Research Topics
| Richard PlattSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control studySusan S Huang
Division of Infectious Diseases and Health Policy Research Institute, University of California Irvine School of Medicine, 100 Theory, Ste 110, Irvine, CA 92697, USA
Crit Care 15:R210. 2011....
Active drug safety surveillance: a tool to improve public healthRichard Platt
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
Pharmacoepidemiol Drug Saf 17:1175-82. 2008....- Cluster randomized trials in comparative effectiveness research: randomizing hospitals to test methods for prevention of healthcare-associated infectionsRichard Platt
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Med Care 48:S52-7. 2010..The need for evidence about the effectiveness of therapeutics and other medical practices has triggered new interest in methods for comparative effectiveness research... 
Speed bumps, potholes, and tollbooths on the road to panacea: making best use of dataRichard Platt
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
Health Aff (Millwood) 26:w153-5. 2007..Realizing databases' potential will require long-term commitment and investment beyond the maintenance of the databases themselves...- The U.S. Food and Drug Administration's Mini-Sentinel program: status and directionRichard Platt
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
Pharmacoepidemiol Drug Saf 21:1-8. 2012.... - Impact of a 16-community trial to promote judicious antibiotic use in MassachusettsJonathan A Finkelstein
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, Sixth Floor Boston, MA 02215, USA
Pediatrics 121:e15-23. 2008..In addition, we sought to compare the intervention's impact on commercially and Medicaid-insured children... - Relationship of pulmonary artery catheter use to mortality and resource utilization in patients with severe sepsisD Tony Yu
Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Crit Care Med 31:2734-41. 2003.... - Early adverse drug event signal detection within population-based health networks using sequential methods: key methodologic considerationsJeffrey S Brown
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Pharmacoepidemiol Drug Saf 18:226-34. 2009..Our objective was to expand our previous signal detection work by investigating the effect on signal detection of alternative study specifications... - Improving the assessment of vancomycin-resistant enterococci by routine screeningSusan S Huang
Brigham and Women s Hospital, Channing Laboratory and Department of Infection Control, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
J Infect Dis 195:339-46. 2007..Routine surveillance cultures can substantially improve prevalence and incidence estimates, and assessing the range of improvement across diverse units is important... - Integrating clinical practice and public health surveillance using electronic medical record systemsMichael Klompas
Harvard Medical School, and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Am J Public Health 102:S325-32. 2012..The ESP platform provides live, automated surveillance for notifiable diseases, influenza-like illness, and diabetes prevalence, care, and complications. Results are automatically transmitted to state health departments... - Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care unitsSusan S Huang
Brigham and Women s Hospital, Channing Laboratory and Infection Control Department, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
J Infect Dis 195:330-8. 2007..In addition, many assessments underestimate the incidence of acquisition by including prevalent carriers in the at-risk population... - FDA drug prescribing warnings: is the black box half empty or half full?Anita K Wagner
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Pharmacoepidemiol Drug Saf 15:369-86. 2006..The purpose of the present study was to assess the frequency of use of BBW medications in ambulatory care and prescribing compliance with BBW recommendations... - Early detection of adverse drug events within population-based health networks: application of sequential testing methodsJeffrey S Brown
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
Pharmacoepidemiol Drug Saf 16:1275-84. 2007.... - Severe sepsis: variation in resource and therapeutic modality use among academic centersD Tony Yu
Brigham and Women's Hospital, Partners HealthCare System, Wellesley, Massachusetts, USA
Crit Care 7:R24-34. 2003..Delay in antibiotic therapy was associated with worse outcome at the center level... - Use of Medicare diagnosis and procedure codes to improve detection of surgical site infections following hip arthroplasty, knee arthroplasty, and vascular surgeryMichael S Calderwood
Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, USA
Infect Control Hosp Epidemiol 33:40-9. 2012..To evaluate the use of routinely collected electronic health data in Medicare claims to identify surgical site infections (SSIs) following hip arthroplasty, knee arthroplasty, and vascular surgery... - Use of Medicare claims to rank hospitals by surgical site infection risk following coronary artery bypass graft surgerySusan S Huang
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA
