Francisco J Quintana

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint DNA vaccines coding for heat-shock proteins (HSPs): tools for the activation of HSP-specific regulatory T cells
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Expert Opin Biol Ther 5:545-54. 2005
  2. doi request reprint Regulatory T cells and immune computation
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02446, USA
    Eur J Immunol 38:903-7. 2008
  3. pmc Regulation of central nervous system autoimmunity by the aryl hydrocarbon receptor
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA
    Semin Immunopathol 35:627-35. 2013
  4. pmc Aryl hydrocarbon receptor control of adaptive immunity
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pharmacol Rev 65:1148-61. 2013
  5. pmc The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Immunology 138:183-9. 2013
  6. pmc Aiolos promotes TH17 differentiation by directly silencing Il2 expression
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 13:770-7. 2012
  7. pmc Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Neuroimmunol 248:53-7. 2012
  8. pmc Antigen microarrays identify CNS-produced autoantibodies in RRMS
    F J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 78:532-9. 2012
  9. pmc Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e9478. 2010
  10. pmc HSP60 as a target of anti-ergotypic regulatory T cells
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 3:e4026. 2008

Detail Information

Publications61

  1. ncbi request reprint DNA vaccines coding for heat-shock proteins (HSPs): tools for the activation of HSP-specific regulatory T cells
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel
    Expert Opin Biol Ther 5:545-54. 2005
    ..Thus, DNA vaccines coding for HSPs may serve not only as tools for the dissection of immunoregulatory mechanisms, but also as agents for the treatment of autoimmune disorders...
  2. doi request reprint Regulatory T cells and immune computation
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02446, USA
    Eur J Immunol 38:903-7. 2008
    ..However, based on the reactive nature of the immune system, we agree with Rolf's third postulate in that Treg cannot know ahead of time an ideal set-point for immune homeostasis...
  3. pmc Regulation of central nervous system autoimmunity by the aryl hydrocarbon receptor
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA
    Semin Immunopathol 35:627-35. 2013
    ..This review discusses the role of AhR in T cells and dendritic cells, its relevance for the control of autoimmunity in the central nervous system, and its potential as a therapeutic target for immune-mediated disorders. ..
  4. pmc Aryl hydrocarbon receptor control of adaptive immunity
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pharmacol Rev 65:1148-61. 2013
    ....
  5. pmc The aryl hydrocarbon receptor: a molecular pathway for the environmental control of the immune response
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Immunology 138:183-9. 2013
    ..AHR also provides a target for therapeutic intervention in immune-mediated disorders. In this review, we discuss the role of AHR in the regulation of T-cell differentiation and autoimmunity...
  6. pmc Aiolos promotes TH17 differentiation by directly silencing Il2 expression
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 13:770-7. 2012
    ..Thus, we have identified a module in the transcriptional program of T(H)17 cells that actively limits IL-2 production and promotes their differentiation...
  7. pmc Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    J Neuroimmunol 248:53-7. 2012
    ..In this review, we discuss the potential use of lipids and the immune response against them as biomarkers of inflammation and neurodegeneration for MS...
  8. pmc Antigen microarrays identify CNS-produced autoantibodies in RRMS
    F J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 78:532-9. 2012
    ..We investigated whether there were unique autoantibodies in the CSF of patients with MS as measured by antigen arrays and whether these antibodies differed from those in serum...
  9. pmc Adaptive autoimmunity and Foxp3-based immunoregulation in zebrafish
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e9478. 2010
    ..Recombinatorial mechanisms also operate in teleosts, but active immunoregulation is thought to be a late incorporation to the vertebrate lineage...
  10. pmc HSP60 as a target of anti-ergotypic regulatory T cells
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 3:e4026. 2008
    ..Thus, by functioning as an ergotope, HSP60 can control both the effector T cells and the regulatory HSP60-specific T cells that control them...
  11. doi request reprint Systems biology approaches for the study of multiple sclerosis
    Francisco J Quintana
    Center for Neurologic Diseases, Harvard Medical School, Boston, MA 02115, USA
    J Cell Mol Med 12:1087-93. 2008
    ....
