Adrienne G Randolph

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis
    Mark Duffett
    Department of Critical Care, McMaster Children s Hospital, 1200 Main St, W, Hamilton, Ontario L8S 4J9, Canada
    Crit Care 11:R66. 2007
  2. ncbi request reprint Reorganizing the delivery of intensive care could improve efficiency and save lives
    Adrienne G Randolph
    Departments of Pediatrics, Harvard Medical School and Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
    J Eval Clin Pract 8:1-8. 2002
  3. ncbi request reprint Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial
    Adrienne G Randolph
    Children s Hospital, MICU, FA 108, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 288:2561-8. 2002
  4. ncbi request reprint The feasibility of conducting clinical trials in infants and children with acute respiratory failure
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 167:1334-40. 2003
  5. pmc The IL12B gene is associated with asthma
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 75:709-15. 2004
  6. ncbi request reprint A practical approach to evidence-based medicine: lessons learned from developing ventilator management protocols
    Adrienne G Randolph
    Division of Critical Care, Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
    Crit Care Clin 19:515-27. 2003
  7. ncbi request reprint Growth of pediatric intensive care units in the United States from 1995 to 2001
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Pediatr 144:792-8. 2004
  8. pmc Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Respir Crit Care Med 172:687-92. 2005
  9. ncbi request reprint Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, MA, USA
    Pediatr Crit Care Med 6:642-7. 2005
  10. pmc IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004

Detail Information

Publications32

  1. pmc Surfactant therapy for acute respiratory failure in children: a systematic review and meta-analysis
    Mark Duffett
    Department of Critical Care, McMaster Children s Hospital, 1200 Main St, W, Hamilton, Ontario L8S 4J9, Canada
    Crit Care 11:R66. 2007
    ..The objective of the present systematic review is to assess the effect of exogenous pulmonary surfactant on all-cause mortality in children mechanically ventilated for acute respiratory failure...
  2. ncbi request reprint Reorganizing the delivery of intensive care could improve efficiency and save lives
    Adrienne G Randolph
    Departments of Pediatrics, Harvard Medical School and Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
    J Eval Clin Pract 8:1-8. 2002
    ..Given the growing evidence supporting the association between specific ICU characteristics and improved patient outcomes, we hope the future realizes broad implementation of these beneficial characteristics...
  3. ncbi request reprint Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial
    Adrienne G Randolph
    Children s Hospital, MICU, FA 108, 300 Longwood Ave, Boston, MA 02115, USA
    JAMA 288:2561-8. 2002
    ..Ventilator management protocols shorten the time required to wean adult patients from mechanical ventilation. The efficacy of such weaning protocols among children has not been studied...
  4. ncbi request reprint The feasibility of conducting clinical trials in infants and children with acute respiratory failure
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 167:1334-40. 2003
    ..6%), and the median duration of ventilation was 7 days. The design of clinical trials in critically ill children is feasible but must account for the diverse population, infrequent mortality, and short duration of mechanical ventilation...
  5. pmc The IL12B gene is associated with asthma
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 75:709-15. 2004
    ..IL12B may be an important asthma gene...
  6. ncbi request reprint A practical approach to evidence-based medicine: lessons learned from developing ventilator management protocols
    Adrienne G Randolph
    Division of Critical Care, Children s Hospital, MICU, FA 108, 300 Longwood Avenue, Boston, MA 02115, USA
    Crit Care Clin 19:515-27. 2003
    ..Finally, protocols must be tended to and updated when new evidence becomes available...
  7. ncbi request reprint Growth of pediatric intensive care units in the United States from 1995 to 2001
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Pediatr 144:792-8. 2004
    ..To describe the growth and distribution of pediatric intensive care unit (PICU) beds in the United States from 1995 to 2001 and the characteristics of PICUs in 2001...
  8. pmc Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Respir Crit Care Med 172:687-92. 2005
    ..The TNF position -308 and LTA NcoI polymorphisms are believed to influence TNF transcription and secretion, respectively...
  9. ncbi request reprint Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, MA, USA
    Pediatr Crit Care Med 6:642-7. 2005
    ..We sought to determine whether cumulative intake minus output (I-O) at the start of weaning predicted weaning duration and whether cumulative I-O at extubation predicted extubation failure...
