Mark Puder

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc A metabolomic analysis of two intravenous lipid emulsions in a murine model
    Brian T Kalish
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e59653. 2013
  2. pmc Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice
    Vincent E de Meijer
    Department of Surgery and Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11256. 2010
  3. pmc Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediators
    Brian T Kalish
    Boston Children s Hospital, 300 Longwood Ave, Fegan Bldg 3rd Floor, Boston, MA 02115
    Am J Physiol Gastrointest Liver Physiol 305:G818-28. 2013
  4. pmc Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury
    Mark Puder
    Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Ann Surg 250:395-402. 2009
  5. pmc Repetitive orogastric gavage affects the phenotype of diet-induced obese mice
    Vincent E de Meijer
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston and Harvard Medical School, MA, USA
    Physiol Behav 100:387-93. 2010
  6. doi request reprint Reduction of hepatocellular injury after common bile duct ligation using omega-3 fatty acids
    Sang Lee
    Department of Surgery, The Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 43:2010-5. 2008
  7. pmc The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model
    Hau D Le
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital and Harvard Medical School, USA
    Metabolism 62:499-508. 2013
  8. doi request reprint Parenteral fish-oil-based lipid emulsion improves fatty acid profiles and lipids in parenteral nutrition-dependent children
    Hau D Le
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston, MA, USA
    Am J Clin Nutr 94:749-58. 2011
  9. pmc Tumor necrosis factor α-converting enzyme inhibition reverses hepatic steatosis and improves insulin sensitivity markers and surgical outcome in mice
    Vincent E de Meijer
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25587. 2011
  10. doi request reprint Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease
    Kathleen M Gura
    Department of Pharmacy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatrics 121:e678-86. 2008

Detail Information

Publications86

  1. pmc A metabolomic analysis of two intravenous lipid emulsions in a murine model
    Brian T Kalish
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 8:e59653. 2013
    ..The biochemical mechanism of this differential effect is unclear. This study compares SO and FO lipid emulsions in a murine model of hepatic steatosis, one of the first hits in PN-associated liver disease...
  2. pmc Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice
    Vincent E de Meijer
    Department of Surgery and Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e11256. 2010
    ..We hypothesized that treatment with a broad-spectrum MMP and TACE-inhibitor (Marimastat) would ameliorate injury and inflammation, leading to decreased fibrogenesis during repeated hepatotoxin-induced liver injury...
  3. pmc Intravenous fish oil lipid emulsion promotes a shift toward anti-inflammatory proresolving lipid mediators
    Brian T Kalish
    Boston Children s Hospital, 300 Longwood Ave, Fegan Bldg 3rd Floor, Boston, MA 02115
    Am J Physiol Gastrointest Liver Physiol 305:G818-28. 2013
    ..In human infants, the transition from SOLE to FOLE was associated with a shift toward a proresolving lipidome. Together, these results demonstrate that the composition of the lipid emulsion directly modifies inflammatory homeostasis. ..
  4. pmc Parenteral fish oil improves outcomes in patients with parenteral nutrition-associated liver injury
    Mark Puder
    Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Ann Surg 250:395-402. 2009
    ..The objective was to determine the safety and efficacy of a fish oil-based intravenous lipid emulsion (ILE) in the treatment of parenteral nutrition-associated liver disease (PNALD)...
  5. pmc Repetitive orogastric gavage affects the phenotype of diet-induced obese mice
    Vincent E de Meijer
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston and Harvard Medical School, MA, USA
    Physiol Behav 100:387-93. 2010
    ..The effects of what may seem to be trivial laboratory routines, such as orogastric gavage, should be taken into account when designing animal studies for drug development...
  6. doi request reprint Reduction of hepatocellular injury after common bile duct ligation using omega-3 fatty acids
    Sang Lee
    Department of Surgery, The Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 43:2010-5. 2008
    ..Omega-3 fatty acids are antiinflammatory. We proposed that omega-3 fatty acid supplementation would reduce hepatocellular damage and cell death in a model of murine common bile duct ligation...
