L Qi

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    JAMA 310:821-8. 2013
  2. pmc Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial
    Min Xu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 127:1283-9. 2013
  3. pmc Diabetes genetic predisposition score and cardiovascular complications among patients with type 2 diabetes
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes Care 36:737-9. 2013
  4. pmc Birth weight, genetic susceptibility, and adulthood risk of type 2 diabetes
    Yanping Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:2479-84. 2012
  5. pmc Genetic predisposition to high blood pressure associates with cardiovascular complications among patients with type 2 diabetes: two independent studies
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes 61:3026-32. 2012
  6. pmc FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial
    Xiaomin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes 61:3005-11. 2012
  7. doi Neuropeptide Y promoter polymorphism modifies effects of a weight-loss diet on 2-year changes of blood pressure: the preventing overweight using novel dietary strategies trial
    Xiaomin Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Hypertension 60:1169-75. 2012
  8. pmc Sugar-sweetened beverages and genetic risk of obesity
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 367:1387-96. 2012
  9. pmc Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 126:1821-7. 2012
  10. pmc ABO blood group and risk of coronary heart disease in two prospective cohort studies
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 32:2314-20. 2012

Collaborators

Detail Information

Publications70

  1. pmc Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    JAMA 310:821-8. 2013
    ..Diabetes is associated with an elevated risk of coronary heart disease (CHD). Previous studies have suggested that the genetic factors predisposing to excess cardiovascular risk may be different in diabetic and nondiabetic individuals...
  2. pmc Genetic determinant for amino acid metabolites and changes in body weight and insulin resistance in response to weight-loss diets: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial
    Min Xu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 127:1283-9. 2013
    ..We tested the effects of a genetic determinant of branched-chain amino acid/aromatic amino acid ratio on changes in body weight and insulin resistance in a 2-year diet intervention trial...
  3. pmc Diabetes genetic predisposition score and cardiovascular complications among patients with type 2 diabetes
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes Care 36:737-9. 2013
    ..To examine the association between genetic predisposition to type 2 diabetes (T2D) and risk of cardiovascular disease (CVD) among patients with T2D...
  4. pmc Birth weight, genetic susceptibility, and adulthood risk of type 2 diabetes
    Yanping Li
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 35:2479-84. 2012
    ..The current study aims to examine the interaction between low birth weight, a surrogate measure of stressful intrauterine milieus, and genetic susceptibility in relation to risk of type 2 diabetes in adulthood...
  5. pmc Genetic predisposition to high blood pressure associates with cardiovascular complications among patients with type 2 diabetes: two independent studies
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes 61:3026-32. 2012
    ..22 [95% CI 1.10-1.35] vs. 1.10 [1.08-1.12]; I² = 71%). Our data indicate that genetic predisposition to high blood pressure is associated with an increased risk of CVD in individuals with T2D...
  6. pmc FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial
    Xiaomin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Diabetes 61:3005-11. 2012
    ..Our data suggest that a high-protein diet may be beneficial for weight loss and improvement of body composition and fat distribution in individuals with the risk allele of the FTO variant rs1558902...
  7. doi Neuropeptide Y promoter polymorphism modifies effects of a weight-loss diet on 2-year changes of blood pressure: the preventing overweight using novel dietary strategies trial
    Xiaomin Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Hypertension 60:1169-75. 2012
    ....
  8. pmc Sugar-sweetened beverages and genetic risk of obesity
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 367:1387-96. 2012
    ..Temporal increases in the consumption of sugar-sweetened beverages have paralleled the rise in obesity prevalence, but whether the intake of such beverages interacts with the genetic predisposition to adiposity is unknown...
  9. pmc Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 126:1821-7. 2012
    ..Previous studies on gene-lifestyle interaction and obesity have focused mostly on the FTO gene and physical activity, whereas little attention has been paid to sedentary behavior as indicated by television (TV) watching...
  10. pmc ABO blood group and risk of coronary heart disease in two prospective cohort studies
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 32:2314-20. 2012
    ..We sought to investigate the associations between ABO blood group and CHD risk in prospective cohort studies...