Infect Control Hosp Epidemiol 32:775-83. 2011..To evaluate whether longitudinal insurer claims data allow reliable identification of elevated hospital surgical site infection (SSI) rates... - Risk of acquiring antibiotic-resistant bacteria from prior room occupantsSusan S Huang
Departments of Medicine and Infection Control, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Arch Intern Med 166:1945-51. 2006.... - Objective surveillance definitions for ventilator-associated pneumoniaMichael Klompas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA
Crit Care Med 40:3154-61. 2012..We explored the feasibility of creating objective surveillance definitions for ventilator-associated pneumonia... - Surveillance for adverse events following receipt of pandemic 2009 H1N1 vaccine in the Post-Licensure Rapid Immunization Safety Monitoring (PRISM) System, 2009-2010W Katherine Yih
Department of Population Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Am J Epidemiol 175:1120-8. 2012..The study did not control for infection prior to Guillain-Barré syndrome, which may have been a confounder. The risks of other health outcomes of interest were generally not significantly elevated after 2009 H1N1 vaccination... - Enhanced identification of postoperative infections among outpatientsAndrew L Miner
Harvard Medical School, Boston, Massachusetts, USA
Emerg Infect Dis 10:1931-7. 2004..Claims data may complement other data sources for identification of surgical site infections following breast surgery and cesarean section... - Evaluating real-time syndromic surveillance signals from ambulatory care data in four statesW Katherine Yih
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
Public Health Rep 125:111-20. 2010..We evaluated a real-time ambulatory care-based syndromic surveillance system in four metropolitan areas of the United States... - Electronic Support for Public Health: validated case finding and reporting for notifiable diseases using electronic medical dataRoss Lazarus
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
J Am Med Inform Assoc 16:18-24. 2009..Source code for this highly interoperable application is freely available under an approved open-source license at http://esphealth.org... - Distributed data processing for public health surveillanceRoss Lazarus
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
BMC Public Health 6:235. 2006.... - Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteremiaSusan S Huang
Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
Clin Infect Dis 43:971-8. 2006..To our knowledge, the relative impact of these interventions has not previously been ascertained... - Rapid and reproducible surveillance for ventilator-associated pneumoniaMichael Klompas
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts 02215, USA
Clin Infect Dis 54:370-7. 2012..The complexity and subjectivity of ventilator-associated pneumonia (VAP) surveillance limit its value in assessing and comparing quality of care for ventilated patients. A simpler, more quantitative VAP definition may increase utility... - Detection of postoperative surgical-site infections: comparison of health plan-based surveillance with hospital-based programsKenneth E Sands
Centers for Disease Control and Prevention, Eastern Massachusetts Prevention Epicenter, Boston, Massachusetts, USA
Infect Control Hosp Epidemiol 24:741-3. 2003..Interpretation of differences among hospitals' infection rates requires case mix adjustment and understanding of variations in hospitals' discharge diagnosis coding practices... - Impact of an environmental cleaning intervention on the presence of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci on surfaces in intensive care unit roomsEric R Goodman
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Infect Control Hosp Epidemiol 29:593-9. 2008.... - Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004Susan S Huang
Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts, USA
Pediatrics 116:e408-13. 2005..This shift toward increased carriage of nonvaccine serotypes warrants vigilance for changes in the epidemiology of invasive pneumococcal disease... - Active influenza vaccine safety surveillance: potential within a healthcare claims environmentJeffrey S Brown
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Med Care 47:1251-7. 2009..Rapid safety assessment of novel vaccines, especially those targeted against pandemic influenza, is a public health priority... - Real-time vaccine safety surveillance for the early detection of adverse eventsTracy A Lieu
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
Med Care 45:S89-95. 2007..Sequential testing procedures are needed to detect vaccine or drug safety problems as soon as possible after introduction... - Gastrointestinal disease outbreak detection using multiple data streams from electronic medical recordsSharon K Greene
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215 3920, USA
Foodborne Pathog Dis 9:431-41. 2012..This study's primary objective was to identify data streams from EMRs that may perform well for GI outbreak detection... - Validation of algorithms to ascertain clinical conditions and medical procedures used during pregnancySusan E Andrade
Meyers Primary Care Institute and University of Massachusetts Medical School, Worcester, MA, USA