  7. pmc The effect of varying ratios of docosahexaenoic acid and arachidonic acid in the prevention and reversal of biochemical essential fatty acid deficiency in a murine model
    Hau D Le
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital and Harvard Medical School, USA
    Metabolism 62:499-508. 2013
    ..This study evaluates the effect of varying dietary ratios of DHA:AA in the prevention and reversal of biochemical EFAD in a murine model...
  8. doi request reprint Parenteral fish-oil-based lipid emulsion improves fatty acid profiles and lipids in parenteral nutrition-dependent children
    Hau D Le
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston, MA, USA
    Am J Clin Nutr 94:749-58. 2011
    ..A fish-oil-based lipid emulsion (FOLE) as a component of PN can reverse PN-cholestasis and has been shown to improve lipid profiles...
  9. pmc Tumor necrosis factor α-converting enzyme inhibition reverses hepatic steatosis and improves insulin sensitivity markers and surgical outcome in mice
    Vincent E de Meijer
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25587. 2011
    ..We hypothesized that treatment with the pharmacologic tumor necrosis factor-α converting enzyme (TACE)-inhibitor Marimastat would reverse established steatosis, leading to improved outcome following hepatectomy...
  10. doi request reprint Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease
    Kathleen M Gura
    Department of Pharmacy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatrics 121:e678-86. 2008
    ..Parenteral nutrition-associated liver disease can be a progressive and fatal entity in children with short-bowel syndrome. Soybean-fat emulsions provided as part of standard parenteral nutrition may contribute to its pathophysiology...
  11. doi request reprint Cholestasis and growth in neonates with gastroschisis
    Erica M Fallon
    The Department of Surgery and The Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 47:1529-36. 2012
    ..The aim of this study was to determine the incidence of cholestasis and the correlation between cholestasis and weight-for-age z scores in parenteral nutrition-dependent neonates with gastroschisis...
  12. doi request reprint Dietary fish oil aggravates paracetamol-induced liver injury in mice
    Vincent E de Meijer
    Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 37:268-73. 2013
    ..Evidence for its use in APAP intoxication, however, is conflicting. The effects of fish oil supplementation on APAP-induced liver failure were investigated...
  13. pmc Dietary fat intake promotes the development of hepatic steatosis independently from excess caloric consumption in a murine model
    Vincent E de Meijer
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston and Harvard Medical School, Boston, MA, USA
    Metabolism 59:1092-105. 2010
    ..Low-fat diets deserve attention in the investigation of a potential treatment of patients with nonalcoholic fatty liver disease...
  14. ncbi request reprint Evaluation of anastomotic strength and drug safety after short-term sunitinib administration in rabbits
    Erica M Fallon
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts
    J Surg Res 187:101-6. 2014
    ..The objective of the present study was to evaluate anastomotic healing and potential drug-related toxicities after short-term sunitinib administration in New Zealand White rabbits...
  15. pmc A critical role for matrix metalloproteinases in liver regeneration
    Ian P J Alwayn
    Department of Surgery and the Vascular Biology Program, Children s Hospital, Boston, Massachusetts 02115, USA
    J Surg Res 145:192-8. 2008
    ..To determine whether MMPs are required for normal hepatic regeneration, we performed 67% hepatectomies on mice treated with a broad-spectrum MMP-inhibitor, and assessed the effect on liver regeneration and urinary MMP activity...
  16. doi request reprint Comparison of 5 intravenous lipid emulsions and their effects on hepatic steatosis in a murine model
    Jonathan A Meisel
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Boston, MA 02115, USA
    J Pediatr Surg 46:666-73. 2011
    ..There is mounting evidence that fish oil-based emulsions may prevent this liver injury. This study compares 5 emulsions with different fat compositions and their effect on hepatic steatosis, one of the first hits in PNALD...
  17. pmc Impact of fish oil-based lipid emulsion on serum triglyceride, bilirubin, and albumin levels in children with parenteral nutrition-associated liver disease
    Sang I Lee
    Department of Surgery, Harvard Medical School, 11 Priscilla Road, No 1, Boston, MA 02135, USA
    Pediatr Res 66:698-703. 2009
    ..These findings may indicate an added benefit of reduced triglyceride levels for patients treated with fish oil and this effect coincides with markers for improved liver function and nutritional status...
