S L Rauch

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 139th Street, 9th Floor, Charlestown, MA 02129, USA
    Psychiatry Res 122:13-9. 2003
  2. ncbi request reprint Volume reduction in the caudate nucleus following stereotactic placement of lesions in the anterior cingulate cortex in humans: a morphometric magnetic resonance imaging study
    S L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurosurg 93:1019-25. 2000
  3. ncbi request reprint Orbitofrontal thickness, retention of fear extinction, and extraversion
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroreport 16:1909-12. 2005
  4. ncbi request reprint Neural activation during sexual and competitive arousal in healthy men
    S L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Psychiatry Res 91:1-10. 1999
  5. ncbi request reprint Neuroimaging studies of amygdala function in anxiety disorders
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Ann N Y Acad Sci 985:389-410. 2003
  6. ncbi request reprint Striatal recruitment during an implicit sequence learning task as measured by functional magnetic resonance imaging
    S L Rauch
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Hum Brain Mapp 5:124-32. 1997
  7. ncbi request reprint A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder
    Scott L Rauch
    Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosurg 104:558-65. 2006
  8. ncbi request reprint Neuroimaging and neurocircuitry models pertaining to the neurosurgical treatment of psychiatric disorders
    Scott L Rauch
    Psychiatric Neuroscience Program, Massachusetts General Hospital East, Bldg 149, 13th Street, Room 9130, Charlestown, MA 02129, USA
    Neurosurg Clin N Am 14:213-23, vii-viii. 2003
  9. ncbi request reprint Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 61:330-6. 2007
  10. ncbi request reprint Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuropsychopharmacology 27:782-91. 2002

Detail Information

Publications97

  1. ncbi request reprint A preliminary morphometric magnetic resonance imaging study of regional brain volumes in body dysmorphic disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 139th Street, 9th Floor, Charlestown, MA 02129, USA
    Psychiatry Res 122:13-9. 2003
    ..the comparison group. Findings with respect to the caudate nucleus are consistent with both the conceptualization of BDD as an obsessive-compulsive spectrum disorder, and the 'striatal topography model' of obsessive-compulsive disorders...
  2. ncbi request reprint Volume reduction in the caudate nucleus following stereotactic placement of lesions in the anterior cingulate cortex in humans: a morphometric magnetic resonance imaging study
    S L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurosurg 93:1019-25. 2000
    ..The goal of this study was to test hypotheses regarding changes in volume in subcortical structures following anterior cingulotomy...
  3. ncbi request reprint Orbitofrontal thickness, retention of fear extinction, and extraversion
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroreport 16:1909-12. 2005
    ..Path analysis indicates that extinction retention mediates the relationship between the medial orbitofrontal cortex thickness and extraversion, thereby illustrating one path through which brain structure influences personality...
  4. ncbi request reprint Neural activation during sexual and competitive arousal in healthy men
    S L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Psychiatry Res 91:1-10. 1999
    ..These results complement findings from studies of other normal and pathological emotional states, and provide new insights regarding the neural substrates of pleasurable arousal in healthy men...
  5. ncbi request reprint Neuroimaging studies of amygdala function in anxiety disorders
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Ann N Y Acad Sci 985:389-410. 2003
    ..We conclude that such tools hold great promise for facilitating progress in relevant basic neuroscience as well as clinical research domains...
  6. ncbi request reprint Striatal recruitment during an implicit sequence learning task as measured by functional magnetic resonance imaging
    S L Rauch
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Hum Brain Mapp 5:124-32. 1997
    ..In particular, results from individual subjects suggest that, during the SRT, the reaction time advantage garnered via implicit sequence learning might be predominantly associated with activity within the putamen...
  7. ncbi request reprint A functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder
    Scott L Rauch
    Division of Psychiatric Neuroscience Research and Neurotherapeutics, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosurg 104:558-65. 2006
    ..The purpose of the current study was to test hypotheses regarding changes in regional cerebral blood flow (rCBF) during acute DBS at the VC/VS target in patients with OCD who were participating in a clinical DBS trial...