  10. pmc IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004
    ..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
  11. doi request reprint Assessment of hemoglobin threshold for packed RBC transfusion in a medical-surgical PICU
    Stacey L Valentine
    1Critical Care Division, Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children s Hospital, Boston, MA 2Harvard Medical School, Boston, MA 3Department of Pediatrics, Division of Pediatric Critical Care, University of Massachusetts Children s Medical Center, Worcester, MA 4Department of Medicine, Boston Children s Hospital, Boston, MA 5Clinical Research Center, Boston Children s Hospital, Boston, MA 6Department of Laboratory and Transfusion Medicine, Boston Children s Hospital, Boston, MA 7Program for Patient Safety and Quality, Boston Children s Hospital, Boston, MA
    Pediatr Crit Care Med 15:e89-94. 2014
    ..We aimed to determine if wide dissemination of this evidence altered the hemoglobin threshold used for RBC transfusions in our pediatric medical-surgical ICU...
  12. pmc Risk of bacterial infection in previously healthy respiratory syncytial virus-infected young children admitted to the intensive care unit
    Adrienne G Randolph
    Department of Anesthesia, Harvard Medical School, Boston, MA, USA
    Pediatr Infect Dis J 23:990-4. 2004
    ..To evaluate the risk of bacterial infection and use of antibiotics in otherwise healthy children infected with respiratory syncytial virus (RSV) admitted to the intensive care unit (ICU)...
  13. doi request reprint Gender differences in research grant applications and funding outcomes for medical school faculty
    Susan E Waisbren
    Children s Hospital, Boston, Massachusetts, USA
    J Womens Health (Larchmt) 17:207-14. 2008
    ..To evaluate whether there were differences in acquisition of research grant support between male and female faculty at eight Harvard Medical School-affiliated institutions...
  14. doi request reprint Management of acute lung injury and acute respiratory distress syndrome in children
    Adrienne G Randolph
    Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital, Boston, MA, USA
    Crit Care Med 37:2448-54. 2009
    ..Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are devastating disorders of overwhelming pulmonary inflammation and hypoxemia, resulting in high morbidity and mortality...
  15. ncbi request reprint A multinational study of thromboprophylaxis practice in critically ill children
    Edward Vincent S Faustino
    1Department of Pediatrics, Yale School of Medicine, New Haven, CT 2Department of Pediatrics, Children s Hospital of Wisconsin, Milwaukee, WI 3Department of Pediatrics, Washington University at St Louis School of Medicine, St Louis, MO 4Department of Pediatrics, CHU Sainte Justine University of Montreal, Montreal, QC, Canada 5Division of Hematology Oncology BMT, Nationwide Children s Hospital, Columbus, OH 6Pediatric Intensive Care Unit, University of Santiago de Compostela, Santiago de Compostela, Spain 7Pediatric Intensive Care Unit, Women s and Children s Hospital, Adelaide, South Australia, Australia 8Department of Pediatrics, Children s Hospital and Medical Center, Omaha, NE 9Yale Center for Analytical Sciences, Yale School of Public Health, New Haven, CT 10Department of Pediatrics, New York Medical College Maria Fareri Children s Hospital, Valhalla, NY 11Department of Anesthesia, Perioperative and Pain Medicine, Boston Children s Hospital, Boston, MA
    Crit Care Med 42:1232-40. 2014
    ..We tested the hypothesis that thromboprophylaxis is infrequently used in critically ill children even for those in whom it is indicated...
  16. ncbi request reprint The financial impact of underestimating personnel needs associated with implementing a computerized patient record in the intensive care unit
    Adrienne G Randolph
    Department of Anesthesia, Children s Hospital, Boston, Boston, MA 02115, USA
    J Crit Care 22:34-9. 2007
    ..We tracked the cost of implementing a computerized patient record across 3 intensive care units at a large pediatric hospital...
  17. doi request reprint The unique challenges of enrolling patients into multiple clinical trials
    Adrienne G Randolph
    Children s Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 37:S107-11. 2009
    ..In conclusion, more vigorous promotion of thoughtful coenrollment policies could increase the efficiency of critical care research...
  18. pmc Assessing the quality of case-control association studies on the genetic basis of sepsis
    Sally H Vitali
    Department of Anesthesia and the Division of Critical Care Medicine, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Crit Care Med 6:S74-7. 2005
    ..To define methodological standards that would improve the quality and reproducibility of case-control genetic association studies in sepsis...
  19. ncbi request reprint Identification of central venous catheter-related infections in infants and children
    Adrienne G Randolph
    Department of Anesthesia, Division of Critical Care, Children s Hospital, Boston, MA, USA
    Pediatr Crit Care Med 6:S19-24. 2005
    ..To define central venous catheter-related infections in infants and children for the purpose of enrolling children in sepsis studies, for epidemiology and surveillance studies, and for clinical management...