  11. pmc Genetic predictors for cardiovascular disease in hispanics
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Trends Cardiovasc Med 21:15-20. 2011
    ....
  12. pmc Genetic predisposition to dyslipidemia and type 2 diabetes risk in two prospective cohorts
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 61:745-52. 2012
    ..In conclusion, genetic predisposition to low HDL cholesterol or high triglycerides is related to elevated type 2 diabetes risk...
  13. pmc Genetic polymorphisms of angiotensin-2 type 1 receptor and angiotensinogen and risk of renal dysfunction and coronary heart disease in type 2 diabetes mellitus
    Julie Lin
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Nephrol 10:9. 2009
    ....
  14. doi Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:1061-5. 2008
    ..The variations in perilipin gene (PLIN) were previously associated with obesity and insulin sensitivity. We examined whether PLIN variability was associated with diabetes risk and obesity status modified such associations...
  15. pmc Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 57:3145-51. 2008
    ..To examine the longitudinal association of fat mass-and obesity-associated (FTO) variant with obesity, circulating adipokine levels, and FTO expression in various materials from human and mouse...
  16. pmc Novel locus FER is associated with serum HMW adiponectin levels
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 60:2197-201. 2011
    ..Previous linkage studies suggest that different genetic components might be involved in determining HMW and total adiponectin levels...
  17. pmc The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA02115, USA
    Hum Mol Genet 17:3502-8. 2008
    ..In addition, the SNP was related to greater long-term weight change and increased risk of diabetes in women...
  18. ncbi Genes, environment, and interactions in prevention of type 2 diabetes: a focus on physical activity and lifestyle changes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Curr Mol Med 8:519-32. 2008
    ..The gene-environment interactions merit extensive exploration in large, prospective studies...
  19. pmc Interleukin-6 receptor gene, plasma C-reactive protein, and diabetes risk in women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 58:275-8. 2009
    ..Because IL6R variants were previously associated with IL-6 levels, we tested whether the associations with CRP were independent of IL-6 and the interactions between IL6R variants and CRP in relation to diabetes risk...
  20. pmc Gene-environment interaction and obesity
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nutr Rev 66:684-94. 2008
    ..Knowledge about the interplay between genetic and environmental components may facilitate the choice of more effective and specific measures for obesity prevention based on the personalized genetic make-up...
  21. pmc Genetic variants at 2q24 are associated with susceptibility to type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, and Brigham and Women s Hospital, Boston, MA, USA
    Hum Mol Genet 19:2706-15. 2010
    ..05). These data suggest that the 2q24 locus may influence the T2D risk by affecting glucose metabolism and insulin resistance...
  22. pmc Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Hum Mol Genet 19:1856-62. 2010
    ..Our findings indicate that the genetic variants at ABO locus affect plasma sE-selectin levels and diabetes risk. The genetic associations with diabetes risk were independent of sE-selectin levels...
  23. pmc Interactions between genetic factors that predict diabetes and dietary factors that ultimately impact on risk of diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Curr Opin Lipidol 21:31-7. 2010
    ..The purpose of the present review is to summarize recent advances in investigations of interactions between established genetic and dietary risk factors for type 2 diabetes (T2D)...
  24. pmc Mendelian randomization in nutritional epidemiology
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Nutr Rev 67:439-50. 2009
    ..However, the application of Mendelian randomization in nutritional epidemiology has some limitations...
  25. pmc Genetic susceptibility to coronary heart disease in type 2 diabetes: 3 independent studies
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    J Am Coll Cardiol 58:2675-82. 2011
    ..The aim of this study was to evaluate whether coronary heart disease (CHD)-susceptibility loci identified by genome-wide association studies of the general population also contribute to CHD in type 2 diabetes...
  26. ncbi Interleukin-6 receptor gene variations, plasma interleukin-6 levels, and type 2 diabetes in U.S. Women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes 56:3075-81. 2007
    ..To examine the associations between common variations in the IL6R gene and circulating interleukin (IL)-6 levels and diabetes risk...