  18. pmc Docosahexaenoic acid and arachidonic acid prevent essential fatty acid deficiency and hepatic steatosis
    Hau D Le
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 36:431-41. 2012
    ..However, the authors hypothesized that docosahexaenoic acid and arachidonic acid can function as the essential fatty acids...
  19. doi request reprint Arachidonic acid and docosahexaenoic acid supplemented to an essential fatty acid-deficient diet alters the response to endotoxin in rats
    Pei Ra Ling
    Laboratory of Nutrition Infection, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 61:395-406. 2012
    ..Feeding an EFAD diet reduces baseline inflammation and inflammatory response to endotoxin long before the development of EFAD, and added AA + DHA modifies this response...
  20. doi request reprint Parenteral fish oil monotherapy in the management of patients with parenteral nutrition-associated liver disease
    Vincent E de Meijer
    Vascular Biology Program, Department of Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Fegan 3, Boston, MA 02115, USA
    Arch Surg 145:547-51. 2010
    ..To update knowledge on the management of parenteral nutrition-associated liver disease (PNALD) and to review the clinical data on the use of parenteral fish oil for reversal of PNALD...
  21. doi request reprint Effects of glucose or fat calories in total parenteral nutrition on fat metabolism and systemic inflammation in rats
    Pei Ra Ling
    Laboratory of Nutrition Infection, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 60:195-205. 2011
    ....
  22. pmc Treatment of parenteral nutrition-associated liver disease: the role of lipid emulsions
    Prathima Nandivada
    Boston Children s Hospital, Boston, MA
    Adv Nutr 4:711-7. 2013
    ..The purpose of this review is to provide an overview of the pathogenetic mechanisms associated with the development of PNALD and the data evaluating currently available treatment strategies. ..
  23. ncbi request reprint Endothelial progenitor cells contribute to accelerated liver regeneration
    Paul Beaudry
    Vascular Biology Program, Department of Surgery, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 42:1190-8. 2007
    ..These results suggest that CEP cells play a role in regulating liver regeneration and that VEGF treatment can mobilize CEP cells to accelerate this process...
  24. doi request reprint Parenteral fish oil as monotherapy improves lipid profiles in children with parenteral nutrition-associated liver disease
    Hau D Le
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    JPEN J Parenter Enteral Nutr 34:477-84. 2010
    ..Because fish oil has been shown to have positive effects on lipid profiles, the authors hypothesize that a parenteral fish oil lipid emulsion will improve lipid profiles in children who are PN dependent...
  25. doi request reprint Provision of a soy-based intravenous lipid emulsion at 1 g/kg/d does not prevent cholestasis in neonates
    Deepika Nehra
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    JPEN J Parenter Enteral Nutr 37:498-505. 2013
    ..The purpose of this study was to determine whether the provision of a soybean oil-based lipid emulsion at 1 g/kg/d compared with 2-3 g/kg/d is associated with a reduced incidence of cholestasis...
  26. doi request reprint Sunitinib reduces recurrent pelvic adhesions in a rabbit model
    Erica M Fallon
    Department of Surgery and Vascular Biology Program, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Surg Res 178:860-5. 2012
    ....
  27. ncbi request reprint Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model
    Ian P J Alwayn
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, MA, USA
    Am J Physiol Gastrointest Liver Physiol 291:G1011-9. 2006
    ..This may be related to increased expression and activation of PPAR-alpha or IL-6, respectively...
  28. pmc Fish oil prevents essential fatty acid deficiency and enhances growth: clinical and biochemical implications
    Robert A M Strijbosch
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Metabolism 57:698-707. 2008
    ..This can presumably be attributed to the fact that fish oil contains not only a small amount of linoleic acid, but also arachidonic acid, which has greater efficiency to meet omega-6 fatty acid requirements...
  29. ncbi request reprint Inhibition of intra-abdominal adhesion formation with the angiogenesis inhibitor sunitinib
    Sendia Kim
    Department of Surgery, Children s Hospital Boston Harvard Medical School, Boston, Massachusetts 02115, USA
    J Surg Res 149:115-9. 2008
    ..To determine the effects of sunitinib, a vascular endothelial growth factor receptor 2 (VEGFR-2) antagonist, on intra-abdominal adhesions...
