BENJAMIN ALEXANDER RABY

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:1449-56. 2002
  2. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
  3. pmc Polymorphisms in IL12A and cockroach allergy in children with asthma
    Michael Pistiner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Mol Allergy 6:6. 2008
  4. ncbi ADAM33 polymorphisms and phenotype associations in childhood asthma
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:1071-8. 2004
  5. ncbi Low-normal gestational age as a predictor of asthma at 6 years of age
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 114:e327-32. 2004
  6. pmc Paternal history of asthma and airway responsiveness in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:552-8. 2005
  7. ncbi Association of vitamin D receptor gene polymorphisms with childhood and adult asthma
    Benjamin A Raby
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1057-65. 2004
  8. pmc T-bet polymorphisms are associated with asthma and airway hyperresponsiveness
    Benjamin A Raby
    M D C M, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:64-70. 2006
  9. ncbi A common mitochondrial haplogroup is associated with elevated total serum IgE levels
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:351-8. 2007
  10. ncbi Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 12:1973-9. 2003

Research Grants

  1. Genetics and Gene Expression Profiling in Asthma
    Benjamin Raby; Fiscal Year: 2007
  2. Fine mapping of an Asthma Locus of Chromosome 12q
    Benjamin Raby; Fiscal Year: 2007
  3. Genetics and Gene Expression Profiling in Asthma
    Benjamin Raby; Fiscal Year: 2009
  4. Structural Genetic Variation in Asthma
    Benjamin Raby; Fiscal Year: 2009
  5. Genetics and Gene Expression Profiling in Asthma
    BENJAMIN ALEXANDER RABY; Fiscal Year: 2010
  6. Genetics and Gene Expression Profiling in Asthma
    Benjamin Raby; Fiscal Year: 2009
  7. Structural Genetic Variation in Asthma
    BENJAMIN ALEXANDER RABY; Fiscal Year: 2010