  8. ncbi request reprint Neuroimaging and neurocircuitry models pertaining to the neurosurgical treatment of psychiatric disorders
    Scott L Rauch
    Psychiatric Neuroscience Program, Massachusetts General Hospital East, Bldg 149, 13th Street, Room 9130, Charlestown, MA 02129, USA
    Neurosurg Clin N Am 14:213-23, vii-viii. 2003
    ..The neuroanatomy of psychiatric neurosurgical procedures and related neuroimaging findings are reviewed. Finally, anticipated future directions of research in this field are discussed...
  9. ncbi request reprint Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 61:330-6. 2007
    ..Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions...
  10. ncbi request reprint Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuropsychopharmacology 27:782-91. 2002
    ..Finally, this pattern is sufficiently robust as to be relatively independent of symptomatic state at the time of tracer uptake...
  11. ncbi request reprint Neuroimaging and attention-deficit/hyperactivity disorder in the 21st century: what to consider and how to proceed
    Scott L Rauch
    Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 USA
    Biol Psychiatry 57:1261-2. 2005
  12. ncbi request reprint Functional imaging of memory retrieval in deficit vs nondeficit schizophrenia
    S Heckers
    Psychotic Disorders Unit, Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Boston, USA
    Arch Gen Psychiatry 56:1117-23. 1999
    ..The deficit and nondeficit forms of schizophrenia were predicted to differ in prefrontal cortical activity, but not in medial temporal lobe activity...
  13. ncbi request reprint Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for obsessive compulsive disorder
    S L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 50:659-67. 2001
    ..Further research, utilizing a prospective design, is indicated to determine the validity and reliability of this finding. If confirmed, an index for noninvasively predicting response to cingulotomy for OCD would be of great value...
  14. ncbi request reprint Prefrontal regions supporting spontaneous and directed application of verbal learning strategies: evidence from PET
    C R Savage
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Brain 124:219-31. 2001
    ..Once initiated, lateral regions of left prefrontal cortex control verbal semantic organization...
  15. ncbi request reprint Strategic processing and episodic memory impairment in obsessive compulsive disorder
    C R Savage
    Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129 2060, USA
    Neuropsychology 14:141-51. 2000
    ..Therefore, verbal and nonverbal episodic memory deficits in OCD are affected by impaired strategic processing. Results are consistent with neurobiological models proposing frontal-striatal system dysfunction in OCD...
  16. ncbi request reprint Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods
    S L Rauch
    Departments of Psychiatry and Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Adv Neurol 85:207-24. 2001
    ....
  17. ncbi request reprint Regional cerebral blood flow during script-driven imagery in childhood sexual abuse-related PTSD: A PET investigation
    L M Shin
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Am J Psychiatry 156:575-84. 1999
    ....
  18. doi request reprint Decreased regional cerebral blood flow in medial prefrontal cortex during trauma-unrelated stressful imagery in Vietnam veterans with post-traumatic stress disorder
    A L Gold
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychol Med 41:2563-72. 2011
    ..In the current study, we sought to determine whether regional cerebral blood flow (rCBF) abnormalities in mPFC and amygdala in PTSD could be observed during the recollection of trauma-unrelated stressful personal events...
  19. ncbi request reprint Recall and recognition memory in obsessive-compulsive disorder
    C R Savage
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    J Neuropsychiatry Clin Neurosci 8:99-103. 1996
    ..These results are interpreted as providing preliminary evidence of a nonverbal memory retrieval deficit consistent with proposed corticostriatal system dysfunction in OCD...
  20. ncbi request reprint The counting Stroop: an interference task specialized for functional neuroimaging--validation study with functional MRI
    G Bush
    Department of Radiology, Massachusetts General Hospital, Boston, USA
    Hum Brain Mapp 6:270-82. 1998
    ..These findings have ramifications for attentional, cognitive interference, learning, and motor control mechanism theories...