  30. doi request reprint Fish oil-based lipid emulsions prevent and reverse parenteral nutrition-associated liver disease: the Boston experience
    Vincent E de Meijer
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 33:541-7. 2009
    ..A prospective randomized trial that is currently under way at the authors' institution will objectively determine the place of fish oil monotherapy in the prevention of PNALD...
  31. pmc The essentiality of arachidonic acid and docosahexaenoic acid
    Hau D Le
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, 300 Longwood Ave, Fegan 3, Boston, MA 02115, USA
    Prostaglandins Leukot Essent Fatty Acids 81:165-70. 2009
    ....
  32. ncbi request reprint Prevention of parenteral nutrition-associated liver disease: role of omega-3 fish oil
    Erica M Fallon
    Department of Surgery and Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Curr Opin Organ Transplant 15:334-40. 2010
    ..In contrast, fish oil-based lipid emulsions are composed mainly of omega-3 polyunsaturated fatty acids and are hypothesized to be hepatoprotective. This review will discuss fish oil-based lipid emulsions in the prevention of PNALD...
  33. doi request reprint Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib
    Carmen M Barnes
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Res 71:168-78. 2012
    ..We investigated the use of dietary omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) in the treatment of neuroblastoma both as a sole agent and in combination with sunitinib, a broad-spectrum tyrosine kinase receptor inhibitor...
  34. ncbi request reprint The route of lipid administration affects parenteral nutrition-induced hepatic steatosis in a mouse model
    Patrick J Javid
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 40:1446-53. 2005
    ..We therefore examined whether the route of lipid administration would affect the development of PN-associated liver injury in a previously established animal model of PN-induced hepatic steatosis...
  35. doi request reprint Sunitinib inhibits postoperative adhesions in a rabbit model
    Jonathan A Meisel
    Department of Surgery and Vascular Biology, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Surgery 150:32-8. 2011
    ..We previously demonstrated the inhibitory effect of sunitinib, a receptor tyrosine kinase inhibitor, on adhesion formation in a murine model, and now investigate its effects in a rabbit model...
  36. pmc Parenteral fish oil as monotherapy prevents essential fatty acid deficiency in parenteral nutrition-dependent patients
    Vincent E de Meijer
    Department of Surgery, and Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Pediatr Gastroenterol Nutr 50:212-8. 2010
    ..The purpose of the present study was to examine fatty acid profiles of patients receiving no enteral energy, while completely dependent on PN and an intravenous fish oil-based lipid emulsion, for onset of EFAD and maintenance of growth...
  37. doi request reprint Surgical intervention in the setting of parenteral nutrition-associated cholestasis may exacerbate liver injury
    Danielle A Arsenault
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 46:122-7. 2011
    ..This study compares postoperative markers of liver injury in patients receiving intravenous fish oil (IFO) with parenteral nutrition (PN)-associated cholestasis (PNAC) to patients with resolved PNAC...
  38. ncbi request reprint Vascular endothelial growth factor accelerates compensatory lung growth after unilateral pneumonectomy
    Maromi K Sakurai
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 292:L742-7. 2007
    ..The fact that bFGF did not accelerate growth in our model when it did accelerate regeneration in the liver model suggests that angiogenesis during organ regeneration is regulated in an organ-specific manner...
  39. ncbi request reprint Reversal of parenteral nutrition-associated liver disease in two infants with short bowel syndrome using parenteral fish oil: implications for future management
    Kathleen M Gura
    Department of Pharmacy, Children s Hospital Boston, 300 Longwood Ave, Boston, Massachusetts 02115, USA
    Pediatrics 118:e197-201. 2006
    ..A randomized, controlled trial is necessary to study the efficacy of this new approach to parenteral nutrition-associated liver disease...
  40. pmc Effects of metalloproteinase inhibition in a murine model of renal ischemia-reperfusion injury
    Katherine B Novak
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Res 67:257-62. 2010
    ..99); however, pretreated mice presented only a slight increase in mean MMP-2 activity (1.57 +/- 0.72) (p < 0.001). In conclusion, these data demonstrate that MMP inhibition is associated with a reduction of IRI in a murine model...
  41. doi request reprint Effect of sunitinib on functional reproductive outcome in a rabbit model
    Erica M Fallon
    Department of Surgery and Vascular Biology Program, Children s Hospital Boston and Harvard Medical School, Boston, Massachusetts, USA
    Fertil Steril 98:496-502. 2012
    ....