Pharmacoepidemiol Drug Saf 20:1168-76. 2011..To evaluate the validity of health plan administrative and claims data to identify pre-gestational and gestational diabetes, obesity, and ultrasounds among pregnant women... - Syndromic surveillance using minimum transfer of identifiable data: the example of the National Bioterrorism Syndromic Surveillance Demonstration ProgramRichard Platt
Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts 02215, USA
J Urban Health 80:i25-31. 2003..If successful, this system will allow any organization with appropriate data to contribute vital information to public health syndromic surveillance systems while preserving individuals' privacy to the greatest extent possible... - Timely detection of localized excess influenza activity in Northern California across patient care, prescription, and laboratory dataSharon K Greene
Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, USA
Stat Med 30:549-59. 2011..Although limited to one health plan, location, and year, these results can inform the choice of data streams for public health surveillance of influenza... - Active surveillance for adverse events: the experience of the Vaccine Safety Datalink projectW Katherine Yih
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Ave, Boston, MA 02215, USA
Pediatrics 127:S54-64. 2011..To describe the Vaccine Safety Datalink (VSD) project's experience with population-based, active surveillance for vaccine safety and draw lessons that may be useful for similar efforts... - Real-time surveillance for tuberculosis using electronic health record data from an ambulatory practice in eastern MassachusettsMichael S Calderwood
Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
Public Health Rep 125:843-50. 2010..We report on the development and validation of a TB detection algorithm for EHR data followed by implementation in a live surveillance and reporting system... - Potential drug-drug interactions in the outpatient settingJennifer Elston Lafata
Henry Ford Health System, Detroit, Michigan 48202, Channing Laboratory, Brigham and Women s Hospital, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Med Care 44:534-41. 2006..Although medication safety research has tended to focus on inpatients, the safety of drug use among outpatients is also a concern... - Community-level predictors of pneumococcal carriage and resistance in young childrenSusan S Huang
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
Am J Epidemiol 159:645-54. 2004..5, 95% confidence interval: 1.0, 11.7). The two- to threefold odds of pneumococcal carriage conferred by certain community characteristics suggest that these measures may target communities for interventions to decrease transmission... - Incidence of outpatient visits and hospitalizations related to influenza in infants and young childrenMegan A O'Brien
Center for Child Health Care Studies, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Pediatrics 113:585-93. 2004.... - The projected health benefits of maternal group B streptococcal vaccination in the era of chemoprophylaxisAnushua Sinha
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Vaccine 23:3187-95. 2005..Maternal GBS vaccination is predicted to prevent more cases of neonatal GBS disease than current practice and would prevent approximately one in 25 very preterm births... - Using electronic medical records to enhance detection and reporting of vaccine adverse eventsVirginia L Hinrichsen
Dept of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, Boston, MA 02215, USA
J Am Med Inform Assoc 14:731-5. 2007..By coupling simplified reporting with the initial prompt, clinicians can consider and report a vaccine adverse event electronically in a few moments during the office visit... - Multivariate scan statistics for disease surveillanceMartin Kulldorff
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
Stat Med 26:1824-33. 2007..The strongest signal was generated by a single data set and due to a familial outbreak of pinworm disease. The second and third strongest signals were generated by the combined strength of two of the three data sets... - Automated identification of acute hepatitis B using electronic medical record data to facilitate public health surveillanceMichael Klompas
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, United States of America
PLoS ONE 3:e2626. 2008..We describe the development and implementation of an algorithm for prospective surveillance of patients with acute hepatitis B using electronic medical record data... - Potential population-based electronic data sources for rapid pandemic influenza vaccine adverse event detection: a survey of health plansKristen M Moore
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Pharmacoepidemiol Drug Saf 17:1137-41. 2008..Many public and private health plans and payers have such information... - Administrative databases provide inaccurate data for surveillance of long-term central venous catheter-associated infectionsSharon B Wright
Centers for Disease Control and Prevention Prevention Epicenter of Eastern Massachusetts, Boston, Massachusetts, USA
