MOHAMMED RAZZAQUE

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Role of macrophage migration inhibitory factor in conjunctival pathology in ocular cicatricial pemphigoid
    Mohammed S Razzaque
    Department of Oral Medicine, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 45:1174-81. 2004
  2. ncbi request reprint Pulmonary fibrosis: cellular and molecular events
    Mohammed S Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Pathol Int 53:133-45. 2003
  3. ncbi request reprint Does renal ageing affect survival?
    M Shawkat Razzaque
    Department of Developmental Biology, Harvard School of Dental Medicine, 190 Longwood Avenue, Boston, MA 02115, USA
    Ageing Res Rev 6:211-22. 2007
  4. pmc Lack of awareness among future medical professionals about the risk of consuming hidden phosphate-containing processed food and drinks
    Yoshiko Shutto
    Department of Health Promotion, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
    PLoS ONE 6:e29105. 2011
  5. pmc Inadequate awareness among chronic kidney disease patients regarding food and drinks containing artificially added phosphate
    Yoshiko Shutto
    Department of Health Promotion, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
    PLoS ONE 8:e78660. 2013
  6. pmc Heat shock protein 47: a novel biomarker of phenotypically altered collagen-producing cells
    Takashi Taguchi
    Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Acta Histochem Cytochem 44:35-41. 2011
  7. doi request reprint Phosphate toxicity and vascular mineralization
    Mohammed S Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Contrib Nephrol 180:74-85. 2013
  8. pmc The role of Klotho in energy metabolism
    M Shawkat Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Research and Education Building, Room 304, 190 Longwood Avenue, Boston, MA 02115, USA
    Nat Rev Endocrinol 8:579-87. 2012
  9. doi request reprint FGF23, klotho and vitamin D interactions: What have we learned from in vivo mouse genetics studies?
    M Shawkat Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
    Adv Exp Med Biol 728:84-91. 2012
  10. pmc FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player?
    M Shawkat Razzaque
    Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Research and Education Bldg, Rm 304, 190 Longwood Ave, Boston, Massuchusetts 02115, USA
    Am J Physiol Renal Physiol 296:F470-6. 2009

Research Grants

  1. In vivo interactions of Fgf-23, klotho and vitamin D
    MOHAMMED RAZZAQUE; Fiscal Year: 2007
  2. In vivo interactions of Fgf-23, klotho and vitamin D
    MOHAMMED RAZZAQUE; Fiscal Year: 2009
  3. In vivo interactions of Fgf-23, klotho and vitamin D
    Mohammed S Razzaque; Fiscal Year: 2010

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Role of macrophage migration inhibitory factor in conjunctival pathology in ocular cicatricial pemphigoid
    Mohammed S Razzaque
    Department of Oral Medicine, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 45:1174-81. 2004
    ..Ocular cicatricial pemphigoid (OCP) is an autoimmune disease in which affected conjunctivae show features of an immunoinflammatory disease. In this study, the role of MIF in the pathogenesis of OCP was examined...
  2. ncbi request reprint Pulmonary fibrosis: cellular and molecular events
    Mohammed S Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Pathol Int 53:133-45. 2003
    ..This review addresses the pathophysiology of wound healing and different phases of pulmonary fibrosis...
  3. ncbi request reprint Does renal ageing affect survival?
    M Shawkat Razzaque
    Department of Developmental Biology, Harvard School of Dental Medicine, 190 Longwood Avenue, Boston, MA 02115, USA
    Ageing Res Rev 6:211-22. 2007
    ..Careful long-term studies are needed to determine the human relevance of these experimental studies...
  4. pmc Lack of awareness among future medical professionals about the risk of consuming hidden phosphate-containing processed food and drinks
    Yoshiko Shutto
    Department of Health Promotion, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
    PLoS ONE 6:e29105. 2011
    ..This survey emphasizes the need for educational initiative to raise awareness of the health risks posed by excessive consumption of phosphate additives...
  5. pmc Inadequate awareness among chronic kidney disease patients regarding food and drinks containing artificially added phosphate
    Yoshiko Shutto
    Department of Health Promotion, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan
    PLoS ONE 8:e78660. 2013
    ....
  6. pmc Heat shock protein 47: a novel biomarker of phenotypically altered collagen-producing cells
    Takashi Taguchi
    Department of Pathology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Acta Histochem Cytochem 44:35-41. 2011
    ..In this brief article, we explained why HSP47 could be used as a universal marker for identifying phenotypically altered collagen-producing cells...
