Benjamin A Raby

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set
    Wai Ki Yip
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Building II, Boston, MA 02115, USA
    BMC Proc 5:S21. 2011
  2. pmc Quantifying differential gene connectivity between disease states for objective identification of disease-relevant genes
    Jen hwa Chu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    BMC Syst Biol 5:89. 2011
  3. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
  4. ncbi request reprint Genetic mapping of pharmacogenetic regulatory variation
    Benjamin A Raby
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    Curr Pharm Des 15:3773-81. 2009
  5. pmc Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Respir Res 10:67. 2009
  6. pmc Variants in TGFB1, dust mite exposure, and disease severity in children with asthma
    Sunita Sharma
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 179:356-62. 2009
  7. pmc Comprehensive testing of positionally cloned asthma genes in two populations
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:849-57. 2007
  8. ncbi request reprint Genetic linkage and association analysis of COPD-related traits on chromosome 8p
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    COPD 3:189-94. 2006
  9. doi request reprint Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 122:93-8, 98.e1-5. 2008
  10. pmc Assessing the reproducibility of asthma candidate gene associations, using genome-wide data
    Angela J Rogers
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:1084-90. 2009

Detail Information

Publications71

  1. pmc Identifying causal rare variants of disease through family-based analysis of Genetics Analysis Workshop 17 data set
    Wai Ki Yip
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Building II, Boston, MA 02115, USA
    BMC Proc 5:S21. 2011
    ..Our results suggest that both linkage and association tests with families show promise for identifying rare variants...
  2. pmc Quantifying differential gene connectivity between disease states for objective identification of disease-relevant genes
    Jen hwa Chu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    BMC Syst Biol 5:89. 2011
    ..Though numerous methods have been proposed and successfully implemented to develop these networks, there are no formal methods for comparing differences in network connectivity patterns as a function of phenotypic trait...
  3. pmc Asthma-susceptibility variants identified using probands in case-control and family-based analyses
    Blanca E Himes
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    BMC Med Genet 11:122. 2010
    ..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs...
  4. ncbi request reprint Genetic mapping of pharmacogenetic regulatory variation
    Benjamin A Raby
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
    Curr Pharm Des 15:3773-81. 2009
    ..The potential use of this approach in the study of pharmacogenetics and for the identification of potentially modifiable drug targets is reviewed here...
  5. pmc Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Respir Res 10:67. 2009
    ..We hypothesize that common IPO13 genetic variation influences the anti-inflammatory effects of inhaled corticosteroids for the treatment of asthma, as measured by change in methacholine airway hyperresponsiveness (AHR-PC20)...
  6. pmc Variants in TGFB1, dust mite exposure, and disease severity in children with asthma
    Sunita Sharma
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Respir Crit Care Med 179:356-62. 2009
    ..Polymorphisms in the gene for transforming growth factor-beta1 (TGFB1) have been associated with asthma, but not with airway responsiveness or disease exacerbations in subjects with asthma...
  7. pmc Comprehensive testing of positionally cloned asthma genes in two populations
    Craig P Hersh
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 176:849-57. 2007
    ..Replication of gene-disease associations has become a requirement in complex trait genetics...
  8. ncbi request reprint Genetic linkage and association analysis of COPD-related traits on chromosome 8p
    Craig P Hersh
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    COPD 3:189-94. 2006
    ..07). Despite the reduced support for linkage upon further analysis, it remains possible that chromosome 8p contains a gene that influences COPD susceptibility. There is marginal, though not convincing, evidence for association with MSR1...
  9. doi request reprint Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
    J Allergy Clin Immunol 122:93-8, 98.e1-5. 2008
    ..The allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10)...
  10. pmc Assessing the reproducibility of asthma candidate gene associations, using genome-wide data
    Angela J Rogers
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 179:1084-90. 2009
    ..Genome-wide genotyping enables simultaneous evaluation of most of this variation, and facilitates more comprehensive analysis of other common genetic variation around these candidate genes for association with asthma...
  11. ncbi request reprint Association of defensin beta-1 gene polymorphisms with asthma
    Hara Levy
    Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
    J Allergy Clin Immunol 115:252-8. 2005
    ..Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness...
  12. pmc Different polymorphisms of the mineralocorticoid receptor gene are associated with either glucocorticoid or mineralocorticoid levels in hypertension
    Bei Sun
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 97:E1825-9. 2012
    ....
  13. pmc Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa Ricans
    Gary M Hunninghake
    Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 177:830-6. 2008
    ....
