Research Topics
Genomes and Genes
| Abrar A QureshiSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
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Detail Information
Publications
A functional SNP in the MDM2 promoter, pigmentary phenotypes, and risk of skin cancerHongmei Nan
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
Cancer Causes Control 20:171-9. 2009..05) than p53 Arg/Arg wild-type group (p, trend, 0.99; p, interaction, 0.07). These results provide evidence for the potential involvement of MDM2 SNP309 in pigmentary traits...- Genetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health StudyHongmei Nan
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
BMC Cancer 9:172. 2009..Overexpression of the FGFR4 protein has been linked to cutaneous melanoma progression. Previous studies reported associations between genetic variants in the FGFR2 and FGFR4 genes and development of various cancers... - Pathway analysis for genome-wide association study of basal cell carcinoma of the skinMingfeng Zhang
Department of Dermatology, Clinical Research Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 6:e22760. 2011..Recently, a pathway-based approach has been developed to evaluate the cumulative contribution of the functionally related genes for genome-wide association studies (GWASs), which may help utilize GWAS data to a greater extent... - Smoking and risk of incident psoriasis among women and men in the United States: a combined analysisWenqing Li
Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Epidemiol 175:402-13. 2012..0001). In this study, smoking was found to be an independent risk factor for psoriasis in both women and men. Psoriasis risk was particularly augmented for heavy smokers and persons with longer durations of smoking... 
Heterogeneity in host risk factors for incident melanoma and non-melanoma skin cancer in a cohort of US womenAbrar A Qureshi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
J Epidemiol 21:197-203. 2011..Melanoma, squamous cell carcinoma (SCC), and basal cell carcinoma (BCC) are 3 types of skin cancer that have distinct biologic characteristics and prognoses. We evaluated phenotypic differences in the risk of these cancers in US women...- Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinomaHongmei Nan
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Hum Mol Genet 20:3718-24. 2011..21 (1.02-1.44); P= 0.03], were associated with an increased risk of SCC. These two variants were not associated with melanoma risk. We conclude that 6p25 and 13q32 are novel loci conferring susceptibility to non-melanoma skin cancer... - Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma riskHongmei Nan
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Hum Mol Genet 20:2673-9. 2011..5 × 10(-6)) and in primary melanoma (P = 4.6 × 10(-4)) compared with the normal skin... - Use of tanning beds and incidence of skin cancerMingfeng Zhang
Brigham and Women s Hospital, Boston, MA, USA
J Clin Oncol 30:1588-93. 2012..We sought to evaluate the risk effect of tanning bed use on skin cancers among teenage and young adults. We also expected to determine whether a dose-response relationship was evident... - A germline variant in the interferon regulatory factor 4 gene as a novel skin cancer risk locusJiali Han
Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 71:1533-9. 2011..6 × 10(-3)). Given that the T allele was shown previously to be associated with increased expression of IRF4 locus, further studies are warranted to elucidate the role of the IRF4 gene in human pigmentation and skin cancer development... - Shorter telomeres associate with a reduced risk of melanoma developmentHongmei Nan
Channing Laboratory, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 71:6758-63. 2011..43 (95% CI: 0.28-0.68; P(trend), 0.0003). Unlike findings for other tumors, shorter telomeres were significantly associated with a decreased risk of melanoma in this study, suggesting a unique role of telomeres in melanoma development... - A prospective study of telomere length and the risk of skin cancerJiali Han
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
J Invest Dermatol 129:415-21. 2009..85 (95% CI, 0.94-3.62) (P, trend=0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations... - Genetic variants in telomere-maintaining genes and skin cancer riskHongmei Nan
Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Hum Genet 129:247-53. 2011..05). We did not observe significant associations for SCC or BCC risk. Our study provides evidence for the contribution of genetic variants in the telomere-maintaining genes to melanoma susceptibility... - Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanomaFangyi Gu
Department of aEpidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
Melanoma Res 18:330-5. 2008..93 to 1.03. We did not find significant results for the SNPs in the other four genes. These data suggest the involvement of IL-6R in melanoma development. Further studies are needed to confirm these findings... 
