Richard Platt

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Enhanced identification of postoperative infections among outpatients
    Andrew L Miner
    Harvard Medical School, Boston, Massachusetts, USA
    Emerg Infect Dis 10:1931-7. 2004
  2. pmc Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study
    Susan S Huang
    Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, 100 Theory, Ste 110, Irvine, CA 92697, USA
    Crit Care 15:R210. 2011
  3. ncbi request reprint Speed bumps, potholes, and tollbooths on the road to panacea: making best use of data
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Health Aff (Millwood) 26:w153-5. 2007
  4. doi request reprint Cluster randomized trials in comparative effectiveness research: randomizing hospitals to test methods for prevention of healthcare-associated infections
    Richard Platt
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Med Care 48:S52-7. 2010
  5. doi request reprint Active drug safety surveillance: a tool to improve public health
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 17:1175-82. 2008
  6. doi request reprint The U.S. Food and Drug Administration's Mini-Sentinel program: status and direction
    Richard Platt
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 21:1-8. 2012
  7. doi request reprint Impact of a 16-community trial to promote judicious antibiotic use in Massachusetts
    Jonathan A Finkelstein
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, Sixth Floor Boston, MA 02215, USA
    Pediatrics 121:e15-23. 2008
  8. doi request reprint Early adverse drug event signal detection within population-based health networks using sequential methods: key methodologic considerations
    Jeffrey S Brown
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 18:226-34. 2009
  9. ncbi request reprint Relationship of pulmonary artery catheter use to mortality and resource utilization in patients with severe sepsis
    D Tony Yu
    Division of General Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 31:2734-41. 2003
  10. ncbi request reprint Improving the assessment of vancomycin-resistant enterococci by routine screening
    Susan S Huang
    Brigham and Women s Hospital, Channing Laboratory and Department of Infection Control, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
    J Infect Dis 195:339-46. 2007

Research Grants

  1. REDUCING ANTIMICROBIAL RESISTANCE: A RANDOMIZED TRIAL
    Richard Platt; Fiscal Year: 2002
  2. Eastern Massachusetts Prevention Epicenters Program II
    Richard Platt; Fiscal Year: 2007
  3. HMO Research Network CERT III
    Richard Platt; Fiscal Year: 2007
  4. Modeling Health System Infectious Disease Data
    Richard Platt; Fiscal Year: 2007

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. pmc Enhanced identification of postoperative infections among outpatients
    Andrew L Miner
    Harvard Medical School, Boston, Massachusetts, USA
    Emerg Infect Dis 10:1931-7. 2004
    ..Claims data may complement other data sources for identification of surgical site infections following breast surgery and cesarean section...
  2. pmc Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study
    Susan S Huang
    Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, 100 Theory, Ste 110, Irvine, CA 92697, USA
    Crit Care 15:R210. 2011
    ....
  3. ncbi request reprint Speed bumps, potholes, and tollbooths on the road to panacea: making best use of data
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Health Aff (Millwood) 26:w153-5. 2007
    ..Realizing databases' potential will require long-term commitment and investment beyond the maintenance of the databases themselves...
  4. doi request reprint Cluster randomized trials in comparative effectiveness research: randomizing hospitals to test methods for prevention of healthcare-associated infections
    Richard Platt
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Med Care 48:S52-7. 2010
    ..The need for evidence about the effectiveness of therapeutics and other medical practices has triggered new interest in methods for comparative effectiveness research...
  5. doi request reprint Active drug safety surveillance: a tool to improve public health
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 17:1175-82. 2008
    ....
  6. doi request reprint The U.S. Food and Drug Administration's Mini-Sentinel program: status and direction
    Richard Platt
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 21:1-8. 2012
    ....
  7. doi request reprint Impact of a 16-community trial to promote judicious antibiotic use in Massachusetts
    Jonathan A Finkelstein
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, Sixth Floor Boston, MA 02215, USA
    Pediatrics 121:e15-23. 2008
    ..In addition, we sought to compare the intervention's impact on commercially and Medicaid-insured children...
  8. doi request reprint Early adverse drug event signal detection within population-based health networks using sequential methods: key methodologic considerations
    Jeffrey S Brown
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 18:226-34. 2009
    ..Our objective was to expand our previous signal detection work by investigating the effect on signal detection of alternative study specifications...
