Adrienne G Randolph

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint The financial impact of underestimating personnel needs associated with implementing a computerized patient record in the intensive care unit
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, Boston, MA 02115, USA
    J Crit Care 22:34-9. 2007
  2. pmc Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
    Oliver Karam
    Pediatric Critical Care Unit, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Canada
    Crit Care 14:R57. 2010
  3. pmc Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume
    Sami I Al-Majed
    Pediatric pulmonary and Intensive Care, Dhahran Health Center, Saudi Aramco, Saudi Arabia
    Crit Care 8:R398-402. 2004
  4. pmc Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Respir Crit Care Med 172:687-92. 2005
  5. doi request reprint The unique challenges of enrolling patients into multiple clinical trials
    Adrienne G Randolph
    Children s Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 37:S107-11. 2009
  6. doi request reprint Management of acute lung injury and acute respiratory distress syndrome in children
    Adrienne G Randolph
    Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital, Boston, MA, USA
    Crit Care Med 37:2448-54. 2009
  7. pmc Critically ill children during the 2009-2010 influenza pandemic in the United States
    Adrienne G Randolph
    Children s Hospital Boston, Boston, MA 02115, USA
    Pediatrics 128:e1450-8. 2011
  8. ncbi request reprint Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, MA, USA
    Pediatr Crit Care Med 6:642-7. 2005
  9. ncbi request reprint The feasibility of conducting clinical trials in infants and children with acute respiratory failure
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 167:1334-40. 2003
  10. pmc The IL12B gene is associated with asthma
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 75:709-15. 2004