  42. doi request reprint Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids
    Deepika Nehra
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Boston, MA, 02115, USA
    Aging Cell 11:1046-54. 2012
    ..Thus, omega-3 fatty acids may provide an effective and practical avenue for delaying ovarian aging and improving oocyte quality at advanced maternal age...
  43. ncbi request reprint Role of parenteral lipid emulsions in the preterm infant
    Prathima Nandivada
    Boston Children s Hospital, Department of Surgery and Vascular Biology Program, 300 Longwood Avenue, Fegan 3, Boston, MA, USA
    Early Hum Dev 89:S45-9. 2013
    ..The purpose of this review is to provide an overview of lipid requirements of the preterm infant and discuss the role of parenteral lipid emulsions in the management of PNALD and other diseases of prematurity. ..
  44. ncbi request reprint A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for metabolic bone disease
    Deepika Nehra
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 37:570-98. 2013
    ..Premature infants are at increased risk for metabolic bone disease, with resulting delayed bone growth, osteopenia, and rickets...
  45. pmc Docosahexaenoic acid, G protein-coupled receptors, and melanoma: is G protein-coupled receptor 40 a potential therapeutic target?
    Deepika Nehra
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts Department of Surgery, Harvard Medical School, Boston, Massachusetts
    J Surg Res 188:451-8. 2014
    ..To determine the effect of docosahexaenoic acid (DHA) on the growth of human melanoma in vitro and in vivo and to better understand the potential role of the G protein-coupled receptors (GPRs) in mediating this effect...
  46. ncbi request reprint Current clinical applications of omega-6 and omega-3 fatty acids
    Sang Lee
    Children s Hospital Boston, 300 Longwood Ave, MA 02115, USA
    Nutr Clin Pract 21:323-41. 2006
    ..The aim of this manuscript is to provide a basic review of current clinical applications of omega-6 and omega-3 fatty acids, with a particular focus on the latter...
  47. doi request reprint The growing role of eicosanoids in tissue regeneration, repair, and wound healing
    Brian T Kalish
    Vascular Biology Program, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    Prostaglandins Other Lipid Mediat 104:130-8. 2013
    ..In this review, we describe how this diverse group of molecules is a key regulator of tissue repair and regeneration in multiple organ systems and biologic contexts. ..
  48. pmc Epoxyeicosanoids promote organ and tissue regeneration
    Dipak Panigrahy
    Vascular Biology Program and Department of Surgery, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:13528-33. 2013
    ..Thus, our observations indicate a central role for EETs in organ and tissue regeneration and their contribution to tissue homeostasis. ..
  49. doi request reprint Purified fish oil eliminating linoleic and alpha linolenic acid meets essential fatty acid requirements in rats
    Pei Ra Ling
    Laboratory of Nutrition Infection, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Metabolism 61:1443-51. 2012
    ..Providing AA, EPA and DHA in EFAD prevents EFAD over the short-term as reflected in Mead acid production, triene:tetraene ratio, and de novo lipogenesis and may reduce the inflammatory response to LPS...
  50. doi request reprint The prevention and treatment of intestinal failure-associated liver disease in neonates and children
    Deepika Nehra
    The Vascular Biology Program, Department of Surgery, Children s Hospital Boston, 1 Blackfan Circle, Boston, MA 02215, USA
    Surg Clin North Am 91:543-63. 2011
    ..Recent work also demonstrates the efficacy of fish-oil based lipid emulsions in the prevention and treatment of IFALD. Transplantation is an option for end-stage liver disease but is associated with significant morbidity and mortality...
  51. doi request reprint Pediatric rib lesions: a 13-year experience
    Sendia Kim
    Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 43:1781-5. 2008
    ..Rib lesions in the pediatric population are rare but significant processes and are often neoplastic...
  52. pmc Innovative parenteral and enteral nutrition therapy for intestinal failure
    Hau D Le
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts, USA
    Semin Pediatr Surg 19:27-34. 2010
    ..Careful monitoring and individualized management to ensure maintenance of growth while avoiding complications are the keys to successful patient outcomes...
