Kenneth D Poss

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration
    Kenneth D Poss
    Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Development 129:5141-9. 2002
  2. ncbi request reprint Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
  3. pmc Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes
    Kazu Kikuchi
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 464:601-5. 2010
  4. pmc Fgfs control homeostatic regeneration in adult zebrafish fins
    Airon A Wills
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:3063-70. 2008
  5. pmc Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Biol 331:270-80. 2009
  6. pmc Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish
    Joshua S Waxman
    Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 15:923-34. 2008
  7. ncbi request reprint Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish
    Airon A Wills
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:183-92. 2008
  8. pmc Regulation of zebrafish heart regeneration by miR-133
    Viravuth P Yin
    Department of Cell Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 365:319-27. 2012
  9. ncbi request reprint Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration
    Alex Nechiporuk
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 258:291-306. 2003
  10. pmc Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish
    Viravuth P Yin
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 22:728-33. 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration
    Kenneth D Poss
    Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Development 129:5141-9. 2002
    ..Furthermore, we show that molecular mechanisms of complex tissue regeneration can now be dissected using zebrafish genetics...
  2. ncbi request reprint Heart regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Science 298:2188-90. 2002
    ..These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration...
  3. pmc Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes
    Kazu Kikuchi
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 464:601-5. 2010
    ..These findings have implications for promoting regeneration of the injured human heart...
  4. pmc Fgfs control homeostatic regeneration in adult zebrafish fins
    Airon A Wills
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:3063-70. 2008
    ..Our experiments reveal that the facultative machinery that regenerates amputated teleost fins also has a surprisingly vigorous role in homeostatic regeneration...
  5. pmc Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish fins
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Dev Biol 331:270-80. 2009
    ..Thus, the fin wound epidermis spatially confines Hh signaling through the activity of Fgf and Wnt pathways, impacting blastemal proliferation during regenerative outgrowth...
  6. pmc Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafish
    Joshua S Waxman
    Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Cell 15:923-34. 2008
    ..Therefore, our results offer new perspectives on the mechanisms regulating organ size and the possible causes of congenital syndromes affecting both the heart and forelimb...
  7. ncbi request reprint Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafish
    Airon A Wills
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 135:183-92. 2008
    ..Our results demonstrate that the adult zebrafish ventricle grows and is maintained by cardiomyocyte hyperplasia, and that epicardial cells are added to the ventricle in an Fgf-dependent fashion to support homeostasis...
  8. pmc Regulation of zebrafish heart regeneration by miR-133
    Viravuth P Yin
    Department of Cell Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
    Dev Biol 365:319-27. 2012
    ..Our results reveal dynamic regulation of miRNAs during heart regeneration, and indicate that miR-133 restricts injury-induced cardiomyocyte proliferation...
  9. ncbi request reprint Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration
    Alex Nechiporuk
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 258:291-306. 2003
    ..sly1 is upregulated in the newly formed blastema as well as during regenerative outgrowth. Thus, sly1 is essential for blastemal organization and proliferation during two stages of fin regeneration...
  10. pmc Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafish
    Viravuth P Yin
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genes Dev 22:728-33. 2008
    ..The Mps1 kinase, an established positive regulator of blastemal proliferation, is an in vivo target of miR-133. Our findings identify miRNA depletion as a new regulatory mechanism for complex tissue regeneration...
  11. pmc Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1
    Kenneth D Poss
    Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 18:1527-32. 2004
    ....
  12. ncbi request reprint A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration
    Alexandra Lepilina
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Cell 127:607-19. 2006
    ..Our findings reveal injury responses by myocardial and epicardial tissues that collaborate in an Fgf-dependent manner to achieve cardiac regeneration...
  13. pmc New regulators of vertebrate appendage regeneration
    Viravuth P Yin
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Curr Opin Genet Dev 18:381-6. 2008
    ..These discoveries establish research avenues that may impact the regenerative capacity of mammalian tissues...
  14. pmc A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development
    Xiuning Le
    Stem Cell Program and Division of Hematology Oncology, Children s Hospital and Dana Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115, USA
    Development 140:2354-64. 2013
    ..Our work demonstrates that the activated pathways in RAS induction during embryogenesis are also important in oncogenesis and that inhibition of these pathways suppresses tumor growth...
  15. ncbi request reprint Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration
    Yoonsung Lee
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Development 132:5173-83. 2005
    ..Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage...
  16. pmc Advances in understanding tissue regenerative capacity and mechanisms in animals
    Kenneth D Poss
    Department of Cell Biology, Howard Hughes Medical Institute, Duke University School of Medicine, Durham, North Carolina 27710, USA
    Nat Rev Genet 11:710-22. 2010
    ....
  17. pmc Cardiac regeneration
    Wen Yee Choi
    Department of Cell Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, USA
    Curr Top Dev Biol 100:319-44. 2012
    ..This review will cover recent progress in the field of heart regeneration with a focus on endogenous regenerative capacity and its potential manipulation...
  18. ncbi request reprint Tales of regeneration in zebrafish
    Kenneth D Poss
    Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Dyn 226:202-10. 2003
    ..Several helpful tools and reagents are available for use with zebrafish, including the potential for genetic approaches to regeneration. Recent studies have shed light on the remarkable ability of zebrafish to regenerate fins...
  19. ncbi request reprint A zebrafish model of germ cell aneuploidy
    Kenneth D Poss
    Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
    Cell Cycle 3:1225-6. 2004
    ..In addition, it introduces the zebrafish as a promising tool with which to further investigate the origins of aneuploidy...
  20. pmc Genetic DISC-section of regeneration in Drosophila
    Gregory Nachtrab
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
    Dev Cell 16:777-8. 2009
    ..In this issue of Developmental Cell, Smith-Bolton et al. introduce a genetic ablation system in Drosophila melanogaster with the potential for large-scale identification of new regulators of regeneration...
  21. ncbi request reprint Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
    David Traver
    Children s Hospital Boston and the Howard Hughes Medical Institute, 320 Longwood Avenue, Enders 720, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1238-46. 2003
    ..Direct visualization of fluorescent donor cells in embryonic recipients allows engraftment and homing events to be imaged in real time. These results provide a cellular context in which to study the genetics of hematopoiesis...
  22. ncbi request reprint Getting to the heart of regeneration in zebrafish
    Kenneth D Poss
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, United States
    Semin Cell Dev Biol 18:36-45. 2007
    ..Recent studies have begun to reveal cellular and molecular mechanisms of this regenerative process that have exciting implications for human cardiac biology and disease...
  23. ncbi request reprint Bmp and Fgf signaling are essential for liver specification in zebrafish
    Donghun Shin
    Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
    Development 134:2041-50. 2007
    ....
  24. pmc Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart
    Sara R Marques
    Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Dev Biol 321:397-406. 2008
    ..Together, our data demonstrate that a single signaling pathway can act reiteratively to coordinate organ size and proportion...
  25. ncbi request reprint Specification of epibranchial placodes in zebrafish
    Alexei Nechiporuk
    Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
    Development 134:611-23. 2007
    ..The coordinated interplay between craniofacial tissues would thus assure proper spatial and temporal interactions in the shaping of the vertebrate head...