Research Grants

Detail Information

Publications31

  1. ncbi request reprint The financial impact of underestimating personnel needs associated with implementing a computerized patient record in the intensive care unit
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, Boston, MA 02115, USA
    J Crit Care 22:34-9. 2007
    ..We tracked the cost of implementing a computerized patient record across 3 intensive care units at a large pediatric hospital...
  2. pmc Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
    Oliver Karam
    Pediatric Critical Care Unit, CHU Sainte Justine, Universite de Montreal, 3175 chemin de la Cote Sainte Catherine, Montreal, Canada
    Crit Care 14:R57. 2010
    ..No prospective study has been conducted in children. Our objectives were to assess the clinical impact of the length of storage of red blood cell units on clinical outcome of critically ill children...
  3. pmc Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume
    Sami I Al-Majed
    Pediatric pulmonary and Intensive Care, Dhahran Health Center, Saudi Aramco, Saudi Arabia
    Crit Care 8:R398-402. 2004
    ..The objective of this laboratory study was to measure the effect of decreased lung compliance and endotracheal tube (ETT) leakage on measured exhaled tidal volume at the airway and at the ventilator, in a research study with a test lung...
  4. pmc Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Respir Crit Care Med 172:687-92. 2005
    ..The TNF position -308 and LTA NcoI polymorphisms are believed to influence TNF transcription and secretion, respectively...
  5. doi request reprint The unique challenges of enrolling patients into multiple clinical trials
    Adrienne G Randolph
    Children s Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 37:S107-11. 2009
    ..In conclusion, more vigorous promotion of thoughtful coenrollment policies could increase the efficiency of critical care research...
  6. doi request reprint Management of acute lung injury and acute respiratory distress syndrome in children
    Adrienne G Randolph
    Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital, Boston, MA, USA
    Crit Care Med 37:2448-54. 2009
    ..Prone positioning, bronchodilators, inhaled nitric oxide, tight glucose control, and high-flow nasal cannula (HFNC) oxygen are therapies that require further study before they can be recommended for children with ALI/ARDS...
  7. pmc Critically ill children during the 2009-2010 influenza pandemic in the United States
    Adrienne G Randolph
    Children s Hospital Boston, Boston, MA 02115, USA
    Pediatrics 128:e1450-8. 2011
    ..Determining the roles of chronic conditions and bacterial coinfection in mortality is difficult because of the limited data for children with pH1N1-related critical illness...
  8. ncbi request reprint Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, MA, USA
    Pediatr Crit Care Med 6:642-7. 2005
    ..We sought to determine whether cumulative intake minus output (I-O) at the start of weaning predicted weaning duration and whether cumulative I-O at extubation predicted extubation failure...
  9. ncbi request reprint The feasibility of conducting clinical trials in infants and children with acute respiratory failure
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 167:1334-40. 2003
    ..6%), and the median duration of ventilation was 7 days. The design of clinical trials in critically ill children is feasible but must account for the diverse population, infrequent mortality, and short duration of mechanical ventilation...
  10. pmc The IL12B gene is associated with asthma
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 75:709-15. 2004
    ..IL12B may be an important asthma gene...
  11. pmc IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004
    ..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
  12. pmc Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit
    Adrienne G Randolph
    Department of Anesthesia, Harvard Medical School, Boston, MA, USA
    Pediatr Infect Dis J 23:990-4. 2004
    ..To evaluate the risk of bacterial infection and use of antibiotics in otherwise healthy children infected with respiratory syncytial virus (RSV) admitted to the intensive care unit (ICU)...
  13. ncbi request reprint Reorganizing the delivery of intensive care could improve efficiency and save lives
    Adrienne G Randolph
    Departments of Pediatrics, Harvard Medical School and Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
    J Eval Clin Pract 8:1-8. 2002
    ..Given the growing evidence supporting the association between specific ICU characteristics and improved patient outcomes, we hope the future realizes broad implementation of these beneficial characteristics...
  14. doi request reprint Gender differences in research grant applications and funding outcomes for medical school faculty
    Susan E Waisbren
    Children s Hospital, Boston, Massachusetts, USA
    J Womens Health (Larchmt) 17:207-14. 2008
    ..To evaluate whether there were differences in acquisition of research grant support between male and female faculty at eight Harvard Medical School-affiliated institutions...
  15. pmc Assessing the quality of case-control association studies on the genetic basis of sepsis
    Sally H Vitali
    Department of Anesthesia and the Division of Critical Care Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Crit Care Med 6:S74-7. 2005
    ..To define methodological standards that would improve the quality and reproducibility of case-control genetic association studies in sepsis...
  16. ncbi request reprint Identification of central venous catheter-related infections in infants and children
    Adrienne G Randolph
    Department of Anesthesia, Division of Critical Care, Children s Hospital, Boston, MA, USA
    Pediatr Crit Care Med 6:S19-24. 2005
    ..To define central venous catheter-related infections in infants and children for the purpose of enrolling children in sepsis studies, for epidemiology and surveillance studies, and for clinical management...
  17. ncbi request reprint A practical approach to evidence-based medicine: lessons learned from developing ventilator management protocols
    Adrienne G Randolph
    Division of Critical Care, Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
    Crit Care Clin 19:515-27. 2003
    ..Finally, protocols must be tended to and updated when new evidence becomes available...
  18. doi request reprint Vitamin D deficiency in critically ill children
    Kate Madden
    Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Pediatrics 130:421-8. 2012
    ..We hypothesized that levels would be lower with increased illness severity and in children with serious infections...
  19. ncbi request reprint Potential for donation after cardiac death in a children's hospital
    Amy L Durall
    Division of Critical Care, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 119:e219-24. 2007
    ..As part of this process, we sought to determine the number of potential kidney donation after cardiac death donors in our PICUs...
  20. doi request reprint Impact of a conservative red blood cell transfusion strategy in children undergoing hematopoietic stem cell transplantation
    Jenifer R Lightdale
    Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Biol Blood Marrow Transplant 18:813-7. 2012
    ..004). Our initial experience suggests that implementation of a conservative transfusion strategy in otherwise stable children undergoing hematopoietic stem cell transplantation appears safe and lowers transfusion exposures...
  21. pmc Fluid balance in critically ill children with acute lung injury
    Stacey L Valentine
    Critical Care Division, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, and Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
    Crit Care Med 40:2883-9. 2012
    ....
  22. doi request reprint Risk factors for central line-associated bloodstream infection in pediatric intensive care units
    Matthew C Wylie
    From the Division of Critical Care Medicine, Department of Anesthesia, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Infect Control Hosp Epidemiol 31:1049-56. 2010
    ..We sought to identify risk factors for central line-associated bloodstream infection (CLABSI) to describe children who might benefit from adjunctive interventions...
  23. ncbi request reprint Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial
    Adrienne G Randolph
    Children s Hospital, MICU, FA 108, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 288:2561-8. 2002
    ..Ventilator management protocols shorten the time required to wean adult patients from mechanical ventilation. The efficacy of such weaning protocols among children has not been studied...
  24. ncbi request reprint Growth of pediatric intensive care units in the United States from 1995 to 2001
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Pediatr 144:792-8. 2004
    ..To describe the growth and distribution of pediatric intensive care unit (PICU) beds in the United States from 1995 to 2001 and the characteristics of PICUs in 2001...
  25. ncbi request reprint Real-time evaluation of patient monitoring algorithms for critical care at the bedside
    Ying Zhang
    Harvard Medical School, MIT Division of Health Sciences and Technology, MIT Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:2783-6. 2007
    ....
  26. ncbi request reprint Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysis
    Caroline Davison
    Department of Anaesthesia, St George s Hospital, Tooting, London, UK
    Pediatr Crit Care Med 5:482-9. 2004
    ..Currently, the mainstay of treatment is supportive care. The effectiveness of treatments used for mechanically ventilated infants with bronchiolitis is unclear...
  27. ncbi request reprint What underlies race and sex differences in acute respiratory distress syndrome-associated mortality?
    Adrienne G Randolph
    Crit Care Med 30:1907-9. 2002
  28. ncbi request reprint How are children mechanically ventilated in pediatric intensive care units?
    Adrienne G Randolph
    Intensive Care Med 30:746-7. 2004
  29. doi request reprint Anemia, blood loss, and blood transfusions in North American children in the intensive care unit
    Scot T Bateman
    Department of Pediatrics, University of Massachusetts Medical Center, H5 524, 55 Lake Avenue, North Worcester, MA 01655, USA
    Am J Respir Crit Care Med 178:26-33. 2008
    ..Minimizing exposure of children to blood products is desirable...
  30. ncbi request reprint Mining for the genetic determinants of septic shock: when is it really gold?
    Adrienne G Randolph
    Crit Care Med 30:1161-3. 2002
  31. ncbi request reprint Pediatric critical care medicine: planning for our research future
    Carol E Nicholson
    National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 2A03 MSC 7510, Bethesda, MD 20892, USA
    Pediatr Crit Care Med 4:196-202. 2003
    ..To introduce to the pediatric critical care medicine community a new program in pediatric critical care medicine at the National Institutes of Health...

Research Grants2

  1. GENETIC EPIDEMIOLOGY OF RSV BRONCHIOLITIS AND ASTHMA
    Adrienne Randolph; Fiscal Year: 2004
    ..Identifying the genes associated with the onset of childhood asthma could lead to targeted interventions aimed at prevention and treatment of this disorder that is increasing at a rate of 5 percent per year. ..
  2. Genetic Epidemiology of Life-Threatening Influenza in Children
    Adrienne G Randolph; Fiscal Year: 2010
    ....