Scott L Rauch

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Selectively reduced regional cortical volumes in post-traumatic stress disorder
    Scott L Rauch
    Psychiatric Neuroimaging Research Group, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroreport 14:913-6. 2003
  2. ncbi request reprint A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Depress Anxiety 25:496-505. 2008
  3. ncbi request reprint Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia
    Daphne J Holt
    Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
    Schizophr Res 82:153-62. 2006
  4. doi request reprint Neurophysiological alterations during strategy-based verbal learning in traumatic brain injury
    GARY E STRANGMAN
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Neurorehabil Neural Repair 23:226-36. 2009
  5. pmc Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 66:1075-82. 2009
  6. ncbi request reprint Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 62:446-54. 2007
  7. ncbi request reprint Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 59:138-46. 2006
  8. pmc Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigm
    Jennifer C Britton
    Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Depress Anxiety 26:796-805. 2009
  9. doi request reprint An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief report
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, 2nd Floor, Charlestown, MA 02129, USA
    Bipolar Disord 10:928-42. 2008
  10. ncbi request reprint Brain activation during implicit sequence learning in individuals with trichotillomania
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 154:233-40. 2007

Detail Information

Publications96

  1. ncbi request reprint Selectively reduced regional cortical volumes in post-traumatic stress disorder
    Scott L Rauch
    Psychiatric Neuroimaging Research Group, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroreport 14:913-6. 2003
    ..These results are consistent with contemporary schemes regarding functional and structural dissection of frontal cortex, and suggest specific regional cortical pathology in PTSD...
  2. ncbi request reprint A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Depress Anxiety 25:496-505. 2008
    ..However, extending earlier findings in healthy subjects, schematic faces appear more effective for probing amygdala responses to arousal-based (Angry versus Neutral) as opposed to valence-based (Angry versus Happy) contrasts...
  3. ncbi request reprint Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia
    Daphne J Holt
    Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
    Schizophr Res 82:153-62. 2006
    ..Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition...
  4. doi request reprint Neurophysiological alterations during strategy-based verbal learning in traumatic brain injury
    GARY E STRANGMAN
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Neurorehabil Neural Repair 23:226-36. 2009
    ..Verbal learning and strategic processing deficits are common sequelae of traumatic brain injury (TBI); however, the neurophysiological mechanisms underlying such deficits remain poorly understood...
  5. pmc Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 66:1075-82. 2009
    ..amygdala, hippocampus, ventromedial prefrontal cortex (vmPFC), and dorsal anterior cingulate cortex (dACC)...
  6. ncbi request reprint Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 62:446-54. 2007
    ..The aim of the present study is to investigate the mediating anatomy of extinction recall in healthy humans...
  7. ncbi request reprint Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 59:138-46. 2006
    ..The most consistently reported cognitive difficulty in euthymic subjects with bipolar disorder is impairment in verbal episodic memory (i.e., the ability to learn new verbal information)...
  8. pmc Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigm
    Jennifer C Britton
    Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Depress Anxiety 26:796-805. 2009
    ..Emotional interference tasks may be useful in probing anterior cingulate cortex (ACC) function to understand abnormal attentional study in individuals with specific phobia...
  9. doi request reprint An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief report
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, 2nd Floor, Charlestown, MA 02129, USA
    Bipolar Disord 10:928-42. 2008
    ..The purpose of the present study was to investigate with fMRI the interaction between acute sadness and working memory functioning in individuals with bipolar disorder...
  10. ncbi request reprint Brain activation during implicit sequence learning in individuals with trichotillomania
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 154:233-40. 2007
    ..Future studies directly comparing OCD and TTM subjects are warranted to confirm the specificity of abnormal striatal and hippocampal findings during implicit sequence learning in OCD...
  11. ncbi request reprint Evidence for reduced cerebellar volumes in trichotillomania
    Nancy J Keuthen
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 61:374-81. 2007
    ..Limited knowledge exists regarding the neurobiology of trichotillomania (TTM). Cerebellum (CBM) volumes were explored, given its role in complex, coordinated motor sequences...