  14. ncbi request reprint TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples
    Ross Lazarus
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 170:594-600. 2004
    ..026 for c.+1031G>A). Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk...
  15. pmc The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sex
    Gary M Hunninghake
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Pulm Med 11:17. 2011
    ..The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known...
  16. pmc Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responses
    Bei Sun
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Renin Angiotensin Aldosterone Syst 12:564-71. 2011
    ....
  17. ncbi request reprint ADAM33 polymorphisms and phenotype associations in childhood asthma
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Allergy Clin Immunol 113:1071-8. 2004
    ..However, genetic linkage of asthma phenotypes to chromosome 20p13 (the location of ADAM33) has not been observed in most asthma genome scans, and it is unclear whether these associations with ADAM33 are broadly generalizable...
  18. pmc Genome-wide association study of the age of onset of childhood asthma
    Erick Forno
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    J Allergy Clin Immunol 130:83-90.e4. 2012
    ..Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children...
  19. ncbi request reprint On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice
    David Fardo
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Genet Epidemiol 31:376-82. 2007
    ..The guidelines are illustrated by an application to an asthma study...
  20. pmc The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics study
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 95:E75-9. 2010
    ..Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists often cause volume retention and edema. A relationship between PPARgamma and renin may play a role in this process...
  21. pmc MMP12, lung function, and COPD in high-risk populations
    Gary M Hunninghake
    Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    N Engl J Med 361:2599-608. 2009
    ..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups...
  22. pmc Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and HTN, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 61:667-71. 2012
    ..05 × 10(-6)). This rare replication of a gene-environment interaction extends the generalizability of the results to hypertension while highlighting this polymorphism as a marker of IR in obese individuals...
  23. pmc Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension
    Luminita H Pojoga
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 96:E1288-92. 2011
    ..Caveolin-1 (CAV1), a gene previously associated with metabolic dysfunction in animal and cellular models, may be a marker for these conditions in humans...
  24. doi request reprint On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts, USA
    Genet Epidemiol 32:273-84. 2008
    ..A software implementation of the approach is freely available at http://www.hsph.harvard.edu/research/iuliana-ionita/software. The approach has also been completely integrated in the PBAT software package...
  25. pmc Parsing the effects of individual SNPs in candidate genes with family data
    Thomas J Hoffmann
    Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
    Hum Hered 69:91-103. 2010
    ..Lastly, we utilize these tests to analyze a continuous lung function phenotype as a proxy for asthma in the Childhood Asthma Management Program. The methods are implemented in the free R package fbati...
  26. pmc Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension
    Jonathan S Williams
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 25:812-7. 2012
    ..The aim of this study was to test the hypothesis that dietary salt influences the activity of a histone-modifying enzyme, lysine-specific demethylase 1 (LSD-1), which in turn is associated with salt-sensitivity of blood pressure (BP)...
  27. ncbi request reprint A common mitochondrial haplogroup is associated with elevated total serum IgE levels
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:351-8. 2007
    ..Mitochondria are inherited exclusively through the maternal line, raising the possibility that sequence variation in the mitochondrial genome contributes to the pathogenesis of asthma and atopy...
  28. ncbi request reprint Association of vitamin D receptor gene polymorphisms with childhood and adult asthma
    Benjamin A Raby
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 170:1057-65. 2004
    ..These results suggest that VDR influences asthma and allergy susceptibility in a complex manner...
  29. pmc IL10 gene polymorphisms are associated with asthma phenotypes in children
    Helen Lyon
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genet Epidemiol 26:155-65. 2004
    ..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children...
  30. ncbi request reprint Eotaxin polymorphisms and serum total IgE levels in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:298-305. 2006
    ..Family-based association studies of CCL11 genetic variants have not been reported to date...
  31. pmc T-bet polymorphisms are associated with asthma and airway hyperresponsiveness
    Benjamin A Raby
    M D C M, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:64-70. 2006
    ..Little is known regarding the role of genetic variation surrounding T-bet in the development of human AHR...
  32. pmc Genetic determinants of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Proc Am Thorac Soc 3:476. 2006
  33. ncbi request reprint Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa Rica
    Ngoc P Ly
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 133:107-14. 2008
    ..Little is known about the determinants of airway hyperresponsiveness (AHR) among children with asthma in Hispanic America...
