Research Topics
| Scott L RauchSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Selectively reduced regional cortical volumes in post-traumatic stress disorderScott L Rauch
Psychiatric Neuroimaging Research Group, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
Neuroreport 14:913-6. 2003..These results are consistent with contemporary schemes regarding functional and structural dissection of frontal cortex, and suggest specific regional cortical pathology in PTSD...- A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorderKarleyton C Evans
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Depress Anxiety 25:496-505. 2008..However, extending earlier findings in healthy subjects, schematic faces appear more effective for probing amygdala responses to arousal-based (Angry versus Neutral) as opposed to valence-based (Angry versus Happy) contrasts... 
Neurophysiological alterations during strategy-based verbal learning in traumatic brain injuryGARY E STRANGMAN
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
Neurorehabil Neural Repair 23:226-36. 2009..Verbal learning and strategic processing deficits are common sequelae of traumatic brain injury (TBI); however, the neurophysiological mechanisms underlying such deficits remain poorly understood...- Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophreniaDaphne J Holt
Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
Schizophr Res 82:153-62. 2006..Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition... 
Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorderMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 66:1075-82. 2009..amygdala, hippocampus, ventromedial prefrontal cortex (vmPFC), and dorsal anterior cingulate cortex (dACC)...- Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigmJennifer C Britton
Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Depress Anxiety 26:796-805. 2009..Emotional interference tasks may be useful in probing anterior cingulate cortex (ACC) function to understand abnormal attentional study in individuals with specific phobia... - Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concertMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 62:446-54. 2007..The aim of the present study is to investigate the mediating anatomy of extinction recall in healthy humans... - An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief reportThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, 2nd Floor, Charlestown, MA 02129, USA
Bipolar Disord 10:928-42. 2008..The purpose of the present study was to investigate with fMRI the interaction between acute sadness and working memory functioning in individuals with bipolar disorder... - Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorderThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 59:138-46. 2006..The most consistently reported cognitive difficulty in euthymic subjects with bipolar disorder is impairment in verbal episodic memory (i.e., the ability to learn new verbal information)... - Novel fearful faces activate the amygdala in healthy young and elderly adultsChristopher I Wright
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, 13th St, Bldg 149, CNY 2613, Charlestown, MA 02129, USA
Neurobiol Aging 27:361-74. 2006..However, there were significantly greater activations in the inferior temporal cortex in the young versus elderly subjects... - Brain activation during implicit sequence learning in individuals with trichotillomaniaScott L Rauch
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Psychiatry Res 154:233-40. 2007..Future studies directly comparing OCD and TTM subjects are warranted to confirm the specificity of abnormal striatal and hippocampal findings during implicit sequence learning in OCD... - Evidence for reduced cerebellar volumes in trichotillomaniaNancy J Keuthen
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 61:374-81. 2007..Limited knowledge exists regarding the neurobiology of trichotillomania (TTM). Cerebellum (CBM) volumes were explored, given its role in complex, coordinated motor sequences... - A diffusion tensor imaging study of white matter in obsessive-compulsive disorderPaul A Cannistraro
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Depress Anxiety 24:440-6. 2007..This could explain why surgically severing these tracts is therapeutic. Additional studies are needed to replicate these findings and to clarify their pathological and clinical significance... - A role for the human dorsal anterior cingulate cortex in fear expressionMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 62:1191-4. 2007..This study examined the role of dACC during fear conditioning in healthy humans with magnetic resonance imaging (MRI)... - Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophreniaFrida E Polli
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Brain 131:971-86. 2008..Impairments in evaluating and learning from errors in schizophrenia may contribute to behaviour that is rigid and perseverative rather than optimally guided by outcomes, and may compromise performance across a wide range of tasks... - Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorderScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 61:330-6. 2007..Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions... - Hemispheric differences in amygdala contributions to response monitoringFrida E Polli