Infect Control Hosp Epidemiol 24:946-9. 2003..Current administrative databases are not ready to be used for electronic surveillance of CVC-associated complications without extensive modification and validation... - Integrating clinical practice and public health surveillance using electronic medical record systemsMichael Klompas
Harvard Medical School and Harvard Pilgrim Health Care Institute, Department of Population Medicine, Boston, Massachusetts 02215, USA
Am J Prev Med 42:S154-62. 2012..The ESP platform provides live, automated surveillance for notifiable diseases, influenza-like illness, and diabetes prevalence, care, and complications. Results are automatically transmitted to state health departments... - Effect of nonpayment for preventable infections in U.S. hospitalsGrace M Lee
Center for Child Health Care Studies, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA, USA
N Engl J Med 367:1428-37. 2012..The effect of this policy on rates of health care-associated infections is unknown... - Developing algorithms for healthcare insurers to systematically monitor surgical site infection ratesSusan S Huang
Channing Laboratory, Department of Medicine Brigham and Women s Hospital Boston, MA, USA
BMC Med Res Methodol 7:20. 2007..We now operationalize this method for use by payers without transfer of protected health information, or any insurer data, to external analytic centers... - Intrapartum antibiotics and neonatal invasive infections caused by organisms other than group B streptococcusAnushua Sinha
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Pediatr 142:492-7. 2003..3 (95% CI, 0.65, 2.8). CONCLUSIONS: The current policy of GBS maternal prophylaxis does not appear to convey excess risk of non-GBS infection to neonates... - Prescription drug use in pregnancySusan E Andrade
Meyers Primary Care Institute Fallon Healthcare System and University of Massachusetts Medical School, 630 Plantation Street, Worcester, MA, USA
Am J Obstet Gynecol 191:398-407. 2004..The purpose of this study was to provide information on the prevalence of the use of prescription drugs among pregnant women in the United States... - Outpatient urticaria diagnosis codes have limited predictive value for same-day influenza vaccine adverse event detectionKristen M Moore
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
J Clin Epidemiol 63:407-11. 2010..To assess the predictive value of claims-based outpatient urticaria diagnosis codes to identify potential vaccine-related adverse events (AEs) when recorded on the same day as influenza vaccination... - A distributed research network model for post-marketing safety studies: the Meningococcal Vaccine StudyPriscilla Velentgas
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
Pharmacoepidemiol Drug Saf 17:1226-34. 2008..Implementation has addressed several issues relevant to creation of a large scale post-marketing drug safety surveillance system envisioned by the FDA's Sentinel Initiative... - Drug safety data mining with a tree-based scan statisticMartin Kulldorff
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA The HMO Research Network Center for Education and Research in Therapeutics
Pharmacoepidemiol Drug Saf 22:517-23. 2013..This methodological paper evaluates the tree-based scan statistic data mining method to enhance drug safety surveillance... - The organizational structure and governing principles of the Food and Drug Administration's Mini-Sentinel pilot programSusan Forrow
Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215, USA
Pharmacoepidemiol Drug Saf 21:12-7. 2012.... - Cluster randomized trials: opportunities and barriers identified by leaders of eight health plansKathleen M Mazor
Meyers Primary Care Institute, University of Massachusetts Medical School, Fallon Clinic Foundation, and Fallon Community Health Plan, Worcester, Massachusetts, USA
Med Care 45:S29-37. 2007.... - Deep infection after total knee replacement: impact of laminar airflow systems and body exhaust suits in the modern operating roomAndrew L Miner
Department of Ambulatory Care and Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Infect Control Hosp Epidemiol 28:222-6. 2007..57 (95% confidence interval, 0.75-3.31) for laminar airflow systems and 0.75 (95% confidence interval, 0.34-1.62) for body exhaust suits suits. The risk was not statistically associated with use of either method, but infections were rare... - Distributed health data networks: a practical and preferred approach to multi-institutional evaluations of comparative effectiveness, safety, and quality of careJeffrey S Brown
Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
Med Care 48:S45-51. 2010.... - Development of an algorithm for surveillance of ventilator-associated pneumonia with electronic data and comparison of algorithm results with clinician diagnoses Michael Klompas
Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA
Infect Control Hosp Epidemiol 29:31-7. 2008..We sought to improve the efficiency and objectivity of VAP surveillance by adapting the CDC criteria to make them amenable to evaluation with electronic data... - Antivirals and antibiotics for influenza in the United States, 1995--2002Jeffrey A Linder
Division of General Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