Obesity and risk of incident psoriatic arthritis in US womenWenqing Li
Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Ann Rheum Dis 71:1267-72. 2012..This study aimed to evaluate the association between obesity and the risk of incident PsA in a large cohort of women...- Geographical variation in residence and risk of multiple nonmelanoma skin cancers in US women and menErin X Wei-Passanese
Harvard Medical School, Boston, MA, USA
Photochem Photobiol 88:483-9. 2012..In conclusion, we found that consistent residence in medium- or high-UVR locations was significantly associated an incremental risk of ≥2 NMSCs later in life... - Smoking and risk of incident psoriatic arthritis in US womenWenqing Li
Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Rheum Dis 71:804-8. 2012..Previous studies have found an association between smoking and psoriasis, but the association with PsA is unclear. The authors aimed to evaluate the association between smoking and the risk of incident PsA in a large cohort of women... - ASIP genetic variants and the number of non-melanoma skin cancersWen Lin
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Cancer Causes Control 22:495-501. 2011..32; 95% CI, 1.07-1.63). The OR increased to 1.45(1.18-1.78) for those with 2-4 NMSCs and 1.84(1.34-2.53) for those with at least five. The findings suggest that ASIP locus is associated with the number of NMSCs... - The association between physical activity and the risk of incident psoriasisHillary C Frankel
Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Arch Dermatol 148:918-24. 2012..To examine the association between total physical activity, walking, and vigorous exercise and the incidence of psoriasis in women... - Integrating pathway analysis and genetics of gene expression for genome-wide association study of basal cell carcinomaMingfeng Zhang
Clinical Research Program, Department of Dermatology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
Hum Genet 131:615-23. 2012..08). Based on the evidence of biological functions of the JAK-STAT pathway on oncogenesis, it is plausible that this pathway is involved in BCC pathogenesis... - No association between telomere length in peripheral blood leukocytes and the risk of nonmelanoma skin cancerGeyu Liang
Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 20:1043-5. 2011..Recent reports have shown that telomere length was associated with the risk of various cancers, but the results have been inconsistent... - PGC-1 Coactivators Regulate MITF and the Tanning ResponseJonathan Shoag
Cardiovascular Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA Division of Health Sciences and Technology, MIT and Harvard Medical School, Cambridge, MA 02139, USA
Mol Cell 49:145-57. 2013..These data identify PGC-1 coactivators as regulators of human tanning... - Genetic variation in DNA repair pathway genes and melanoma riskMingfeng Zhang
Clinical Research Program, Department of Dermatology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
DNA Repair (Amst) 10:111-6. 2011..Further work on fine-mapping and on the functional characterization of this and linked SNPs in this region is required... - Psoriasis and risk of type 2 diabetes among women and men in the United States: a population-based cohort studyWenqing Li
Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Invest Dermatol 132:291-8. 2012..In addition, the risk of T2D was much higher for those developing psoriasis at an early age. In conclusion, we found an association between psoriasis and the risk of T2D among individuals younger than 60 years... - No association between Parkinson disease alleles and the risk of melanomaShasha Meng
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Cancer Epidemiol Biomarkers Prev 21:243-5. 2012..It has been hypothesized that these two diseases may share common genetic and environmental risk factors... - Sunlight exposure, vitamin D, and risk of non-Hodgkin lymphoma in the Nurses' Health StudyKimberly A Bertrand
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
Cancer Causes Control 22:1731-41. 2011..Evidence from prospective cohort studies, however, is limited and inconsistent. We evaluated the association between ambient ultraviolet radiation (UV) exposure and NHL in a nationwide cohort of women, the Nurses' Health Study (NHS)... - Rotating night shifts and risk of skin cancer in the nurses' health studyEva S Schernhammer
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Boston, MA 02115, USA
J Natl Cancer Inst 103:602-6. 2011..005). Hair color, a surrogate for an individual's susceptibility to skin cancer, was a statistically significant effect modifier for the observed associations; darker-haired women had the lowest risk (P(interaction) = .02)... - Smoking and risk of skin cancer: a prospective analysis and a meta-analysisFengju Song
Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China
Int J Epidemiol 41:1694-705. 2012..The association between smoking and the risk of skin cancer has not been well established... - Exploring Priority Research Areas in Psoriasis and Psoriatic Arthritis from Dermatologists' Perspective: A Report from the GRAPPA 2011 Annual MeetingApril W Armstrong
From the Department of Dermatology, University of California Davis, Sacramento, California University of Utah, Salt Lake City, Utah Boston University Department of Dermatology, Boston, Massachusetts University of Pennsylvania Health System, Philadelphia, Pennsylvania Tufts Medical Center, Boston, Massachusetts Brigham and Women s Hospital, Boston, Massachusetts, USA and Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
J Rheumatol 39:2204-10. 2012..Finally, the members supported continued efforts to explore the genetic basis of psoriasis and more studies focused on comparative effectiveness of existing treatments... - Management of psoriasis and psoriatic arthritis in a combined dermatology and rheumatology clinicNicole F Velez
Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Arch Dermatol Res 304:7-13. 2012..Our data can be used to support the efforts to provide integrated rheumatologic and dermatologic care for this population... - Psoriasis and the risk of diabetes and hypertension: a prospective study of US female nursesAbrar A Qureshi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 45 Francis St, 221L, Boston, MA 02115, USA
Arch Dermatol 145:379-82. 2009..To evaluate the independent association between psoriasis and risk of diabetes and hypertension... - Psoriatic arthritis screening toolsAbrar A Qureshi
Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Rheumatol 35:1423-5. 2008..The development and validation of these screening tools was a major focus at the GRAPPA annual meeting at Boston in September 2007; we summarize that portion of the meeting... - Increased caffeine intake is associated with reduced risk of basal cell carcinoma of the skinFengju Song
Department of Dermatology, Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 72:3282-9. 2012..In contrast, caffeine intake was not found to be inversely associated with risks of SCC or melanoma. Our findings argue that caffeine intake in men and women is inversely associated with risk of BCC... - Genome-wide association study of tanning phenotype in a population of European ancestryHongmei Nan
Channing Laboratory, Department of Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Invest Dermatol 129:2250-7. 2009..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color... - Geographic variation and risk of skin cancer in US women. Differences between melanoma, squamous cell carcinoma, and basal cell carcinomaAbrar A Qureshi
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Arch Intern Med 168:501-7. 2008..Our goal was to evaluate differences in risk of these skin cancers according to residence at varying UV indices at 3 time points... - Prevalence of the metabolic syndrome in psoriasis: results from the National Health and Nutrition Examination Survey, 2003-2006Thorvardur Jon Love
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Arch Dermatol 147:419-24. 2011..To estimate the prevalence of the metabolic syndrome among individuals with psoriasis and to examine the association between these 2 conditions in the general US population... - Alcohol intake and risk of incident psoriasis in US women: a prospective studyAbrar A Qureshi
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Arch Dermatol 146:1364-9. 2010..To evaluate the independent association between alcohol consumption and risk of developing psoriasis and to determine if this risk is associated with different types of alcoholic beverages... - ABO blood group and incidence of skin cancerJing Xie
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
PLoS ONE 5:e11972. 2010..Previous studies have examined the association between ABO blood group and the risk of some malignancies. However, no prospective cohort study to date has examined the association between ABO blood group and the risk of skin cancer... - Summary of minutes of the GRAPPA meeting adjacent to the American Academy of Dermatology 67th Annual MeetingWolf Henning Boehncke
Department of Dermatology, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
J Rheumatol 38:553-6. 2011..Key results and minutes of the San Francisco meeting were presented at the 2009 GRAPPA annual meeting in Stockholm, Sweden, and are summarized here... - Histopathologic spectrum of psoriasiform skin reactions associated with tumor necrosis factor-α inhibitor therapy. A study of 16 biopsiesAlvaro C Laga
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Dermatopathol 32:568-73. 2010..Because the different histopathologic findings may be subtle, clinical correlation is crucial to make the diagnosis... - Extranodal natural killer cell/t-cell lymphoma, nasal type, presenting as cutaneous nodules and a small-bowel perforationPriyanka Agarwal
Department of Dermatology, Brigham Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Dermatopathol 32:83-5. 2010..Repeat biopsies and close clinicopathologic correlation are essential for establishment of correct diagnosis... - Psoriatic arthritis and psoriasis: need for a multidisciplinary approachAbrar A Qureshi
Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02114, USA
Semin Cutan Med Surg 24:46-51. 2005..Because dermatologists are on the front-line of psoriasis management, we are perfectly poised to identify and help improve care for patients who suffer from both psoriasis and psoriatic arthritis... - Willingness-to-pay stated preferences for telemedicine versus in-person visits in patients with a history of psoriasis or melanomaAbrar A Qureshi
Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Telemed J E Health 12:639-43. 2006..This preliminary work suggests that dermatology patients prefer telemedicine if this modality provides quicker access to their physician... - Willingness-to-pay stated preferences for 8 health-related quality-of-life domains in psoriasis: a pilot studyMatthew Delfino
Department of Dermatology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Acad Dermatol 59:439-47. 2008.... - Development of screening tools to identify psoriatic arthritisPatrick Dominguez
Department of Dermatology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Curr Rheumatol Rep 12:295-9. 2010.... - Willingness-to-pay stated preferences for 8 health-related quality-of-life domains in psoriatic arthritis: a pilot studyStephanie W Hu
Harvard Medical School, Boston, MA, USA
Semin Arthritis Rheum 39:384-97. 2010.... - Validity, reliability, and sensitivity-to-change properties of the psoriatic arthritis screening and evaluation questionnairePatrick Lee Dominguez
Department of Dermatology, Center for Skin and Related Musculoskeletal Diseases, Brigham and Women s Hospital BWH, Harvard Medical School, Boston, MA 02115, USA
Arch Dermatol Res 301:573-9. 2009..034). The PASE questionnaire is a valid and reliable tool to screen for active PsA among individuals with psoriasis. PASE scores may be used as a marker of therapeutic response...