  7. doi request reprint Phosphate toxicity and vascular mineralization
    Mohammed S Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Contrib Nephrol 180:74-85. 2013
    ....
  8. pmc The role of Klotho in energy metabolism
    M Shawkat Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Research and Education Building, Room 304, 190 Longwood Avenue, Boston, MA 02115, USA
    Nat Rev Endocrinol 8:579-87. 2012
    ....
  9. doi request reprint FGF23, klotho and vitamin D interactions: What have we learned from in vivo mouse genetics studies?
    M Shawkat Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
    Adv Exp Med Biol 728:84-91. 2012
    ..In this brief chapter, I will summarize the possible in vivo interactions of FGF23, klotho and vitamin D, in the light of recent mouse genetics studies...
  10. pmc FGF23-mediated regulation of systemic phosphate homeostasis: is Klotho an essential player?
    M Shawkat Razzaque
    Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Research and Education Bldg, Rm 304, 190 Longwood Ave, Boston, Massuchusetts 02115, USA
    Am J Physiol Renal Physiol 296:F470-6. 2009
    ..This article briefly summarizes how FGF23 might coordinately regulate systemic phosphate homeostasis and how Klotho is involved in such regulation...
  11. ncbi request reprint FGF-23, vitamin D and calcification: the unholy triad
    Mohammed S Razzaque
    Department of Oral and Developmental Biology, Research and Educational Building, Room 312, Harvard School of Dental of Medicine, 190 Longwood Ave, Boston, MA 02115, USA
    Nephrol Dial Transplant 20:2032-5. 2005
  12. ncbi request reprint Can patient-specific stem cell therapy enhance renal repair?
    Mohammed Shawkat Razzaque
    Department of Developmental Biology, Harvard School of Dental Medicine, Research and Education Building, Room 304, 190 Longwood Avenue, Boston, MA 02115, USA
    Nephrol Dial Transplant 23:1826-30. 2008
  13. ncbi request reprint Can fibroblast growth factor 23 fine-tune therapies for diseases of abnormal mineral ion metabolism?
    M Shawkat Razzaque
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Nat Clin Pract Endocrinol Metab 3:788-9. 2007
  14. ncbi request reprint Lipid formulations of polyene antifungal drugs and attenuation of associated nephrotoxicity
    M S Razzaque
    Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, Mass 02115, USA
    Nephron 89:251-4. 2001
    ..We summarize herein the existing information about newer lipid formulations of polyene antifungal drugs, which could attenuate associated nephrotoxicity...
  15. ncbi request reprint Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice
    Mohammed S Razzaque
    Department of Developmental Biology, Harvard School of Dental Medicine, Research and Educational Building, 190 Longwood Avenue, Boston, MA 02115, USA
    Trends Mol Med 12:298-305. 2006
    ..Such in vivo experimental studies indicated that excessive vitamin-D activity and altered mineral-ion homeostasis could accelerate the aging process...
  16. ncbi request reprint Heat shock protein 47 and renal fibrogenesis
    Mohammed S Razzaque
    Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Contrib Nephrol 148:57-69. 2005
    ..In this brief article, we review the role of HSP47 in renal fibrotic diseases and its relevance to other scarring diseases...
  17. ncbi request reprint Involvement of stress proteins in renal diseases
    Mohammed S Razzaque
    Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Contrib Nephrol 148:1-7. 2005
    ..This brief review summarizes some of the important aspects of HSPs and their relevance to various renal diseases...
  18. pmc The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis
    M Shawkat Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Nat Rev Endocrinol 5:611-9. 2009
    ....
  19. pmc Phosphate toxicity: new insights into an old problem
    M Shawkat Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Clin Sci (Lond) 120:91-7. 2011
    ..The cause and consequences of phosphate toxicity will be briefly summarized in the present review...
  20. pmc The dualistic role of vitamin D in vascular calcifications
    M Shawkat Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Kidney Int 79:708-14. 2011
    ..This article will briefly summarize the dual effects of vitamin D in vascular calcification and will provide evidence of vitamin D-dependent and -independent vascular calcification...