  9. ncbi request reprint Relationship of pulmonary artery catheter use to mortality and resource utilization in patients with severe sepsis
    D Tony Yu
    Division of General Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 31:2734-41. 2003
    ..To examine the relationship of pulmonary artery catheter (PAC) use to patient outcomes, including mortality rate and resource utilization, in patients with severe sepsis in eight academic medical centers...
  10. ncbi request reprint Improving the assessment of vancomycin-resistant enterococci by routine screening
    Susan S Huang
    Brigham and Women s Hospital, Channing Laboratory and Department of Infection Control, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
    J Infect Dis 195:339-46. 2007
    ..Routine surveillance cultures can substantially improve prevalence and incidence estimates, and assessing the range of improvement across diverse units is important...
  11. pmc Integrating clinical practice and public health surveillance using electronic medical record systems
    Michael Klompas
    Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Am J Public Health 102:S325-32. 2012
    ..The ESP platform provides live, automated surveillance for notifiable diseases, influenza-like illness, and diabetes prevalence, care, and complications. Results are automatically transmitted to state health departments...
  12. ncbi request reprint Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care units
    Susan S Huang
    Brigham and Women s Hospital, Channing Laboratory and Infection Control Department, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
    J Infect Dis 195:330-8. 2007
    ..In addition, many assessments underestimate the incidence of acquisition by including prevalent carriers in the at-risk population...
  13. ncbi request reprint FDA drug prescribing warnings: is the black box half empty or half full?
    Anita K Wagner
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 15:369-86. 2006
    ..The purpose of the present study was to assess the frequency of use of BBW medications in ambulatory care and prescribing compliance with BBW recommendations...
  14. ncbi request reprint Early detection of adverse drug events within population-based health networks: application of sequential testing methods
    Jeffrey S Brown
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 16:1275-84. 2007
    ....
  15. pmc Severe sepsis: variation in resource and therapeutic modality use among academic centers
    D Tony Yu
    Brigham and Women s Hospital, Partners HealthCare System, Wellesley, Massachusetts, USA
    Crit Care 7:R24-34. 2003
    ..The objective of the present study was to assess intercenter variation in resource and therapeutic modality use in patients with severe sepsis...
  16. doi request reprint Use of Medicare diagnosis and procedure codes to improve detection of surgical site infections following hip arthroplasty, knee arthroplasty, and vascular surgery
    Michael S Calderwood
    Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, USA
    Infect Control Hosp Epidemiol 33:40-9. 2012
    ..To evaluate the use of routinely collected electronic health data in Medicare claims to identify surgical site infections (SSIs) following hip arthroplasty, knee arthroplasty, and vascular surgery...
  17. doi request reprint Use of Medicare claims to rank hospitals by surgical site infection risk following coronary artery bypass graft surgery
    Susan S Huang
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 32:775-83. 2011
    ..To evaluate whether longitudinal insurer claims data allow reliable identification of elevated hospital surgical site infection (SSI) rates...
  18. ncbi request reprint Risk of acquiring antibiotic-resistant bacteria from prior room occupants
    Susan S Huang
    Departments of Medicine and Infection Control, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:1945-51. 2006
    ....
  19. doi request reprint Drug safety data mining with a tree-based scan statistic
    Martin Kulldorff
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 22:517-23. 2013
    ..This methodological paper evaluates the tree-based scan statistic data mining method to enhance drug safety surveillance...
  20. doi request reprint Use of Medicare claims to identify US hospitals with a high rate of surgical site infection after hip arthroplasty
    Michael S Calderwood
    Departmentof Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02115, USA
    Infect Control Hosp Epidemiol 34:31-9. 2013
    ..To assess the ability of Medicare claims to identify US hospitals with high rates of surgical site infection (SSI) after hip arthroplasty...
  21. doi request reprint Objective surveillance definitions for ventilator-associated pneumonia
    Michael Klompas
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Crit Care Med 40:3154-61. 2012
    ..We explored the feasibility of creating objective surveillance definitions for ventilator-associated pneumonia...
  22. doi request reprint Surveillance for adverse events following receipt of pandemic 2009 H1N1 vaccine in the Post-Licensure Rapid Immunization Safety Monitoring (PRISM) System, 2009-2010
    W Katherine Yih
    Department of Population Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Am J Epidemiol 175:1120-8. 2012
    ..The study did not control for infection prior to Guillain-Barré syndrome, which may have been a confounder. The risks of other health outcomes of interest were generally not significantly elevated after 2009 H1N1 vaccination...
