Research Topics
Genomes and Genes
| Benjamin A RabySummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
Quantifying differential gene connectivity between disease states for objective identification of disease-relevant genesJen hwa Chu
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
BMC Syst Biol 5:89. 2011..Though numerous methods have been proposed and successfully implemented to develop these networks, there are no formal methods for comparing differences in network connectivity patterns as a function of phenotypic trait...- Asthma-susceptibility variants identified using probands in case-control and family-based analysesBlanca E Himes
Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
BMC Med Genet 11:122. 2010..We sought to find asthma-susceptibility variants by using probands from a single population in both family-based and case-control association designs... - Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthmaBenjamin A Raby
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Respir Res 10:67. 2009..We hypothesize that common IPO13 genetic variation influences the anti-inflammatory effects of inhaled corticosteroids for the treatment of asthma, as measured by change in methacholine airway hyperresponsiveness (AHR-PC20)... 
Genetic mapping of pharmacogenetic regulatory variationBenjamin A Raby
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston MA 02115, USA
Curr Pharm Des 15:3773-81. 2009..The potential use of this approach in the study of pharmacogenetics and for the identification of potentially modifiable drug targets is reviewed here...- Variants in TGFB1, dust mite exposure, and disease severity in children with asthmaSunita Sharma
Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Respir Crit Care Med 179:356-62. 2009..Polymorphisms in the gene for transforming growth factor-beta1 (TGFB1) have been associated with asthma, but not with airway responsiveness or disease exacerbations in subjects with asthma... - Genetic linkage and association analysis of COPD-related traits on chromosome 8pCraig P Hersh
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
COPD 3:189-94. 2006..07). Despite the reduced support for linkage upon further analysis, it remains possible that chromosome 8p contains a gene that influences COPD susceptibility. There is marginal, though not convincing, evidence for association with MSR1... - Comprehensive testing of positionally cloned asthma genes in two populationsCraig P Hersh
Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 176:849-57. 2007..Replication of gene-disease associations has become a requirement in complex trait genetics... - Assessing the reproducibility of asthma candidate gene associations, using genome-wide dataAngela J Rogers
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 179:1084-90. 2009..Genome-wide genotyping enables simultaneous evaluation of most of this variation, and facilitates more comprehensive analysis of other common genetic variation around these candidate genes for association with asthma... 
Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbationsGary M Hunninghake
Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02115, USA
J Allergy Clin Immunol 122:93-8, 98.e1-5. 2008..The allergenicity of dust mite exposure might be dependent on variants in the gene for IL-10 (IL10)...- Association of defensin beta-1 gene polymorphisms with asthmaHara Levy
Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
J Allergy Clin Immunol 115:252-8. 2005..Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness... - Different polymorphisms of the mineralocorticoid receptor gene are associated with either glucocorticoid or mineralocorticoid levels in hypertensionBei Sun
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 97:E1825-9. 2012.... - Sex-stratified linkage analysis identifies a female-specific locus for IgE to cockroach in Costa RicansGary M Hunninghake
Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 177:830-6. 2008.... - TOLL-like receptor 10 genetic variation is associated with asthma in two independent samplesRoss Lazarus
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 170:594-600. 2004..026 for c.+1031G>A). Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk... - Renin gene polymorphism: its relationship to hypertension, renin levels and vascular responsesBei Sun
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Renin Angiotensin Aldosterone Syst 12:564-71. 2011.... - The CD4+ T-cell transcriptome and serum IgE in asthma: IL17RB and the role of sexGary M Hunninghake
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
BMC Pulm Med 11:17. 2011..The relationships between total serum IgE levels and gene expression patterns in peripheral blood CD4+ T cells (in all subjects and within each sex specifically) are not known... - ADAM33 polymorphisms and phenotype associations in childhood asthmaBenjamin A Raby
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
J Allergy Clin Immunol 113:1071-8. 2004..However, genetic linkage of asthma phenotypes to chromosome 20p13 (the location of ADAM33) has not been observed in most asthma genome scans, and it is unclear whether these associations with ADAM33 are broadly generalizable... - Genome-wide association study of the age of onset of childhood asthmaErick Forno
Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
