Harsha Radhakrishnan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Fast optical signal not detected in awake behaving monkeys
    Harsha Radhakrishnan
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149, 13th Street, Rm 2277, Charlestown, MA 02129, USA
    Neuroimage 45:410-9. 2009
  2. pmc Study of neurovascular coupling by modulating neuronal activity with GABA
    Harsha Radhakrishnan
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Brain Res 1372:1-12. 2011
  3. pmc Optical coherence tomography for the quantitative study of cerebrovascular physiology
    Vivek J Srinivasan
    Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 31:1339-45. 2011
  4. pmc Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography
    Jonghwan Lee
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 33:819-25. 2013
  5. pmc Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation
    Mohammad A Yaseen
    Department of Radiology, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 31:1051-63. 2011
  6. pmc Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast
    Vivek J Srinivasan
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    Opt Express 20:2220-39. 2012
  7. pmc The effect of different anesthetics on neurovascular coupling
    Maria Angela Franceschini
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 51:1367-77. 2010
  8. pmc Optical coherence tractography using intrinsic contrast
    Craig J Goergen
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Opt Lett 37:3882-4. 2012
  9. pmc Rapid volumetric angiography of cortical microvasculature with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 35:43-5. 2010
  10. pmc Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates
    Nadege Roche-Labarbe
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA Laboratoire Psychologie des Actions Langagières et Motrices, Universite de Caen Basse Normandie, France Electronic address
    Neuroimage 85:279-86. 2014

Collaborators

Detail Information

Publications11

  1. pmc Fast optical signal not detected in awake behaving monkeys
    Harsha Radhakrishnan
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, 149, 13th Street, Rm 2277, Charlestown, MA 02129, USA
    Neuroimage 45:410-9. 2009
    ..Based on these negative results, despite the optimal experimental conditions, we doubt the usefulness of non-invasive fast optical signal measurements with NIRS...
  2. pmc Study of neurovascular coupling by modulating neuronal activity with GABA
    Harsha Radhakrishnan
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Brain Res 1372:1-12. 2011
    ..These results suggest that the hemodynamic response is predominantly driven by cortico-cortical interactions and not by the initial thalamocortical activity in layer IV...
  3. pmc Optical coherence tomography for the quantitative study of cerebrovascular physiology
    Vivek J Srinivasan
    Department of Radiology, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 31:1339-45. 2011
    ..Moreover, DOCT flow values correlate with hydrogen clearance flow values when both are measured simultaneously. These data validate DOCT as a noninvasive quantitative method to measure tissue perfusion over a physiologic range...
  4. pmc Quantitative imaging of cerebral blood flow velocity and intracellular motility using dynamic light scattering-optical coherence tomography
    Jonghwan Lee
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Cereb Blood Flow Metab 33:819-25. 2013
    ..This result supports that the IM measured in this study represent the cellular energy metabolism-related active motion of intracellular organelles rather than free diffusion of intracellular macromolecules...
  5. pmc Microvascular oxygen tension and flow measurements in rodent cerebral cortex during baseline conditions and functional activation
    Mohammad A Yaseen
    Department of Radiology, MGH MIT HMS Athinuola A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    J Cereb Blood Flow Metab 31:1051-63. 2011
    ..Understanding O(2) supply on a microscopic level will yield better insight into brain function and the underlying mechanisms of various neuropathologies...
  6. pmc Optical coherence microscopy for deep tissue imaging of the cerebral cortex with intrinsic contrast
    Vivek J Srinivasan
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts, 02129, USA
    Opt Express 20:2220-39. 2012
    ..Lastly, we show that OCM enables direct visualization of cellular changes during cell depolarization and may therefore provide novel optical markers of cell viability...
  7. pmc The effect of different anesthetics on neurovascular coupling
    Maria Angela Franceschini
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Neuroimage 51:1367-77. 2010
    ..Baseline cerebral blood flow (CBF) interacts with neural activity and influences the evoked hemodynamic responses. Finally, neurovascular coupling appears to be the same across all anesthetics used...
  8. pmc Optical coherence tractography using intrinsic contrast
    Craig J Goergen
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Opt Lett 37:3882-4. 2012
    ..Moreover, as these techniques use intrinsic signals and do not require tissue slicing and staining, they can be used for high-throughput, nondestructive evaluation of fiber architecture across large tissue volumes...
  9. pmc Rapid volumetric angiography of cortical microvasculature with optical coherence tomography
    Vivek J Srinivasan
    Photon Migration Imaging Laboratory, MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Opt Lett 35:43-5. 2010
    ..By imaging during hypercapnia and comparing with simultaneous CCD imaging, the sources of contrast of OCT angiography are investigated...
  10. pmc Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates
    Nadege Roche-Labarbe
    A A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA Laboratoire Psychologie des Actions Langagières et Motrices, Universite de Caen Basse Normandie, France Electronic address
    Neuroimage 85:279-86. 2014
    ....
  11. pmc Motion correction for phase-resolved dynamic optical coherence tomography imaging of rodent cerebral cortex
    Jonghwan Lee
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Opt Express 19:21258-70. 2011
    ..5 to 0.8 in terms of the cross-correlation over 4 s of dynamic imaging, and reduced phase noise by two orders of magnitude in ~8% voxels...