  12. ncbi request reprint Novel fearful faces activate the amygdala in healthy young and elderly adults
    Christopher I Wright
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, 13th St, Bldg 149, CNY 2613, Charlestown, MA 02129, USA
    Neurobiol Aging 27:361-74. 2006
    ..However, there were significantly greater activations in the inferior temporal cortex in the young versus elderly subjects...
  13. ncbi request reprint A diffusion tensor imaging study of white matter in obsessive-compulsive disorder
    Paul A Cannistraro
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Depress Anxiety 24:440-6. 2007
    ..This could explain why surgically severing these tracts is therapeutic. Additional studies are needed to replicate these findings and to clarify their pathological and clinical significance...
  14. ncbi request reprint A role for the human dorsal anterior cingulate cortex in fear expression
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 62:1191-4. 2007
    ..This study examined the role of dACC during fear conditioning in healthy humans with magnetic resonance imaging (MRI)...
  15. ncbi request reprint Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Brain 131:971-86. 2008
    ..Impairments in evaluating and learning from errors in schizophrenia may contribute to behaviour that is rigid and perseverative rather than optimally guided by outcomes, and may compromise performance across a wide range of tasks...
  16. ncbi request reprint Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 61:330-6. 2007
    ..Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions...
  17. ncbi request reprint Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia
    Christopher I Wright
    Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 54:1067-76. 2003
    ..However, it is not clear to what extent this concept applies across anxiety disorders. Several studies have examined brain function in specific phobias but did not demonstrate amygdala responses or use specific probes of the amygdala...
  18. pmc Hemispheric differences in amygdala contributions to response monitoring
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neuroreport 20:398-402. 2009
    ....
  19. doi request reprint Prediction of memory rehabilitation outcomes in traumatic brain injury by using functional magnetic resonance imaging
    GARY E STRANGMAN
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Arch Phys Med Rehabil 89:974-81. 2008
    ..To evaluate the ability of functional magnetic resonance imaging (fMRI) measures collected from people with traumatic brain injury (TBI) to provide predictive value for rehabilitation outcomes over and above standard predictors...
  20. ncbi request reprint Amygdala responses to human faces in obsessive-compulsive disorder
    Paul A Cannistraro
    Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital, Building 149, Thirteenth Street, Charlestown, MA 02129, USA
    Biol Psychiatry 56:916-20. 2004
    ..To assess the amygdala response to emotional faces in obsessive-compulsive disorder (OCD) using functional magnetic resonance imaging (fMRI)...
  21. pmc Dysfunction of a cortical midline network during emotional appraisals in schizophrenia
    Daphne J Holt
    Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
    Schizophr Bull 37:164-76. 2011
    ..These findings suggest that impaired functioning of cortical midline structures in schizophrenia may underlie faulty interpretations of social events, contributing to delusion formation...
  22. pmc RESEARCH: Cognitive rehabilitation for bipolar disorder: An open trial for employed patients with residual depressive symptoms
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    CNS Neurosci Ther 16:298-307. 2010
    ..These findings suggest that treating residual depressive symptoms and cognitive impairment may be an avenue to improving occupational and overall functioning in individuals with bipolar disorder...
  23. ncbi request reprint Sustained activation of the hippocampus in response to fearful faces in schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 57:1011-9. 2005
    ..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that habituation of the medial temporal lobe is reduced in schizophrenia...
  24. ncbi request reprint Regional cerebral brain metabolism correlates of neuroticism and extraversion
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 23:133-8. 2006
    ..No significant correlations were found involving anterior cingulate, amygdala, or ventral striatum. Neuroticism and Extraversion are associated with activity in insular cortex and orbitofrontal cortex, respectively...
  25. ncbi request reprint The misattribution of salience in delusional patients with schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:247-56. 2006
    ..In this study, we tested the hypothesis that delusional schizophrenia patients are more likely than non-delusional schizophrenia patients and healthy participants to assign affective meanings to neutral stimuli...