  34. pmc Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP
    Xiaobo Zhou
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Hum Mol Genet 21:1325-35. 2012
    ..Together, our findings reveal one mechanism through which SNPs upstream of the HHIP gene modulate the expression of HHIP and functionally implicate reduced HHIP gene expression in the pathogenesis of COPD...
  35. pmc Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes
    Nancy E Lange
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    BMC Med Genet 12:26. 2011
    ..We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts...
  36. pmc Folliculin mutations are not associated with severe COPD
    Michael H Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Med Genet 9:120. 2008
    ....
  37. pmc Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes
    Amy Murphy
    Channing Laboratory, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hum Mol Genet 19:4745-57. 2010
    ..Population-based integrative genetic approaches can help identify such variation and enhance our understanding of the genetic basis of complex traits...
  38. pmc The impact of self-identified race on epidemiologic studies of gene expression
    Sunita Sharma
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Genet Epidemiol 35:93-101. 2011
    ....
  39. ncbi request reprint Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhood
    Gary M Hunninghake
    Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:84-90. 2007
    ..It is unclear whether single nucleotide polymorphisms (SNPs) in the gene for IL-13 (IL13) influence asthma severity and/or asthma morbidity...
  40. pmc Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary disease
    Michael H Cho
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Cell Mol Biol 40:751-5. 2009
    ..Two common nonsynonymous SNPs did not demonstrate significant associations in either a family-based or case-control analysis. Exonic SNPs in the elastin gene do not appear to be common risk factors for severe COPD...
  41. pmc On the frequency of copy number variants
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Bioinformatics 24:2350-5. 2008
    ..We employ a two-step procedure for the CNV frequency estimation process. We use family information a posteriori to select only the most reliable CNV regions, i.e. those showing high rates of Mendelian transmission...
  42. pmc Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells
    Xiaobo Zhou
    Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Genomics 101:263-72. 2013
    ..Thus, we identified potential HHIP targets in human bronchial epithelial cells that may contribute to COPD pathogenesis...
  43. ncbi request reprint Low-normal gestational age as a predictor of asthma at 6 years of age
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 114:e327-32. 2004
    ..However, the role of these factors in the development of asthma in later life among children who do not develop perinatal respiratory disease remains unclear...
  44. ncbi request reprint Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 12:1973-9. 2003
    ..Fine mapping efforts for these loci are warranted...
  45. ncbi request reprint Ala92 type 2 deiodinase allele increases risk for the development of hypertension
    Olga Gumieniak
    Endocrinology, Diabetes, and Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Hypertension 49:461-6. 2007
    ..These data support an important role for genetic variation in the hypothalamic-pituitary-thyroid pathway in influencing susceptibility to hypertension...
  46. ncbi request reprint The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)
    Juan C Celedon
    Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:1649-56. 2004
    ..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers...
  47. pmc Association of SERPINE2 with asthma
    Blanca E Himes
    Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 140:667-74. 2011
    ..We sought to determine whether SERPINE2 is associated with asthma and asthma-related phenotypes...
  48. pmc Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:977-84. 2006
    ..This variation may reflect different COPD subtypes, which may have different genetic predispositions...
  49. ncbi request reprint Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthma
    Eric S Silverman
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 169:214-9. 2004
    ..We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription...
  50. pmc Paternal history of asthma and airway responsiveness in children with asthma
    Benjamin A Raby
    Channing Laboratory, Department of Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:552-8. 2005
    ..Little is known regarding the relationship between parental history of asthma and subsequent airway hyperresponsiveness (AHR) in children with asthma...
  51. ncbi request reprint Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthma
    Angela J Rogers
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 120:1332-7. 2007
    ..The role of these mutations in the development of asthma is less clear, particularly in patients who do not have coincident atopic dermatitis...
  52. pmc In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthma
    Robyn T Cohen
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachussetts, USA
    J Allergy Clin Immunol 126:491-7. 2010
    ..Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma...
  53. pmc Copy number variation genotyping using family information
    Jen hwa Chu
    Channing Division of Network Medicine, Brigham and Women s Hospital, MA, USA
    BMC Bioinformatics 14:157. 2013
    ....
  54. pmc Risk factors and predictive clinical scores for asthma exacerbations in childhood
    Erick Forno
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Chest 138:1156-65. 2010
    ..Primary-care providers lack efficient tools to identify children at high risk for exacerbations. We aimed to construct a clinical score to help providers to identify such children...
  55. ncbi request reprint Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies
    Ross Lazarus
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Genomics 81:85-91. 2003
    ..This study suggests that there is substantial diversity in human TLR9, possibly associated with asthma in Europeans but not African Americans. No association was detected with three other diseases potentially related to innate immunity...