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neuroreport 20:398-402. 2009.... - Amygdala responses to human faces in obsessive-compulsive disorderPaul A Cannistraro
Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital, Building 149, Thirteenth Street, Charlestown, MA 02129, USA
Biol Psychiatry 56:916-20. 2004..Therefore, the present findings are consistent with abnormal amygdala function in OCD and are of a character that may distinguish OCD from other anxiety disorders... - Amygdala and insular responses to emotionally valenced human faces in small animal specific phobiaChristopher I Wright
Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 54:1067-76. 2003..g., posttraumatic stress disorder). This suggests a restricted role for the amygdala in specific phobia. The insular hyperresponsivity to fearful versus neutral faces in the subjects with specific phobias warrants further study... - Prediction of memory rehabilitation outcomes in traumatic brain injury by using functional magnetic resonance imagingGARY E STRANGMAN
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
Arch Phys Med Rehabil 89:974-81. 2008..To evaluate the ability of functional magnetic resonance imaging (fMRI) measures collected from people with traumatic brain injury (TBI) to provide predictive value for rehabilitation outcomes over and above standard predictors... - The misattribution of salience in delusional patients with schizophreniaDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, United States
Schizophr Res 83:247-56. 2006..In this study, we tested the hypothesis that delusional schizophrenia patients are more likely than non-delusional schizophrenia patients and healthy participants to assign affective meanings to neutral stimuli... - A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorderScott L Rauch
Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosurg 104:558-65. 2006..The purpose of the current study was to test hypotheses regarding changes in regional cerebral blood flow (rCBF) during acute DBS at the VC/VS target in patients with OCD who were participating in a clinical DBS trial... - Regional cerebral brain metabolism correlates of neuroticism and extraversionThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital, Boston, USA
Depress Anxiety 23:133-8. 2006..No significant correlations were found involving anterior cingulate, amygdala, or ventral striatum. Neuroticism and Extraversion are associated with activity in insular cortex and orbitofrontal cortex, respectively... - Sustained activation of the hippocampus in response to fearful faces in schizophreniaDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 57:1011-9. 2005..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that habituation of the medial temporal lobe is reduced in schizophrenia... - Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and futureScott L Rauch
Psychiatric Neuroscience Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
Biol Psychiatry 60:376-82. 2006..The recent development of such imaging probes now sets the stage for directly testing hypotheses regarding the neural substrates of fear conditioning and extinction abnormalities in PTSD... - RESEARCH: Cognitive rehabilitation for bipolar disorder: An open trial for employed patients with residual depressive symptomsThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital, Boston, USA
CNS Neurosci Ther 16:298-307. 2010..These findings suggest that treating residual depressive symptoms and cognitive impairment may be an avenue to improving occupational and overall functioning in individuals with bipolar disorder... - Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin studyMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States
J Psychiatr Res 42:515-20. 2008..Furthermore, they support the conclusion that this deficit is acquired as a result of combat trauma leading to PTSD, rather than being a predisposing factor to developing PTSD upon the stress of combat... - Dysfunction of a cortical midline network during emotional appraisals in schizophreniaDaphne J Holt
Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA, USA
Schizophr Bull 37:164-76. 2011..These findings suggest that impaired functioning of cortical midline structures in schizophrenia may underlie faulty interpretations of social events, contributing to delusion formation... - Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorderSabine Wilhelm
Obsessive Compulsive Disorder Clinic, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 165:335-41; quiz 409. 2008..This study examined whether d-cycloserine, a partial agonist at the N-methyl-D-aspartate (NMDA) glutamatergic receptor, enhances the efficacy of behavior therapy for obsessive-compulsive disorder (OCD)... - Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memoryMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:10706-11. 2005..e., greater extinction memory). These results suggest that the size of the vmPFC might explain individual differences in the ability to modulate fear among humans... - Fear extinction in rats: implications for human brain imaging and anxiety disordersMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Bldg 149 13th St, Charlestown, 02129, USA