  23. pmc Evaluating real-time syndromic surveillance signals from ambulatory care data in four states
    W Katherine Yih
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
    Public Health Rep 125:111-20. 2010
    ..We evaluated a real-time ambulatory care-based syndromic surveillance system in four metropolitan areas of the United States...
  24. pmc Distributed data processing for public health surveillance
    Ross Lazarus
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Public Health 6:235. 2006
    ....
  25. pmc Electronic Support for Public Health: validated case finding and reporting for notifiable diseases using electronic medical data
    Ross Lazarus
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    J Am Med Inform Assoc 16:18-24. 2009
    ..Source code for this highly interoperable application is freely available under an approved open-source license at http://esphealth.org...
  26. ncbi request reprint Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteremia
    Susan S Huang
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Infect Dis 43:971-8. 2006
    ..To our knowledge, the relative impact of these interventions has not previously been ascertained...
  27. doi request reprint Rapid and reproducible surveillance for ventilator-associated pneumonia
    Michael Klompas
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, USA
    Clin Infect Dis 54:370-7. 2012
    ..The complexity and subjectivity of ventilator-associated pneumonia (VAP) surveillance limit its value in assessing and comparing quality of care for ventilated patients. A simpler, more quantitative VAP definition may increase utility...
  28. ncbi request reprint Real-time vaccine safety surveillance for the early detection of adverse events
    Tracy A Lieu
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Med Care 45:S89-95. 2007
    ..Sequential testing procedures are needed to detect vaccine or drug safety problems as soon as possible after introduction...
  29. ncbi request reprint Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004
    Susan S Huang
    Channing Laboratory, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Pediatrics 116:e408-13. 2005
    ..Analysis of colonizing serotypes among healthy children in the community provides critical data on such changes...
  30. doi request reprint Active influenza vaccine safety surveillance: potential within a healthcare claims environment
    Jeffrey S Brown
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Med Care 47:1251-7. 2009
    ..Rapid safety assessment of novel vaccines, especially those targeted against pandemic influenza, is a public health priority...
  31. pmc Impact of an environmental cleaning intervention on the presence of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci on surfaces in intensive care unit rooms
    Eric R Goodman
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Infect Control Hosp Epidemiol 29:593-9. 2008
    ....
  32. ncbi request reprint Detection of postoperative surgical-site infections: comparison of health plan-based surveillance with hospital-based programs
    Kenneth E Sands
    Centers for Disease Control and Prevention, Eastern Massachusetts Prevention Epicenter, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 24:741-3. 2003
    ..We compared these two methods for identifying SSIs following coronary artery bypass graft (CABG) procedures...
  33. ncbi request reprint Administrative databases provide inaccurate data for surveillance of long-term central venous catheter-associated infections
    Sharon B Wright
    Centers for Disease Control and Prevention Prevention Epicenter of Eastern Massachusetts, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 24:946-9. 2003
    ..Automated medical records and claims data have been used for surveillance of these infections without evaluation of their accuracy or validity...
  34. pmc Gastrointestinal disease outbreak detection using multiple data streams from electronic medical records
    Sharon K Greene
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215 3920, USA
    Foodborne Pathog Dis 9:431-41. 2012
    ..This study's primary objective was to identify data streams from EMRs that may perform well for GI outbreak detection...
  35. doi request reprint Validation of algorithms to ascertain clinical conditions and medical procedures used during pregnancy
    Susan E Andrade
    Meyers Primary Care Institute and University of Massachusetts Medical School, Worcester, MA, USA
    Pharmacoepidemiol Drug Saf 20:1168-76. 2011
    ..To evaluate the validity of health plan administrative and claims data to identify pre-gestational and gestational diabetes, obesity, and ultrasounds among pregnant women...
  36. pmc Syndromic surveillance using minimum transfer of identifiable data: the example of the National Bioterrorism Syndromic Surveillance Demonstration Program
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Urban Health 80:i25-31. 2003
    ..If successful, this system will allow any organization with appropriate data to contribute vital information to public health syndromic surveillance systems while preserving individuals' privacy to the greatest extent possible...
  37. ncbi request reprint Potential drug-drug interactions in the outpatient setting
    Jennifer Elston Lafata
    Henry Ford Health System, Detroit, Michigan 48202, Channing Laboratory, Brigham and Women s Hospital, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Med Care 44:534-41. 2006
    ..Although medication safety research has tended to focus on inpatients, the safety of drug use among outpatients is also a concern...
