Scott L Pomeroy

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Prediction of central nervous system embryonal tumour outcome based on gene expression
    Scott L Pomeroy
    Division of Neuroscience, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:436-42. 2002
  2. pmc Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation
    BORIS G WILSON
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
    Cancer Cell 18:316-28. 2010
  3. pmc miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma
    Shyamal D Weeraratne
    Department of Neurology, Children s Hospital Boston Harvard Medical School, 3 Blackfan Circle, CLS 14072, Boston, MA 02115, USA
    Neuro Oncol 13:165-75. 2011
  4. ncbi request reprint Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice
    John Y H Kim
    Department of Neurology, Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 263:50-66. 2003
  5. ncbi request reprint Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas
    Ana Fernandez-Teijeiro
    Division of Neuroscience, Department of Neurology, Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston MA 02115, USA
    J Clin Oncol 22:994-8. 2004
  6. pmc Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability
    Elizabeth S McKenna
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 28:6223-33. 2008
  7. ncbi request reprint Transverse myelitis after therapy for primitive neuroectodermal tumors
    Nicole J Ullrich
    Department of Neurology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Pediatr Neurol 35:122-5. 2006
  8. doi request reprint Long-term clinical outcomes following treatment of childhood craniopharyngioma
    Karen M Winkfield
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Blood Cancer 56:1120-6. 2011
  9. ncbi request reprint Molecular genetics of pediatric central nervous system tumors
    Nicole J Ullrich
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    Curr Oncol Rep 8:423-9. 2006
  10. pmc Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
    Yoon Jae Cho
    Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Oncol 29:1424-30. 2011

Detail Information

Publications49

  1. ncbi request reprint Prediction of central nervous system embryonal tumour outcome based on gene expression
    Scott L Pomeroy
    Division of Neuroscience, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 415:436-42. 2002
    ..We show further that the clinical outcome of children with medulloblastomas is highly predictable on the basis of the gene expression profiles of their tumours at diagnosis...
  2. pmc Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation
    BORIS G WILSON
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Children s Hospital Boston, Harvard Medical School, MA 02115, USA
    Cancer Cell 18:316-28. 2010
    ..Finally, using conditional mouse models, we show that inactivation of Ezh2 blocks tumor formation driven by Snf5 loss...
  3. pmc miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma
    Shyamal D Weeraratne
    Department of Neurology, Children s Hospital Boston Harvard Medical School, 3 Blackfan Circle, CLS 14072, Boston, MA 02115, USA
    Neuro Oncol 13:165-75. 2011
    ..Our work establishes a role for miR-34a in modulating responsiveness to chemotherapy in medulloblastoma and presents a novel positive feedback mechanism involving miR-34a and p53, via direct targeting of MAGE-A...
  4. ncbi request reprint Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice
    John Y H Kim
    Department of Neurology, Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 263:50-66. 2003
    ..These results indicate that Ptc heterozygosity contributes to tumorigenesis by predisposing a subset of granule cell precursors to the formation of proliferative rests and subsequent dysregulation of developmental gene expression...
  5. ncbi request reprint Combining gene expression profiles and clinical parameters for risk stratification in medulloblastomas
    Ana Fernandez-Teijeiro
    Division of Neuroscience, Department of Neurology, Department of Medicine, Children s Hospital, 300 Longwood Ave, Boston MA 02115, USA
    J Clin Oncol 22:994-8. 2004
    ..Outcome predictions on the basis of microarray gene expression profiles have been the most accurate to date. We ask in a multivariate model whether clinical parameters enhance survival predictions of gene expression profiles...
  6. pmc Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability
    Elizabeth S McKenna
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Division of Hematology Oncology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 28:6223-33. 2008
    ....
  7. ncbi request reprint Transverse myelitis after therapy for primitive neuroectodermal tumors
    Nicole J Ullrich
    Department of Neurology, Children s Hospital Boston and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    Pediatr Neurol 35:122-5. 2006
    ....
  8. doi request reprint Long-term clinical outcomes following treatment of childhood craniopharyngioma
    Karen M Winkfield
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Blood Cancer 56:1120-6. 2011
    ....