Biol Psychol 73:61-71. 2006.... - Altered processing of contextual information during fear extinction in PTSD: an fMRI studyAnsgar Rougemont-Bücking
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
CNS Neurosci Ther 17:227-36. 2011..This impairment is manifest even prior to a physiologically-measured, cue-elicited fear response, and characterized by hypoactivation in vmPFC and hyperactivation in dACC... - Decreased striatal D1 binding as measured using PET and [11C]SCH 23,390 in patients with major depression with anger attacksDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, Boston, USA
Depress Anxiety 23:175-7. 2006..These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression... - A PET study of tiagabine treatment implicates ventral medial prefrontal cortex in generalized social anxiety disorderKarleyton C Evans
Department of Psychiatry, Psychiatric Neuroscience Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
Neuropsychopharmacology 34:390-8. 2009..Given the pharmacological profile of tiagabine, these findings suggest that its therapeutic effects in gSAD may be mediated by GABAergic modulation within the vmPFC... - Ventromedial prefrontal cortex and amygdala dysfunction during an anger induction positron emission tomography study in patients with major depressive disorder with anger attacksDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Arch Gen Psychiatry 61:795-804. 2004.... - Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humansMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Behav Neurosci 120:1196-203. 2006..On Day 2, men and early cycle women expressed greater extinction memory than midcycle women. These data confirm sex differences in conditioned fear acquisition and suggest that midcycle hormones attenuate extinction recall... - Enhanced amygdala responses to emotional versus neutral schematic facial expressionsChristopher I Wright
Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY-9, Charlestown, MA 02129, USA
Neuroreport 13:785-90. 2002.... - Role of medial cortical networks for anticipatory processing in obsessive-compulsive disorderKristina T Ciesielski
Department of Radiology, MGH MIT HMS A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital and McLean Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
Hum Brain Mapp 33:2125-34. 2012.... - Metabolic activity in the insular cortex and hypothalamus predicts hot flashes: an FDG-PET studyHadine Joffe
Center for Women s Mental Health, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts 02114, USA
J Clin Endocrinol Metab 97:3207-15. 2012..Previous studies have implicated the insula during the perception of hot flashes and the hypothalamus in thermoregulatory dysfunction... - Neuroimaging-genetic paradigms: a new approach to investigate the pathophysiology and treatment of cognitive deficits in schizophreniaJoshua L Roffman
Harvard Medical School and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, USA
Harv Rev Psychiatry 14:78-91. 2006..The potential of this approach for improving patient care will depend on its ability to predict outcomes with greater accuracy and sensitivity than current clinical measures... - Sleep promotes generalization of extinction of conditioned fearEdward F Pace-Schott
Harvard Medical School, Department of Psychiatry, Center for Sleep and Cognition, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
Sleep 32:19-26. 2009..To examine the effects of sleep on fear conditioning, extinction, extinction recall, and generalization of extinction recall in healthy humans... - Spontaneous and directed application of verbal learning strategies in bipolar disorder and obsessive-compulsive disorderThilo Deckersbach
Harvard Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Bipolar Disord 7:166-75. 2005.... - Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorderJean A Frazier
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Bipolar Disord 7:555-69. 2005..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD... - Differential amygdala habituation to neutral faces in young and elderly adultsMichelle M Wedig
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, 2nd Floor, Charlestown, MA 02129, USA
Neurosci Lett 385:114-9. 2005..We conclude that, in healthy elderly adults, the amygdala retains its adaptive habituation response, but speculate that intrinsic changes in amygdala anatomy during aging may modulate its laterality... - D-cycloserine inhibits amygdala responses during repeated presentations of facesJennifer C Britton
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
CNS Spectr 12:600-5. 2007..However, the underlying brain mechanisms mediating this fear reduction have yet to be determined... - Orbitofrontal thickness, retention of fear extinction, and extraversionScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Neuroreport 16:1909-12. 2005..Path analysis indicates that extinction retention mediates the relationship between the medial orbitofrontal cortex thickness and extraversion, thereby illustrating one path through which brain structure influences personality... - Auditory stimulus repetition effects on cortical hemoglobin oxygenation: a near-infrared spectroscopy investigationAnthony P Weiss