Pharmacoepidemiol Drug Saf 14:531-6. 2005..To measure the rates of antiviral and antibiotic prescribing for patients diagnosed with influenza in the United States... - Effect of increased cost-sharing on oral hypoglycemic use in five managed care organizations: how much is too much?Douglas W Roblin
Research Department, Kaiser Permanente, Atlanta, Georgia 30305, and the Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
Med Care 43:951-9. 2005..For patients with a chronic disease, increased cost-sharing for medications may lead to unintended consequences, including reduced use of medications essential for control of their disease... - Enhanced identification of postoperative infections among inpatientsDeborah S Yokoe
Brigham and Women s Hospital, Boston, Massachusetts, USA
Emerg Infect Dis 10:1924-30. 2004..This screening method was efficient, readily standardized, and suitable for most hospitals... - A generalized linear mixed models approach for detecting incident clusters of disease in small areas, with an application to biological terrorismKen Kleinman
Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA 02215 3920, USA
Am J Epidemiol 159:217-24. 2004..The authors argue that there is great value in using the geographic data... - Antibiotic-resistant Streptococcus pneumoniae in the heptavalent pneumococcal conjugate vaccine era: predictors of carriage in a multicommunity sampleJonathan A Finkelstein
Department of Ambulatory Care and Prevention, Harvard Medical School HPHC, Boston, Massachusetts 02215, USA
Pediatrics 112:862-9. 2003..Data on carriage of resistant organisms by healthy children in communities in which immunization with PCV7 has been implemented will help to define and decrease these risks further... - Predictive value of clinical diagnostic codes for the CDC case definition of pelvic inflammatory disease (PID): implications for surveillanceSylvie Ratelle
Division of STD Prevention, Massachusetts Department of Public Health, Boston, Massachusetts 02130, USA
Sex Transm Dis 30:866-70. 2003..Reporting burden can be alleviated with the use of administrative data... - Telephone triage service data for detection of influenza-like illnessW Katherine Yih
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
PLoS ONE 4:e5260. 2009..Nontraditional sources of data for influenza and ILI surveillance are of interest to public health authorities if their validity can be established... - Computerized prescribing alerts and group academic detailing to reduce the use of potentially inappropriate medications in older peopleSteven R Simon
HMO Research Network Center for Education and Research in Therapeutics, Harvard Medical School and Harvard Pilgrim Healthcare, Boston, MA 02215, USA
J Am Geriatr Soc 54:963-8. 2006.... - Design of a national distributed health data networkJudith C Maro
Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Ann Intern Med 151:341-4. 2009..Some of the challenges and potential methods of operation of a multipurpose, multi-institutional distributed health data network are described... - Attitudes of healthcare workers in U.S. hospitals regarding smallpox vaccinationW Katherine Yih
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
BMC Public Health 3:20. 2003..Vaccination is voluntary, and it is unknown what factors drive vaccine acceptance. This study's aims were to estimate the proportion of workers willing to accept vaccination and to identify factors likely to influence their decisions... - Epidemiology of neonatal infections: experience during and after hospitalizationAnushua Sinha
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Pediatr Infect Dis J 22:244-51. 2003..We assessed the epidemiology of neonatal infections coming to medical attention among inpatient and outpatient newborn infants within a defined health care maintenance organization (HMO) population... - Reduced risk of neonatal respiratory infections among breastfed girls but not boysAnushua Sinha
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Pediatrics 112:e303. 2003..We therefore chose respiratory tract infections diagnosed after nursery discharge as representative of neonatal community-acquired infection and studied the impact of breastfeeding on this neonatal infection syndrome... - Health and economic impact of surgical site infections diagnosed after hospital dischargeEli N Perencevich
Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Emerg Infect Dis 9:196-203. 2003..Average total costs during the 8 weeks after discharge were US dollars 5,155 for patients with SSI and US dollars 1,773 for controls (p<0.001)... - Using automated health plan data to assess infection risk from coronary artery bypass surgeryRichard Platt
Centers for Disease Control and Prevention Eastern Massachusetts Prevention Epicenter, Boston, USA
Emerg Infect Dis 8:1433-41. 2002.... - A beneficial side effect of the Medicare drug benefitRichard Platt
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, USA
N Engl J Med 353:2742-3. 2005 - A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agentsK Arnold Chan
Department of Medicine, Brigham and Women's Hospital, Boston, Mass, USA
Arch Intern Med 163:728-34. 2003..CONCLUSIONS: Acute liver failure or injury not clearly attributable to other known causes occurred on the order of 1 per 10,000 person-years among diabetic patients treated with oral hypoglycemic drugs or insulin... - Evaluating spatial surveillance: detection of known outbreaks in real dataKen Kleinman
