Adrienne G Randolph
Affiliation: Harvard University
- Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysisMark Duffett
Department of Critical Care, McMaster Children s Hospital, 1200 Main St, W, Hamilton, Ontario L8S 4J9, Canada
Crit Care 11:R66. 2007..The objective of the present systematic review is to assess the effect of exogenous pulmonary surfactant on all-cause mortality in children mechanically ventilated for acute respiratory failure...
- Reorganizing the delivery of intensive care could improve efficiency and save livesAdrienne G Randolph
Departments of Pediatrics, Harvard Medical School and Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
J Eval Clin Pract 8:1-8. 2002..Given the growing evidence supporting the association between specific ICU characteristics and improved patient outcomes, we hope the future realizes broad implementation of these beneficial characteristics...
- The IL12B gene is associated with asthmaAdrienne G Randolph
Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
Am J Hum Genet 75:709-15. 2004..IL12B may be an important asthma gene...
- Growth of pediatric intensive care units in the United States from 1995 to 2001Adrienne G Randolph
Department of Anesthesia, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Pediatr 144:792-8. 2004..To describe the growth and distribution of pediatric intensive care unit (PICU) beds in the United States from 1995 to 2001 and the characteristics of PICUs in 2001...
- A practical approach to evidence-based medicine: lessons learned from developing ventilator management protocolsAdrienne G Randolph
Division of Critical Care, Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
Crit Care Clin 19:515-27. 2003..Finally, protocols must be tended to and updated when new evidence becomes available...
- The feasibility of conducting clinical trials in infants and children with acute respiratory failureAdrienne G Randolph
Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 167:1334-40. 2003..6%), and the median duration of ventilation was 7 days. The design of clinical trials in critically ill children is feasible but must account for the diverse population, infrequent mortality, and short duration of mechanical ventilation...
- Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trialAdrienne G Randolph
Children s Hospital, MICU, FA 108, 300 Longwood Ave, Boston, MA 02115, USA
JAMA 288:2561-8. 2002..Ventilator management protocols shorten the time required to wean adult patients from mechanical ventilation. The efficacy of such weaning protocols among children has not been studied...
- Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypesAdrienne G Randolph
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Respir Crit Care Med 172:687-92. 2005..The TNF position -308 and LTA NcoI polymorphisms are believed to influence TNF transcription and secretion, respectively...
- Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in childrenAdrienne G Randolph
Department of Anesthesia, Children's Hospital, Boston, MA, USA
Pediatr Crit Care Med 6:642-7. 2005....
- IL10 gene polymorphisms are associated with asthma phenotypes in childrenHelen Lyon
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Genet Epidemiol 26:155-65. 2004..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
- Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unitAdrienne G Randolph
Department of Anesthesia, Harvard Medical School, Boston, MA, USA
Pediatr Infect Dis J 23:990-4. 2004..Although bacterial pneumonia in this cohort may be more prevalent, overdiagnosis is common...
- Gender differences in research grant applications and funding outcomes for medical school facultySusan E Waisbren
Children s Hospital, Boston, Massachusetts, USA
J Womens Health (Larchmt) 17:207-14. 2008..To evaluate whether there were differences in acquisition of research grant support between male and female faculty at eight Harvard Medical School-affiliated institutions...
- Management of acute lung injury and acute respiratory distress syndrome in childrenAdrienne G Randolph
Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital, Boston, MA, USA
Crit Care Med 37:2448-54. 2009..Prone positioning, bronchodilators, inhaled nitric oxide, tight glucose control, and high-flow nasal cannula (HFNC) oxygen are therapies that require further study before they can be recommended for children with ALI/ARDS...
- The unique challenges of enrolling patients into multiple clinical trialsAdrienne G Randolph
Children s Hospital, Harvard Medical School, Boston, MA, USA
Crit Care Med 37:S107-11. 2009..In conclusion, more vigorous promotion of thoughtful coenrollment policies could increase the efficiency of critical care research...
- The financial impact of underestimating personnel needs associated with implementing a computerized patient record in the intensive care unitAdrienne G Randolph
Department of Anesthesia, Children s Hospital, Boston, Boston, MA 02115, USA
J Crit Care 22:34-9. 2007..We tracked the cost of implementing a computerized patient record across 3 intensive care units at a large pediatric hospital...
- Identification of central venous catheter-related infections in infants and childrenAdrienne G Randolph
Department of Anesthesia, Division of Critical Care, Children's Hospital, Boston, MA, USA
Pediatr Crit Care Med 6:S19-24. 2005....
- Assessing the quality of case-control association studies on the genetic basis of sepsisSally H Vitali
Department of Anesthesia and the Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Pediatr Crit Care Med 6:S74-7. 2005..It is important, however, to understand the limitations of these studies and the need for replication...
- Real-time evaluation of patient monitoring algorithms for critical care at the bedsideYing Zhang
Harvard Medical School, MIT Division of Health Sciences and Technology, MIT Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA
Conf Proc IEEE Eng Med Biol Soc 2007:2783-6. 2007....
- Potential for donation after cardiac death in a children's hospitalAmy L Durall
Division of Critical Care, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
Pediatrics 119:e219-24. 2007..As part of this process, we sought to determine the number of potential kidney donation after cardiac death donors in our PICUs...
- Risk factors for central line-associated bloodstream infection in pediatric intensive care unitsMatthew C Wylie
From the Division of Critical Care Medicine, Department of Anesthesia, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
Infect Control Hosp Epidemiol 31:1049-56. 2010..We sought to identify risk factors for central line-associated bloodstream infection (CLABSI) to describe children who might benefit from adjunctive interventions...
- Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysisCaroline Davison
Department of Anaesthesia, St. George's Hospital, Tooting, London, UK
Pediatr Crit Care Med 5:482-9. 2004..Surfactant seems to be a promising intervention, and corticosteroids or ribavirin may also be beneficial...
- How are children mechanically ventilated in pediatric intensive care units?Adrienne G Randolph
Intensive Care Med 30:746-7. 2004
- What underlies race and sex differences in acute respiratory distress syndrome-associated mortality?Adrienne G Randolph
Crit Care Med 30:1907-9. 2002
- Pediatric critical care medicine: planning for our research futureCarol E Nicholson
National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 2A03 MSC 7510, Bethesda, MD 20892, USA
Pediatr Crit Care Med 4:196-202. 2003..To introduce to the pediatric critical care medicine community a new program in pediatric critical care medicine at the National Institutes of Health...
- Anemia, blood loss, and blood transfusions in North American children in the intensive care unitScot T Bateman
Department of Pediatrics, University of Massachusetts Medical Center, H5 524, 55 Lake Avenue, North Worcester, MA 01655, USA
Am J Respir Crit Care Med 178:26-33. 2008..Minimizing exposure of children to blood products is desirable...
- Mining for the genetic determinants of septic shock: when is it really gold?Adrienne G Randolph
Crit Care Med 30:1161-3. 2002
- Effect of lung compliance and endotracheal tube leakage on measurement of tidal volumeSami I Al-Majed
Pediatric pulmonary and Intensive Care, Dhahran Health Center, Saudi Aramco, Saudi Arabia
Crit Care 8:R398-402. 2004..The objective of this laboratory study was to measure the effect of decreased lung compliance and endotracheal tube (ETT) leakage on measured exhaled tidal volume at the airway and at the ventilator, in a research study with a test lung...