J Allergy Clin Immunol 130:83-90.e4. 2012..Although an earlier onset has been associated with more severe disease, there has been no genome-wide association study of the age of onset of asthma in children... - On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choiceDavid Fardo
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
Genet Epidemiol 31:376-82. 2007..The guidelines are illustrated by an application to an asthma study... - The relationship between peroxisome proliferator-activated receptor-gamma and renin: a human genetics studyPatricia C Underwood
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 95:E75-9. 2010..Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists often cause volume retention and edema. A relationship between PPARgamma and renin may play a role in this process... - MMP12, lung function, and COPD in high-risk populationsGary M Hunninghake
Channing Laboratory and Center for Genomic Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
N Engl J Med 361:2599-608. 2009..Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups... - Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistancePatricia C Underwood
Division of Endocrinology, Diabetes, and HTN, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Metabolism 61:667-71. 2012..05 × 10(-6)). This rare replication of a gene-environment interaction extends the generalizability of the results to hypertension while highlighting this polymorphism as a marker of IR in obese individuals... - Parsing the effects of individual SNPs in candidate genes with family dataThomas J Hoffmann
Department of Biostatistics, Harvard School of Public Health, Boston, Mass 02115, USA
Hum Hered 69:91-103. 2010..Lastly, we utilize these tests to analyze a continuous lung function phenotype as a proxy for asthma in the Childhood Asthma Management Program. The methods are implemented in the free R package fbati... - Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertensionLuminita H Pojoga
Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Clin Endocrinol Metab 96:E1288-92. 2011..Caveolin-1 (CAV1), a gene previously associated with metabolic dysfunction in animal and cellular models, may be a marker for these conditions in humans... - On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association testIuliana Ionita-Laza
Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, Massachusetts, USA
Genet Epidemiol 32:273-84. 2008..A software implementation of the approach is freely available at http://www.hsph.harvard.edu/research/iuliana-ionita/software. The approach has also been completely integrated in the PBAT software package... - Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertensionJonathan S Williams
Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Am J Hypertens 25:812-7. 2012..The aim of this study was to test the hypothesis that dietary salt influences the activity of a histone-modifying enzyme, lysine-specific demethylase 1 (LSD-1), which in turn is associated with salt-sensitivity of blood pressure (BP)... - Paternal asthma, mold exposure, and increased airway responsiveness among children with asthma in Costa RicaNgoc P Ly
Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
Chest 133:107-14. 2008..Little is known about the determinants of airway hyperresponsiveness (AHR) among children with asthma in Hispanic America... - A common mitochondrial haplogroup is associated with elevated total serum IgE levelsBenjamin A Raby
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 120:351-8. 2007..Mitochondria are inherited exclusively through the maternal line, raising the possibility that sequence variation in the mitochondrial genome contributes to the pathogenesis of asthma and atopy... - T-bet polymorphisms are associated with asthma and airway hyperresponsivenessBenjamin A Raby
M D C M, Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 173:64-70. 2006..Little is known regarding the role of genetic variation surrounding T-bet in the development of human AHR... - Eotaxin polymorphisms and serum total IgE levels in children with asthmaBenjamin A Raby
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 117:298-305. 2006..Family-based association studies of CCL11 genetic variants have not been reported to date... - Association of vitamin D receptor gene polymorphisms with childhood and adult asthmaBenjamin A Raby
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 170:1057-65. 2004..These results suggest that VDR influences asthma and allergy susceptibility in a complex manner... - IL10 gene polymorphisms are associated with asthma phenotypes in childrenHelen Lyon
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Genet Epidemiol 26:155-65. 2004..008 and 0.043, respectively). Polymorphisms in IL10 are associated with asthma phenotypes in this cohort. Further studies of variation in the IL10 gene may help elucidate the mechanism of asthma development in children... - Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypesNancy E Lange
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
BMC Med Genet 12:26. 2011..We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts... - Folliculin mutations are not associated with severe COPDMichael H Cho
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
BMC Med Genet 9:120. 2008.... - Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIPXiaobo Zhou
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 21:1325-35. 2012..Together, our findings reveal one mechanism through which SNPs upstream of the HHIP gene modulate the expression of HHIP and functionally implicate reduced HHIP gene expression in the pathogenesis of COPD... - Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytesAmy Murphy
