innate to adaptive immunity
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Immunobiology 209:191-8. 2004
    ..A review of recent literature, unpublished observations, and future challenges is presented here...
  4. ncbi IL-10 released by concomitant TLR2 stimulation blocks the induction of a subset of Th1 cytokines that are specifically induced by TLR4 or TLR3 in human dendritic cells
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    J Immunol 173:7548-55. 2004
    ..Cross-talk between different TLRs may modify the primary responses of TLR to their agonist, adding a further level of complexity to the regulation of innate immunity...
  5. ncbi Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin
    Athmane Teghanemt
    Department of Internal Medicine and The Inflammation Program, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Biol Chem 283:1257-66. 2008
    ..CD14 and, together with Phe(126), in activation of TLR4 by bound E.MD-2. These findings strongly suggest that the structural properties of E.MD-2, not E alone, determine agonist or antagonist effects on TLR4...
  6. ncbi Toll-like receptor 2 (TLR2) and TLR4 differentially activate human dendritic cells
    F Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Biol Chem 276:37692-9. 2001
    ..Thus, TLRs can translate the information regarding the nature of pathogens into differences in the cytokines and chemokines produced by dendritic cells and therefore may contribute to the polarization of the acquired immune response...
  7. ncbi Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain
    Polonca Prohinar
    Inflammation Program, Department of Internal Medicine, Roy J and Lucille A Carver College of Medicine, University of Iowa, and Veterans Affairs Medical Center, Iowa City, Iowa 52242, USA
    J Biol Chem 282:1010-7. 2007
    ..MD-2/TLR4 complex. The ability to assay specific high affinity interactions of monomeric endotoxin.protein complexes with TLR4ECD should allow better definition of the structural requirements for endotoxin-induced TLR4 activation...
  8. ncbi Cell activation by Toll-like receptors: role of LBP and CD14
    Robert W Finberg
    Department of Medicine, University of Massachusetts Medical School, 264 Plantation Street, Worcester, Massachusetts 01605, USA
    J Endotoxin Res 10:413-8. 2004
    ..Here we report on the role of these proteins in the response to yeast zymosan. The requirements for this response (which unlike the response to LPS is a response to a particulate antigen) and the role of other serum proteins are defined...
  9. pmc HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes
    Fred Chang
    Department of Microbiology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Mol Biol Cell 15:1793-801. 2004
    ..These defects in cell division and centrosomes might account for some of the pathological effects associated with HIV-1 infection...
  10. pmc Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling
    Frantisek Sandor
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605 2324, USA
    J Cell Biol 162:1099-110. 2003
    ..The domains from each receptor did not need to be contained within a single contiguous protein. Chimeric TLR analysis further defined the toll/IL-1R domains as the area of crucial intracellular TLR1-TLR2 interaction...
  11. ncbi Innate immune response to Francisella tularensis is mediated by TLR2 and caspase-1 activation
    Hanfen Li
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Leukoc Biol 80:766-73. 2006
    ..Our results identified activation of TLR2 and caspase-1 as the two main cellular pathways responsible for the inflammatory response to F. tularensis...
  12. ncbi Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation
    Fabio Re
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:2264-73. 2002
    ..This function of GM-CSF is distinct from its primary function in cell proliferation and survival...
  13. pmc Chlamydia pneumoniae--induced macrophage foam cell formation is mediated by Toll-like receptor 2
    Fei Cao
    Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Infect Immun 75:753-9. 2007
    ..pneumoniae, Pam, and E. coli LPS). Overall, our results suggest that activation of the LXR signaling pathway may affect potentially atherogenic processes modulated by the TLR ligands...