  38. doi request reprint Active surveillance for adverse events: the experience of the Vaccine Safety Datalink project
    W Katherine Yih
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Ave, Boston, MA 02215, USA
    Pediatrics 127:S54-64. 2011
    ..To describe the Vaccine Safety Datalink (VSD) project's experience with population-based, active surveillance for vaccine safety and draw lessons that may be useful for similar efforts...
  39. pmc Timely detection of localized excess influenza activity in Northern California across patient care, prescription, and laboratory data
    Sharon K Greene
    Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Stat Med 30:549-59. 2011
    ..Although limited to one health plan, location, and year, these results can inform the choice of data streams for public health surveillance of influenza...
  40. pmc Real-time surveillance for tuberculosis using electronic health record data from an ambulatory practice in eastern Massachusetts
    Michael S Calderwood
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Public Health Rep 125:843-50. 2010
    ..We report on the development and validation of a TB detection algorithm for EHR data followed by implementation in a live surveillance and reporting system...
  41. ncbi request reprint Incidence of outpatient visits and hospitalizations related to influenza in infants and young children
    Megan A O'Brien
    Center for Child Health Care Studies, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    Pediatrics 113:585-93. 2004
    ....
  42. ncbi request reprint Community-level predictors of pneumococcal carriage and resistance in young children
    Susan S Huang
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Am J Epidemiol 159:645-54. 2004
    ..5, 95% confidence interval: 1.0, 11.7). The two- to threefold odds of pneumococcal carriage conferred by certain community characteristics suggest that these measures may target communities for interventions to decrease transmission...
  43. pmc Enhanced identification of postoperative infections among inpatients
    Deborah S Yokoe
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Emerg Infect Dis 10:1924-30. 2004
    ..This screening method was efficient, readily standardized, and suitable for most hospitals...
  44. doi request reprint Risk of Guillain-Barré syndrome after meningococcal conjugate vaccination
    Priscilla Velentgas
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 21:1350-8. 2012
    ..We conducted a study to assess the risk of GBS after MCV4 vaccination using health plan administrative and claims data together with the review of primary medical records of potential cases...
  45. pmc Automated identification of acute hepatitis B using electronic medical record data to facilitate public health surveillance
    Michael Klompas
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2626. 2008
    ..We describe the development and implementation of an algorithm for prospective surveillance of patients with acute hepatitis B using electronic medical record data...
  46. pmc Using electronic medical records to enhance detection and reporting of vaccine adverse events
    Virginia L Hinrichsen
    Dept of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, Boston, MA 02215, USA
    J Am Med Inform Assoc 14:731-5. 2007
    ..By coupling simplified reporting with the initial prompt, clinicians can consider and report a vaccine adverse event electronically in a few moments during the office visit...
  47. ncbi request reprint Multivariate scan statistics for disease surveillance
    Martin Kulldorff
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
    Stat Med 26:1824-33. 2007
    ..The strongest signal was generated by a single data set and due to a familial outbreak of pinworm disease. The second and third strongest signals were generated by the combined strength of two of the three data sets...
  48. ncbi request reprint The projected health benefits of maternal group B streptococcal vaccination in the era of chemoprophylaxis
    Anushua Sinha
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Vaccine 23:3187-95. 2005
    ..Maternal GBS vaccination is predicted to prevent more cases of neonatal GBS disease than current practice and would prevent approximately one in 25 very preterm births...
  49. doi request reprint Potential population-based electronic data sources for rapid pandemic influenza vaccine adverse event detection: a survey of health plans
    Kristen M Moore
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 17:1137-41. 2008
    ..Many public and private health plans and payers have such information...
  50. pmc Automated influenza-like illness reporting-an efficient adjunct to traditional sentinel surveillance
    W Katherine Yih
    Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA
    Public Health Rep 129:55-63. 2014
    ..We compared an electronic health record-based influenza-like illness (ILI) surveillance system with manual sentinel surveillance and virologic data to evaluate the utility of the automated system for routine ILI surveillance...
  51. pmc Using automated health plan data to assess infection risk from coronary artery bypass surgery
    Richard Platt
    Centers for Disease Control and Prevention Eastern Massachusetts Prevention Epicenter, Boston, USA
    Emerg Infect Dis 8:1433-41. 2002
    ....