  12. pmc Induction of IgG3 to LPS via Toll-like receptor 4 co-stimulation
    Francisco J Quintana
    Center for Neurologic Diseases, Harvard Medical School, Boston, MA, USA
    PLoS ONE 3:e3509. 2008
    ..Vaccines might exploit BCR/TLR synergism to rapidly induce antigen-specific antibodies before significant T-cell responses arise...
  13. pmc An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis
    Francisco J Quintana
    Center for Neurologic Diseases, The Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:20768-73. 2010
    ....
  14. doi request reprint The HSP60 immune system network
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston MA, USA
    Trends Immunol 32:89-95. 2011
    ..Thus, the dual role of HSP60 as an immune modulator and a biomarker, provides an opportunity to modulate immunity for therapeutic purposes, and to monitor the immune response in health and disease...
  15. ncbi request reprint DNA fragments of the human 60-kDa heat shock protein (HSP60) vaccinate against adjuvant arthritis: identification of a regulatory HSP60 peptide
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 171:3533-41. 2003
    ..These results show that regulatory mechanisms can be activated by immunization with relevant self-HSP60 epitopes...
  16. ncbi request reprint Inhibition of adjuvant-induced arthritis by DNA vaccination with the 70-kd or the 90-kd human heat-shock protein: immune cross-regulation with the 60-kd heat-shock protein
    Francisco J Quintana
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Arthritis Rheum 50:3712-20. 2004
    ..We have recently demonstrated that vaccination with human Hsp60 DNA inhibits AIA. The present study was undertaken to analyze the role of the T cell responses to self HSP molecules other than Hsp60 in the control of AIA...
  17. pmc IL-27 acts on DCs to suppress the T cell response and autoimmunity by inducing expression of the immunoregulatory molecule CD39
    Ivan D Mascanfroni
    1 Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA 2
    Nat Immunol 14:1054-63. 2013
    ..Finally, therapeutic vaccination with IL-27-conditioned DCs suppressed established relapsing-remitting EAE. Thus, IL-27 signaling in DCs limited pathogenic T cell responses and the development of autoimmunity. ..
  18. pmc The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
    Lionel Apetoh
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:854-61. 2010
    ..Manipulating AhR signaling could therefore be beneficial in the resolution of excessive inflammatory responses...
  19. pmc Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis
    Ada Yeste
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 109:11270-5. 2012
    ..Thus, NPs are potential new tools to induce functional Tregs in autoimmune disorders...
  20. pmc Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell-like and Foxp3(+) regulatory T cells
    Roopali Gandhi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nat Immunol 11:846-53. 2010
    ..Thus, AhR is a potential target through which functional iT(reg) cells could be induced in human autoimmune disorders...
  21. ncbi request reprint T-cell inactivation and immunosuppressive activity induced by HIV gp41 via novel interacting motif
    Itai Bloch
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, 76100 Israel
    FASEB J 21:393-401. 2007
    ..Deciphering the molecular mechanism of the immunosuppressive activity of FP provides a new potential target to overcome the immunosuppressant activity of HIV, and in addition a tool for down-regulating immune mediated inflammation...
  22. doi request reprint Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nature 453:65-71. 2008
    ..Thus, AHR regulates both T(reg) and T(H)17 cell differentiation in a ligand-specific fashion, constituting a unique target for therapeutic immunomodulation...
  23. pmc Functional immunomics: microarray analysis of IgG autoantibody repertoires predicts the future response of mice to induced diabetes
    Francisco J Quintana
    Department of Immunology, Weizmann Institute of Science, Rehovot 76100, Israel
    Proc Natl Acad Sci U S A 101:14615-21. 2004
    ..Repertoires matter...
  24. ncbi request reprint A structurally altered D,L-amino acid TCRalpha transmembrane peptide interacts with the TCRalpha and inhibits T-cell activation in vitro and in an animal model
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100 Israel
    Biochemistry 46:2317-25. 2007
    ....