  27. ncbi Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women
    L Qi
    Department of Nutrition, Harvard Medical School of Public Health, Boston, MA 02115, USA
    Diabet Med 24:1187-91. 2007
    ..2 gene (KCNJ11). Both HNF4A and KCNJ11 have previously been associated with diabetes risk but little is known whether the variations in these genes interact with each other...
  28. ncbi Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 29:1501-5. 2006
    ..The purpose of this study was to examine the associations of dietary fibers and glycemic load with plasma adiponectin in diabetic women and investigate the modification effect of obesity...
  29. ncbi The +276 polymorphism of the APM1 gene, plasma adiponectin concentration, and cardiovascular risk in diabetic men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes 54:1607-10. 2005
    ..0019). In conclusion, our study showed significant associations between APM1 G276T and decreased CVD risk and increased plasma adiponectin levels in diabetic men...
  30. ncbi HFE genetic variability, body iron stores, and the risk of type 2 diabetes in U.S. women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Massachusetts 02115, USA
    Diabetes 54:3567-72. 2005
    ..Our data indicate significant effects of H63D and C282Y on body iron stores and suggest a potential interaction between HFE genotypes and heme iron intake in relation to the risk of type 2 diabetes...
  31. ncbi Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Diabetes Care 29:207-11. 2006
    ..To evaluate the dietary predictors for the markers of systemic inflammation and endothelial dysfunction in patients with type 2 diabetes...
  32. ncbi Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Diabetes 55:1512-6. 2006
    ..In conclusion, ADIPOQ promoter polymorphism -11365C-->G was associated with plasma adiponectin levels, whereas polymorphisms -4034A-->C and +276G-->T were associated with CVD risk in diabetic patients...
  33. ncbi Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 15:1914-20. 2006
    ..In summary, the data in this study do not support substantial associations between the common polymorphisms in IL6 gene and circulating IL-6 levels and the risk of type 2 diabetes...
  34. ncbi Heme iron from diet as a risk factor for coronary heart disease in women with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Diabetes Care 30:101-6. 2007
    ..Diabetes-related metabolic abnormality may aggravate the adverse effects of iron overload on cardiovascular health. However, little is known about whether iron consumption affects coronary heart disease (CHD) risk in diabetes...
  35. ncbi Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetes
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, United States
    Atherosclerosis 192:204-10. 2007
    ..006), whereas APOA4 +347T/A showed significant associations with lower levels of HDL-C (P=0.017). Our results indicate that the variability in APOA1/C3/A4/A5 gene cluster may affect TG and HDL levels in women with type 2 diabetes...
  36. ncbi Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Diabetes 56:1586-91. 2007
    ..In conclusion, our data indicate significant associations between ADIPOR1 haplotypes and diabetes risk but do not support a relation between ADIPOR2 variability and the disease...
  37. ncbi Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals
    Lu Qi
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 92:3618-25. 2007
    ..IL-6 (IL6) is an immune-modulating cytokine associated with obesity in humans...
  38. pmc Genetic risk score and risk of myocardial infarction in Hispanics
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 123:374-80. 2011
    ..This study evaluated whether genetic markers previously identified in whites are associated with nonfatal acute myocardial infarction (MI) in Hispanics...
  39. pmc Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:327-32. 2010
    ..To investigate the associations between obesity-predisposing genetic variants, cardiovascular biomarkers, and cardiovascular disease (CVD) risk in women with preexisting type 2 diabetes mellitus...
  40. ncbi Gender-specific association of a perilipin gene haplotype with obesity risk in a white population
    Lu Qi
    Nutrition and Genomics Laboratories, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Obes Res 12:1758-65. 2004
    ..Our purpose was to examine the association between common single-nucleotide polymorphisms (SNPs) at the perilipin (PLIN) locus and obesity, as well as related phenotypes, in unrelated American adults...
  41. ncbi Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women
    L Qi
    The Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Genet 66:299-310. 2004
    ..58, 95% confidence interval (CI): 0.38-0.93 and OR = 0.56, 95% CI: 0.36-0.89, respectively]. In summary, our data suggest that common alleles at the PLIN locus modulate body weight and metabolic variables in humans...