  21. ncbi request reprint Factors regulating the progression of hypertensive nephrosclerosis
    Mohammed S Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Mass, USA
    Contrib Nephrol 139:173-86. 2003
  22. pmc Osteo-renal regulation of systemic phosphate metabolism
    Mohammed Shawkat Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA, USA
    IUBMB Life 63:240-7. 2011
    ..This article will briefly summarize how osteo-renal miscommunication can induce phosphate toxicity, resulting in extensive tissue injuries...
  23. pmc Therapeutic potential of klotho-FGF23 fusion polypeptides: WO2009095372
    Mohammed S Razzaque
    Harvard School of Dental Medicine, Department of Oral Medicine, Infection and Immunity, 190 Longwood Avenue, Boston, MA 02115, USA
    Expert Opin Ther Pat 20:981-5. 2010
    ..The patent (WO2009095372) under discussion proposes using fusion polypeptides to manipulate the FGF23-klotho system...
  24. pmc The emerging role of the fibroblast growth factor-23-klotho axis in renal regulation of phosphate homeostasis
    Mohammed S Razzaque
    Department of Developmental Biology, Harvard School of Dental Medicine, Research and Education Building, Room 304, 190 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Endocrinol 194:1-10. 2007
    ..In this brief article, we will summarize how the FGF23-klotho axis might coordinately regulate normal mineral ion homeostasis, and how their abnormal regulation could severely disrupt such homeostasis to induce disease pathology...
  25. ncbi request reprint Role of collagen-binding heat shock protein 47 and transforming growth factor-beta1 in conjunctival scarring in ocular cicatricial pemphigoid
    Mohammed S Razzaque
    Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 44:1616-21. 2003
    ..Heat shock protein 47 (HSP47), a collagen-binding protein, plays an important role in the biosynthesis of procollagens. In the present study, we examined the role of HSP47 in conjunctival scarring in patients with OCP...
  26. pmc Genetic ablation of vitamin D activation pathway reverses biochemical and skeletal anomalies in Fgf-23-null animals
    Despina Sitara
    Department of Developmental Biology, Harvard School of Dental Medicine, REB 303, 188 Longwood Ave, Boston, MA 02115, USA, and The Genetics Unit, Shriners Hospital, Montreal, Quebec, Canada
    Am J Pathol 169:2161-70. 2006
    ....
  27. ncbi request reprint Role of enhanced expression of m-CSF in conjunctiva affected by cicatricial pemphigoid
    Mohammed S Razzaque
    Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 43:2977-83. 2002
    ....
  28. ncbi request reprint Role of connective tissue growth factor in the pathogenesis of conjunctival scarring in ocular cicatricial pemphigoid
    Mohammed S Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 44:1998-2003. 2003
    ..Hence, studying the mechanism by which CTGF influences TGF-beta1-induced synthesis of collagen in conjunctiva of patients with OCP would provide insight into the mechanism of conjunctival fibrosis in patients with OCP...
  29. ncbi request reprint Effects of IL-4 on conjunctival fibroblasts: possible role in ocular cicatricial pemphigoid
    Mohammed S Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 44:3417-23. 2003
    ..Interleukin (IL)-4 plays an important role in both the inflammatory and fibrotic events in several human and experimental diseases. In the present study, the possible role of IL-4 in the pathogenesis of OCP was investigated...
  30. ncbi request reprint Role of apoptosis in fibrogenesis
    Mohammed S Razzaque
    Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Boston, Mass, USA
    Nephron 90:365-72. 2002
  31. ncbi request reprint Immunoinflammatory responses and fibrogenesis
    Abdallah Azouz
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Med Electron Microsc 37:141-8. 2004
    ..In this article, we briefly present the relevance of Th1 and Th2 responses and the significance of interactions between matrix-producing cells and inflammatory cells during granuloma tissue and scar tissue formation...
  32. pmc Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process
    Mohammed S Razzaque
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts 02115, USA
    FASEB J 20:720-2. 2006
    ..Finally, our data support a new model of interactions among Fgf-23, vitamin D, and klotho, a gene described as being associated with premature aging process...
  33. pmc Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    Despina Sitara
    Department of Oral and Developmental Biology, The Forsyth Institute, Harvard School of Dental Medicine, 140 The Fenway, Boston, MA, 02115, USA
    Matrix Biol 23:421-32. 2004
    ....
  34. pmc Genetic evidence of serum phosphate-independent functions of FGF-23 on bone
    Despina Sitara
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, Massachusetts, United States of America
    PLoS Genet 4:e1000154. 2008
    ....