  56. pmc High-resolution melting curve analysis of genomic and whole-genome amplified DNA
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Chem 54:2055-8. 2008
    ..Few studies have compared the performance of high-resolution DNA melting curve analysis (HRM) in genomic and whole-genome amplified (WGA) DNA...
  57. pmc Genetic association analysis of copy-number variation (CNV) in human disease pathogenesis
    Iuliana Ionita-Laza
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Genomics 93:22-6. 2009
    ..Instead, development of novel technical, statistical, and epidemiologic methods will be necessary to optimally capture this newly-appreciated form of genetic variation in a meaningful manner...
  58. pmc Polymorphisms in IL12A and cockroach allergy in children with asthma
    Michael Pistiner
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Clin Mol Allergy 6:6. 2008
    ..IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases...
  59. pmc Using canonical correlation analysis to discover genetic regulatory variants
    Melissa G Naylor
    Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS ONE 5:e10395. 2010
    ..We assess the potential of applying canonical correlation analysis to partitioned genomewide data as a method for discovering regulatory variants...
  60. ncbi request reprint Asthma genetics 2003
    Scott T Weiss
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 13:R83-9. 2004
    ..These discoveries open new avenues for research in asthma and allergy, and highlight the power (and limitations) of positional cloning for the identification of asthma genes, and complex trait genes in general...
  61. pmc Endotoxin exposure and eczema in the first year of life
    Wanda Phipatanakul
    Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 114:13-8. 2004
    ..The objective of this study was to examine the relation between endotoxin exposure in early life and eczema in the first year of life in children with parental history of asthma or allergies...
  62. ncbi request reprint Family-based association test for time-to-onset data with time-dependent differences between the hazard functions
    Hongyu Jiang
    Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Genet Epidemiol 30:124-32. 2006
    ..In addition to power increases of 100% over the original FBAT-Logrank test, we also gain insight into the age at which a genotype exerts the greatest influence on disease risk...
  63. pmc On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples
    Amy Murphy
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Genet Epidemiol 34:582-90. 2010
    ..The advantages of the approach in practice are demonstrated by an application to a genome-wide association study for body mass index...
  64. pmc Data structures and algorithms for analysis of genetics of gene expression with Bioconductor: GGtools 3.x
    Vincent J Carey
    Channing Laboratory, Department of Medicine, I2B2 National Center for Biocomputing, Brigham and Women s Hospital, Boston, MA 02115, USA
    Bioinformatics 25:1447-8. 2009
    ..Using R/Bioconductor facilities, Phase II HapMap genotypes and Illumina 47K expression assay results archived on multiple populations may be interactively explored and analyzed using commodity hardware...
  65. doi request reprint Asthma genetics and genomics 2009
    Scott T Weiss
    Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Curr Opin Genet Dev 19:279-82. 2009
    ..For asthma genetics to begin to have an impact on clinical medicine we need to consider epistatic interaction...
  66. pmc A graphical model approach for inferring large-scale networks integrating gene expression and genetic polymorphism
    Jen hwa Chu
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    BMC Syst Biol 3:55. 2009
    ..Estimation of such networks has been a challenging problem when the genes considered greatly outnumber the samples, and the situation is exacerbated when one wishes to consider the impact of polymorphisms (SNPs) in genes...
  67. ncbi request reprint Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 166:1449-56. 2002
    ..Based on these results, we found no evidence that genetic variation in TLR4 contributes to asthma susceptibility...
  68. pmc TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids
    Kelan G Tantisira
    Channing Laboratory and Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:18099-104. 2004
    ..TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids...
  69. pmc Pulmonary function and emphysema in Williams-Beuren syndrome
    Emily S Wan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Med Genet A 152:653-6. 2010
    ..Further investigation may elucidate the pathogenesis of non-smoking-related emphysema...
  70. ncbi request reprint ADAM33: where are we now?
    Benjamin A Raby
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 31:1-2. 2004
  71. ncbi request reprint Sex-specific linkage to total serum immunoglobulin E in families of children with asthma in Costa Rica
    Benjamin A Raby
    Channing Laboratory and Respiratory Disorders Program, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Hum Mol Genet 16:243-53. 2007
    ..JAG1 is a hematopoetic cell growth factor that may regulate normal B-cell development. This is the first demonstration of a possible genetic basis for differences in total IgE between sexes...