  53. doi request reprint APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development
    Wolfram Goessling
    Stem Cell Program and Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, HHMI, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 320:161-74. 2008
    ..These studies reveal an important and time-dependent role for wnt signaling during liver development and regeneration...
  54. doi request reprint The role of the ω-3 fatty acid DHA in the human life cycle
    Sarah J Carlson
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    JPEN J Parenter Enteral Nutr 37:15-22. 2013
    ..3s may also play important roles in adult neurophysiology and disease prevention...
  55. pmc The use of fish oil lipid emulsion in the treatment of intestinal failure associated liver disease (IFALD)
    Melissa I Chang
    Boston Children s Hospital, Boston, MA 02215, USA
    Nutrients 4:1828-50. 2012
    ..This review will discuss the experience to date with this lipid emulsion along with the rational for its use, controversies and concerns...
  56. pmc Ablation of leptin signaling disrupts the establishment, development, and maintenance of endometriosis-like lesions in a murine model
    Aaron K Styer
    Massachusetts General Hospital, Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Boston, MA 02114, USA
    Endocrinology 149:506-14. 2008
    ..Our results confirm that leptin signaling is a necessary component in lesion proliferation, early vascular recruitment, and maintenance of neoangiogenesis in a murine model of endometriosis...
  57. ncbi request reprint The role of an intravenous fat emulsion composed of fish oil in a parenteral nutrition-dependent patient with hypertriglyceridemia
    Kathleen Gura
    Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Nutr Clin Pract 22:664-72. 2007
    ..This suggests that using fish-oil-based IVFE may be an effective alternative to conventional IVFE in PN-dependent patients whose clinical course is complicated by hypertriglyceridemia...
  58. ncbi request reprint Omega-3 fatty acids improve hepatic steatosis in a murine model: potential implications for the marginal steatotic liver donor
    Ian P J Alwayn
    Department of Surgery, Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Transplantation 79:606-8. 2005
    ....
  59. pmc Acid sphingomyelinase involvement in tumor necrosis factor alpha-regulated vascular and steroid disruption during luteolysis in vivo
    Luiz E Henkes
    Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:7670-5. 2008
    ..Together these data provide evidence that TNF plays an active role in luteolysis. Further studies are required to determine the deleterious effects of anti-inflammatory agents on basic ovarian processes...
  60. doi request reprint A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for necrotizing enterocolitis
    Erica M Fallon
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    JPEN J Parenter Enteral Nutr 36:506-23. 2012
    ..Necrotizing enterocolitis (NEC) is one of the most devastating diseases in the neonatal population, with extremely low birth weight and extremely preterm infants at greatest risk...
  61. pmc Early development of essential fatty acid deficiency in rats: fat-free vs. hydrogenated coconut oil diet
    Pei Ra Ling
    The Laboratory of Nutrition Infection, Beth Israel Deaconess Medical Center, Room 605, Baker Building, One Deaconess Road, 330 Brookline Ave, Boston, MA 02215, USA
    Prostaglandins Leukot Essent Fatty Acids 83:229-37. 2010
    ..Thus, these secondary effects of an EFAD diet on fatty acid metabolism can be modified by the saturated fat in the diet while the primary impact of both diets on development of EFAD is unaffected...
  62. ncbi request reprint Use of a fish oil-based lipid emulsion to treat essential fatty acid deficiency in a soy allergic patient receiving parenteral nutrition
    Kathleen M Gura
    Department of Pharmacy, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Clin Nutr 24:839-47. 2005
    ....
  63. doi request reprint Neonatal intestinal physiology and failure
    Sarah J Carlson
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital, 300 Longwood Ave, Fegan 3, Boston, Massachusetts 02115
    Semin Pediatr Surg 22:190-4. 2013
    ..Parenteral nutrition remains the mainstay of treatment for neonatal intestinal failure. ..
  64. doi request reprint Rapid infusion of fish oil-based emulsion in infants does not appear to be associated with fat overload syndrome
    Kathleen M Gura
    Department of Pharmacy, Children s Hospital Boston, Boston, Massachusetts, USA
    Nutr Clin Pract 25:399-402. 2010
    ..The aim of this investigation was to determine whether infants receiving a rapid infusion of a fish oil lipid emulsion exhibited symptoms consistent with fat overload syndrome...