  52. doi request reprint Impact of Medicare's payment policy on mediastinitis following coronary artery bypass graft surgery in US hospitals
    Michael S Calderwood
    Division of Infectious Diseases, Brigham and Women s Hospital, Boston, Massachusetts
    Infect Control Hosp Epidemiol 35:144-51. 2014
    ..The Centers for Medicare and Medicaid Services (CMS) implemented a policy in October 2008 to eliminate additional Medicare payment for mediastinitis following coronary artery bypass graft (CABG) surgery...
  53. doi request reprint Effect of nonpayment for preventable infections in U.S. hospitals
    Grace M Lee
    Center for Child Health Care Studies, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA
    N Engl J Med 367:1428-37. 2012
    ..The effect of this policy on rates of health care-associated infections is unknown...
  54. doi request reprint Integrating clinical practice and public health surveillance using electronic medical record systems
    Michael Klompas
    Harvard Medical School and Harvard Pilgrim Health Care Institute, Department of Population Medicine, Boston, Massachusetts 02215, USA
    Am J Prev Med 42:S154-62. 2012
    ..The ESP platform provides live, automated surveillance for notifiable diseases, influenza-like illness, and diabetes prevalence, care, and complications. Results are automatically transmitted to state health departments...
  55. pmc Developing algorithms for healthcare insurers to systematically monitor surgical site infection rates
    Susan S Huang
    Channing Laboratory, Department of Medicine Brigham and Women s Hospital Boston, MA, USA
    BMC Med Res Methodol 7:20. 2007
    ..We now operationalize this method for use by payers without transfer of protected health information, or any insurer data, to external analytic centers...
  56. ncbi request reprint Intrapartum antibiotics and neonatal invasive infections caused by organisms other than group B streptococcus
    Anushua Sinha
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Pediatr 142:492-7. 2003
    ..We conducted a nested case-control study to define the association between maternal intrapartum antibiotics and risk of neonatal non-GBS infection...
  57. doi request reprint A distributed research network model for post-marketing safety studies: the Meningococcal Vaccine Study
    Priscilla Velentgas
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 17:1226-34. 2008
    ..Implementation has addressed several issues relevant to creation of a large scale post-marketing drug safety surveillance system envisioned by the FDA's Sentinel Initiative...
  58. doi request reprint Outpatient urticaria diagnosis codes have limited predictive value for same-day influenza vaccine adverse event detection
    Kristen M Moore
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    J Clin Epidemiol 63:407-11. 2010
    ..To assess the predictive value of claims-based outpatient urticaria diagnosis codes to identify potential vaccine-related adverse events (AEs) when recorded on the same day as influenza vaccination...
  59. ncbi request reprint Prescription drug use in pregnancy
    Susan E Andrade
    Meyers Primary Care Institute Fallon Healthcare System and University of Massachusetts Medical School, 630 Plantation Street, Worcester, MA, USA
    Am J Obstet Gynecol 191:398-407. 2004
    ..The purpose of this study was to provide information on the prevalence of the use of prescription drugs among pregnant women in the United States...
  60. doi request reprint The organizational structure and governing principles of the Food and Drug Administration's Mini-Sentinel pilot program
    Susan Forrow
    Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 21:12-7. 2012
    ....
  61. doi request reprint Development of an algorithm for surveillance of ventilator-associated pneumonia with electronic data and comparison of algorithm results with clinician diagnoses
    Michael Klompas
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 29:31-7. 2008
    ..We sought to improve the efficiency and objectivity of VAP surveillance by adapting the CDC criteria to make them amenable to evaluation with electronic data...
  62. doi request reprint Distributed health data networks: a practical and preferred approach to multi-institutional evaluations of comparative effectiveness, safety, and quality of care
    Jeffrey S Brown
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Med Care 48:S45-51. 2010
    ....
  63. ncbi request reprint A generalized linear mixed models approach for detecting incident clusters of disease in small areas, with an application to biological terrorism
    Ken Kleinman
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA 02215 3920, USA
    Am J Epidemiol 159:217-24. 2004
    ..The authors argue that there is great value in using the geographic data...
  64. ncbi request reprint Antivirals and antibiotics for influenza in the United States, 1995--2002
    Jeffrey A Linder
    Division of General Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 14:531-6. 2005
    ..To measure the rates of antiviral and antibiotic prescribing for patients diagnosed with influenza in the United States...