  21. ncbi request reprint Enhanced amygdala responses to emotional versus neutral schematic facial expressions
    Christopher I Wright
    Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroreport 13:785-90. 2002
    ....
  22. ncbi request reprint Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia
    Daphne J Holt
    Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
    Schizophr Res 82:153-62. 2006
    ..Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition...
  23. ncbi request reprint A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Depress Anxiety 25:496-505. 2008
    ..However, extending earlier findings in healthy subjects, schematic faces appear more effective for probing amygdala responses to arousal-based (Angry versus Neutral) as opposed to valence-based (Angry versus Happy) contrasts...
  24. ncbi request reprint A functional MRI study of human amygdala responses to facial expressions of fear versus anger
    P J Whalen
    Department of Psychiatry, University of Wisconsin Madison, 53705, USA
    Emotion 1:70-83. 2001
    ..Thus, activity in the amygdala is greater to fearful facial expressions when contrasted with either neutral or angry faces. Furthermore, directly contrasting fear with angry faces highlighted involvement of the dorsal amygdaloid region...
  25. ncbi request reprint Is age at symptom onset associated with severity of memory impairment in adults with obsessive-compulsive disorder?
    A Henin
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129 2060, USA
    Am J Psychiatry 158:137-9. 2001
    ..Age at onset is a potentially important marker for neurobiological features of obsessive-compulsive disorder (OCD). This study examined the relationship between age at symptom onset and memory impairment in adults with OCD...
  26. ncbi request reprint Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge
    P J Whalen
    Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Neurosci 18:411-8. 1998
    ..This study, using fMRI in conjunction with masked stimulus presentations, represents an initial step toward determining the role of the amygdala in nonconscious processing...
  27. ncbi request reprint Fear extinction in rats: implications for human brain imaging and anxiety disorders
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Bldg 149 13th St, Charlestown, 02129, USA
    Biol Psychol 73:61-71. 2006
    ....
  28. ncbi request reprint Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future
    Scott L Rauch
    Psychiatric Neuroscience Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Biol Psychiatry 60:376-82. 2006
    ..The recent development of such imaging probes now sets the stage for directly testing hypotheses regarding the neural substrates of fear conditioning and extinction abnormalities in PTSD...
  29. ncbi request reprint Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia
    Christopher I Wright
    Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 54:1067-76. 2003
    ..However, it is not clear to what extent this concept applies across anxiety disorders. Several studies have examined brain function in specific phobias but did not demonstrate amygdala responses or use specific probes of the amygdala...
  30. pmc Functional MRI study of specific animal phobia using an event-related emotional counting stroop paradigm
    Jennifer C Britton
    Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Depress Anxiety 26:796-805. 2009
    ..Emotional interference tasks may be useful in probing anterior cingulate cortex (ACC) function to understand abnormal attentional study in individuals with specific phobia...
  31. ncbi request reprint Ventromedial prefrontal cortex and amygdala dysfunction during an anger induction positron emission tomography study in patients with major depressive disorder with anger attacks
    Darin D Dougherty
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Arch Gen Psychiatry 61:795-804. 2004
    ....
  32. ncbi request reprint Sustained activation of the hippocampus in response to fearful faces in schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 57:1011-9. 2005
    ..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that habituation of the medial temporal lobe is reduced in schizophrenia...
  33. ncbi request reprint Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 62:446-54. 2007
    ..The aim of the present study is to investigate the mediating anatomy of extinction recall in healthy humans...
  34. ncbi request reprint Novel fearful faces activate the amygdala in healthy young and elderly adults
    Christopher I Wright
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, 13th St, Bldg 149, CNY 2613, Charlestown, MA 02129, USA
    Neurobiol Aging 27:361-74. 2006
    ..However, there were significantly greater activations in the inferior temporal cortex in the young versus elderly subjects...
  35. ncbi request reprint Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortex
    Christopher I Wright
    Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroimage 18:660-9. 2003
    ....