  26. ncbi request reprint A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder
    Scott L Rauch
    Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosurg 104:558-65. 2006
    ..The purpose of the current study was to test hypotheses regarding changes in regional cerebral blood flow (rCBF) during acute DBS at the VC/VS target in patients with OCD who were participating in a clinical DBS trial...
  27. ncbi request reprint Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future
    Scott L Rauch
    Psychiatric Neuroscience Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Biol Psychiatry 60:376-82. 2006
    ..The recent development of such imaging probes now sets the stage for directly testing hypotheses regarding the neural substrates of fear conditioning and extinction abnormalities in PTSD...
  28. pmc Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States
    J Psychiatr Res 42:515-20. 2008
    ..Furthermore, they support the conclusion that this deficit is acquired as a result of combat trauma leading to PTSD, rather than being a predisposing factor to developing PTSD upon the stress of combat...
  29. doi request reprint A PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Psychiatric Neuroscience Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    Neuropsychopharmacology 34:390-8. 2009
    ..Given the pharmacological profile of tiagabine, these findings suggest that its therapeutic effects in gSAD may be mediated by GABAergic modulation within the vmPFC...
  30. ncbi request reprint Fear extinction in rats: implications for human brain imaging and anxiety disorders
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Bldg 149 13th St, Charlestown, 02129, USA
    Biol Psychol 73:61-71. 2006
    ....
  31. pmc Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:10706-11. 2005
    ..e., greater extinction memory). These results suggest that the size of the vmPFC might explain individual differences in the ability to modulate fear among humans...
  32. doi request reprint Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder
    Sabine Wilhelm
    Obsessive Compulsive Disorder Clinic, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 165:335-41; quiz 409. 2008
    ..This study examined whether d-cycloserine, a partial agonist at the N-methyl-D-aspartate (NMDA) glutamatergic receptor, enhances the efficacy of behavior therapy for obsessive-compulsive disorder (OCD)...
  33. ncbi request reprint Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humans
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Behav Neurosci 120:1196-203. 2006
    ..On Day 2, men and early cycle women expressed greater extinction memory than midcycle women. These data confirm sex differences in conditioned fear acquisition and suggest that midcycle hormones attenuate extinction recall...
  34. ncbi request reprint Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacks
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 23:175-7. 2006
    ..These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression...
  35. ncbi request reprint Ventromedial prefrontal cortex and amygdala dysfunction during an anger induction positron emission tomography study in patients with major depressive disorder with anger attacks
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Arch Gen Psychiatry 61:795-804. 2004
    ....
  36. doi request reprint Altered processing of contextual information during fear extinction in PTSD: an fMRI study
    Ansgar Rougemont-Bücking
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    CNS Neurosci Ther 17:227-36. 2011
    ..This impairment is manifest even prior to a physiologically-measured, cue-elicited fear response, and characterized by hypoactivation in vmPFC and hyperactivation in dACC...
  37. ncbi request reprint Enhanced amygdala responses to emotional versus neutral schematic facial expressions
    Christopher I Wright
    Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroreport 13:785-90. 2002
    ....
  38. doi request reprint Metabolic activity in the insular cortex and hypothalamus predicts hot flashes: an FDG-PET study
    Hadine Joffe
    Center for Women s Mental Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:3207-15. 2012
    ..Previous studies have implicated the insula during the perception of hot flashes and the hypothalamus in thermoregulatory dysfunction...
  39. pmc Role of medial cortical networks for anticipatory processing in obsessive-compulsive disorder
    Kristina T Ciesielski
    Department of Radiology, MGH MIT HMS A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and McLean Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Hum Brain Mapp 33:2125-34. 2012
    ....
  40. ncbi request reprint Neuroimaging-genetic paradigms: a new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophrenia
    Joshua L Roffman
    Harvard Medical School and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, USA
    Harv Rev Psychiatry 14:78-91. 2006
    ..The potential of this approach for improving patient care will depend on its ability to predict outcomes with greater accuracy and sensitivity than current clinical measures...
