I Scott Ramsey

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Rapid vesicular translocation and insertion of TRP channels
    Vassilios J Bezzerides
    Howard Hughes Medical Institute, Cardiovascular Department, Children s Hospital and Harvard Medical School, Enders 1309 320 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 6:709-20. 2004
  2. ncbi request reprint An introduction to TRP channels
    I Scott Ramsey
    Howard Hughes Medical Institute, Cardiovascular Department, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 68:619-47. 2006
  3. pmc Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis
    Bimal N Desai
    Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children s Hospital Boston, and Department of Neurobiology, Harvard Medical School, Enders Building 1309, 320 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 22:1149-62. 2012
  4. pmc All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
    Huayu Qi
    Department of Cardiology, Howard Hughes Medical Institute, and Department of Neurobiology, Harvard Medical School, Enders 1309, Children s Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:1219-23. 2007
  5. doi request reprint An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1
    I Scott Ramsey
    Howard Hughes Medical Institute, Department of Cardiology and Manton Center for Orphan Disease, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Struct Mol Biol 17:869-75. 2010
  6. ncbi request reprint A voltage-gated proton-selective channel lacking the pore domain
    I Scott Ramsey
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 440:1213-6. 2006
  7. pmc Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst
    I Scott Ramsey
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, and Department of Cardiovascular Research, Manton Center for Orphan Disease, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:7642-7. 2009

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Rapid vesicular translocation and insertion of TRP channels
    Vassilios J Bezzerides
    Howard Hughes Medical Institute, Cardiovascular Department, Children s Hospital and Harvard Medical School, Enders 1309 320 Longwood Avenue, Boston, MA 02115, USA
    Nat Cell Biol 6:709-20. 2004
    ..The increase in TRPC5 availability affects neurite extension rates in cultured hippocampal neurons, and may be a general mechanism for initiating Ca(2+) influx and cell morphological changes in response to stimuli...
  2. ncbi request reprint An introduction to TRP channels
    I Scott Ramsey
    Howard Hughes Medical Institute, Cardiovascular Department, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Physiol 68:619-47. 2006
    ..The TRP channel gene family and its nomenclature, the encoded proteins and alternatively spliced variants, and the rapidly expanding pharmacology of TRP channels are summarized in online supplemental material...
  3. pmc Cleavage of TRPM7 releases the kinase domain from the ion channel and regulates its participation in Fas-induced apoptosis
    Bimal N Desai
    Department of Cardiology, Howard Hughes Medical Institute, Manton Center for Orphan Disease, Children s Hospital Boston, and Department of Neurobiology, Harvard Medical School, Enders Building 1309, 320 Longwood Avenue, Boston, MA 02115, USA
    Dev Cell 22:1149-62. 2012
    ..These findings raise the possibility that other members of the TRP channel superfamily are also regulated by caspase-mediated cleavage, with wide-ranging implications for cell death and differentiation...
  4. pmc All four CatSper ion channel proteins are required for male fertility and sperm cell hyperactivated motility
    Huayu Qi
    Department of Cardiology, Howard Hughes Medical Institute, and Department of Neurobiology, Harvard Medical School, Enders 1309, Children s Hospital Boston, 320 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:1219-23. 2007
    ..Direct protein interactions among CatSpers, the sperm specificity of these proteins, and loss of ICatSper in each of the four CatSper-/- mice indicate that CatSpers are highly specialized flagellar proteins...
  5. doi request reprint An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1
    I Scott Ramsey
    Howard Hughes Medical Institute, Department of Cardiology and Manton Center for Orphan Disease, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Struct Mol Biol 17:869-75. 2010
    ..Our results indicate that Hv1 most likely forms an internal water wire for selective proton transfer and that interactions between water molecules and S4 arginines may underlie coupling between voltage- and pH-gradient sensing...
  6. ncbi request reprint A voltage-gated proton-selective channel lacking the pore domain
    I Scott Ramsey
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Harvard Medical School, Enders 1309, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 440:1213-6. 2006
    ..The data presented here identify H(v)1 as a long-sought voltage-gated H+ channel and establish H(v)1 as the founding member of a family of mammalian VSD proteins...
  7. pmc Hv1 proton channels are required for high-level NADPH oxidase-dependent superoxide production during the phagocyte respiratory burst
    I Scott Ramsey
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, and Department of Cardiovascular Research, Manton Center for Orphan Disease, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:7642-7. 2009
    ..Despite significant reduction in superoxide production, Hv1(-/-) mice are able to clear several types of bacterial infections...