Detail Information

Publications46

  1. ncbi Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:1449-56. 2002
    ..Based on these results, we found no evidence that genetic variation in TLR4 contributes to asthma susceptibility...
  2. pmc Asthma and genes encoding components of the vitamin D pathway
    Yohan Bosse
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Canada
    Respir Res 10:98. 2009
    ..Genetic variants at the vitamin D receptor (VDR) locus are associated with asthma and atopy. We hypothesized that polymorphisms in other genes of the vitamin D pathway are associated with asthma or atopy...
  3. pmc Polymorphisms in IL12A and cockroach allergy in children with asthma
    Michael Pistiner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Mol Allergy 6:6. 2008
    ..IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases...
  4. ncbi ADAM33 polymorphisms and phenotype associations in childhood asthma
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:1071-8. 2004
    ..However, genetic linkage of asthma phenotypes to chromosome 20p13 (the location of ADAM33) has not been observed in most asthma genome scans, and it is unclear whether these associations with ADAM33 are broadly generalizable...
  5. ncbi Low-normal gestational age as a predictor of asthma at 6 years of age
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 114:e327-32. 2004
    ..However, the role of these factors in the development of asthma in later life among children who do not develop perinatal respiratory disease remains unclear...
  6. pmc Paternal history of asthma and airway responsiveness in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:552-8. 2005
    ..Little is known regarding the relationship between parental history of asthma and subsequent airway hyperresponsiveness (AHR) in children with asthma...
  7. ncbi Association of vitamin D receptor gene polymorphisms with childhood and adult asthma
    Benjamin A Raby
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1057-65. 2004
    ..These results suggest that VDR influences asthma and allergy susceptibility in a complex manner...
  8. pmc T-bet polymorphisms are associated with asthma and airway hyperresponsiveness
    Benjamin A Raby
    M D C M, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:64-70. 2006
    ..Little is known regarding the role of genetic variation surrounding T-bet in the development of human AHR...
  9. ncbi A common mitochondrial haplogroup is associated with elevated total serum IgE levels
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:351-8. 2007
    ..Mitochondria are inherited exclusively through the maternal line, raising the possibility that sequence variation in the mitochondrial genome contributes to the pathogenesis of asthma and atopy...
  10. ncbi Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 12:1973-9. 2003
    ..Fine mapping efforts for these loci are warranted...
  11. ncbi Eotaxin polymorphisms and serum total IgE levels in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:298-305. 2006
    ..Family-based association studies of CCL11 genetic variants have not been reported to date...
  12. pmc A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma
    Sunita Sharma
    Channing Laboratory, Center for Genomic Medicine, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 181:328-36. 2010
    ..Animal models demonstrate that aberrant gene expression in utero can result in abnormal pulmonary phenotypes...
  13. pmc The IL12B gene is associated with asthma
    Adrienne G Randolph
    Channing Laboratory, Brigham and Women s Hospital, Department of Anesthesia, Children s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 75:709-15. 2004
    ..IL12B may be an important asthma gene...
  14. ncbi Genomic screening and replication using the same data set in family-based association testing
    Kristel Van Steen
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nat Genet 37:683-91. 2005
    ..Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do...
  15. ncbi A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies
    Christoph Lange
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 56:10-7. 2003
    ..The practical importance of our testing strategy is illustrated by applications to the Childhood Asthma Management Program asthma data sets...
  16. pmc Impact of population stratification on family-based association tests with longitudinal measurements
    Xiao Ding
    Harvard School of Public Health
    Stat Appl Genet Mol Biol 8:Article 17. 2009
    ..An application of these approaches to the Childhood Asthma Management Program (CAMP) study data for testing an association between body mass index and a previously reported candidate SNP is given as an example...
  17. ncbi Genetic linkage and association analysis of COPD-related traits on chromosome 8p
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    COPD 3:189-94. 2006
    ..07). Despite the reduced support for linkage upon further analysis, it remains possible that chromosome 8p contains a gene that influences COPD susceptibility. There is marginal, though not convincing, evidence for association with MSR1...
  18. pmc The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts
    Helen N Lyon
    Program in Genomics, Divisions of Genetics and Endocrinology, Children s Hospital, Boston, Massachusetts, USA
    PLoS Genet 3:e61. 2007
    ....
  19. ncbi Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa Rica
    Ngoc P Ly
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 133:107-14. 2008
    ..Little is known about the determinants of airway hyperresponsiveness (AHR) among children with asthma in Hispanic America...
  20. ncbi Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
    Gary M Hunninghake
    Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:84-90. 2007
    ..It is unclear whether single nucleotide polymorphisms (SNPs) in the gene for IL-13 (IL13) influence asthma severity and/or asthma morbidity...
  21. doi On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts, USA
    Genet Epidemiol 32:273-84. 2008
    ..A software implementation of the approach is freely available at http://www.hsph.harvard.edu/research/iuliana-ionita/software. The approach has also been completely integrated in the PBAT software package...
  22. pmc Comprehensive testing of positionally cloned asthma genes in two populations
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:849-57. 2007
    ..Replication of gene-disease associations has become a requirement in complex trait genetics...
  23. pmc Genomics and genome-wide association studies: an integrative approach to expression QTL mapping
    James H Degnan
    Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA
    Genomics 92:129-33. 2008
    ..We demonstrate that our family-based screening approach performs well in the analysis of integrative genomic datasets and that screening using either heritability or conditional power produces similar, though not identical, results...
  24. doi Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 122:93-8, 98.e1-5. 2008
    ..The allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10)...
  25. pmc On the replication of genetic associations: timing can be everything!
    Jessica Lasky-Su
    SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Am J Hum Genet 82:849-58. 2008
    ..If the specifics of age- or time-varying genetic effects are not considered in the selection of both the follow-up samples and in the statistical analysis, important genetic associations may be missed...
  26. ncbi Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma
    Angela J Rogers
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1332-7. 2007
    ..The role of these mutations in the development of asthma is less clear, particularly in patients who do not have coincident atopic dermatitis...
  27. pmc Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans
    Gary M Hunninghake
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 177:830-6. 2008
    ....
  28. ncbi On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice
    David Fardo
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 31:376-82. 2007
    ..The guidelines are illustrated by an application to an asthma study...
  29. ncbi Ala92 type 2 deiodinase allele increases risk for the development of hypertension
    Olga Gumieniak
    Endocrinology, Diabetes, and Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 49:461-6. 2007
    ..These data support an important role for genetic variation in the hypothalamic-pituitary-thyroid pathway in influencing susceptibility to hypertension...
  30. ncbi Sex-specific linkage to total serum immunoglobulin E in families of children with asthma in Costa Rica
    Benjamin A Raby
    Channing Laboratory and Respiratory Disorders Program, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 16:243-53. 2007
    ..JAG1 is a hematopoetic cell growth factor that may regulate normal B-cell development. This is the first demonstration of a possible genetic basis for differences in total IgE between sexes...
  31. ncbi Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma
    Eric S Silverman
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 169:214-9. 2004
    ..We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription...
  32. pmc IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004
    ..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
  33. ncbi Asthma genetics 2003
    Scott T Weiss
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 13:R83-9. 2004
    ..These discoveries open new avenues for research in asthma and allergy, and highlight the power (and limitations) of positional cloning for the identification of asthma genes, and complex trait genes in general...
  34. ncbi The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  35. ncbi TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples
    Ross Lazarus
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 170:594-600. 2004
    ..026 for c.+1031G>A). Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk...
  36. ncbi ADAM33: where are we now?
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 31:1-2. 2004
  37. pmc Endotoxin exposure and eczema in the first year of life
    Wanda Phipatanakul
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 114:13-8. 2004
    ..The objective of this study was to examine the relation between endotoxin exposure in early life and eczema in the first year of life in children with parental history of asthma or allergies...
  38. pmc TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory and Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18099-104. 2004
    ..TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids...
  39. ncbi Association of defensin beta-1 gene polymorphisms with asthma
    Hara Levy
    Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
    J Allergy Clin Immunol 115:252-8. 2005
    ..Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness...
  40. pmc A functional mutation in the terminal exon of elastin in severe, early-onset chronic obstructive pulmonary disease
    Cassandra M Kelleher
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Respir Cell Mol Biol 33:355-62. 2005
    ..These results suggest that the G773D variant confers structural and functional consequences relevant to the pathogenesis of COPD...
  41. ncbi Family-based association test for time-to-onset data with time-dependent differences between the hazard functions
    Hongyu Jiang
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Genet Epidemiol 30:124-32. 2006
    ..In addition to power increases of 100% over the original FBAT-Logrank test, we also gain insight into the age at which a genotype exerts the greatest influence on disease risk...
  42. pmc Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:977-84. 2006
    ..This variation may reflect different COPD subtypes, which may have different genetic predispositions...
  43. pmc Genetic determinants of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:476. 2006
  44. ncbi Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies
    Ross Lazarus
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Genomics 81:85-91. 2003
    ..This study suggests that there is substantial diversity in human TLR9, possibly associated with asthma in Europeans but not African Americans. No association was detected with three other diseases potentially related to innate immunity...
  45. ncbi Beta-2 adrenergic receptor diplotype defines a subset of salt-sensitive hypertension
    Luminita Pojoga
    Brigham and Women s Hospital, Division of Endocrinology, Diabetes, and Hypertension, 221 Longwood Ave, Boston, MA 02115, USA
    Hypertension 48:892-900. 2006
    ..Importantly, this association could only be detected with an intermediate and not a distant phenotype...
  46. ncbi The molecular basis of glutamate formiminotransferase deficiency
    John F Hilton
    Department of Biology, McGill University, Montreal, Quebec, Canada
    Hum Mutat 22:67-73. 2003
    ..These mutations are the first identified in glutamate formiminotransferase deficiency and demonstrate that mutations in FTCD represent the molecular basis for the mild phenotype of this disease...