Channing Laboratory, Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Mol Genet 19:4745-57. 2010..Population-based integrative genetic approaches can help identify such variation and enhance our understanding of the genetic basis of complex traits... - The impact of self-identified race on epidemiologic studies of gene expressionSunita Sharma
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Genet Epidemiol 35:93-101. 2011.... - Analysis of exonic elastin variants in severe, early-onset chronic obstructive pulmonary diseaseMichael H Cho
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Am J Respir Cell Mol Biol 40:751-5. 2009..Two common nonsynonymous SNPs did not demonstrate significant associations in either a family-based or case-control analysis. Exonic SNPs in the elastin gene do not appear to be common risk factors for severe COPD... - Polymorphisms in IL13, total IgE, eosinophilia, and asthma exacerbations in childhoodGary M Hunninghake
Channing Laboratory Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 120:84-90. 2007..It is unclear whether single nucleotide polymorphisms (SNPs) in the gene for IL-13 (IL13) influence asthma severity and/or asthma morbidity... - On the frequency of copy number variantsIuliana Ionita-Laza
Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA
Bioinformatics 24:2350-5. 2008.... - Genetic determinants of functional impairment in chronic obstructive pulmonary diseaseCraig P Hersh
Channing Laboratory, Brigham and Women's Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Proc Am Thorac Soc 3:476. 2006 - Association of SERPINE2 with asthmaBlanca E Himes
Channing Laboratory, 181 Longwood Ave, Boston, MA 02115, USA
Chest 140:667-74. 2011..We sought to determine whether SERPINE2 is associated with asthma and asthma-related phenotypes... - Low-normal gestational age as a predictor of asthma at 6 years of ageBenjamin A Raby
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatrics 114:e327-32. 2004..However, the role of these factors in the development of asthma in later life among children who do not develop perinatal respiratory disease remains unclear... - The transforming growth factor-beta1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD)Juan C Celedon
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Hum Mol Genet 13:1649-56. 2004..We hypothesize that genetic variants in or near the TGFB1 gene influence the pathogenesis of COPD among cigarette smokers... - Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypesBenjamin A Raby
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Hum Mol Genet 12:1973-9. 2003..Fine mapping efforts for these loci are warranted... - Ala92 type 2 deiodinase allele increases risk for the development of hypertensionOlga Gumieniak
Endocrinology, Diabetes, and Hypertension Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Hypertension 49:461-6. 2007..These data support an important role for genetic variation in the hypothalamic-pituitary-thyroid pathway in influencing susceptibility to hypertension... - Genetic association analysis of functional impairment in chronic obstructive pulmonary diseaseCraig P Hersh
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Respir Crit Care Med 173:977-84. 2006..This variation may reflect different COPD subtypes, which may have different genetic predispositions... - Paternal history of asthma and airway responsiveness in children with asthmaBenjamin A Raby
Channing Laboratory, Department of Medicine, and Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 172:552-8. 2005..Little is known regarding the relationship between parental history of asthma and subsequent airway hyperresponsiveness (AHR) in children with asthma... - Filaggrin mutations confer susceptibility to atopic dermatitis but not to asthmaAngela J Rogers
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 120:1332-7. 2007..The role of these mutations in the development of asthma is less clear, particularly in patients who do not have coincident atopic dermatitis... - Transforming growth factor-beta1 promoter polymorphism C-509T is associated with asthmaEric S Silverman
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 169:214-9. 2004..We conclude that the T allele of C-509T is associated with the diagnosis of asthma and may enhance TGF-beta1 gene transcription... - In utero smoke exposure and impaired response to inhaled corticosteroids in children with asthmaRobyn T Cohen
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachussetts, USA
J Allergy Clin Immunol 126:491-7. 2010..Few studies have examined the effects of in utero smoke exposure (IUS) on lung function in children with asthma, and there are no published data on the impact of IUS on treatment outcomes in children with asthma... - High-resolution melting curve analysis of genomic and whole-genome amplified DNAMichael H Cho
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Chem 54:2055-8. 2008..Few studies have compared the performance of high-resolution DNA melting curve analysis (HRM) in genomic and whole-genome amplified (WGA) DNA... - Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studiesRoss Lazarus