  42. pmc TCF7L2, dietary carbohydrate, and risk of type 2 diabetes in US women
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 89:1256-62. 2009
    ..Dietary factors that increase the insulin demand might enhance the risk of T2D associated with TCF7L2 variants...
  43. pmc Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 89:1453-8. 2009
    ..A widely held hypothesis is that interactions between genetic predisposition and Western-type lifestyle contribute to the epidemic of type 2 diabetes (T2D). No study has tested this hypothesis...
  44. pmc Whole-grain, cereal fiber, bran, and germ intake and the risks of all-cause and cardiovascular disease-specific mortality among women with type 2 diabetes mellitus
    Meian He
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 121:2162-8. 2010
    ..This study investigated whole grain and its components cereal fiber, bran, and germ in relation to all-cause and CVD-specific mortality in patients with type 2 diabetes mellitus...
  45. pmc Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels
    Meian He
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 30:885-90. 2010
    ..We sought to identify the common genetic variants associated with IL-18 levels...
  46. ncbi Genetic variation at the hormone sensitive lipase: gender-specific association with plasma lipid and glucose concentrations
    L Qi
    Nutrition and Genomics Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Clin Genet 65:93-100. 2004
    ..These SNPs were not significantly associated with anthropometrical variables. In summary, variation at this locus showed gender-specific associations with lipids and glucose measures, and the latter was influenced by alcohol drinking...
  47. ncbi Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population
    Lu Qi
    Nutrition and Genomics Laboratory, Lipid Metabolism Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    J Mol Med (Berl) 83:448-56. 2005
    ..28 (95% CI 1.45-3.57) and Indians OR 2.04 (95% CI 1.08-3.64). These results support the role of the PLIN locus as an ethnically dependent modulator of obesity risk in humans...
  48. pmc Phobic anxiety is associated with higher serum concentrations of adipokines and cytokines in women with diabetes
    Aoife M Brennan
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 32:926-31. 2009
    ..We aimed to determine whether associations of phobic anxiety with several known markers of CVD might be contributors...
  49. ncbi Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women
    Esther Lopez-Garcia
    Department of Nutrition and Epidemiology, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 84:888-93. 2006
    ..In several short-term studies, coffee consumption has been associated with impairment of endothelial function...
  50. ncbi Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction
    Dolores Corella
    Nutrition and Genomics Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, Massachusetts 02111, USA
    J Clin Endocrinol Metab 90:5121-6. 2005
    ..Adipose tissue has been the focus of efforts to identify candidate genes. Perilipin is a major protein found in adipocytes, and perilipin knockout mice are lean and resistant to diet-induced obesity...
  51. ncbi Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet
    Dolores Corella
    Nutrition and Genomics Laboratory, JM USDA HNRCA at Tufts University, 711 Washington St, Boston, MA 02111, USA
    Diabetes Care 29:1313-9. 2006
    ..To investigate the association between genetic variation in the adipocyte protein perilipin (PLIN) and insulin resistance in an Asian population as well as to examine their modulation by macronutrient intake...
  52. pmc Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry
    Marilyn C Cornelis
    Harvard School of Public Health, Channing Laboratory, Boston, MA 02115, USA
    Ann Intern Med 150:541-50. 2009
    ..Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk...
  53. pmc Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function
    Jessica L Fargnoli
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, ST816, Boston, Massachusetts 02115, USA
    Eur J Endocrinol 162:281-8. 2010
    ..It remains to be elucidated which of these adipokines is associated primarily with biomarkers of all or only some of these categories, i.e. biomarkers of inflammation, endothelial dysfunction, and/or insulin secretion or insulinemia...
  54. pmc Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
    Richa Saxena
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Genet 42:142-8. 2010
    ..Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18))...
  55. pmc New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
    Josee Dupuis
    Department of Biostatistics, Boston University School of Public Health, Massachusetts, USA
    Nat Genet 42:105-16. 2010
    ....
  56. pmc Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    Elizabeth K Speliotes
    Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
    Nat Genet 42:937-48. 2010
    ..Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation...
  57. ncbi Variant of transcription factor 7-like 2 (TCF7L2) gene and the risk of type 2 diabetes in large cohorts of U.S. women and men
    Cuilin Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Diabetes 55:2645-8. 2006
    ..48-fold increased risk (P < 10(-16)). Our findings confirm that the TCF7L2 gene represents an important locus for predicting inherited susceptibility to type 2 diabetes...