  25. pmc Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:1383-92. 2010
    ..Our data uncover a novel mechanism by which the Tim-3/Gal-9 pathway regulates immune responses and identifies this pathway as a therapeutic target in diseases where myeloid-derived suppressor cells are disadvantageous...
  26. pmc DNA vaccination with CD25 protects rats from adjuvant arthritis and induces an antiergotypic response
    Avishai Mimran
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 113:924-32. 2004
    ..Thus, CD25 DNA vaccination may induce protection from autoimmunity by inducing a cytokine shift in both the antiergotypic response and the response to the antigens targeted in the disease...
  27. ncbi request reprint DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes
    Francisco J Quintana
    Department of Immunology, Weizmann Institute of Science, Rehovot, 76100 Israel
    J Immunol 169:6030-5. 2002
    ....
  28. pmc T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice
    ROSELYNN RODRIGUEZ-MANZANET
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:8706-11. 2010
    ....
  29. pmc Antigen microarrays identify unique serum autoantibody signatures in clinical and pathologic subtypes of multiple sclerosis
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:18889-94. 2008
    ..The demonstration of unique serum immune signatures linked to different stages and pathologic processes in MS provides an avenue to monitor MS and to characterize immunopathogenic mechanisms and therapeutic targets in the disease...
  30. ncbi request reprint Angiogenesis-inflammation cross-talk: vascular endothelial growth factor is secreted by activated T cells and induces Th1 polarization
    Felix Mor
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Immunol 172:4618-23. 2004
    ..Thus, T cells can play a role in angiogenesis by delivering VEGF to inflammatory sites, and VEGF can augment proinflammatory T cell differentiation...
  31. pmc Tregs in T cell vaccination: exploring the regulation of regulation
    Irun R Cohen
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 114:1227-32. 2004
    ....
  32. ncbi request reprint Anti-ergotypic T cells in naïve rats
    Avishai Mimran
    Department of Immunology, The Weizmann Institute of Science, Herzel Street, Rehovot 76100, Israel
    J Autoimmun 24:191-201. 2005
    ..The existence of anti-ergotypic T cells in naive animals suggests that these cells might have a role in the regulation and maintenance of the immune system...
  33. ncbi request reprint IL-21 induces IL-22 production in CD4+ T cells
    Ada Yeste
    1 Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA 2
    Nat Commun 5:3753. 2014
    ..Thus, we have identified IL-21 as an inducer of IL-22 production in CD4+ T cells in vitro and in vivo. ..
  34. pmc Overexpression of the Ctla-4 isoform lacking exons 2 and 3 causes autoimmunity
    Sue M Liu
    Center for Neurologic Diseases, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 188:155-62. 2012
    ..Collectively, these data suggest that the function of the 1/4CTLA-4 isoform is distinct from that of CTLA-4 in that it enhances T cell activation and promotes autoimmunity rather than inhibiting immune responses...
  35. pmc In vivo induction of Tr1 cells via mucosal dendritic cells and AHR signaling
    Henry Yim Wu
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23618. 2011
    ..However, effective strategies that specifically induce Tr1 cells in vivo are limited. Furthermore, the pathways controlling the induction of these cells in vivo are not well understood...
  36. pmc Cutting edge: human latency-associated peptide+ T cells: a novel regulatory T cell subset
    Roopali Gandhi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 184:4620-4. 2010
    ..In conclusion, we have characterized a novel population of human LAP(+) Tregs that is different from classic CD4(+)Foxp3(+)CD25(high) natural Tregs...
  37. pmc Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice
    Sheng Xiao
    Center for Neurologic Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 109:12105-10. 2012
    ..Thus, Tim-1 plays a critical role in maintaining suppressive Breg function, and our data also demonstrate an unexpected role of the Tim-1 mucin domain in regulating Breg function and maintaining self-tolerance...
  38. ncbi request reprint Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60
    Francisco J Quintana
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 169:3422-8. 2002
    ..Our results support a regulatory role for HSP60 autoreactivity in AA and demonstrate that this control mechanism can be activated by DNA vaccination with both HSP60 or HSP65...
