B J Quade

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyoma
    B J Quade
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 154:945-50. 1999
  2. ncbi request reprint Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case
    Bradley J Quade
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mod Pathol 15:351-6. 2002
  3. ncbi request reprint Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63
    G L Mutter
    Division of Women's and Perinatal Pathology, Boston, Massachusetts 02115, USA
    Gynecol Oncol 80:30-6. 2001
  4. ncbi request reprint h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors
    M R Nucci
    Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 25:455-63. 2001
  5. ncbi request reprint HMGIC expression in human adult and fetal tissues and in uterine leiomyomata
    G J Gattas
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Chromosomes Cancer 25:316-22. 1999
  6. ncbi request reprint Expression of the p53 homologue p63 in early cervical neoplasia
    B J Quade
    Division of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gynecol Oncol 80:24-9. 2001
  7. ncbi request reprint Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva
    M R Nucci
    Division of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Genes Chromosomes Cancer 32:172-6. 2001
  8. pmc The human VASA gene is specifically expressed in the germ cell lineage
    D H Castrillon
    Women s and Perinatal Pathology Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9585-90. 2000
  9. ncbi request reprint Adenomyosis demonstrates increased expression of the basic fibroblast growth factor receptor/ligand system compared with autologous endometrium
    A M Propst
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Menopause 8:368-71. 2001
  10. ncbi request reprint Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia
    J T Keating
    Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Surg Pathol 25:884-91. 2001