  20. doi request reprint Impact of a conservative red blood cell transfusion strategy in children undergoing hematopoietic stem cell transplantation
    Jenifer R Lightdale
    Department of Medicine, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Biol Blood Marrow Transplant 18:813-7. 2012
    ..004). Our initial experience suggests that implementation of a conservative transfusion strategy in otherwise stable children undergoing hematopoietic stem cell transplantation appears safe and lowers transfusion exposures...
  21. pmc Fluid balance in critically ill children with acute lung injury
    Stacey L Valentine
    Critical Care Division, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, and Department of Anesthesia, Harvard Medical School, Boston, MA 02115, USA
    Crit Care Med 40:2883-9. 2012
    ....
  22. pmc Vitamin D deficiency in critically ill children
    Kate Madden
    Division of Critical Care Medicine, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, Boston, MA 02115, USA
    Pediatrics 130:421-8. 2012
    ..We hypothesized that levels would be lower with increased illness severity and in children with serious infections...
  23. ncbi request reprint Potential for donation after cardiac death in a children's hospital
    Amy L Durall
    Division of Critical Care, Department of Anesthesia, Perioperative and Pain Medicine, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 119:e219-24. 2007
    ..As part of this process, we sought to determine the number of potential kidney donation after cardiac death donors in our PICUs...
  24. doi request reprint Risk factors for central line-associated bloodstream infection in pediatric intensive care units
    Matthew C Wylie
    From the Division of Critical Care Medicine, Department of Anesthesia, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Infect Control Hosp Epidemiol 31:1049-56. 2010
    ..We sought to identify risk factors for central line-associated bloodstream infection (CLABSI) to describe children who might benefit from adjunctive interventions...
  25. ncbi request reprint Real-time evaluation of patient monitoring algorithms for critical care at the bedside
    Ying Zhang
    Harvard Medical School, MIT Division of Health Sciences and Technology, MIT Department of Electrical Engineering and Computer Science, Cambridge, MA 02139, USA
    Conf Proc IEEE Eng Med Biol Soc 2007:2783-6. 2007
    ....
  26. ncbi request reprint How are children mechanically ventilated in pediatric intensive care units?
    Adrienne G Randolph
    Intensive Care Med 30:746-7. 2004
  27. ncbi request reprint What underlies race and sex differences in acute respiratory distress syndrome-associated mortality?
    Adrienne G Randolph
    Crit Care Med 30:1907-9. 2002
  28. pmc Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysis
    Caroline Davison
    Department of Anaesthesia, St George s Hospital, Tooting, London, UK
    Pediatr Crit Care Med 5:482-9. 2004
    ..Currently, the mainstay of treatment is supportive care. The effectiveness of treatments used for mechanically ventilated infants with bronchiolitis is unclear...
  29. ncbi request reprint Anemia, blood loss, and blood transfusions in North American children in the intensive care unit
    Scot T Bateman
    Department of Pediatrics, University of Massachusetts Medical Center, H5 524, 55 Lake Avenue, North Worcester, MA 01655, USA
    Am J Respir Crit Care Med 178:26-33. 2008
    ..Minimizing exposure of children to blood products is desirable...
  30. pmc Effect of lung compliance and endotracheal tube leakage on measurement of tidal volume
    Sami I Al-Majed
    Pediatric pulmonary and Intensive Care, Dhahran Health Center, Saudi Aramco, Saudi Arabia
    Crit Care 8:R398-402. 2004
    ..The objective of this laboratory study was to measure the effect of decreased lung compliance and endotracheal tube (ETT) leakage on measured exhaled tidal volume at the airway and at the ventilator, in a research study with a test lung...
  31. ncbi request reprint Pediatric critical care medicine: planning for our research future
    Carol E Nicholson
    National Institute of Child Health and Human Development, 6100 Executive Boulevard, Room 2A03 MSC 7510, Bethesda, MD 20892, USA
    Pediatr Crit Care Med 4:196-202. 2003
    ..To introduce to the pediatric critical care medicine community a new program in pediatric critical care medicine at the National Institutes of Health...
  32. ncbi request reprint Mining for the genetic determinants of septic shock: when is it really gold?
    Adrienne G Randolph
    Crit Care Med 30:1161-3. 2002