  36. ncbi request reprint Differential prefrontal cortex and amygdala habituation to repeatedly presented emotional stimuli
    C I Wright
    Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    Neuroreport 12:379-83. 2001
    ..We speculate that the right amygdala is part of a dynamic emotional stimulus detection system, while the left is specialized for sustained stimulus evaluations...
  37. ncbi request reprint Neurocircuitry of anxiety disorders
    Justine M Kent
    Department of Psychiatry, Columbia University, 1051 Riverside Drive, Unit 41 NYSPI, New York, NY 10032, USA
    Curr Psychiatry Rep 5:266-73. 2003
    ..Herewith, the authors review neuroimaging findings contributing to the development and refinement of neuroanatomic models for post-traumatic stress disorder, panic disorder, and social anxiety disorder...
  38. ncbi request reprint A study of parallel implicit and explicit information processing in patients with obsessive-compulsive disorder
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital East, Building 149, 13th Street, 9th Floor, Charlestown, MA 02129, USA
    Am J Psychiatry 159:1780-2. 2002
    ..Neuroimaging data suggest that during implicit learning, OCD patients use neural systems normally active during explicit learning to compensate for striatal dysfunction...
  39. ncbi request reprint Amygdala responses to human faces in obsessive-compulsive disorder
    Paul A Cannistraro
    Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital, Building 149, Thirteenth Street, Charlestown, MA 02129, USA
    Biol Psychiatry 56:916-20. 2004
    ..To assess the amygdala response to emotional faces in obsessive-compulsive disorder (OCD) using functional magnetic resonance imaging (fMRI)...
  40. ncbi request reprint Strategic memory in adults with anorexia nervosa: are there similarities to obsessive compulsive spectrum disorders?
    Bonnie J Sherman
    Center for Excellence in Women s Health, Boston University Medical Center, and Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Eat Disord 39:468-76. 2006
    ..This study evaluated nonverbal strategic memory in AN outpatients using an approach previously applied to OC spectrum disorders...
  41. doi request reprint An fMRI investigation of working memory and sadness in females with bipolar disorder: a brief report
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, 2nd Floor, Charlestown, MA 02129, USA
    Bipolar Disord 10:928-42. 2008
    ..The purpose of the present study was to investigate with fMRI the interaction between acute sadness and working memory functioning in individuals with bipolar disorder...
  42. ncbi request reprint Neural substrates of anorexia nervosa: a behavioral challenge study with positron emission tomography
    C M Gordon
    Divisions of Adolescent/Young Adult Medicine and Endocrinology, Children's Hospital, Boston, Massachusetts, USA
    J Pediatr 139:51-7. 2001
    ..The high-calorie food phobia exhibited by patients with AN appears to be associated with exaggerated responses in visual association cortex, as has been previously observed in studies of specific phobias...
  43. ncbi request reprint Test-retest reliability of a functional MRI working memory paradigm in normal and schizophrenic subjects
    D S Manoach
    Behavioral Neurology Unit, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Psychiatry 158:955-8. 2001
    ..To interpret the findings, however, it is crucial to know the test-retest reliability of the measures used...
  44. ncbi request reprint Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for treatment of major depression
    Darin D Dougherty
    Department of Psychiatry, Radiology, Neurosurgery, and Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurosurg 99:1010-7. 2003
    ..The purpose of this study was to identify possible neuroimaging predictors of treatment response to anterior cingulotomy in patients with major depression...
  45. ncbi request reprint Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 59:138-46. 2006
    ..The most consistently reported cognitive difficulty in euthymic subjects with bipolar disorder is impairment in verbal episodic memory (i.e., the ability to learn new verbal information)...
  46. pmc Hemispheric differences in amygdala contributions to response monitoring
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neuroreport 20:398-402. 2009
    ....
  47. ncbi request reprint Regional cerebral brain metabolism correlates of neuroticism and extraversion
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 23:133-8. 2006
    ..No significant correlations were found involving anterior cingulate, amygdala, or ventral striatum. Neuroticism and Extraversion are associated with activity in insular cortex and orbitofrontal cortex, respectively...