  65. ncbi request reprint Deep infection after total knee replacement: impact of laminar airflow systems and body exhaust suits in the modern operating room
    Andrew L Miner
    Department of Ambulatory Care and Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Infect Control Hosp Epidemiol 28:222-6. 2007
    ..57 (95% confidence interval, 0.75-3.31) for laminar airflow systems and 0.75 (95% confidence interval, 0.34-1.62) for body exhaust suits suits. The risk was not statistically associated with use of either method, but infections were rare...
  66. ncbi request reprint Antibiotic-resistant Streptococcus pneumoniae in the heptavalent pneumococcal conjugate vaccine era: predictors of carriage in a multicommunity sample
    Jonathan A Finkelstein
    Department of Ambulatory Care and Prevention, Harvard Medical School HPHC, Boston, Massachusetts 02215, USA
    Pediatrics 112:862-9. 2003
    ..Data on carriage of resistant organisms by healthy children in communities in which immunization with PCV7 has been implemented will help to define and decrease these risks further...
  67. ncbi request reprint Effect of increased cost-sharing on oral hypoglycemic use in five managed care organizations: how much is too much?
    Douglas W Roblin
    Research Department, Kaiser Permanente, Atlanta, Georgia 30305, and the Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Med Care 43:951-9. 2005
    ..For patients with a chronic disease, increased cost-sharing for medications may lead to unintended consequences, including reduced use of medications essential for control of their disease...
  68. ncbi request reprint Cluster randomized trials: opportunities and barriers identified by leaders of eight health plans
    Kathleen M Mazor
    Meyers Primary Care Institute, University of Massachusetts Medical School, Fallon Clinic Foundation, and Fallon Community Health Plan, Worcester, Massachusetts, USA
    Med Care 45:S29-37. 2007
    ....
  69. ncbi request reprint Predictive value of clinical diagnostic codes for the CDC case definition of pelvic inflammatory disease (PID): implications for surveillance
    Sylvie Ratelle
    Division of STD Prevention, Massachusetts Department of Public Health, Boston, Massachusetts 02130, USA
    Sex Transm Dis 30:866-70. 2003
    ..Reporting burden can be alleviated with the use of administrative data...
  70. ncbi request reprint Design of a national distributed health data network
    Judith C Maro
    Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Ann Intern Med 151:341-4. 2009
    ..Some of the challenges and potential methods of operation of a multipurpose, multi-institutional distributed health data network are described...
  71. ncbi request reprint Computerized prescribing alerts and group academic detailing to reduce the use of potentially inappropriate medications in older people
    Steven R Simon
    HMO Research Network Center for Education and Research in Therapeutics, Harvard Medical School and Harvard Pilgrim Healthcare, Boston, MA 02215, USA
    J Am Geriatr Soc 54:963-8. 2006
    ....
  72. pmc Telephone triage service data for detection of influenza-like illness
    W Katherine Yih
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    PLoS ONE 4:e5260. 2009
    ..Nontraditional sources of data for influenza and ILI surveillance are of interest to public health authorities if their validity can be established...
  73. pmc Health and economic impact of surgical site infections diagnosed after hospital discharge
    Eli N Perencevich
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Emerg Infect Dis 9:196-203. 2003
    ..Average total costs during the 8 weeks after discharge were US dollars 5,155 for patients with SSI and US dollars 1,773 for controls (p<0.001)...
  74. ncbi request reprint Reduced risk of neonatal respiratory infections among breastfed girls but not boys
    Anushua Sinha
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 112:e303. 2003
    ..We therefore chose respiratory tract infections diagnosed after nursery discharge as representative of neonatal community-acquired infection and studied the impact of breastfeeding on this neonatal infection syndrome...
  75. pmc Attitudes of healthcare workers in U.S. hospitals regarding smallpox vaccination
    W Katherine Yih
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    BMC Public Health 3:20. 2003
    ..Vaccination is voluntary, and it is unknown what factors drive vaccine acceptance. This study's aims were to estimate the proportion of workers willing to accept vaccination and to identify factors likely to influence their decisions...
  76. ncbi request reprint Epidemiology of neonatal infections: experience during and after hospitalization
    Anushua Sinha
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pediatr Infect Dis J 22:244-51. 2003
    ..We assessed the epidemiology of neonatal infections coming to medical attention among inpatient and outpatient newborn infants within a defined health care maintenance organization (HMO) population...
  77. ncbi request reprint A beneficial side effect of the Medicare drug benefit
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, USA
    N Engl J Med 353:2742-3. 2005
  78. ncbi request reprint A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents
    K Arnold Chan
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Arch Intern Med 163:728-34. 2003
    ..The incidence of acute liver failure or serious liver injury in diabetic patients is needed to evaluate the safety of hypoglycemic drug therapy...