  35. pmc FGF-23-Klotho signaling stimulates proliferation and prevents vitamin D-induced apoptosis
    Damian Medici
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    J Cell Biol 182:459-65. 2008
    ..These data provide new insights into the physiological roles of FGF-23 and Klotho...
  36. ncbi request reprint Role of heat shock protein 47 on tubulointerstitium in experimental radiation nephropathy
    Diange Liu
    Second Department of Pathology, Nagasaki University School of Medicine, Sakamoto, Nagasaki, Japan
    Pathol Int 52:340-7. 2002
    ..Overexpression of HSP47 by phenotypically altered tubulointerstitial cells might play a role in excessive assembly/synthesis of collagens and could contribute to tubulointerstitial fibrosis in radiation nephropathy...
  37. ncbi request reprint Pathological significance of renal expression of NF-kappa B
    Mehmet S Inan
    Genomic Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA
    Contrib Nephrol 139:90-101. 2003
  38. ncbi request reprint Expression profiles of collagens, HSP47, TGF-beta1, MMPs and TIMPs in epidermolysis bullosa acquisita
    Mohammed S Razzaque
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA
    Cytokine 21:207-13. 2003
    ..The presented data is preliminary and could serve as a basis for further studies to enhance our understanding about the molecular mechanisms of conjunctival scarring in patients with EBA...
  39. ncbi request reprint Oxidant stress in renal pathophysiology
    M Ruhul Abid
    Division of Molecular and Vascular Medicine, Department of Medicine, Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass, USA
    Contrib Nephrol 148:135-53. 2005
    ..In this article, we will briefly present the relevance of the oxidant stress in the pathogenesis of various renal diseases...
  40. ncbi request reprint Conditional deletion of Indian hedgehog from collagen type 2alpha1-expressing cells results in abnormal endochondral bone formation
    Mohammed S Razzaque
    Department of Oral and Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    J Pathol 207:453-61. 2005
    ..Understanding the exact functions of the molecules involved in endochondral bone formation will form the basis for further study to determine the molecular mechanisms of skeletal diseases involving various cellular components of bone...
  41. pmc Indian Hedgehog produced by postnatal chondrocytes is essential for maintaining a growth plate and trabecular bone
    Yukiko Maeda
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:6382-7. 2007
    ..These results demonstrate, for the first time, that postnatal chondrocyte-derived Ihh is essential for maintaining the growth plate and articular surface and is required for sustaining trabecular bone and skeletal growth...
  42. pmc Dietary and genetic evidence for enhancing glucose metabolism and reducing obesity by inhibiting klotho functions
    Mutsuko Ohnishi
    Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Research and Education Bldg, 190 Longwood Ave, Boston, MA 02115, USA
    FASEB J 25:2031-9. 2011
    ..The results of our dietary and genetic manipulation studies provide in vivo evidence for a role of klotho in obesity and offer a novel target to manipulate obesity and associated complications...
  43. ncbi request reprint Expression of apoptotic epithelial cells within lamina propria beneath the basement membrane triggers dextran sulfate sodium-induced colitis
    Kazuko Shichijo
    Division of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, Japan
    Dig Dis Sci 53:2443-51. 2008
    ..Our results suggest that interventions directed toward the apoptotic process may be beneficial in the treatment of ulcerative colitis...

Research Grants4

  1. In vivo interactions of Fgf-23, klotho and vitamin D
    MOHAMMED RAZZAQUE; Fiscal Year: 2007
    ..and defective skeletal mineralization in wide range of diseases including rickets/osteomalacia, tumoral calcinosis and chronic renal failure, by developing novel therapies and fine tuning of the existing therapeutic modalities ..
  2. In vivo interactions of Fgf-23, klotho and vitamin D
    MOHAMMED RAZZAQUE; Fiscal Year: 2009
    ..and defective skeletal mineralization in wide range of diseases including rickets/osteomalacia, tumoral calcinosis and chronic renal failure, by developing novel therapies and fine tuning of the existing therapeutic modalities ..
  3. In vivo interactions of Fgf-23, klotho and vitamin D
    Mohammed S Razzaque; Fiscal Year: 2010
    ..and defective skeletal mineralization in wide range of diseases including rickets/osteomalacia, tumoral calcinosis and chronic renal failure, by developing novel therapies and fine tuning of the existing therapeutic modalities ..