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Neuroreport 19:161-5. 2008..These findings provide preliminary support for a relationship between the perceptual characteristics of auditory stimuli and modulation of cortical oxygenation as measured via an emerging neuromonitoring technique... - Neuroimaging and the functional neuroanatomy of psychotherapyJoshua L Roffman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Psychol Med 35:1385-98. 2005..This review examines initial attempts to measure directly the effects of psychotherapy on brain function in patients with depression or anxiety disorders... - Brain correlates of negative visuospatial priming in healthy childrenChristopher I Wright
Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 2, Charlestown, MA 02129, USA
Psychiatry Res 139:41-52. 2005..In conjunction with fMRI, the visuospatial priming task described in the current study may be useful for studying the pathophysiology of childhood-onset neuropsychiatric disorders characterized by deficient inhibitory processing... - Physiologic responses to loud tones in individuals with obsessive-compulsive disorderUlrike Buhlmann
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Psychosom Med 69:166-72. 2007..To determine if individuals with obsessive-compulsive disorder (OCD) are characterized by larger eyeblink and/or autonomic responses to sudden, loud (startling) tones... - A magnetic resonance imaging study of cortical thickness in animal phobiaScott L Rauch
Department of Psychiatry, Massachusetts General Hospital-East, 2nd Floor, Building 149, 13th Street, Charlestown, MA 02129, USA
Biol Psychiatry 55:946-52. 2004..Further research will be necessary to replicate these findings and to determine their specificity as well as their pathophysiologic significance... - A study of parallel implicit and explicit information processing in patients with obsessive-compulsive disorderThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital-East, Building 149, 13th Street, 9th Floor, Charlestown, MA 02129, USA
Am J Psychiatry 159:1780-2. 2002..CONCLUSIONS: These results are consistent with the hypothesis that concurrent explicit and implicit information-processing demands interfere with implicit learning in OCD patients... - Mindfulness-based cognitive therapy for nonremitted patients with bipolar disorderThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
CNS Neurosci Ther 18:133-41. 2012..Despite periods of symptomatic recovery, many individuals with bipolar disorder continue to experience substantial residual mood symptoms that often lead to the recurrence of mood episodes... - Obsessive-compulsive disorder: beyond segregated cortico-striatal pathwaysMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Trends Cogn Sci 16:43-51. 2012.... - Brain correlates of negative and positive visuospatial priming in adultsChristopher I Wright
Psychiatric Neuroimaging Research Program and Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 30:983-91. 2006..In conjunction with functional MRI, this visuospatial priming task may be useful for studying the pathophysiology of neuropsychiatric disorders in which deficient inhibitory processing or excessive facilitation is a feature... - Neural circuitry of anxiety: evidence from structural and functional neuroimaging studiesPaul A Cannistraro
Massachusetts General Hospital, Charlestown, MA 02129, USA
Psychopharmacol Bull 37:8-25. 2003..A brief review of specific findings from neuroimaging studies of posttraumatic stress disorder, specific phobia, social phobia, obsessive-compulsive disorder, and generalized anxiety disorder is also provided... - Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortexChristopher I Wright
Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
Neuroimage 18:660-9. 2003.... - Neurocircuitry of anxiety disordersJustine M Kent
Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 41 NYSPI, New York, NY 10032, USA
Curr Psychiatry Rep 5:266-73. 2003..Herewith, the authors review neuroimaging findings contributing to the development and refinement of neuroanatomic models for post-traumatic stress disorder, panic disorder, and social anxiety disorder... - Using neuroimaging to predict treatment response in mood and anxiety disordersKarleyton C Evans
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Ann Clin Psychiatry 18:33-42. 2006..However, the actual clinical utility of such tests remains to be shown... - Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depressionDarin D Dougherty
Department of Psychiatry, Radiology, Neurosurgery, and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
J Neurosurg 99:1010-7. 2003..If confirmed, the availability of an index for noninvasively predicting a patient's response to cingulotomy for the treatment of major depression would be of great clinical value... - Inhibited and uninhibited infants "grown up": adult amygdalar response to noveltyCarl E Schwartz
Developmental Psychopathology Research Group, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, 13th Street, Building 149, CNY 9, Charlestown, MA 02129, USA
Science 300:1952-3. 2003.... - Neuroimaging studies of amygdala function in anxiety disordersScott L Rauch
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