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, USA
Stat Med 25:755-69. 2006..They can be used to assess whether the new system works in that it detects the outbreaks better than chance would suggest and can also determine if the new systems' signals are generated earlier than an extant system... - Pharmacy data for tuberculosis surveillance and assessment of patient managementDeborah S Yokoe
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Emerg Infect Dis 10:1426-31. 2004..Pharmacy data can help public health officials to find TB cases and assess their management in populations that receive care in the private sector... - Use of automated ambulatory-care encounter records for detection of acute illness clusters, including potential bioterrorism eventsRoss Lazarus
Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Emerg Infect Dis 8:753-60. 2002..This system complements emergency room- and hospital-based surveillance by adding the capacity to rapidly identify clusters of illness, including potential bioterrorism events... - Chronic disease score as a predictor of hospitalizationKathleen G Putnam
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Epidemiology 13:340-6. 2002..9 to 10.2. CONCLUSIONS: The Chronic Disease Score predicts hospitalization and therefore may be a useful indicator of baseline comorbidity for control of confounding... - Improvement of intraoperative antibiotic prophylaxis in prolonged cardiac surgery by automated alerts in the operating roomGiorgio Zanetti
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, and the CDC Eastern Massachusetts Prevention Epicenter, Boston, Massachusetts, USA
Infect Control Hosp Epidemiol 24:13-6. 2003..02). CONCLUSION: The use of an automatic reminder system in the operating room improved compliance with guidelines on perioperative antibiotic prophylaxis... - Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonizationSusan S Huang
Channing Laboratory, Brigham and Women s Hospital, Division of Infectious Diseases, Boston, MA 02115, USA
Clin Infect Dis 36:281-5. 2003..Accurate assessment of the risk of MRSA-associated sequelae requires prolonged follow-up after discharge... - Gastric and duodenal safety of daily alendronateJames G Donahue
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
Arch Intern Med 162:936-42. 2002.... - Resource utilization among patients with sepsis syndromeDavid W Bates
Division of General Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Infect Control Hosp Epidemiol 24:62-70. 2003..Additional investigation is required to determine how much of the excess post-onset LOS and charges are attributable to sepsis syndrome rather than the underlying medical conditions... - Reduction in antibiotic use among US children, 1996-2000Jonathan A Finkelstein
HMO Research Network Centers for Education and Research on Therapeutics Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
Pediatrics 112:620-7. 2003..The Centers for Disease Control and Prevention, in collaboration with other national and state level organizations, have actively promoted more judicious prescribing for children... - Male sexual dysfunction associated with antiretroviral therapyAmy E Colson
Channing Laboratory, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
J Acquir Immune Defic Syndr 30:27-32. 2002..69; 95% CI, 0.84-3.37; p =.14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p =.32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p =.60). We conclude that PIs, especially ritonavir, appear to increase the risk of sexual dysfunction... - Infection control practices to reduce airborne bacteria during total knee replacement: a hospital survey in four statesAndrew L Miner
Department of Ambulatory Care and Prevention and Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Infect Control Hosp Epidemiol 26:910-5. 2005..Better information about their impact on current practice and more explicit guidelines may aid decisions about the use of these resource-intensive infection control practices... - Validation of diagnoses of peptic ulcers and bleeding from administrative databases: a multi-health maintenance organization studySusan E Andrade
Meyers Primary Care Institute-Fallon Healthcare System and University of Massachusetts Medical School, Worcester, MA 01605, USA
J Clin Epidemiol 55:310-3. 2002..This study, using data from a large number of health plans located in different geographical regions, underscores the importance of evaluating the accuracy of the diagnoses from automated health plan databases... - Simulated anthrax attacks and syndromic surveillanceJames D Nordin
HealthPartners Research Foundation, Minneapolis, Minnesota 55440 1524, USA
Emerg Infect Dis 11:1394-8. 2005..Timeliness and completeness of detection of events varied by rate of infection. First detection of events ranged from days 3 to 6. Similar modeling may be possible with other surveillance systems and should be a part of their evaluation... - Progress in surgical-site infection surveillanceRichard Platt
Infect Control Hosp Epidemiol 23:361-3. 2002 - Frequency of high-risk use of QT-prolonging medicationsNancy M Allen LaPointe
