Research Topics
| B J QuadeSummaryAffiliation: Harvard University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyomaB J Quade
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Pathol 154:945-50. 1999..In contrast to other chromosomes studied, LOH on chromosome 10 was frequent in leiomyosarcomas and absent in benign leiomyomas...
Intravenous leiomyomatosis: molecular and cytogenetic analysis of a caseBradley J Quade
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Mod Pathol 15:351-6. 2002..This pattern of X inactivation is most consistent with origin from a single transformation event, and in this regard, IVL more closely resembles disseminated peritoneal leiomyomatosis than typical uterine leiomyomata...- Identification of a basal/reserve cell immunophenotype in benign and neoplastic endometrium: a study with the p53 homologue p63G L Mutter
Division of Women's and Perinatal Pathology, Boston, Massachusetts 02115, USA
Gynecol Oncol 80:30-6. 2001..Whether these cells signify specialized multipotential endometrial cells is not clear, but the similarity of these cells to basal/reserve cells of the cervix and their association with neoplasia merit further study... - h-Caldesmon expression effectively distinguishes endometrial stromal tumors from uterine smooth muscle tumorsM R Nucci
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Surg Pathol 25:455-63. 2001..h-Caldesmon appears to be a more sensitive and specific marker of smooth muscle differentiation in the uterus than desmin and may be a useful tool for distinguishing and classifying uterine mesenchymal tumors... - HMGIC expression in human adult and fetal tissues and in uterine leiomyomataG J Gattas
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Chromosomes Cancer 25:316-22. 1999..Transcripts of HMGIC can also be detected after in vitro cell culture, suggesting that HMGIC expression may be affected by factors present in culture media and serum. Genes Chromosomes Cancer 25:316-322, 1999... - Expression of the p53 homologue p63 in early cervical neoplasiaB J Quade
Division of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Gynecol Oncol 80:24-9. 2001.... - Chromosomal translocation t(8;12) induces aberrant HMGIC expression in aggressive angiomyxoma of the vulvaM R Nucci
Division of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Genes Chromosomes Cancer 32:172-6. 2001..Understanding the pathogenetic mechanism may also be helpful in developing new diagnostic tools for identifying residual disease... - The human VASA gene is specifically expressed in the germ cell lineageD H Castrillon
Women s and Perinatal Pathology Division, Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 97:9585-90. 2000..The gene we have isolated is thus a highly specific marker of germ cells and should be useful for studies of human germ cell determination and function... - Adenomyosis demonstrates increased expression of the basic fibroblast growth factor receptor/ligand system compared with autologous endometriumA M Propst
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Menopause 8:368-71. 2001..CONCLUSIONS: Upregulation of the bFGF receptor/ligand system and increased cellular proliferation in adenomyosis may contribute to the pathogenesis of abnormal uterine bleeding associated with adenomyosis... - Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasiaJ T Keating
Division of Women's and Perinatal Pathology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Am J Surg Pathol 25:884-91. 2001.... - Constitutional rearrangement of the architectural factor HMGA2: a novel human phenotype including overgrowth and lipomasAzra H Ligon
Department of Pathology, Gynecology and Reproductive Biology, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Am J Hum Genet 76:340-8. 2005..Systematic genetic analysis and clinical studies of this child may offer unique insights into the role of HMGA2 in adipogenesis, osteogenesis, and general growth control... - Uterine leiomyomata with t(10;17) disrupt the histone acetyltransferase MORFSteven D P Moore
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA
Cancer Res 64:5570-7. 2004..Involvement of MORF in four uterine leiomyomata with chromosomal rearrangements involving 10q22 and 17q21 suggests a role for this histone acetyltransferase and altered chromatin regulation in uterine mesenchymal neoplasia... - Molecular pathogenesis of uterine smooth muscle tumors from transcriptional profilingBradley J Quade
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Chromosomes Cancer 40:97-108. 2004..These genes define a tumor signature for uterine smooth muscle neoplasia, and they suggest that the molecular pathways in leiomyoma and leiomyosarcoma are distinct... - Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative techniqueElizabeth A Stewart
Departments of Obstetrics, Gynecology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Obstet Gynecol 189:48-54. 2003..The purpose of this study was to determine the safety and efficacy of focused ultrasound surgery with magnetic resonance imaging guidance for the noninvasive treatment of uterine leiomyomas... - Cervical cancer screening: from the Papanicolaou smear to the vaccine eraChristopher P Crum
