A J Quayle
Affiliation: Harvard University
- Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tractA J Quayle
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Am J Pathol 152:1247-58. 1998..We hypothesize that HD-5 is an intrinsic component of the female urogenital innate immune defense system and that its expression may be modulated by hormonal and proinflammatory factors...
- Detection of HIV-1-specific CTLs in the semen of HIV-infected individualsA J Quayle
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Immunol 161:4406-10. 1998..In summary, our results demonstrate the presence of a broad CTL response to HIV in the urogenital tract and provide a rationale for further studies of local enhancement of genital mucosal responses by anti-HIV immunization...
- Human beta-defensin-1: an antimicrobial peptide of urogenital tissuesE V Valore
Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, California 90095, USA
J Clin Invest 101:1633-42. 1998..coli in unconcentrated (low conductance) urine, and the 36 aa form was microbicidal even in normal (high conductance) urine. Production of HBD-1 in the urogenital tract could contribute to local antimicrobial defense...