  79. pmc Use of automated ambulatory-care encounter records for detection of acute illness clusters, including potential bioterrorism events
    Ross Lazarus
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Emerg Infect Dis 8:753-60. 2002
    ..This system complements emergency room- and hospital-based surveillance by adding the capacity to rapidly identify clusters of illness, including potential bioterrorism events...
  80. pmc Pharmacy data for tuberculosis surveillance and assessment of patient management
    Deborah S Yokoe
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Emerg Infect Dis 10:1426-31. 2004
    ..Pharmacy data can help public health officials to find TB cases and assess their management in populations that receive care in the private sector...
  81. ncbi request reprint Chronic disease score as a predictor of hospitalization
    Kathleen G Putnam
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 13:340-6. 2002
    ..We compared four versions of the score for their ability to predict hospitalization among members of eight health maintenance organizations nationwide...
  82. ncbi request reprint Evaluating spatial surveillance: detection of known outbreaks in real data
    Ken Kleinman
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, USA
    Stat Med 25:755-69. 2006
    ..They can be used to assess whether the new system works in that it detects the outbreaks better than chance would suggest and can also determine if the new systems' signals are generated earlier than an extant system...
  83. ncbi request reprint Improvement of intraoperative antibiotic prophylaxis in prolonged cardiac surgery by automated alerts in the operating room
    Giorgio Zanetti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, and the CDC Eastern Massachusetts Prevention Epicenter, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 24:13-6. 2003
    ..To assess the impact of an automated intraoperative alert to redose prophylactic antibiotics in prolonged cardiac operations...
  84. ncbi request reprint Gastric and duodenal safety of daily alendronate
    James G Donahue
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Intern Med 162:936-42. 2002
    ..This study was conducted to estimate the excess risk of hospitalizations for gastric or duodenal perforations, ulcers, and bleeding associated with alendronate use...
  85. ncbi request reprint Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization
    Susan S Huang
    Channing Laboratory, Brigham and Women s Hospital, Division of Infectious Diseases, Boston, MA 02115, USA
    Clin Infect Dis 36:281-5. 2003
    ..Accurate assessment of the risk of MRSA-associated sequelae requires prolonged follow-up after discharge...
  86. ncbi request reprint Resource utilization among patients with sepsis syndrome
    David W Bates
    Division of General Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Infect Control Hosp Epidemiol 24:62-70. 2003
    ..To assess the resource utilization associated with sepsis syndrome in academic medical centers...
  87. ncbi request reprint Reduction in antibiotic use among US children, 1996-2000
    Jonathan A Finkelstein
    HMO Research Network Centers for Education and Research on Therapeutics Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    Pediatrics 112:620-7. 2003
    ..The Centers for Disease Control and Prevention, in collaboration with other national and state level organizations, have actively promoted more judicious prescribing for children...
  88. ncbi request reprint Male sexual dysfunction associated with antiretroviral therapy
    Amy E Colson
    Channing Laboratory, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Acquir Immune Defic Syndr 30:27-32. 2002
    ..69; 95% CI, 0.84-3.37; p =.14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p =.32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p =.60). We conclude that PIs, especially ritonavir, appear to increase the risk of sexual dysfunction...
  89. ncbi request reprint Infection control practices to reduce airborne bacteria during total knee replacement: a hospital survey in four states
    Andrew L Miner
    Department of Ambulatory Care and Prevention and Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 26:910-5. 2005
    ..To describe the use of laminar airflow, body exhaust, and ultraviolet lights during total knee replacement (TKR) in four U.S. states...
  90. ncbi request reprint The impact of prescribing safety alerts for elderly persons in an electronic medical record: an interrupted time series evaluation
    David H Smith
    Kaiser Permanente Center for Health Research, Portland, OR 97227, USA
    Arch Intern Med 166:1098-104. 2006
    ..The objective of this study was to examine the effects of computerized provider order entry with clinical decision support in reducing the use of potentially contraindicated agents in elderly persons...
  91. ncbi request reprint Estimation of the period prevalence of inflammatory bowel disease among nine health plans using computerized diagnoses and outpatient pharmacy dispensings
    Lisa J Herrinton
    Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
    Inflamm Bowel Dis 13:451-61. 2007
    ..There are few contemporary estimates of prevalence rates for inflammatory bowel disease (IBD) in diverse North American communities...