Ann N Y Acad Sci 985:389-410. 2003..We conclude that such tools hold great promise for facilitating progress in relevant basic neuroscience as well as clinical research domains... - Functional imaging of mood and anxiety disordersThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neuroimaging 16:1-10. 2006..We review functional neuroimaging findings pertaining to mood disorders (major depression, bipolar disorders) as well as selected anxiety disorders (posttraumatic stress disorder [PTSD] and obsessive-compulsive disorder [OCD])... - Brain correlates of antidepressant treatment outcome from neuroimaging studies in depressionDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
Psychiatr Clin North Am 30:91-103. 2007.... - Somatic therapies for treatment-resistant depression: new neurotherapeutic interventionsDarin D Dougherty
Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA
Psychiatr Clin North Am 30:31-7. 2007..Although the future of neurotherapeutic interventions in psychiatry is hard to predict, it is clear that these treatments will have a growing role in the field... - Context modulation of memory for fear extinction in humansMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Psychophysiology 42:456-64. 2005..This finding demonstrates context dependency of extinction recall in humans... - MRI-based surface-assisted parcellation of human cerebellar cortex: an anatomically specified method with estimate of reliabilityNikos Makris
Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 25:1146-60. 2005..933. Whereas the individual units provide a high level of detail and anatomical specificity, the clusters add flexibility to the analysis by providing higher reliability... - Testosterone administration attenuates regional brain hypometabolism in women with anorexia nervosaKaren K Miller
Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, BUL 457B, Boston, MA 02114, USA
Psychiatry Res 132:197-207. 2004..Further study is warranted to replicate these findings, as well as to determine their physiological and clinical significance... - Near-infrared spectroscopy and imaging for investigating stroke rehabilitation: test-retest reliability and review of the literatureGary Strangman
Division of Psychiatric Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Arch Phys Med Rehabil 87:S12-9. 2006..To review the use of near-infrared spectroscopy (NIRS) in stroke rehabilitation and to evaluate NIRS test-retest reliability within-session on a motor control task commonly used in neuroimaging of stroke recovery... - Neuroimaging and neurocircuitry models pertaining to the neurosurgical treatment of psychiatric disordersScott L Rauch
Psychiatric Neuroscience Program, Massachusetts General Hospital East, Bldg 149, 13th Street, Room 9130, Charlestown, MA 02129, USA
Neurosurg Clin N Am 14:213-23, vii-viii. 2003..The neuroanatomy of psychiatric neurosurgical procedures and related neuroimaging findings are reviewed. Finally, anticipated future directions of research in this field are discussed... - Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorderDiego A Pizzagalli
Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
Am J Psychiatry 166:702-10. 2009.... - Neuroimaging and attention-deficit/hyperactivity disorder in the 21st century: what to consider and how to proceedScott L Rauch
Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129. USA
Biol Psychiatry 57:1261-2. 2005 - Neural and endocrine correlates of sadness in women: implications for neural network regulation of HPA activityWilliam E Ottowitz
Department of Nuclear Medicine, St Elizabeth s Hospital, Boston Massachusetts, USA
J Neuropsychiatry Clin Neurosci 16:446-55. 2004..Dysfunction of these sites may contribute to the cortisol dysregulation observed in some subjects with major depression... - Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation studyScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuropsychopharmacology 27:782-91. 2002..Finally, this pattern is sufficiently robust as to be relatively independent of symptomatic state at the time of tracer uptake... - Anxiety sensitivity correlates with two indices of right anterior insula structure in specific animal phobiaIsabelle M Rosso
Neuroimaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
Depress Anxiety 27:1104-10. 2010..We examined whether AS was significantly correlated with right anterior insula volume and thickness among adults with specific animal phobia (SAP) and healthy comparison (HC) subjects... - Neural correlates of anxiety sensitivity during masked presentation of affective facesWilliam D S Killgore
Affective Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts
Depress Anxiety 28:243-9. 2011..We hypothesized that insular responses to fear-related stimuli would be primarily related to the Physical Concerns subscale of the ASI, particularly for a sample of subjects with specific phobias... - Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commissionFrida E Polli
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
Proc Natl Acad Sci U S A 102:15700-5. 2005..These results show that accurate performance involves deactivation of the rACC and other default mode regions and suggest that both rACC and dACC contribute to the evaluation of error responses... - Meditation experience is associated with increased cortical thicknessSara W Lazar
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA
Neuroreport 16:1893-7. 2005..Finally, the thickness of two regions correlated with meditation experience. These data provide the first structural evidence for experience-dependent cortical plasticity associated with meditation practice... - Cognitive retraining for organizational impairment in obsessive-compulsive disorderUlrike Buhlmann
Department of Psychiatry OCD Clinic, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
Psychiatry Res 144:109-16. 2006..These findings support a distinction in OCD between failure to utilize a strategy and incapacity to implement a strategy... - Stereotactic cingulotomyG Rees Cosgrove
Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, ACC Suite 331, Boston, MA, USA
Neurosurg Clin N Am 14:225-35. 2003..Many patients are greatly improved after cingulotomy, and the complications or side effects are few. Cingulotomy remains an important therapeutic option for disabling psychiatric disease and is probably underutilized... - A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorderScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 139th Street, 9th Floor, Charlestown, MA 02129, USA
Psychiatry Res 122:13-9. 2003..the comparison group. Findings with respect to the caudate nucleus are consistent with both the conceptualization of BDD as an obsessive-compulsive spectrum disorder, and the 'striatal topography model' of obsessive-compulsive disorders... - The counting Stroop: a cognitive interference taskGeorge Bush
Psychiatric Neuroscience Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Nat Protoc 1:230-3. 2006.... - The role of the orbitofrontal cortex in anxiety disordersMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Ann N Y Acad Sci 1121:546-61. 2007..We will also review the role of the OFC in fear extinction and the implications of this role to the pathophysiology of anxiety disorders... - Episodic memory impairment in bipolar disorder and obsessive-compulsive disorder: the role of memory strategiesThilo Deckersbach
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Bipolar Disord 6:233-44. 2004.... - Temperament and its implications for neuroimaging of anxiety disordersCarl E Schwartz
Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School, Boston, 02129, USA
CNS Spectr 9:284-91. 2004..Longitudinal studies are a unique tool for understanding the developmental and temperamental risk factors for psychiatric disorder... - Amygdala and fusiform gyrus temporal dynamics: responses to negative facial expressionsJennifer C Britton
Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
BMC Neurosci 9:44. 2008..Percent signal changes within anatomic regions-of-interest (amygdala and fusiform gyrus) were calculated to examine the temporal dynamics of neural response and any response differences based on face type... - Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categoriesAnthony Pinto
Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
Psychiatry Res 160:83-93. 2008..The results support investigation of this multidimensional model in OCD genetic linkage studies... - Hippocampal function in posttraumatic stress disorderLisa M Shin
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
Hippocampus 14:292-300. 2004.... - Magnetic resonance imaging-guided stereotactic limbic leukotomy for treatment of intractable psychiatric diseaseAlonso Montoya
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Neurosurgery 50:1043-9; discussion 1049-52. 2002..Adverse consequences associated with the procedure included affective, cognitive, and visceromotor sequelae, which were generally transient... - Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSDLisa M Shin
Department of Psychology, Tufts University, Medford, MA 02155, USA
Arch Gen Psychiatry 61:168-76. 2004..However, the functional relationship between these brain regions in PTSD has not been directly examined... - Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorderKiyoto Kasai
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Biol Psychiatry 63:550-6. 2008..We employed a case-control design in monozygotic twin pairs discordant for combat exposure to address the preexisting versus acquired origin of brain morphometric abnormalities in PTSD... - A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorderLisa M Shin
Department of Psychology, Tufts University, Medford, Mass, USA
Arch Gen Psychiatry 62:273-81. 2005.... - Strategic memory in adults with anorexia nervosa: are there similarities to obsessive compulsive spectrum disorders?Bonnie J Sherman
Center for Excellence in Women s Health, Boston University Medical Center, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Eat Disord 39:468-76. 2006..This study evaluated nonverbal strategic memory in AN outpatients using an approach previously applied to OC spectrum disorders... - Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorderJean A Frazier
Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
Am J Psychiatry 162:1256-65. 2005..On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities... - Functional magnetic resonance imaging evidence for a lack of striatal dysfunction during implicit sequence learning in individuals with animal phobiaBrian Martis
Massachusetts General Hospital, Harvard Medical School, USA
Am J Psychiatry 161:67-71. 2004..This approach offers promise for demonstrating diagnostic specificity across different neuropsychiatric disorders based on the presence or absence of deficient striatal activation...