Research Grants9

  1. Genetics and Gene Expression Profiling in Asthma
    Benjamin Raby; Fiscal Year: 2007
    ..These findings could ultimately lead to the development of novel therapies and a clinical prognostic test for this common disease. ..
  2. Fine mapping of an Asthma Locus of Chromosome 12q
    Benjamin Raby; Fiscal Year: 2007
    ..Identification of these variants may have a significant impact on the public health of asthma patients. ..
  3. Genetics and Gene Expression Profiling in Asthma
    Benjamin Raby; Fiscal Year: 2009
    ..These findings could ultimately lead to the development of novel therapies and a clinical prognostic test for this common disease. ..
  4. Structural Genetic Variation in Asthma
    Benjamin Raby; Fiscal Year: 2009
    ..Defining the genetic determinants of asthma will ultimately lead to the development of novel therapies and diagnostic tests. ..
  5. Genetics and Gene Expression Profiling in Asthma
    BENJAMIN ALEXANDER RABY; Fiscal Year: 2010
    ..These findings could ultimately lead to the development of novel therapies and a clinical prognostic test for this common disease. ..
  6. Genetics and Gene Expression Profiling in Asthma
    Benjamin Raby; Fiscal Year: 2009
    ..These findings could ultimately lead to the development of novel therapies and a clinical prognostic test for this common disease. ..
  7. Structural Genetic Variation in Asthma
    BENJAMIN ALEXANDER RABY; Fiscal Year: 2010
    ..Defining the genetic determinants of asthma will ultimately lead to the development of novel therapies and diagnostic tests. ..