Research Topics
| Harsha RadhakrishnanSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
Fast optical signal not detected in awake behaving monkeysHarsha Radhakrishnan
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149, 13th Street, Rm 2277, Charlestown, MA 02129, USA
Neuroimage 45:410-9. 2009..Based on these negative results, despite the optimal experimental conditions, we doubt the usefulness of non-invasive fast optical signal measurements with NIRS...- Study of neurovascular coupling by modulating neuronal activity with GABAHarsha Radhakrishnan
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
Brain Res 1372:1-12. 2011..These results suggest that the hemodynamic response is predominantly driven by cortico-cortical interactions and not by the initial thalamocortical activity in layer IV... - Optical coherence tomography for the quantitative study of cerebrovascular physiologyVivek J Srinivasan
Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Cereb Blood Flow Metab 31:1339-45. 2011..Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range... - Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activationMohammad A Yaseen
Department of Radiology, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
J Cereb Blood Flow Metab 31:1051-63. 2011..Understanding O(2) supply on a microscopic level will yield better insight into brain function and the underlying mechanisms of various neuropathologies... - Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrastVivek J Srinivasan
MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, 02129, USA
Opt Express 20:2220-39. 2012..Lastly, we show that OCM enables direct visualization of cellular changes during cell depolarization and may therefore provide novel optical markers of cell viability... - The effect of different anesthetics on neurovascular couplingMaria Angela Franceschini
Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Neuroimage 51:1367-77. 2010..Baseline cerebral blood flow (CBF) interacts with neural activity and influences the evoked hemodynamic responses. Finally, neurovascular coupling appears to be the same across all anesthetics used... - Rapid volumetric angiography of cortical microvasculature with optical coherence tomographyVivek J Srinivasan
Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
Opt Lett 35:43-5. 2010..By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated... 
Optical coherence tractography using intrinsic contrastCraig J Goergen
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Opt Lett 37:3882-4. 2012..Moreover, as these techniques use intrinsic signals and do not require tissue slicing and staining, they can be used for high-throughput, nondestructive evaluation of fiber architecture across large tissue volumes...- Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortexJonghwan Lee
Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Charlestown, MA 02129, USA
Opt Express 19:21258-70. 2011..5 to 0.8 in terms of the cross-correlation over 4 s of dynamic imaging, and reduced phase noise by two orders of magnitude in ~8% voxels...