  41. ncbi request reprint Spontaneous and directed application of verbal learning strategies in bipolar disorder and obsessive-compulsive disorder
    Thilo Deckersbach
    Harvard Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Bipolar Disord 7:166-75. 2005
    ....
  42. pmc Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 7:555-69. 2005
    ..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD...
  43. ncbi request reprint Differential amygdala habituation to neutral faces in young and elderly adults
    Michelle M Wedig
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, 2nd Floor, Charlestown, MA 02129, USA
    Neurosci Lett 385:114-9. 2005
    ..We conclude that, in healthy elderly adults, the amygdala retains its adaptive habituation response, but speculate that intrinsic changes in amygdala anatomy during aging may modulate its laterality...
  44. pmc Sleep promotes generalization of extinction of conditioned fear
    Edward F Pace-Schott
    Harvard Medical School, Department of Psychiatry, Center for Sleep and Cognition, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
    Sleep 32:19-26. 2009
    ..To examine the effects of sleep on fear conditioning, extinction, extinction recall, and generalization of extinction recall in healthy humans...
  45. ncbi request reprint Neuroimaging and the functional neuroanatomy of psychotherapy
    Joshua L Roffman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychol Med 35:1385-98. 2005
    ..This review examines initial attempts to measure directly the effects of psychotherapy on brain function in patients with depression or anxiety disorders...
  46. doi request reprint Auditory stimulus repetition effects on cortical hemoglobin oxygenation: a near-infrared spectroscopy investigation
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Neuroreport 19:161-5. 2008
    ..These findings provide preliminary support for a relationship between the perceptual characteristics of auditory stimuli and modulation of cortical oxygenation as measured via an emerging neuromonitoring technique...
  47. ncbi request reprint D-cycloserine inhibits amygdala responses during repeated presentations of faces
    Jennifer C Britton
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    CNS Spectr 12:600-5. 2007
    ..However, the underlying brain mechanisms mediating this fear reduction have yet to be determined...
  48. ncbi request reprint Orbitofrontal thickness, retention of fear extinction, and extraversion
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroreport 16:1909-12. 2005
    ..Path analysis indicates that extinction retention mediates the relationship between the medial orbitofrontal cortex thickness and extraversion, thereby illustrating one path through which brain structure influences personality...
  49. ncbi request reprint Brain correlates of negative visuospatial priming in healthy children
    Christopher I Wright
    Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 2, Charlestown, MA 02129, USA
    Psychiatry Res 139:41-52. 2005
    ..In conjunction with fMRI, the visuospatial priming task described in the current study may be useful for studying the pathophysiology of childhood-onset neuropsychiatric disorders characterized by deficient inhibitory processing...
  50. ncbi request reprint A magnetic resonance imaging study of cortical thickness in animal phobia
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital East, 2nd Floor, Building 149, 13th Street, Charlestown, MA 02129, USA
    Biol Psychiatry 55:946-52. 2004
    ....
  51. ncbi request reprint Physiologic responses to loud tones in individuals with obsessive-compulsive disorder
    Ulrike Buhlmann
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychosom Med 69:166-72. 2007
    ..To determine if individuals with obsessive-compulsive disorder (OCD) are characterized by larger eyeblink and/or autonomic responses to sudden, loud (startling) tones...
  52. ncbi request reprint A study of parallel implicit and explicit information processing in patients with obsessive-compulsive disorder
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital East, Building 149, 13th Street, 9th Floor, Charlestown, MA 02129, USA
    Am J Psychiatry 159:1780-2. 2002
    ..Neuroimaging data suggest that during implicit learning, OCD patients use neural systems normally active during explicit learning to compensate for striatal dysfunction...
  53. doi request reprint Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Trends Cogn Sci 16:43-51. 2012
    ....
  54. pmc Mindfulness-based cognitive therapy for nonremitted patients with bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    CNS Neurosci Ther 18:133-41. 2012
    ..Despite periods of symptomatic recovery, many individuals with bipolar disorder continue to experience substantial residual mood symptoms that often lead to the recurrence of mood episodes...
  55. ncbi request reprint Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortex
    Christopher I Wright
    Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroimage 18:660-9. 2003
    ....