  65. ncbi request reprint Partial hepatectomy in the mouse: technique and perioperative management
    Arin K Greene
    Department of Surgical Research, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Invest Surg 16:99-102. 2003
    ..In addition, the general operative technique and perioperative management of these mice may be applied to all types of murine intra-abdominal procedures used for surgical research...
  66. doi request reprint Newborn and toddler intestinal obstruction owing to congenital mesenteric defects
    Matthew P Page
    Department of Surgery, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Surg 43:755-8. 2008
    ....
  67. doi request reprint A tutorial on fatty acid biology
    Brian T Kalish
    Department of Surgery, Boston Children s Hospital, Boston, Massachusetts 02115, USA
    JPEN J Parenter Enteral Nutr 36:380-8. 2012
    ....
  68. doi request reprint Fish oil-based lipid emulsion in the treatment of parenteral nutrition-associated liver disease
    Eileen Cowan
    Department of Surgery and the Vascular Biology Program, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 25:193-200. 2013
    ..Here, we review the most recent literature involving a fish oil-based lipid emulsion (FOLE) and its effects on PNALD...
  69. ncbi request reprint Targeting angiogenesis with a conjugate of HPMA copolymer and TNP-470
    Ronit Satchi-Fainaro
    Vascular Biology Program and Department of Surgery, Boston Children s Hospital and Harvard Medical School, 1 Blackfan Circle, New Research Building, Boston, Massachusetts 02115, USA
    Nat Med 10:255-61. 2004
    ..This new approach for targeting angiogenesis inhibitors specifically to the tumor vasculature may provide a new strategy for the rational design of cancer therapies...
  70. pmc Endothelial-directed hepatic regeneration after partial hepatectomy
    Arin K Greene
    Department of Surgery, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Hunnewell 103, Boston, MA 02115, USA
    Ann Surg 237:530-5. 2003
    ..To determine the role of the microvascular endothelium in the regulation of regenerating liver mass after partial hepatectomy...
  71. ncbi request reprint Omega-3 fatty acid supplementation prevents hepatic steatosis in a murine model of nonalcoholic fatty liver disease
    Ian P J Alwayn
    Department of Surgery and the Vascular Biology Program, The Children s Hospital, Boston, MA 02115, USA
    Pediatr Res 57:445-52. 2005
    ..v. lipid emulsions fail to improve dietary-induced steatotic injury to the liver, i.v. supplementation of omega-3 fatty acids partially and enteral supplementation completely protects the liver against such injury...
  72. ncbi request reprint Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin
    Ronit Satchi-Fainaro
    Children s Hospital Boston and Harvard Medical School, Vascular Biology Program, Department of Surgery, 1 Blackfan Circle, Karp Family Research Laboratories, Floor 12, Boston, Massachusetts 02115, USA
    Cancer Cell 7:251-61. 2005
    ..This activity likely contributes to TNP-470's antiangiogenic effect and suggests that caplostatin can be used in the treatment of cancer and inflammation...
  73. doi request reprint Controlled release of vascular endothelial growth factor enhances intestinal adaptation in rats with extensive small intestinal resection
    Nan Ye Lei
    Department of Surgery, University of California, Los Angeles, CA 90095, USA
    Surgery 150:186-90. 2011
    ..The present study investigates the controlled release of VEGF as a way to improve intestinal adaptation...
  74. ncbi request reprint Recent developments in aluminium contamination of products used in parenteral nutrition
    Kathleen M Gura
    Department of Pharmacy, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Clin Nutr Metab Care 9:239-46. 2006
    ..This review also summarizes the issues associated with aluminium toxicity, the patient populations at risk, treatment options, and compounding considerations...
  75. ncbi request reprint Urinary matrix metalloproteinases and their endogenous inhibitors predict hepatic regeneration after murine partial hepatectomy
    Arin K Greene
    Department of Surgery and the Vascular Biology Program, Children s Hospital, 300 Longwood Avenue, Boston, MA 02115, USA
    Transplantation 78:1139-44. 2004
    ..We therefore hypothesized that urinary MMPs and their endogenous tissue inhibitors of matrix metalloproteinases (TIMPs) might also provide important information regarding initiation and progression of liver regeneration...
