Research Topics
Genomes and GenesSpecies | Kenneth D PossSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regenerationKenneth D Poss
Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Development 129:5141-9. 2002..Furthermore, we show that molecular mechanisms of complex tissue regeneration can now be dissected using zebrafish genetics...- Heart regeneration in zebrafishKenneth D Poss
Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
Science 298:2188-90. 2002..These findings indicate that zebrafish will be useful for genetically dissecting the molecular mechanisms of cardiac regeneration... 
Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytesKazu Kikuchi
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Nature 464:601-5. 2010..These findings have implications for promoting regeneration of the injured human heart...- Fgfs control homeostatic regeneration in adult zebrafish finsAiron A Wills
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Development 135:3063-70. 2008..Our experiments reveal that the facultative machinery that regenerates amputated teleost fins also has a surprisingly vigorous role in homeostatic regeneration... - Maintenance of blastemal proliferation by functionally diverse epidermis in regenerating zebrafish finsYoonsung Lee
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Dev Biol 331:270-80. 2009..Thus, the fin wound epidermis spatially confines Hh signaling through the activity of Fgf and Wnt pathways, impacting blastemal proliferation during regenerative outgrowth... - Hoxb5b acts downstream of retinoic acid signaling in the forelimb field to restrict heart field potential in zebrafishJoshua S Waxman
Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Dev Cell 15:923-34. 2008..Therefore, our results offer new perspectives on the mechanisms regulating organ size and the possible causes of congenital syndromes affecting both the heart and forelimb... - Regulated addition of new myocardial and epicardial cells fosters homeostatic cardiac growth and maintenance in adult zebrafishAiron A Wills
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Development 135:183-92. 2008..Our results demonstrate that the adult zebrafish ventricle grows and is maintained by cardiomyocyte hyperplasia, and that epicardial cells are added to the ventricle in an Fgf-dependent fashion to support homeostasis... - Regulation of zebrafish heart regeneration by miR-133Viravuth P Yin
Department of Cell Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA
Dev Biol 365:319-27. 2012..Our results reveal dynamic regulation of miRNAs during heart regeneration, and indicate that miR-133 restricts injury-induced cardiomyocyte proliferation... - Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regenerationAlex Nechiporuk
Howard Hughes Medical Institute, Department of Cardiology, Children s Hospital, Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
Dev Biol 258:291-306. 2003..sly1 is upregulated in the newly formed blastema as well as during regenerative outgrowth. Thus, sly1 is essential for blastemal organization and proliferation during two stages of fin regeneration... - Fgf-dependent depletion of microRNA-133 promotes appendage regeneration in zebrafishViravuth P Yin
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Genes Dev 22:728-33. 2008..The Mps1 kinase, an established positive regulator of blastemal proliferation, is an in vivo target of miR-133. Our findings identify miRNA depletion as a new regulatory mechanism for complex tissue regeneration... - A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regenerationAlexandra Lepilina
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Cell 127:607-19. 2006..Our findings reveal injury responses by myocardial and epicardial tissues that collaborate in an Fgf-dependent manner to achieve cardiac regeneration... - Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1Kenneth D Poss
Howard Hughes Medical Institute, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Genes Dev 18:1527-32. 2004.... - New regulators of vertebrate appendage regenerationViravuth P Yin
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Curr Opin Genet Dev 18:381-6. 2008..These discoveries establish research avenues that may impact the regenerative capacity of mammalian tissues... - Advances in understanding tissue regenerative capacity and mechanisms in animalsKenneth D Poss
Department of Cell Biology, Howard Hughes Medical Institute, Duke University School of Medicine, Durham, North Carolina 27710, USA
Nat Rev Genet 11:710-22. 2010.... - Fgf signaling instructs position-dependent growth rate during zebrafish fin regenerationYoonsung Lee
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Development 132:5173-83. 2005..Our results demonstrate that Fgf signaling defines position-dependent blastemal properties and growth rates for the regenerating zebrafish appendage... - Cardiac regenerationWen Yee Choi
Department of Cell Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, USA
Curr Top Dev Biol 100:319-44. 2012..This review will cover recent progress in the field of heart regeneration with a focus on endogenous regenerative capacity and its potential manipulation... - Tales of regeneration in zebrafishKenneth D Poss
Howard Hughes Medical Institute, Department of Cardiology, Children's Hospital, Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
Dev Dyn 226:202-10. 2003..Several helpful tools and reagents are available for use with zebrafish, including the potential for genetic approaches to regeneration. Recent studies have shed light on the remarkable ability of zebrafish to regenerate fins... - A zebrafish model of germ cell aneuploidyKenneth D Poss
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina, USA
Cell Cycle 3:1225-6. 2004..In addition, it introduces the zebrafish as a promising tool with which to further investigate the origins of aneuploidy... - Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutantsDavid Traver
Children s Hospital Boston and the Howard Hughes Medical Institute, 320 Longwood Avenue, Enders 720, Boston, Massachusetts 02115, USA
Nat Immunol 4:1238-46. 2003..Direct visualization of fluorescent donor cells in embryonic recipients allows engraftment and homing events to be imaged in real time. These results provide a cellular context in which to study the genetics of hematopoiesis... - Genetic DISC-section of regeneration in DrosophilaGregory Nachtrab
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA
Dev Cell 16:777-8. 2009..In this issue of Developmental Cell, Smith-Bolton et al. introduce a genetic ablation system in Drosophila melanogaster with the potential for large-scale identification of new regulators of regeneration... - Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heartSara R Marques
Developmental Genetics Program and Department of Cell Biology, Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
Dev Biol 321:397-406. 2008..Together, our data demonstrate that a single signaling pathway can act reiteratively to coordinate organ size and proportion... - Bmp and Fgf signaling are essential for liver specification in zebrafishDonghun Shin
Department of Biochemistry and Biophysics, Programs in Developmental Biology, Genetics and Human Genetics, Liver Center, University of California, San Francisco, CA 94158, USA
Development 134:2041-50. 2007.... - Getting to the heart of regeneration in zebrafishKenneth D Poss
Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, United States
Semin Cell Dev Biol 18:36-45. 2007..Recent studies have begun to reveal cellular and molecular mechanisms of this regenerative process that have exciting implications for human cardiac biology and disease... - Specification of epibranchial placodes in zebrafishAlexei Nechiporuk
Department of Biological Structure, University of Washington, Seattle, WA 98195 7420, USA
Development 134:611-23. 2007..The coordinated interplay between craniofacial tissues would thus assure proper spatial and temporal interactions in the shaping of the vertebrate head...