Collaborators

Detail Information

Publications31

  1. pmc Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyoma
    B J Quade
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 154:945-50. 1999
    ..In contrast to other chromosomes studied, LOH on chromosome 10 was frequent in leiomyosarcomas and absent in benign leiomyomas...
  2. ncbi request reprint Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case
    Bradley J Quade
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mod Pathol 15:351-6. 2002
    ..This pattern of X inactivation is most consistent with origin from a single transformation event, and in this regard, IVL more closely resembles disseminated peritoneal leiomyomatosis than typical uterine leiomyomata...
  3. ncbi request reprint Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63
    G L Mutter
    Division of Women's and Perinatal Pathology, Boston, Massachusetts 02115, USA
    Gynecol Oncol 80:30-6. 2001
    ..Whether these cells signify specialized multipotential endometrial cells is not clear, but the similarity of these cells to basal/reserve cells of the cervix and their association with neoplasia merit further study...
  4. ncbi request reprint h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumors
    M R Nucci
    Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Surg Pathol 25:455-63. 2001
    ..h-Caldesmon appears to be a more sensitive and specific marker of smooth muscle differentiation in the uterus than desmin and may be a useful tool for distinguishing and classifying uterine mesenchymal tumors...
  5. ncbi request reprint HMGIC expression in human adult and fetal tissues and in uterine leiomyomata
    G J Gattas
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Chromosomes Cancer 25:316-22. 1999
    ..Transcripts of HMGIC can also be detected after in vitro cell culture, suggesting that HMGIC expression may be affected by factors present in culture media and serum. Genes Chromosomes Cancer 25:316-322, 1999...
  6. ncbi request reprint Expression of the p53 homologue p63 in early cervical neoplasia
    B J Quade
    Division of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Gynecol Oncol 80:24-9. 2001
    ....
  7. ncbi request reprint Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulva
    M R Nucci
    Division of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Genes Chromosomes Cancer 32:172-6. 2001
    ..Understanding the pathogenetic mechanism may also be helpful in developing new diagnostic tools for identifying residual disease...
  8. pmc The human VASA gene is specifically expressed in the germ cell lineage
    D H Castrillon
    Women s and Perinatal Pathology Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:9585-90. 2000
    ..The gene we have isolated is thus a highly specific marker of germ cells and should be useful for studies of human germ cell determination and function...
  9. ncbi request reprint Adenomyosis demonstrates increased expression of the basic fibroblast growth factor receptor/ligand system compared with autologous endometrium
    A M Propst
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Menopause 8:368-71. 2001
    ..CONCLUSIONS: Upregulation of the bFGF receptor/ligand system and increased cellular proliferation in adenomyosis may contribute to the pathogenesis of abnormal uterine bleeding associated with adenomyosis...
  10. ncbi request reprint Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia
    J T Keating
    Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Surg Pathol 25:884-91. 2001
    ....
  11. pmc Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomas
    Azra H Ligon
    Department of Pathology, Gynecology and Reproductive Biology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Am J Hum Genet 76:340-8. 2005
    ..Systematic genetic analysis and clinical studies of this child may offer unique insights into the role of HMGA2 in adipogenesis, osteogenesis, and general growth control...
  12. ncbi request reprint Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORF
    Steven D P Moore
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cancer Res 64:5570-7. 2004
    ..Involvement of MORF in four uterine leiomyomata with chromosomal rearrangements involving 10q22 and 17q21 suggests a role for this histone acetyltransferase and altered chromatin regulation in uterine mesenchymal neoplasia...
  13. ncbi request reprint Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profiling
    Bradley J Quade
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Chromosomes Cancer 40:97-108. 2004
    ..These genes define a tumor signature for uterine smooth muscle neoplasia, and they suggest that the molecular pathways in leiomyoma and leiomyosarcoma are distinct...
  14. ncbi request reprint Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique
    Elizabeth A Stewart
    Departments of Obstetrics, Gynecology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Obstet Gynecol 189:48-54. 2003
    ..The purpose of this study was to determine the safety and efficacy of focused ultrasound surgery with magnetic resonance imaging guidance for the noninvasive treatment of uterine leiomyomas...
  15. ncbi request reprint Cervical cancer screening: from the Papanicolaou smear to the vaccine era
    Christopher P Crum
    Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 21:224s-230s. 2003
    ..If so, previous strategies may become obsolete as the balance of cervical cancer prevention shifts from traditional screening to primary prevention coupled with HPV testing...
  16. ncbi request reprint Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15
    Bradley J Quade
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 63:1351-8. 2003
    ..The pattern of rearrangements suggests dysregulated expression of HMGA2, most often by translocation of chromosome 14 sequence 5' to this gene...
  17. pmc Molecular and cytogenetic characterization of plexiform leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroids
    Jennelle C Hodge
    Brigham and Women s Hospital, Department of Obstetrics and Gynecology and Reproductive Biology, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Am J Pathol 172:1403-10. 2008
    ..We further suggest that plexiform UL should be classified among tumors with extensive hyalinization rather than with "true" epithelioid smooth muscle neoplasms...
  18. ncbi request reprint MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility study
    Clare M C Tempany
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
    Radiology 226:897-905. 2003
    ..MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences...
  19. ncbi request reprint Biomarkers in diagnostic obstetric and gynecologic pathology: a review
    Marisa R Nucci
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA
    Adv Anat Pathol 10:55-68. 2003
    ....
  20. ncbi request reprint Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)
    Paola Dal Cin
    Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Genes Chromosomes Cancer 36:205-6. 2003
    ..We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15-qter and/or loss of 14q24-qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation...
  21. pmc Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosis
    Shashikant Kulkarni
    Division of Women s and Perinatal Pathology and Clinical Cytogenetics Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Med Genet A 146:1117-27. 2008
    ..These data suggest that haploinsufficiency for CHD2 could result in a complex of abnormal human phenotypes that includes scoliosis and possibly features similar to CHARGE syndrome...
  22. doi request reprint Intraplacental choriocarcinoma arising in a second trimester placenta with partial hydatidiform mole
    Fabiola Medeiros
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Int J Gynecol Pathol 27:247-51. 2008
    ....
  23. ncbi request reprint Extensive molecular genetic analysis of the 3p14.3 region in patients with Zimmermann-Laband syndrome
    Benjamin Abo-Dalo
    Institut fur Humangenetik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Am J Med Genet A 143:2668-74. 2007
    ....
  24. pmc NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects
    Weining Lu
    Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 3:e80. 2007
    ....
  25. pmc Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice
    Natalia T Leach
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 80:792-9. 2007
    ..These findings implicate DGKD disruption by the t(X;2)(p11.2;q37)dn in the observed phenotype and support a more general role for DGKD in the etiology of seizures...
  26. pmc Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux
    Weining Lu
    Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hum Genet 80:616-32. 2007
    ..Adult heterozygous and mosaic mutant mice with reduced Robo2 gene dosage also exhibit striking CAKUT-VUR phenotypes. Collectively, these results implicate the SLIT-ROBO signaling pathway in the pathogenesis of a subset of human VUR...
  27. ncbi request reprint Candidate loci for Zimmermann-Laband syndrome at 3p14.3
    Hyung Goo Kim
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 143:107-11. 2007
    ....
  28. ncbi request reprint Uterine leiomyomata with deletions of Ip represent a distinct cytogenetic subgroup associated with unusual histologic features
    Nicole C Christacos
    Department of Obstetrics, Gynecology, and Reproductive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Genes Chromosomes Cancer 45:304-12. 2006
    ..Furthermore, 1p-- appears to be associated with a specific histologic phenotype. The similarity between the transcriptional profiles of LMS and UL with 1p-- suggests the possibility of a common pathogenetic mechanism...
  29. pmc p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract
    Tan A Ince
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Pathol 161:1111-7. 2002
    ..The second is necessary for the generation of multipotential reserve cells in the cervix and may be operative in other epithelial stromal interactions integral to the emergence of uterine basal cells later in life...
  30. ncbi request reprint The role of CD10 staining in distinguishing invasive endometrial adenocarcinoma from adenocarcinoma involving adenomyosis
    Alessandra F Nascimento
    Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Mod Pathol 16:22-7. 2003
    ..In contrast, absence of CD10 expression excludes involvement of adenomyosis by adenocarcinoma...
  31. pmc Human chromosome 7: DNA sequence and biology
    Stephen W Scherer
    Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
    Science 300:767-72. 2003
    ..This approach enabled the discovery of candidate genes for developmental diseases including autism...