  56. ncbi request reprint Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies
    Paul A Cannistraro
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    Psychopharmacol Bull 37:8-25. 2003
    ..A brief review of specific findings from neuroimaging studies of posttraumatic stress disorder, specific phobia, social phobia, obsessive-compulsive disorder, and generalized anxiety disorder is also provided...
  57. ncbi request reprint Neurocircuitry of anxiety disorders
    Justine M Kent
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 41 NYSPI, New York, NY 10032, USA
    Curr Psychiatry Rep 5:266-73. 2003
    ..Herewith, the authors review neuroimaging findings contributing to the development and refinement of neuroanatomic models for post-traumatic stress disorder, panic disorder, and social anxiety disorder...
  58. ncbi request reprint Brain correlates of negative and positive visuospatial priming in adults
    Christopher I Wright
    Psychiatric Neuroimaging Research Program and Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 30:983-91. 2006
    ..In conjunction with functional MRI, this visuospatial priming task may be useful for studying the pathophysiology of neuropsychiatric disorders in which deficient inhibitory processing or excessive facilitation is a feature...
  59. ncbi request reprint Using neuroimaging to predict treatment response in mood and anxiety disorders
    Karleyton C Evans
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Ann Clin Psychiatry 18:33-42. 2006
    ..Given the variance in patient responses to psychiatric treatments, the use of such predictive tools could be tremendously valuable, especially in situations where treatments carry substantial risks or costs...
  60. ncbi request reprint Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression
    Darin D Dougherty
    Department of Psychiatry, Radiology, Neurosurgery, and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurosurg 99:1010-7. 2003
    ..The purpose of this study was to identify possible neuroimaging predictors of treatment response to anterior cingulotomy in patients with major depression...
  61. doi request reprint Deficits in conditioned fear extinction in obsessive-compulsive disorder and neurobiological changes in the fear circuit
    Mohammed R Milad
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Charlestown 02129, USA
    JAMA Psychiatry 70:608-18; quiz 554. 2013
    ..Elevated fear and anxiety are common characteristics of this disorder. The neurobiology of fear regulation and consolidation of safety memories have not been examined in this patient population...
  62. ncbi request reprint Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosa
    Karen K Miller
    Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457B, Boston, MA 02114, USA
    Psychiatry Res 132:197-207. 2004
    ..Further study is warranted to replicate these findings, as well as to determine their physiological and clinical significance...
  63. ncbi request reprint Brain correlates of antidepressant treatment outcome from neuroimaging studies in depression
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 30:91-103. 2007
    ....
  64. ncbi request reprint Somatic therapies for treatment-resistant depression: new neurotherapeutic interventions
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
    Psychiatr Clin North Am 30:31-7. 2007
    ..Although the future of neurotherapeutic interventions in psychiatry is hard to predict, it is clear that these treatments will have a growing role in the field...
  65. ncbi request reprint Neuroimaging studies of amygdala function in anxiety disorders
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Ann N Y Acad Sci 985:389-410. 2003
    ..We conclude that such tools hold great promise for facilitating progress in relevant basic neuroscience as well as clinical research domains...
  66. ncbi request reprint Near-infrared spectroscopy and imaging for investigating stroke rehabilitation: test-retest reliability and review of the literature
    Gary Strangman
    Division of Psychiatric Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Arch Phys Med Rehabil 87:S12-9. 2006
    ..To review the use of near-infrared spectroscopy (NIRS) in stroke rehabilitation and to evaluate NIRS test-retest reliability within-session on a motor control task commonly used in neuroimaging of stroke recovery...
  67. ncbi request reprint Context modulation of memory for fear extinction in humans
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Psychophysiology 42:456-64. 2005
    ..This finding demonstrates context dependency of extinction recall in humans...
  68. ncbi request reprint MRI-based surface-assisted parcellation of human cerebellar cortex: an anatomically specified method with estimate of reliability
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 25:1146-60. 2005
    ..933. Whereas the individual units provide a high level of detail and anatomical specificity, the clusters add flexibility to the analysis by providing higher reliability...