  9. ncbi request reprint Molecular genetics of pediatric central nervous system tumors
    Nicole J Ullrich
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    Curr Oncol Rep 8:423-9. 2006
    ..All new protocols involving treatments for brain tumors in children include studies of biomarkers and biologic correlates as a means to identify new targets for therapeutics and possible intervention strategies...
  10. pmc Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
    Yoon Jae Cho
    Children s Hospital Boston, Boston, MA 02115, USA
    J Clin Oncol 29:1424-30. 2011
    ....
  11. doi request reprint Pleiotropic effects of miR-183~96~182 converge to regulate cell survival, proliferation and migration in medulloblastoma
    Shyamal Dilhan Weeraratne
    Department of Neurology, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    Acta Neuropathol 123:539-52. 2012
    ..Thus, the miR-183 cluster regulates multiple biological programs that converge to support the maintenance and metastatic potential of medulloblastoma...
  12. ncbi request reprint Stereotactic radiotherapy for localized low-grade gliomas in children: final results of a prospective trial
    Karen J Marcus
    Children s Hospital, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 61:374-9. 2005
    ..To evaluate the efficacy of stereotactic radiotherapy (SRT) for small, localized, pediatric brain tumors and to determine the patterns of failure...
  13. ncbi request reprint Neuropsychological functioning after surgery in children treated for brain tumor
    Sarah C Carpentieri
    Division of Psychology, Department of Psychiatry, Children s Hospital, Boston, MA, USA
    Neurosurgery 52:1348-56; discussion 1356-7. 2003
    ..Subsequent reports will describe the neuropsychological functioning of children treated with surgery and stereotactic radiation therapy on Dana-Farber Cancer Institute 92-077...
  14. pmc Inactivation of the Snf5 tumor suppressor stimulates cell cycle progression and cooperates with p53 loss in oncogenic transformation
    Michael S Isakoff
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:17745-50. 2005
    ..Further, conditional mouse models demonstrate that inactivation of p16Ink4a or Rb (retinoblastoma) does not accelerate tumor formation in Snf5 conditional mice, whereas mutation of p53 leads to a dramatic acceleration of tumor formation...
  15. ncbi request reprint Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor
    Mary Ann Zimmerman
    Department of Pediatric Oncology, Pediatric Neuro Oncology, Dana Farber Cancer Institute, Rm SW331, 44 Binny Street, Boston, MA 02115, USA
    J Neurooncol 72:77-84. 2005
    ..More importantly, we report on the first two survivors after relapse with multi-agent intravenous and intrathecal chemotherapy treated with this modified regimen...
  16. ncbi request reprint A novel role for extracellular signal-regulated kinase 5 and myocyte enhancer factor 2 in medulloblastoma cell death
    Lisa Marie Sturla
    Program in Neuroscience, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 65:5683-9. 2005
    ....
  17. ncbi request reprint Gene expression-based classification of malignant gliomas correlates better with survival than histological classification
    Catherine L Nutt
    Department of Pathology and Neurosurgical Service, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer Res 63:1602-7. 2003
    ..These data suggest that class prediction models, based on defined molecular profiles, classify diagnostically challenging malignant gliomas in a manner that better correlates with clinical outcome than does standard pathology...
  18. pmc Medulloblastoma biology in the post-genomic era
    Tenley C Archer
    Department of Neurology, Children s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Fegan 1103, Boston, MA 02115, USA
    Future Oncol 8:1597-604. 2012
    ..Presently, medulloblastoma reinforces epigenetic mechanisms as a tantalizing therapeutic target in cancers...
  19. pmc A novel syndrome caused by the E410K amino acid substitution in the neuronal β-tubulin isotype 3
    Sheena Chew
    Department of Neurology, Boston Children s Hospital, Boston, MA 02115, USA
    Brain 136:522-35. 2013
    ..The definition of the TUBB3 E410K syndrome will allow clinicians to identify affected individuals and predict the mutation based on clinical features alone...
  20. ncbi request reprint Sleep dysfunction in long term survivors of craniopharyngioma
    Peter E Manley
    Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02215, USA
    J Neurooncol 108:543-9. 2012
    ..Patients with a higher BMI were more likely to experience sleep disturbance. Formal sleep evaluations should be considered in all patients with craniopharyngioma...