  48. ncbi request reprint The misattribution of salience in delusional patients with schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02129, United States
    Schizophr Res 83:247-56. 2006
    ..In this study, we tested the hypothesis that delusional schizophrenia patients are more likely than non-delusional schizophrenia patients and healthy participants to assign affective meanings to neutral stimuli...
  49. ncbi request reprint A diffusion tensor imaging study of white matter in obsessive-compulsive disorder
    Paul A Cannistraro
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Depress Anxiety 24:440-6. 2007
    ..This could explain why surgically severing these tracts is therapeutic. Additional studies are needed to replicate these findings and to clarify their pathological and clinical significance...
  50. ncbi request reprint Differential amygdala habituation to neutral faces in young and elderly adults
    Michelle M Wedig
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, 2nd Floor, Charlestown, MA 02129, USA
    Neurosci Lett 385:114-9. 2005
    ..We conclude that, in healthy elderly adults, the amygdala retains its adaptive habituation response, but speculate that intrinsic changes in amygdala anatomy during aging may modulate its laterality...
  51. ncbi request reprint Improvement in severe self-mutilation following limbic leucotomy: a series of 5 consecutive cases
    B H Price
    Department of Neurology, McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 62:925-32. 2001
    ..We report the effects of limbic leucotomy in 5 consecutive patients with severe self-mutilation behaviors...
  52. pmc Neural correlates of anxiety sensitivity during masked presentation of affective faces
    William D S Killgore
    Affective Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts
    Depress Anxiety 28:243-9. 2011
    ..We hypothesized that insular responses to fear-related stimuli would be primarily related to the Physical Concerns subscale of the ASI, particularly for a sample of subjects with specific phobias...
  53. ncbi request reprint Episodic memory impairment in bipolar disorder and obsessive-compulsive disorder: the role of memory strategies
    Thilo Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Bipolar Disord 6:233-44. 2004
    ....
  54. ncbi request reprint Physiologic responses to loud tones in individuals with obsessive-compulsive disorder
    Ulrike Buhlmann
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychosom Med 69:166-72. 2007
    ..To determine if individuals with obsessive-compulsive disorder (OCD) are characterized by larger eyeblink and/or autonomic responses to sudden, loud (startling) tones...
  55. ncbi request reprint The counting Stroop: a cognitive interference task
    George Bush
    Psychiatric Neuroscience Division, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Protoc 1:230-3. 2006
    ....
  56. ncbi request reprint The role of the orbitofrontal cortex in anxiety disorders
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 1121:546-61. 2007
    ..We will also review the role of the OFC in fear extinction and the implications of this role to the pathophysiology of anxiety disorders...
  57. ncbi request reprint A role for the human dorsal anterior cingulate cortex in fear expression
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 62:1191-4. 2007
    ..This study examined the role of dACC during fear conditioning in healthy humans with magnetic resonance imaging (MRI)...
  58. doi request reprint Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder
    Sabine Wilhelm
    Obsessive Compulsive Disorder Clinic, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 165:335-41; quiz 409. 2008
    ..This study examined whether d-cycloserine, a partial agonist at the N-methyl-D-aspartate (NMDA) glutamatergic receptor, enhances the efficacy of behavior therapy for obsessive-compulsive disorder (OCD)...
  59. pmc Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States
    J Psychiatr Res 42:515-20. 2008
    ..Furthermore, they support the conclusion that this deficit is acquired as a result of combat trauma leading to PTSD, rather than being a predisposing factor to developing PTSD upon the stress of combat...
  60. doi request reprint Prediction of memory rehabilitation outcomes in traumatic brain injury by using functional magnetic resonance imaging
    GARY E STRANGMAN
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Arch Phys Med Rehabil 89:974-81. 2008
    ..To evaluate the ability of functional magnetic resonance imaging (fMRI) measures collected from people with traumatic brain injury (TBI) to provide predictive value for rehabilitation outcomes over and above standard predictors...