  69. ncbi request reprint Functional imaging of mood and anxiety disorders
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neuroimaging 16:1-10. 2006
    ..We review functional neuroimaging findings pertaining to mood disorders (major depression, bipolar disorders) as well as selected anxiety disorders (posttraumatic stress disorder [PTSD] and obsessive-compulsive disorder [OCD])...
  70. ncbi request reprint Inhibited and uninhibited infants "grown up": adult amygdalar response to novelty
    Carl E Schwartz
    Developmental Psychopathology Research Group, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, 13th Street, Building 149, CNY 9, Charlestown, MA 02129, USA
    Science 300:1952-3. 2003
    ....
  71. pmc Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:15700-5. 2005
    ..These results show that accurate performance involves deactivation of the rACC and other default mode regions and suggest that both rACC and dACC contribute to the evaluation of error responses...
  72. pmc Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
    Am J Psychiatry 166:702-10. 2009
    ....
  73. ncbi request reprint Temperament and its implications for neuroimaging of anxiety disorders
    Carl E Schwartz
    Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School, Boston, 02129, USA
    CNS Spectr 9:284-91. 2004
    ..Longitudinal studies are a unique tool for understanding the developmental and temperamental risk factors for psychiatric disorder...
  74. ncbi request reprint Neuroimaging and attention-deficit/hyperactivity disorder in the 21st century: what to consider and how to proceed
    Scott L Rauch
    Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 USA
    Biol Psychiatry 57:1261-2. 2005
  75. pmc Anxiety sensitivity correlates with two indices of right anterior insula structure in specific animal phobia
    Isabelle M Rosso
    Neuroimaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Depress Anxiety 27:1104-10. 2010
    ..We examined whether AS was significantly correlated with right anterior insula volume and thickness among adults with specific animal phobia (SAP) and healthy comparison (HC) subjects...
  76. pmc Neural correlates of anxiety sensitivity during masked presentation of affective faces
    William D S Killgore
    Affective Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts
    Depress Anxiety 28:243-9. 2011
    ..We hypothesized that insular responses to fear-related stimuli would be primarily related to the Physical Concerns subscale of the ASI, particularly for a sample of subjects with specific phobias...
  77. ncbi request reprint Neural and endocrine correlates of sadness in women: implications for neural network regulation of HPA activity
    William E Ottowitz
    Department of Nuclear Medicine, St Elizabeth s Hospital, Boston Massachusetts, USA
    J Neuropsychiatry Clin Neurosci 16:446-55. 2004
    ..Dysfunction of these sites may contribute to the cortisol dysregulation observed in some subjects with major depression...
  78. pmc Meditation experience is associated with increased cortical thickness
    Sara W Lazar
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Neuroreport 16:1893-7. 2005
    ..Finally, the thickness of two regions correlated with meditation experience. These data provide the first structural evidence for experience-dependent cortical plasticity associated with meditation practice...
  79. ncbi request reprint Stereotactic cingulotomy
    G Rees Cosgrove
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, ACC Suite 331, Boston, MA, USA
    Neurosurg Clin N Am 14:225-35. 2003
    ..Many patients are greatly improved after cingulotomy, and the complications or side effects are few. Cingulotomy remains an important therapeutic option for disabling psychiatric disease and is probably underutilized...
  80. ncbi request reprint Episodic memory impairment in bipolar disorder and obsessive-compulsive disorder: the role of memory strategies
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Bipolar Disord 6:233-44. 2004
    ....
  81. ncbi request reprint A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 139th Street, 9th Floor, Charlestown, MA 02129, USA
    Psychiatry Res 122:13-9. 2003
    ..the comparison group. Findings with respect to the caudate nucleus are consistent with both the conceptualization of BDD as an obsessive-compulsive spectrum disorder, and the 'striatal topography model' of obsessive-compulsive disorders...