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Genomics 81:85-91. 2003..This study suggests that there is substantial diversity in human TLR9, possibly associated with asthma in Europeans but not African Americans. No association was detected with three other diseases potentially related to innate immunity... - Risk factors and predictive clinical scores for asthma exacerbations in childhoodErick Forno
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Chest 138:1156-65. 2010..Primary-care providers lack efficient tools to identify children at high risk for exacerbations. We aimed to construct a clinical score to help providers to identify such children... - Genetic association analysis of copy-number variation (CNV) in human disease pathogenesisIuliana Ionita-Laza
Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
Genomics 93:22-6. 2009..Instead, development of novel technical, statistical, and epidemiologic methods will be necessary to optimally capture this newly-appreciated form of genetic variation in a meaningful manner... - Polymorphisms in IL12A and cockroach allergy in children with asthmaMichael Pistiner
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Clin Mol Allergy 6:6. 2008..IL12A has been implicated in T-cell development and may thus influence the development of atopy and allergic diseases... - Asthma genetics 2003Scott T Weiss
Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Hum Mol Genet 13:R83-9. 2004..These discoveries open new avenues for research in asthma and allergy, and highlight the power (and limitations) of positional cloning for the identification of asthma genes, and complex trait genes in general... - Data structures and algorithms for analysis of genetics of gene expression with Bioconductor: GGtools 3.xVincent J Carey
Channing Laboratory, Department of Medicine, I2B2 National Center for Biocomputing, Brigham and Women s Hospital, Boston, MA 02115, USA
Bioinformatics 25:1447-8. 2009..AVAILABILITY AND IMPLEMENTATION: Open Source. Bioconductor 2.3 packages GGtools, GGBase, GGdata, hmyriB36. Freely available on the web at (http://www.bioconductor.org)... - Endotoxin exposure and eczema in the first year of lifeWanda Phipatanakul
Department of Pediatrics, Division of Allergy and Immunology, Children s Hospital, Boston, Massachusetts 02115, USA
Pediatrics 114:13-8. 2004..The objective of this study was to examine the relation between endotoxin exposure in early life and eczema in the first year of life in children with parental history of asthma or allergies... - Using canonical correlation analysis to discover genetic regulatory variantsMelissa G Naylor
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, United States of America
PLoS ONE 5:e10395. 2010..We assess the potential of applying canonical correlation analysis to partitioned genomewide data as a method for discovering regulatory variants... - Asthma genetics and genomics 2009Scott T Weiss
Harvard Medical School, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Curr Opin Genet Dev 19:279-82. 2009..For asthma genetics to begin to have an impact on clinical medicine we need to consider epistatic interaction... - Family-based association test for time-to-onset data with time-dependent differences between the hazard functionsHongyu Jiang
Department of Biostatistics, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
Genet Epidemiol 30:124-32. 2006..In addition to power increases of 100% over the original FBAT-Logrank test, we also gain insight into the age at which a genotype exerts the greatest influence on disease risk... - On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samplesAmy Murphy
Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
Genet Epidemiol 34:582-90. 2010..The advantages of the approach in practice are demonstrated by an application to a genome-wide association study for body mass index... - A graphical model approach for inferring large-scale networks integrating gene expression and genetic polymorphismJen hwa Chu
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
BMC Syst Biol 3:55. 2009..Estimation of such networks has been a challenging problem when the genes considered greatly outnumber the samples, and the situation is exacerbated when one wishes to consider the impact of polymorphisms (SNPs) in genes... - TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroidsKelan G Tantisira
Channing Laboratory and Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:18099-104. 2004..TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids... - Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypesBenjamin A Raby
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 166:1449-56. 2002..Based on these results, we found no evidence that genetic variation in TLR4 contributes to asthma susceptibility... - Pulmonary function and emphysema in Williams-Beuren syndromeEmily S Wan
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Med Genet A 152:653-6. 2010..Further investigation may elucidate the pathogenesis of non-smoking-related emphysema... - ADAM33: where are we now?Benjamin A Raby
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Respir Cell Mol Biol 31:1-2. 2004 - Sex-specific linkage to total serum immunoglobulin E in families of children with asthma in Costa RicaBenjamin A Raby
Channing Laboratory and Respiratory Disorders Program, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Hum Mol Genet 16:243-53. 2007..JAG1 is a hematopoetic cell growth factor that may regulate normal B-cell development. This is the first demonstration of a possible genetic basis for differences in total IgE between sexes...