Duke Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
Pharmacoepidemiol Drug Saf 15:361-8. 2006..Concurrent use of more than one QT-prolonging drug or a QT-prolonging drug with a drug that alters its pharmacokinetic profile is an important risk factor for adverse outcomes... - Risk factors for statin-associated rhabdomyolysisStephanie Schech
Center for Health Care Policy and Evaluation, Eden Prairie, MN 55344, USA
Pharmacoepidemiol Drug Saf 16:352-8. 2007..To identify and characterize risk factors for rhabdomyolysis in patients prescribed statin monotherapy or statin plus fibrate therapy... - Estimation of the period prevalence of inflammatory bowel disease among nine health plans using computerized diagnoses and outpatient pharmacy dispensingsLisa J Herrinton
Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
Inflamm Bowel Dis 13:451-61. 2007..There are few contemporary estimates of prevalence rates for inflammatory bowel disease (IBD) in diverse North American communities... - Use of prescription medications with a potential for fetal harm among pregnant womenSusan E Andrade
Meyers Primary Care Institute University of Massachusetts Medical School, the Fallon Foundation, and Fallon Community Health Plan, Worcester, MA 01605, USA
Pharmacoepidemiol Drug Saf 15:546-54. 2006..To estimate the prevalence of use of prescription drugs with a potential for fetal harm among pregnant women in the United States... - Liver and thyroid monitoring in ambulatory patients prescribed amiodarone in 10 HMOsMarsha A Raebel
Kaiser Permanente Colorado Clinical Research Unit, P O Box 378066, Denver, CO 80237 8066, USA
J Manag Care Pharm 12:656-64. 2006..Amiodarone can cause liver and thyroid toxicity, but little is known about compliance with laboratory tests to evaluate liver and thyroid function among ambulatory patients who are dispensed amiodarone... - Reducing warfarin medication interactions: an interrupted time series evaluationAdrianne C Feldstein
Center for Health Research, Kaiser Permanente, 3800 N Interstate Avenue, Portland, OR 97227, USA
Arch Intern Med 166:1009-15. 2006..The usefulness of academic detailing to enhance the effectiveness of medication interaction alerts also is uncertain... - The impact of prescribing safety alerts for elderly persons in an electronic medical record: an interrupted time series evaluationDavid H Smith
Kaiser Permanente Center for Health Research, Portland, OR 97227, USA
Arch Intern Med 166:1098-104. 2006..The objective of this study was to examine the effects of computerized provider order entry with clinical decision support in reducing the use of potentially contraindicated agents in elderly persons... - Antibiotic prophylaxis for cardiac surgery: does the past predict the future?Giorgio Zanetti
Clin Infect Dis 38:1364-6. 2004 - Supplementary table: epidemiology of neonatal infections: experience during and after hospitalizationAnushua Sinha
Pediatr Infect Dis J 22:E1-5. 2003 - Adverse events associated with prolonged antibiotic useSharon B Meropol
Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
Pharmacoepidemiol Drug Saf 17:523-32. 2008.... - Laboratory evaluation of potassium and creatinine among ambulatory patients prescribed spironolactone: are we monitoring for hyperkalemia?Marsha A Raebel
Kaiser Permanente Colorado Clinical Research Unit and School of Pharmacy, University of Colorado at Denver and Health Sciences Center, Denver, CO 80237, USA
Ann Pharmacother 41:193-200. 2007..Serum potassium and creatinine evaluation is recommended in patients prescribed spironolactone, yet the proportion of ambulatory patients chronically dispensed spironolactone receiving evaluation is not well understood... - Liver function testing in patients on HMG-CoA reductase inhibitorsSusan E Andrade
Department of Applied Pharmaceutical Sciences, University of Rhode Island, Kingston, RI, USA
Pharmacoepidemiol Drug Saf 12:307-13. 2003..We sought to determine the frequency and patterns of LFT screening in patients receiving HMG-CoA reductase inhibitors... - Use of antidepressant medications during pregnancy: a multisite studySusan E Andrade
Meyers Primary Care Institute, Worcester, MA 01605, USA
Am J Obstet Gynecol 198:194.e1-5. 2008..This study was undertaken to provide information on the prevalence of use of antidepressant drugs among pregnant women in the United States...
Research Grants
- REDUCING ANTIMICROBIAL RESISTANCE: A RANDOMIZED TRIALRichard Platt; Fiscal Year: 2002..Cost-effectiveness analysis will estimate the financial and other costs per resistant infection avoided. ..
- Eastern Massachusetts Prevention Epicenters Program IIRichard Platt; Fiscal Year: 2007..RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page................................................................................................................................................. 1 Description, ..
- HMO Research Network CERT IIIRichard Platt; Fiscal Year: 2007....
- Modeling Health System Infectious Disease DataRichard Platt; Fiscal Year: 2007..The models and methods will be evaluated using both historical data from these health systems and simulated data based on different infectious disease transmission dynamics models. ..