Division of Women s and Perinatal Pathology, Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Clin Oncol 21:224s-230s. 2003..If so, previous strategies may become obsolete as the balance of cervical cancer prevention shifts from traditional screening to primary prevention coupled with HPV testing... - Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15Bradley J Quade
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 63:1351-8. 2003..The pattern of rearrangements suggests dysregulated expression of HMGA2, most often by translocation of chromosome 14 sequence 5' to this gene... - Molecular and cytogenetic characterization of plexiform leiomyomata provide further evidence for genetic heterogeneity underlying uterine fibroidsJennelle C Hodge
Brigham and Women s Hospital, Department of Obstetrics and Gynecology and Reproductive Biology, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
Am J Pathol 172:1403-10. 2008..We further suggest that plexiform UL should be classified among tumors with extensive hyalinization rather than with "true" epithelioid smooth muscle neoplasms... - MR imaging-guided focused ultrasound surgery of uterine leiomyomas: a feasibility studyClare M C Tempany
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis St, Boston, MA 02115, USA
Radiology 226:897-905. 2003..MR imaging-guided focused ultrasound causes thermocoagulation and necrosis in uterine leiomyomas and is feasible and safe, without serious consequences... - Biomarkers in diagnostic obstetric and gynecologic pathology: a reviewMarisa R Nucci
Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachussetts 02115, USA
Adv Anat Pathol 10:55-68. 2003.... - Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24)Paola Dal Cin
Department of Pathology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Genes Chromosomes Cancer 36:205-6. 2003..We propose that IVL arises from a uterine leiomyoma with a t(12;14)(q15;q24). The presence of an extra copy of 12q15-qter and/or loss of 14q24-qter may be a critical genetic event(s) leading to intravascular intrusion and proliferation... - Disruption of chromodomain helicase DNA binding protein 2 (CHD2) causes scoliosisShashikant Kulkarni
Division of Women s and Perinatal Pathology and Clinical Cytogenetics Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Med Genet A 146:1117-27. 2008..These data suggest that haploinsufficiency for CHD2 could result in a complex of abnormal human phenotypes that includes scoliosis and possibly features similar to CHARGE syndrome... 
Intraplacental choriocarcinoma arising in a second trimester placenta with partial hydatidiform moleFabiola Medeiros
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Int J Gynecol Pathol 27:247-51. 2008....- Extensive molecular genetic analysis of the 3p14.3 region in patients with Zimmermann-Laband syndromeBenjamin Abo-Dalo
Institut fur Humangenetik, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
Am J Med Genet A 143:2668-74. 2007.... - NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defectsWeining Lu
Genetics Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
PLoS Genet 3:e80. 2007.... - Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and miceNatalia T Leach
Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Am J Hum Genet 80:792-9. 2007..These findings implicate DGKD disruption by the t(X;2)(p11.2;q37)dn in the observed phenotype and support a more general role for DGKD in the etiology of seizures... - Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral refluxWeining Lu
Genetics Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Am J Hum Genet 80:616-32. 2007..Adult heterozygous and mosaic mutant mice with reduced Robo2 gene dosage also exhibit striking CAKUT-VUR phenotypes. Collectively, these results implicate the SLIT-ROBO signaling pathway in the pathogenesis of a subset of human VUR... - Candidate loci for Zimmermann-Laband syndrome at 3p14.3Hyung Goo Kim
Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Am J Med Genet A 143:107-11. 2007.... - Uterine leiomyomata with deletions of Ip represent a distinct cytogenetic subgroup associated with unusual histologic featuresNicole C Christacos
Department of Obstetrics, Gynecology, and Reproductive Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Genes Chromosomes Cancer 45:304-12. 2006..Furthermore, 1p-- appears to be associated with a specific histologic phenotype. The similarity between the transcriptional profiles of LMS and UL with 1p-- suggests the possibility of a common pathogenetic mechanism... - p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tractTan A Ince
Department of Pathology, Division of Women s and Perinatal Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Pathol 161:1111-7. 2002..The second is necessary for the generation of multipotential reserve cells in the cervix and may be operative in other epithelial stromal interactions integral to the emergence of uterine basal cells later in life... - The role of CD10 staining in distinguishing invasive endometrial adenocarcinoma from adenocarcinoma involving adenomyosisAlessandra F Nascimento
Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Mod Pathol 16:22-7. 2003..In contrast, absence of CD10 expression excludes involvement of adenomyosis by adenocarcinoma... - Human chromosome 7: DNA sequence and biologyStephen W Scherer
Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8
Science 300:767-72. 2003..This approach enabled the discovery of candidate genes for developmental diseases including autism...