  61. pmc Amygdala and fusiform gyrus temporal dynamics: responses to negative facial expressions
    Jennifer C Britton
    Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    BMC Neurosci 9:44. 2008
    ..Percent signal changes within anatomic regions-of-interest (amygdala and fusiform gyrus) were calculated to examine the temporal dynamics of neural response and any response differences based on face type...
  62. ncbi request reprint Neurophysiological alterations during strategy-based verbal learning in traumatic brain injury
    GARY E STRANGMAN
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, USA
    Neurorehabil Neural Repair 23:226-36. 2009
    ..Verbal learning and strategic processing deficits are common sequelae of traumatic brain injury (TBI); however, the neurophysiological mechanisms underlying such deficits remain poorly understood...
  63. pmc Sleep promotes generalization of extinction of conditioned fear
    Edward F Pace-Schott
    Harvard Medical School, Department of Psychiatry, Center for Sleep and Cognition, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
    Sleep 32:19-26. 2009
    ..To examine the effects of sleep on fear conditioning, extinction, extinction recall, and generalization of extinction recall in healthy humans...
  64. ncbi request reprint Functional magnetic resonance imaging evidence for a lack of striatal dysfunction during implicit sequence learning in individuals with animal phobia
    Brian Martis
    Massachusetts General Hospital, Harvard Medical School, USA
    Am J Psychiatry 161:67-71. 2004
    ..This study investigated the neural substrates of implicit sequence learning in subjects with and without small animal phobia, in a follow-up to analogous studies of obsessive-compulsive disorder (OCD)...
  65. pmc Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
    Am J Psychiatry 166:702-10. 2009
    ....
  66. ncbi request reprint Brain activation during implicit sequence learning in individuals with trichotillomania
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 154:233-40. 2007
    ..Future studies directly comparing OCD and TTM subjects are warranted to confirm the specificity of abnormal striatal and hippocampal findings during implicit sequence learning in OCD...
  67. pmc Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 66:1075-82. 2009
    ..amygdala, hippocampus, ventromedial prefrontal cortex (vmPFC), and dorsal anterior cingulate cortex (dACC)...
  68. pmc Anxiety sensitivity correlates with two indices of right anterior insula structure in specific animal phobia
    Isabelle M Rosso
    Neuroimaging Center, McLean Hospital, Belmont, Massachusetts 02478, USA
    Depress Anxiety 27:1104-10. 2010
    ..We examined whether AS was significantly correlated with right anterior insula volume and thickness among adults with specific animal phobia (SAP) and healthy comparison (HC) subjects...
  69. ncbi request reprint Near-infrared spectroscopy and imaging for investigating stroke rehabilitation: test-retest reliability and review of the literature
    Gary Strangman
    Division of Psychiatric Neuroscience, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Arch Phys Med Rehabil 87:S12-9. 2006
    ..To review the use of near-infrared spectroscopy (NIRS) in stroke rehabilitation and to evaluate NIRS test-retest reliability within-session on a motor control task commonly used in neuroimaging of stroke recovery...
  70. ncbi request reprint Neural circuitry of anxiety: evidence from structural and functional neuroimaging studies
    Paul A Cannistraro
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    Psychopharmacol Bull 37:8-25. 2003
    ..A brief review of specific findings from neuroimaging studies of posttraumatic stress disorder, specific phobia, social phobia, obsessive-compulsive disorder, and generalized anxiety disorder is also provided...
  71. ncbi request reprint Inhibited and uninhibited infants "grown up": adult amygdalar response to novelty
    Carl E Schwartz
    Developmental Psychopathology Research Group, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, 13th Street, Building 149, CNY 9, Charlestown, MA 02129, USA
    Science 300:1952-3. 2003
    ....