  82. ncbi request reprint Cognitive retraining for organizational impairment in obsessive-compulsive disorder
    Ulrike Buhlmann
    Department of Psychiatry OCD Clinic, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Psychiatry Res 144:109-16. 2006
    ..These findings support a distinction in OCD between failure to utilize a strategy and incapacity to implement a strategy...
  83. ncbi request reprint Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuropsychopharmacology 27:782-91. 2002
    ..Finally, this pattern is sufficiently robust as to be relatively independent of symptomatic state at the time of tracer uptake...
  84. ncbi request reprint Neuroimaging and neurocircuitry models pertaining to the neurosurgical treatment of psychiatric disorders
    Scott L Rauch
    Psychiatric Neuroscience Program, Massachusetts General Hospital East, Bldg 149, 13th Street, Room 9130, Charlestown, MA 02129, USA
    Neurosurg Clin N Am 14:213-23, vii-viii. 2003
    ..The neuroanatomy of psychiatric neurosurgical procedures and related neuroimaging findings are reviewed. Finally, anticipated future directions of research in this field are discussed...
  85. ncbi request reprint The counting Stroop: a cognitive interference task
    George Bush
    Psychiatric Neuroscience Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Protoc 1:230-3. 2006
    ....
  86. pmc Amygdala and fusiform gyrus temporal dynamics: responses to negative facial expressions
    Jennifer C Britton
    Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    BMC Neurosci 9:44. 2008
    ..Percent signal changes within anatomic regions-of-interest (amygdala and fusiform gyrus) were calculated to examine the temporal dynamics of neural response and any response differences based on face type...
  87. ncbi request reprint The role of the orbitofrontal cortex in anxiety disorders
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 1121:546-61. 2007
    ..We will also review the role of the OFC in fear extinction and the implications of this role to the pathophysiology of anxiety disorders...
  88. ncbi request reprint Magnetic resonance imaging-guided stereotactic limbic leukotomy for treatment of intractable psychiatric disease
    Alonso Montoya
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neurosurgery 50:1043-9; discussion 1049-52. 2002
    ..To assess the efficacy and complication rates of magnetic resonance imaging-guided stereotactic limbic leukotomy for the treatment of intractable major depressive disorder (MDD) and obsessive-compulsive disorder (OCD)...
  89. ncbi request reprint A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, Mass, USA
    Arch Gen Psychiatry 62:273-81. 2005
    ..Previous functional neuroimaging studies have demonstrated exaggerated amygdala responses and diminished medial prefrontal cortex responses during the symptomatic state in posttraumatic stress disorder (PTSD)...
  90. ncbi request reprint Hippocampal function in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Hippocampus 14:292-300. 2004
    ....
  91. pmc Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biol Psychiatry 63:550-6. 2008
    ..We employed a case-control design in monozygotic twin pairs discordant for combat exposure to address the preexisting versus acquired origin of brain morphometric abnormalities in PTSD...
  92. ncbi request reprint Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder
    Jean A Frazier
    Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Am J Psychiatry 162:1256-65. 2005
    ..On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities...
  93. ncbi request reprint Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Arch Gen Psychiatry 61:168-76. 2004
    ..However, the functional relationship between these brain regions in PTSD has not been directly examined...
  94. ncbi request reprint Strategic memory in adults with anorexia nervosa: are there similarities to obsessive compulsive spectrum disorders?
    Bonnie J Sherman
    Center for Excellence in Women s Health, Boston University Medical Center, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Eat Disord 39:468-76. 2006
    ..This study evaluated nonverbal strategic memory in AN outpatients using an approach previously applied to OC spectrum disorders...
  95. pmc Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 160:83-93. 2008
    ..The results support investigation of this multidimensional model in OCD genetic linkage studies...
  96. ncbi request reprint Functional magnetic resonance imaging evidence for a lack of striatal dysfunction during implicit sequence learning in individuals with animal phobia
    Brian Martis
    Massachusetts General Hospital, Harvard Medical School, USA
    Am J Psychiatry 161:67-71. 2004
    ..This study investigated the neural substrates of implicit sequence learning in subjects with and without small animal phobia, in a follow-up to analogous studies of obsessive-compulsive disorder (OCD)...