  76. pmc Prevention of intra-abdominal adhesions using the antiangiogenic COX-2 inhibitor celecoxib
    Arin K Greene
    Department of Surgery, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Ann Surg 242:140-6. 2005
    ..To determine the effects of COX-2 specific inhibitors on postoperative adhesion formation...
  77. ncbi request reprint Determining the need for simulated training of invasive procedures
    Arin K Greene
    Department of Surgery, Children s Hospital, Boston, MA 02115, USA
    Adv Health Sci Educ Theory Pract 11:41-9. 2006
    ..05). Simulation should be incorporated into the education of medical students and residents as a tool to practice invasive procedures prior to working on patients...
  78. ncbi request reprint Acute necrotizing cholecystitis: a rare complication of ceftriaxone-associated pseudolithiasis
    Sendia Kim
    Surgery and Vascular Biology, Children s Hospital Boston, Fegan 3, 300 Longwood Avenue, Boston, MA 02115, USA
    Pediatr Surg Int 22:562-4. 2006
  79. ncbi request reprint Pediatric anorectal impalement with bladder rupture: case report and review of the literature
    Sendia Kim
    Vascular Biology Lab, Children s Hospital Boston, Boston, MA 02115, USA
    J Pediatr Surg 41:E1-3. 2006
    ..We report a rectal impalement with extraperitoneal bladder injury in a 12-year-old boy and review the literature on treatment of these injuries...
  80. ncbi request reprint Microdeformational wound therapy: effects on angiogenesis and matrix metalloproteinases in chronic wounds of 3 debilitated patients
    Arin K Greene
    Division of Plastic Surgery, Harvard Plastic Surgery Program, Brigham and Women s Hospital, Boston, MA 02115, USA
    Ann Plast Surg 56:418-22. 2006
    ..MDWT provides a favorable wound-healing environment by increasing angiogenesis and decreasing MMP activity in chronic wounds...
  81. ncbi request reprint Analysis of tumor-associated stromal cells using SCID GFP transgenic mice: contribution of local and bone marrow-derived host cells
    Taturo Udagawa
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston and Harvard Medical School, Karp Family Research Laboratories, Boston, MA 02115, USA
    FASEB J 20:95-102. 2006
    ....
  82. ncbi request reprint Pneumonectomy in the mouse: technique and perioperative management
    Maromi K Sakurai
    Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Invest Surg 18:201-5. 2005
    ..Minimal long-term morbidity was appreciated. This general operative technique and perioperative management may be applied to all types of murine thoracic procedures used for surgical research...
  83. ncbi request reprint Hepatic exstrophy complicating Poland's anomaly
    Mark Puder
    Department of Pediatric Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Pediatr Surg 37:1203-4. 2002
    ..Associated defects may include syndactyly osseous and cartilagenous costal aplasia and adactyly. A case of hepatic exstrophy through a full-thickness chest wall defect in an infant with Poland's anomaly is reported...
  84. ncbi request reprint Do polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREPB-1 suppression or by correcting essential fatty acid deficiency
    Ian P J Alwayn
    Hepatology 39:1176-7; author reply 1177-8. 2004
  85. ncbi request reprint Omega-3 fatty acids and liver disease
    Sang Lee
    Hepatology 45:841-5. 2007
  86. doi request reprint Re: Influence of different intravenous lipid emulsions on hepatobiliary dysfunction in a rabbit model
    Sang Lee
    J Pediatr Gastroenterol Nutr 46:224-5; author reply 225. 2008

Research Grants7

  1. Mechanisms of Hepatic Steatosis Prevention
    Mark Puder; Fiscal Year: 2007
    ..This award would provide me with protected time to pursue these research and training objectives, and greatly facilitate my transition to an independent researcher in the study of this devastating disease ..
  2. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Use of PN with fish oil base emulsion may prevent liver dysfunction resulting generally in better heath outcomes for these children. ..
  3. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Although the proposed study is not a randomized trial, it is thought that sufficient evidence could be generated that would result in FDA approval of an lFE such as Omegaven. ..
  4. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
    ..Although the proposed study is not a randomized trial, it is thought that sufficient evidence could be generated that would result in FDA approval of an lFE such as Omegaven. ..