  72. ncbi request reprint Stereotactic cingulotomy
    G Rees Cosgrove
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, 15 Parkman Street, ACC Suite 331, Boston, MA, USA
    Neurosurg Clin N Am 14:225-35. 2003
    ..Many patients are greatly improved after cingulotomy, and the complications or side effects are few. Cingulotomy remains an important therapeutic option for disabling psychiatric disease and is probably underutilized...
  73. pmc Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 102:15700-5. 2005
    ..These results show that accurate performance involves deactivation of the rACC and other default mode regions and suggest that both rACC and dACC contribute to the evaluation of error responses...
  74. pmc Meditation experience is associated with increased cortical thickness
    Sara W Lazar
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA
    Neuroreport 16:1893-7. 2005
    ..Finally, the thickness of two regions correlated with meditation experience. These data provide the first structural evidence for experience-dependent cortical plasticity associated with meditation practice...
  75. ncbi request reprint Selectively reduced regional cortical volumes in post-traumatic stress disorder
    Scott L Rauch
    Psychiatric Neuroimaging Research Group, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroreport 14:913-6. 2003
    ..These results are consistent with contemporary schemes regarding functional and structural dissection of frontal cortex, and suggest specific regional cortical pathology in PTSD...
  76. ncbi request reprint MRI-based surface-assisted parcellation of human cerebellar cortex: an anatomically specified method with estimate of reliability
    Nikos Makris
    Center for Morphometric Analysis, MGH East, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 25:1146-60. 2005
    ..933. Whereas the individual units provide a high level of detail and anatomical specificity, the clusters add flexibility to the analysis by providing higher reliability...
  77. ncbi request reprint Neural and endocrine correlates of sadness in women: implications for neural network regulation of HPA activity
    William E Ottowitz
    Department of Nuclear Medicine, St Elizabeth s Hospital, Boston Massachusetts, USA
    J Neuropsychiatry Clin Neurosci 16:446-55. 2004
    ..Dysfunction of these sites may contribute to the cortisol dysregulation observed in some subjects with major depression...
  78. ncbi request reprint Magnetic resonance imaging-guided stereotactic limbic leukotomy for treatment of intractable psychiatric disease
    Alonso Montoya
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Neurosurgery 50:1043-9; discussion 1049-52. 2002
    ..To assess the efficacy and complication rates of magnetic resonance imaging-guided stereotactic limbic leukotomy for the treatment of intractable major depressive disorder (MDD) and obsessive-compulsive disorder (OCD)...
  79. ncbi request reprint Cognitive retraining for organizational impairment in obsessive-compulsive disorder
    Ulrike Buhlmann
    Department of Psychiatry OCD Clinic, Massachusetts General Hospital, Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Psychiatry Res 144:109-16. 2006
    ..These findings support a distinction in OCD between failure to utilize a strategy and incapacity to implement a strategy...
  80. ncbi request reprint Evidence for reduced cerebellar volumes in trichotillomania
    Nancy J Keuthen
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 61:374-81. 2007
    ..Limited knowledge exists regarding the neurobiology of trichotillomania (TTM). Cerebellum (CBM) volumes were explored, given its role in complex, coordinated motor sequences...
  81. ncbi request reprint Human anterior cingulate neurons and the integration of monetary reward with motor responses
    Ziv M Williams
    Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Neurosci 7:1370-5. 2004
    ..These findings suggest that the dACC in humans plays an important role in linking reward-related information with alternative actions...
  82. ncbi request reprint Placebo-controlled trial of fluoxetine and phenelzine for obsessive-compulsive disorder
    M A Jenike
    Department of Psychiatry, Massachusetts General Hospital, Charlestown 02129, USA
    Am J Psychiatry 154:1261-4. 1997
    ..The authors conducted a 10-week placebo-controlled trial of these two agents in patients who met DSM-III-R criteria for OCD...
  83. pmc The influence of gonadal hormones on conditioned fear extinction in healthy humans
    M R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Neuroscience 168:652-8. 2010
    ..Lower estradiol may impair extinction consolidation in women. These findings could have practical applications in the treatment of anxiety disorders through cognitive and behavioral therapies...