  92. ncbi request reprint Liver and thyroid monitoring in ambulatory patients prescribed amiodarone in 10 HMOs
    Marsha A Raebel
    Kaiser Permanente Colorado Clinical Research Unit, P O Box 378066, Denver, CO 80237 8066, USA
    J Manag Care Pharm 12:656-64. 2006
    ..Amiodarone can cause liver and thyroid toxicity, but little is known about compliance with laboratory tests to evaluate liver and thyroid function among ambulatory patients who are dispensed amiodarone...
  93. ncbi request reprint Supplementary table: epidemiology of neonatal infections: experience during and after hospitalization
    Anushua Sinha
    Pediatr Infect Dis J 22:E1-5. 2003
  94. ncbi request reprint Frequency of high-risk use of QT-prolonging medications
    Nancy M Allen LaPointe
    Duke Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Pharmacoepidemiol Drug Saf 15:361-8. 2006
    ..Concurrent use of more than one QT-prolonging drug or a QT-prolonging drug with a drug that alters its pharmacokinetic profile is an important risk factor for adverse outcomes...
  95. pmc Simulated anthrax attacks and syndromic surveillance
    James D Nordin
    HealthPartners Research Foundation, Minneapolis, Minnesota 55440 1524, USA
    Emerg Infect Dis 11:1394-8. 2005
    ..Timeliness and completeness of detection of events varied by rate of infection. First detection of events ranged from days 3 to 6. Similar modeling may be possible with other surveillance systems and should be a part of their evaluation...
  96. ncbi request reprint Use of prescription medications with a potential for fetal harm among pregnant women
    Susan E Andrade
    Meyers Primary Care Institute University of Massachusetts Medical School, the Fallon Foundation, and Fallon Community Health Plan, Worcester, MA 01605, USA
    Pharmacoepidemiol Drug Saf 15:546-54. 2006
    ..To estimate the prevalence of use of prescription drugs with a potential for fetal harm among pregnant women in the United States...
  97. ncbi request reprint Reducing warfarin medication interactions: an interrupted time series evaluation
    Adrianne C Feldstein
    Center for Health Research, Kaiser Permanente, 3800 N Interstate Avenue, Portland, OR 97227, USA
    Arch Intern Med 166:1009-15. 2006
    ..The usefulness of academic detailing to enhance the effectiveness of medication interaction alerts also is uncertain...
  98. ncbi request reprint Antibiotic prophylaxis for cardiac surgery: does the past predict the future?
    Giorgio Zanetti
    Clin Infect Dis 38:1364-6. 2004
  99. ncbi request reprint Validation of diagnoses of peptic ulcers and bleeding from administrative databases: a multi-health maintenance organization study
    Susan E Andrade
    Meyers Primary Care Institute Fallon Healthcare System and University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Clin Epidemiol 55:310-3. 2002
    ..This study, using data from a large number of health plans located in different geographical regions, underscores the importance of evaluating the accuracy of the diagnoses from automated health plan databases...
  100. doi request reprint Adverse events associated with prolonged antibiotic use
    Sharon B Meropol
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Pharmacoepidemiol Drug Saf 17:523-32. 2008
    ....
  101. ncbi request reprint Risk factors for statin-associated rhabdomyolysis
    Stephanie Schech
    Center for Health Care Policy and Evaluation, Eden Prairie, MN 55344, USA
    Pharmacoepidemiol Drug Saf 16:352-8. 2007
    ..To identify and characterize risk factors for rhabdomyolysis in patients prescribed statin monotherapy or statin plus fibrate therapy...

Research Grants9

  1. REDUCING ANTIMICROBIAL RESISTANCE: A RANDOMIZED TRIAL
    Richard Platt; Fiscal Year: 2002
    ..Cost-effectiveness analysis will estimate the financial and other costs per resistant infection avoided. ..
  2. Eastern Massachusetts Prevention Epicenters Program II
    Richard Platt; Fiscal Year: 2007
    ..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page................................................................................................................................................. 1 Description, ..
  3. HMO Research Network CERT III
    Richard Platt; Fiscal Year: 2007
    ....
  4. Modeling Health System Infectious Disease Data
    Richard Platt; Fiscal Year: 2007
    ..The models and methods will be evaluated using both historical data from these health systems and simulated data based on different infectious disease transmission dynamics models. ..