  58. ncbi Dietary glycemic load, whole grains, and systemic inflammation in diabetes: the epidemiological evidence
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Curr Opin Lipidol 18:3-8. 2007
    ..The aim of this article is to present recent findings from epidemiological studies on the effects of dietary glycemic load and whole grain foods on systemic inflammation in diabetic patients and to postulate potential mechanisms...
  59. ncbi Intake of added sugar and sugar-sweetened drink and serum uric acid concentration in US men and women
    Xiang Gao
    Department of Nutrition, Harvard University School of Public Health, Boston, MA 02115, USA
    Hypertension 50:306-12. 2007
    ..2; P for interaction <0.01). Further research is needed to confirm causality of these associations and the observed difference by gender...
  60. ncbi Dietary glycemic index, glycemic load, cereal fiber, and plasma adiponectin concentration in diabetic men
    Lu Qi
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Diabetes Care 28:1022-8. 2005
    ..Adiponectin may improve insulin sensitivity, reduce inflammation, and ameliorate glycemic control. However, few studies have evaluated dietary predictors of plasma adiponectin levels, especially among subjects with type 2 diabetes...
  61. pmc Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels
    Qi Sun
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Hum Mol Genet 19:1846-55. 2010
    ..These data provide novel evidence revealing the role of polymorphisms in LEPR in modulating plasma levels of sOB-R and may further our understanding of the complex relationships among leptin, leptin receptor and diabetes-related traits...
  62. pmc Exposure to the chinese famine in early life and the risk of metabolic syndrome in adulthood
    Yanping Li
    National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing, China
    Diabetes Care 34:1014-8. 2011
    ..To examine whether exposure to the Chinese famine during fetal life and early childhood is associated with the risks of metabolic syndrome and whether this association is modified by later life environment...
  63. ncbi Uncoupling protein 2 promoter polymorphism -866G/A, central adiposity, and metabolic syndrome in Asians
    Haiqing Shen
    Nutrition and Genomics Laboratory, US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Obesity (Silver Spring) 14:656-61. 2006
    ..Our findings indicate that the uncoupling protein 2 gene -866G/A polymorphism may increase the risks of central obesity and metabolic syndrome, with greater effects on Asian men...
  64. ncbi Interaction between dietary fat intake and the cholesterol ester transfer protein TaqIB polymorphism in relation to HDL-cholesterol concentrations among US diabetic men
    Tricia Y Li
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 86:1524-9. 2007
    ..Cholesterol ester transfer protein (CETP) plays an important role in the regulation of HDL metabolism, and the TaqIB polymorphism of the CETP gene has been associated with elevated HDL concentrations...
  65. pmc Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
    Benjamin F Voight
    Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA
    Nat Genet 42:579-89. 2010
    ..We also show that a high proportion of T2D susceptibility loci harbor independent association signals influencing apparently unrelated complex traits...
  66. ncbi Hearts and bones
    L Qi
    Nutrition and Genomics Laboratory, JM USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Nutr Metab Cardiovasc Dis 13:165-74. 2003
    ....
  67. pmc Insulin receptor substrate 1 gene variation modifies insulin resistance response to weight-loss diets in a 2-year randomized trial: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial
    Qibin Qi
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 124:563-71. 2011
    ..We examined whether the best-associated variant modifies the long-term changes in insulin resistance and body weight in response to weight-loss diets in Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial...
  68. ncbi Is IL12B a potential genetic target for the prevention of type 1 diabetes through dietary intervention?
    Jose M Ordovas
    USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
    Nutr Rev 60:182-6. 2002
    ..Thus, this genetic predisposition could be modulated by dietary factors. However, there is no consistency among populations in relation to relevance of this locus as a candidate gene for T1D...
  69. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  70. pmc Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
    Eleftheria Zeggini
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Nat Genet 40:638-45. 2008
    ..1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions. Our results illustrate the value of large discovery and follow-up samples for gaining further insights into the inherited basis of T2D...