  84. ncbi request reprint Cognitive and affective probes of the HPA axis: a SPECT study
    W E Ottowitz
    Massachusetts General Hospital, Psychiatric Neuroscience Program, Charlestown, MA, USA
    Brain Cogn 54:138-40. 2004
  85. ncbi request reprint Characteristics of non-verbal memory impairment in bipolar disorder: the role of encoding strategies
    T Deckersbach
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
    Psychol Med 34:823-32. 2004
    ....
  86. ncbi request reprint Isolation rearing impairs wound healing and is associated with increased locomotion and decreased immediate early gene expression in the medial prefrontal cortex of juvenile rats
    J B Levine
    Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuroscience 151:589-603. 2008
    ..Implications of the findings for understanding, assessing, and treating the maladaptive effects of psychosocial deprivation on physical healing during childhood are discussed...
  87. ncbi request reprint Management of the prescription-drug-dependent adult: case of meprobamate abuse and its treatment
    J J Gonzales
    Department of Psychiatry, Georgetown University Medical Center, Boston, Massachusetts, USA
    J Geriatr Psychiatry Neurol 9:91-6. 1996
    ..This paper, using case examples of meprobamate abuse, describes how physicians can recognize, manage, and treat a patient who is abusing a non-narcotic CNS depressant...
  88. pmc Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 160:83-93. 2008
    ..The results support investigation of this multidimensional model in OCD genetic linkage studies...
  89. ncbi request reprint Reduced error-related activation in two anterior cingulate circuits is related to impaired performance in schizophrenia
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Brain 131:971-86. 2008
    ..Impairments in evaluating and learning from errors in schizophrenia may contribute to behaviour that is rigid and perseverative rather than optimally guided by outcomes, and may compromise performance across a wide range of tasks...
  90. ncbi request reprint Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder
    Jean A Frazier
    Child and Adolescent Neuropsychiatric Research Program, Cambridge Health Alliance Mystic Center, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Am J Psychiatry 162:1256-65. 2005
    ..On the basis of adult studies, the authors hypothesized a priori that youths with bipolar disorder would have amygdalar, hippocampal, and thalamic volume abnormalities...
  91. doi request reprint Auditory stimulus repetition effects on cortical hemoglobin oxygenation: a near-infrared spectroscopy investigation
    Anthony P Weiss
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Neuroreport 19:161-5. 2008
    ..These findings provide preliminary support for a relationship between the perceptual characteristics of auditory stimuli and modulation of cortical oxygenation as measured via an emerging neuromonitoring technique...
  92. pmc Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biol Psychiatry 63:550-6. 2008
    ..We employed a case-control design in monozygotic twin pairs discordant for combat exposure to address the preexisting versus acquired origin of brain morphometric abnormalities in PTSD...
  93. pmc Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder
    Jean A Frazier
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 7:555-69. 2005
    ..Cortical gray matter (GM) volume deficits have been reported in some studies of adults with BPD; this study assessed the presence of such deficits in children with BPD...
  94. ncbi request reprint A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, Mass, USA
    Arch Gen Psychiatry 62:273-81. 2005
    ..Previous functional neuroimaging studies have demonstrated exaggerated amygdala responses and diminished medial prefrontal cortex responses during the symptomatic state in posttraumatic stress disorder (PTSD)...
  95. ncbi request reprint Hippocampal function in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Hippocampus 14:292-300. 2004
    ....
  96. ncbi request reprint Temperament and its implications for neuroimaging of anxiety disorders
    Carl E Schwartz
    Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School, Boston, 02129, USA
    CNS Spectr 9:284-91. 2004
    ..Longitudinal studies are a unique tool for understanding the developmental and temperamental risk factors for psychiatric disorder...
  97. ncbi request reprint Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Arch Gen Psychiatry 61:168-76. 2004
    ..However, the functional relationship between these brain regions in PTSD has not been directly examined...