  21. ncbi request reprint Diencephalic syndrome: a cause of failure to thrive and a model of partial growth hormone resistance
    Amy Fleischman
    Division of Endocrinology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Pediatrics 115:e742-8. 2005
    ..This study emphasizes diencephalic syndrome as a model for additional study of growth hormone resistance and metabolic regulation of adiposity...
  22. pmc Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma
    Natalia Teider
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    Neuro Oncol 12:1244-56. 2010
    ..From these studies, we conclude that NEURL1 is a candidate tumor suppressor in MB, at least in part through its effects on the Notch pathway...
  23. ncbi request reprint A developmental program drives aggressive embryonal brain tumors
    Tenley C Archer
    Department of Neurology, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Genet 46:2-3. 2014
    ..A new study shows that these tumors are universally driven by fusion of the promoter of a gene with brain-specific expression, TTYH1, to C19MC, the largest human microRNA cluster, activating a fetal neural development program. ..
  24. pmc α5-GABAA receptors negatively regulate MYC-amplified medulloblastoma growth
    Soma Sengupta
    Department of Neurology, Boston Children s Hospital, Boston, MA, USA
    Acta Neuropathol 127:593-603. 2014
    ....
  25. ncbi request reprint Craniopharyngioma therapy: long-term effects on hypothalamic function
    Nicole J Ullrich
    Division of Neuroscience, Department of Neurology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Neurologist 11:55-60. 2005
    ..Craniopharyngiomas are the most common intracranial tumor of extraneural origin in childhood...
  26. ncbi request reprint Magnetic resonance imaging of patched heterozygous and xenografted mouse brain tumors
    Aaron L Nelson
    Division of Neurology, Department of Neurosciences, Children s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    J Neurooncol 62:259-67. 2003
    ..Results also show that experimental mice, even symptomatic mice, tolerate repeated serial imaging studies over weeks to months to follow tumor progression and to visualize placement of an intracerebral drug delivery system...
  27. ncbi request reprint Everyday cognitive function after craniopharyngioma in childhood
    Deborah P Waber
    Division of Psychology, Department of Psychiatry, Children s Hospital Boston, MA 02115, USA
    Pediatr Neurol 34:13-9. 2006
    ..The extent of self-rated cognitive problems is related to spatial working memory and somatic concerns...
  28. pmc Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1
    Lori A Ramkissoon
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 110:8188-93. 2013
    ..Our results define clinically relevant molecular subclasses of diffuse PLGGs and highlight a potential role for the MYB family in the biology of low-grade gliomas...
  29. ncbi request reprint Molecular biology of medulloblastoma therapy
    Scott L Pomeroy
    Department of Neurology, Enders 260, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Pediatr Neurosurg 39:299-304. 2003
    ..Consequently, a new approach to tissue collection is required for molecular analysis as we enter the next era of brain tumor therapy...
  30. pmc Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences
    Leonora Balaj
    Department of Neurology, Harvard Medical School, Boston, MA 02129, USA
    Nat Commun 2:180. 2011
    ..Thus, tumour microvesicles contain a repertoire of genetic information available for horizontal gene transfer and potential use as blood biomarkers for cancer...
  31. doi request reprint Cardiac risk after craniopharyngioma therapy
    Sandy Mong
    Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Neurol 38:256-60. 2008
    ..QTc-prolonging medication and stimulants should be used with caution in this population, and routine electrocardiogram screening may identify those at highest risk...
  32. pmc The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
    Susanne Schlisio
    Department of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 22:884-93. 2008
    ....
  33. ncbi request reprint Pediatric brain tumors
    Nicole J Ullrich
    Department of Neurology, Children s Hospital, Boston, 300 Longwood Avenue, Enders 260, Boston, MA 02115, USA
    Neurol Clin 21:897-913. 2003
    ..Despite the improved treatments and prognostic data, however, many long-term survivors experience significant neurocognitive and developmental deficits...
  34. pmc Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance
    Max A Tischfield
    Department of Neurology, Children s Hospital Boston, Boston, MA 02115, USA
    Cell 140:74-87. 2010
    ..These findings demonstrate that normal TUBB3 is required for axon guidance and maintenance in mammals...