  39. pmc HIV-1 fusion peptide targets the TCR and inhibits antigen-specific T cell activation
    Francisco J Quintana
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 115:2149-58. 2005
    ..Disassociated from HIV, however, the FP molecule provides a novel reagent for downregulating undesirable immune responses, exemplified here by adjuvant arthritis...
  40. ncbi request reprint The natural autoantibody repertoire and autoimmune disease
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biomed Pharmacother 58:276-81. 2004
    ..The development of new tools to undertake large-scale NA analysis could also enhance our understanding of the immune system, and leave us in a better position to face the up-coming epidemics of autoimmune disorders...
  41. pmc Environmental control of Th17 differentiation
    Francisco J Quintana
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Eur J Immunol 39:655-7. 2009
    ..In this viewpoint, we discuss some of the mechanisms by which microbes, dietary components and environmental toxins influence the Th17 response...
  42. pmc Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics
    Yifat Merbl
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Clin Invest 117:712-8. 2007
    ..Thus, the obviously benign autoimmunity prevalent at birth may provide the basis for the emergence of some autoimmune diseases relatively prevalent later in life...
  43. pmc A systems immunology approach to the host-tumor interaction: large-scale patterns of natural autoantibodies distinguish healthy and tumor-bearing mice
    Yifat Merbl
    Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS ONE 4:e6053. 2009
    ..Thus, low-titer autoantibodies that are not the direct products of tumor-specific immunization can still generate an immune biomarker of the body-tumor interaction. System-wide profiling of autoantibody repertoires can be informative...
  44. ncbi request reprint Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells
    Pedro M M Moraes-Vieira
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil Department of Medicine, Harvard Medical School, Beth Israel Medical Deaconess Center, Transplant Institute, Boston, MA, USA
    Eur J Immunol 44:794-806. 2014
    ..These data indicate important roles for leptin in DC homeostasis and the initiation and maintenance of inflammatory and regulatory immune responses by DCs. ..
  45. doi request reprint Antigen microarrays for the study of autoimmune diseases
    Ada Yeste
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 59:1036-44. 2013
    ..Although several techniques have been developed to study the molecular pathways that control immunity, there is a need for high-throughput assays to monitor the specificity of the immune response...
  46. ncbi request reprint Experimental autoimmune myasthenia gravis in naive non-obese diabetic (NOD/LtJ) mice: susceptibility associated with natural IgG antibodies to the acetylcholine receptor
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Int Immunol 15:11-6. 2003
    ..These results support the association between specific, natural IgG autoantibodies and susceptibility to the induction of a particular autoimmune disease...
  47. ncbi request reprint D-enantiomer peptide of the TCRalpha transmembrane domain inhibits T-cell activation in vitro and in vivo
    Doron Gerber
    Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot, Israel
    FASEB J 19:1190-2. 2005
    ..In clinical terms, our results demonstrate that D-stereoisomers retain the therapeutic properties of their L-stereoisomers, while they benefit from an increased resistance to degradation...
  48. pmc Oral administration of OKT3 monoclonal antibody to human subjects induces a dose-dependent immunologic effect in T cells and dendritic cells
    Yaron Ilan
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Immunol 30:167-77. 2010
    ..Oral administration of anti-CD3 has not been tested in humans, but suppresses autoimmunity in animal models. Beta-glucosylceramide enhances NKT cell and regulatory T cell activity and enhances the effects of oral anti-CD3 in animals...
  49. pmc Nasal anti-CD3 antibody ameliorates lupus by inducing an IL-10-secreting CD4+ CD25- LAP+ regulatory T cell and is associated with down-regulation of IL-17+ CD4+ ICOS+ CXCR5+ follicular helper T cells
    Henry Yim Wu
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:6038-50. 2008
    ..Our results demonstrate that nasal anti-CD3 induces CD4(+)CD25(-)LAP(+) regulatory T cells that suppress lupus in mice and that it is associated with down-regulation of T cell help for autoantibody production...