  35. doi request reprint Clinical practice guidelines and practice parameters for the child neurologist
    Alan Leviton
    Department of Neurology, Boston Children s Hospital and Harvard Medical School, Boston, MA, USA
    J Child Neurol 28:917-25. 2013
    ..and adhered to, what influences acceptance and adherence, do guidelines improve care, do they reduce costs, will they be viewed by courts as the standard of care, how can they be updated and improved, and are there better alternatives?..
  36. pmc Medulloblastomas and primitive neuroectodermal tumors rarely contain polyomavirus DNA sequences
    John Y H Kim
    Division of Neuroscience, Department of Neurology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Neuro Oncol 4:165-70. 2002
    ..In contrast to childhood ependymomas and choroid plexus tumors, medulloblastomas and sPNETs infrequently express evidence of polyomavirus infection...
  37. ncbi request reprint Application of microarrays to neurological disease
    Lisa Marie Sturla
    Division of Neuroscience, Department of Neurology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Neurol 60:676-82. 2003
  38. ncbi request reprint Focus on central nervous system neoplasia
    David N Louis
    Department of Pathology and Neurosurgical Service, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Cell 1:125-8. 2002
  39. ncbi request reprint High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors
    Anita Bhattacharyya
    Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Neurobiol 51:302-12. 2002
    ..Collectively, these results indicate activated Trk within axons travel in vesicles and dynein is the motor that drives these vesicles towards the cell bodies...
  40. ncbi request reprint A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma
    Karen J Marcus
    Department of Medicine, Division of Radiation Oncology, Children s Hospital, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 55:1182-5. 2003
    ..To determine the toxicity and maximum tolerated dose of etanidazole administered concurrently with hyperfractionated radiation therapy (HRT) for children with brainstem glioma...
  41. ncbi request reprint Progressive myoclonus in a child with a deep cerebellar mass
    Jonathan W Mink
    University of Rochester School of Medicine and Golisano Children s Hospital at Strong, Rochester, NY, USA
    Neurology 61:829-31. 2003
    ..They hypothesize that abnormal paroxysmal discharge of neurons in the cerebellar nuclei can generate myoclonus...
  42. ncbi request reprint Gain of 1q is a potential univariate negative prognostic marker for survival in medulloblastoma
    Ken C Lo
    Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, New York 14263, USA
    Clin Cancer Res 13:7022-8. 2007
    ..In this context, current strategies for risk assessment, which are based on clinical parameters, remain unsatisfactory...
  43. ncbi request reprint Overlay analysis of the oligonucleotide array gene expression profiles and copy number abnormalities as determined by array comparative genomic hybridization in medulloblastomas
    Ken C Lo
    Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Genes Chromosomes Cancer 46:53-66. 2007
    ....
  44. pmc Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8
    Massimiliano De Bortoli
    Texas Children s Cancer Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA
    BMC Cancer 6:223. 2006
    ..In the present study, we applied cytogenetic characterization to guide the identification of biologically significant genes from gene expression microarray profiles of medulloblastoma...
  45. pmc Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers
    Alvin T Kho
    Children s Hospital Informatics Program, Children s Hospital Boston, MA 02115, USA
    Genes Dev 18:629-40. 2004
    ....
  46. ncbi request reprint Marked regression of metastatic pilocytic astrocytoma during treatment with imatinib mesylate (STI-571, Gleevec): a case report and laboratory investigation
    Margaret E McLaughlin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Pediatr Hematol Oncol 25:644-8. 2003
    ....
  47. ncbi request reprint INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma
    Alexander R Judkins
    Department of Pathology, University of Pennsylvania School of Medicine and Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Neuropathol Exp Neurol 64:391-7. 2005
    ..This expression pattern seems to better define the 2 groups of tumors than does light or electron microscopy, routine immunohistochemistry, or cytogenetic analysis alone...
  48. ncbi request reprint Ataxia and shaking in a 2-year-old girl: acute marijuana intoxication presenting as seizure
    Joshua L Bonkowsky
    Division of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84158, USA
    Pediatr Emerg Care 21:527-8. 2005
  49. pmc Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    Aravind Subramanian
    Broad Institute of Massachusetts Institute of Technology and Harvard, 320 Charles Street, Cambridge, MA 02141, USA
    Proc Natl Acad Sci U S A 102:15545-50. 2005
    ..The GSEA method is embodied in a freely available software package, together with an initial database of 1,325 biologically defined gene sets...