  50. ncbi request reprint Knock-out of the histidine decarboxylase gene modifies the repertoire of natural autoantibodies
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Autoimmun 22:297-305. 2004
    ..These results demonstrate that endogenous histamine can influence the self-reactivity of the NA repertoire...
  51. ncbi request reprint Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function
    Dror S Shouval
    Division of Gastroenterology, Hepatology and Nutrition, Boston Children s Hospital, Boston, MA 02115, USA Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA interNational Early Onset Paediatric IBD Cohort Study NEOPICS
    Immunity 40:706-19. 2014
    ..Collectively, our studies define innate immune IL-10R signaling as a key factor regulating mucosal immune homeostasis in mice and humans...
  52. pmc Induction and molecular signature of pathogenic TH17 cells
    Youjin Lee
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 13:991-9. 2012
    ..Moreover, TGF-β3-induced T(H)17 cells were functionally and molecularly distinct from TGF-β1-induced T(H)17 cells and had a molecular signature that defined pathogenic effector T(H)17 cells in autoimmune disease...
  53. ncbi request reprint Cluster analysis of human autoantibody reactivities in health and in type 1 diabetes mellitus: a bio-informatic approach to immune complexity
    Francisco J Quintana
    Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Autoimmun 21:65-75. 2003
    ..The results show that despite the wide prevalence of autoantibodies, the patterns of reactivity to defined subsets of self-antigens can provide information about the state of the body...
  54. ncbi request reprint Heat shock proteins as endogenous adjuvants in sterile and septic inflammation
    Francisco J Quintana
    Department of Immunology, Weizmann Institute of Science, Rehovot, Israel
    J Immunol 175:2777-82. 2005
    ..Endogenous HSPs are key players in the modulation of these two modes of inflammation, and as such, they are potential targets for new and more efficient therapies for cancer, infections, and autoimmunity...
  55. ncbi request reprint HSP60 speaks to the immune system in many voices
    Francisco J Quintana
    Center for Neurologic Diseases, Harvard Medical School, Boston, MA 02115, USA
    Novartis Found Symp 291:101-11; discussion 111-4, 137-40. 2008
    ..Herein, we discuss the relevance of HSP and their immune activities for the regulation and monitoring of inflammation and autoimmune disease...
  56. pmc Activated human CD4+CD45RO+ memory T-cells indirectly inhibit NLRP3 inflammasome activation through downregulation of P2X7R signalling
    Vanessa Beynon
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 7:e39576. 2012
    ..Thus, our data demonstrate that human P2X7R-mediated NLRP3 inflammasome activation is regulated by activated CD4+CD45RO+ memory T cells, and provide new information on the mechanisms mediating the therapeutic effects of IFNβ in MS...
  57. pmc Gut-tropic T cells that express integrin α4β7 and CCR9 are required for induction of oral immune tolerance in mice
    Barbara Cassani
    Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 141:2109-18. 2011
    ..We investigated whether gut-tropic T cells that express the integrin α4β7 and the chemokine receptor CCR9 are required for OT...
  58. pmc Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis
    Alexandre S Basso
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1532-43. 2008
    ..Our data demonstrate the neuroprotective effect of treatment with a fullerene compound combined with a NMDA receptor antagonist, which may be useful in the treatment of progressive MS and other neurodegenerative diseases...
  59. pmc Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses
    Nicole Joller
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Immunity 40:569-81. 2014
    ..TIGIT expression therefore identifies a Treg cell subset that demonstrates selectivity for suppression of Th1 and Th17 cell but not Th2 cell responses...
  60. pmc Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
    Mauricio F Farez
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Immunol 10:958-64. 2009
    ..PARP-1 activity was higher in monocytes of patients with SPMS, and PARP-1 inhibition suppressed the progression of EAE. Thus, the TLR2-PARP-1 pathway is a potential new therapeutic target in SPMS...
  61. pmc The innate immune system in demyelinating disease
    Lior Mayo
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Immunol Rev 248:170-87. 2012
    ..Given the pivotal role of the innate immune system, it is possible that targeting these cells may provide an effective therapeutic approach for demyelinating diseases...