R Platt

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Using automated medical records for rapid identification of illness syndromes (syndromic surveillance): the example of lower respiratory infection
    R Lazarus
    Chanming Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    BMC Public Health 1:9. 2001
  2. pmc Automated methods for surveillance of surgical site infections
    R Platt
    Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Emerg Infect Dis 7:212-6. 2001
  3. ncbi request reprint Multicenter epidemiologic and health services research on therapeutics in the HMO Research Network Center for Education and Research on Therapeutics
    R Platt
    Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 10:373-7. 2001
  4. pmc Can managed health care help manage health care-associated infections?
    R Platt
    Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Emerg Infect Dis 7:358-62. 2001
  5. pmc Syndromic surveillance using minimum transfer of identifiable data: the example of the National Bioterrorism Syndromic Surveillance Demonstration Program
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Urban Health 80:i25-31. 2003
  6. pmc Supplementing tuberculosis surveillance with automated data from health maintenance organizations
    D S Yokoe
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Emerg Infect Dis 5:779-87. 1999
  7. ncbi request reprint Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women
    K A Chan
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Lancet 355:2185-8. 2000
  8. doi request reprint Impact of a 16-community trial to promote judicious antibiotic use in Massachusetts
    Jonathan A Finkelstein
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, Sixth Floor Boston, MA 02215, USA
    Pediatrics 121:e15-23. 2008
  9. ncbi request reprint Ambulatory-care diagnoses as potential indicators of outbreaks of gastrointestinal illness--Minnesota
    Katherine W Yih
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    MMWR Morb Mortal Wkly Rep 54:157-62. 2005
  10. ncbi request reprint Efficient identification of postdischarge surgical site infections: use of automated pharmacy dispensing information, administrative data, and medical record information
    K Sands
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Infect Dis 179:434-41. 1999

Detail Information

Publications111 found, 100 shown here

  1. pmc Using automated medical records for rapid identification of illness syndromes (syndromic surveillance): the example of lower respiratory infection
    R Lazarus
    Chanming Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
    BMC Public Health 1:9. 2001
    ..Knowledge of disease patterns in real time may also help clinicians to manage patients, and assist health plan administrators in allocating resources efficiently...
  2. pmc Automated methods for surveillance of surgical site infections
    R Platt
    Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Emerg Infect Dis 7:212-6. 2001
    ..Potential improvements include better sensitivity, less susceptibility to interobserver variation, more uniform availability of data, more precise estimates of infection rates, and better adjustment for patients' coexisting illness...
  3. ncbi request reprint Multicenter epidemiologic and health services research on therapeutics in the HMO Research Network Center for Education and Research on Therapeutics
    R Platt
    Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 10:373-7. 2001
    ....
  4. pmc Can managed health care help manage health care-associated infections?
    R Platt
    Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Emerg Infect Dis 7:358-62. 2001
    ..It will be important to articulate clear goals and standards that can be readily understood and widely adopted...
  5. pmc Syndromic surveillance using minimum transfer of identifiable data: the example of the National Bioterrorism Syndromic Surveillance Demonstration Program
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Urban Health 80:i25-31. 2003
    ..If successful, this system will allow any organization with appropriate data to contribute vital information to public health syndromic surveillance systems while preserving individuals' privacy to the greatest extent possible...
  6. pmc Supplementing tuberculosis surveillance with automated data from health maintenance organizations
    D S Yokoe
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Emerg Infect Dis 5:779-87. 1999
    ....
  7. ncbi request reprint Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women
    K A Chan
    Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Lancet 355:2185-8. 2000
    ..We undertook a population-based case-control study at six health-maintenance organisations in the USA to investigate further the relation between statin use and fracture risk among older women...
  8. doi request reprint Impact of a 16-community trial to promote judicious antibiotic use in Massachusetts
    Jonathan A Finkelstein
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Ave, Sixth Floor Boston, MA 02215, USA
    Pediatrics 121:e15-23. 2008
    ..In addition, we sought to compare the intervention's impact on commercially and Medicaid-insured children...
  9. ncbi request reprint Ambulatory-care diagnoses as potential indicators of outbreaks of gastrointestinal illness--Minnesota
    Katherine W Yih
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    MMWR Morb Mortal Wkly Rep 54:157-62. 2005
    ..Syndromic surveillance's capability to augment existing surveillance for community-acquired gastrointestinal disease is unknown...
  10. ncbi request reprint Efficient identification of postdischarge surgical site infections: use of automated pharmacy dispensing information, administrative data, and medical record information
    K Sands
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Infect Dis 179:434-41. 1999
    ..Thus, information routinely collected by health care systems can be the basis of an efficient, largely passive, surveillance system for postdischarge SSIs...
  11. ncbi request reprint National Bioterrorism Syndromic Surveillance Demonstration Program
    W Katherine Yih
    Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
    MMWR Morb Mortal Wkly Rep 53:43-9. 2004
    ..Ongoing activities include evaluating the system's ability to detect naturally occurring outbreaks and simulated terrorism events, automating and testing alerts and response capability, and evaluating alternative data sources...
  12. ncbi request reprint Connecting health departments and providers: syndromic surveillance's last mile
    James B Daniel
    Bureau of Communicable Disease Control, Massachusetts Department of Public Health, State Laboratory Institute, Boston, Massachusetts 02130, USA
    MMWR Morb Mortal Wkly Rep 54:147-50. 2005
    ..This effort is based on CDC's Health Alert Network program and includes automated generation and notification of signals and a mechanism to obtain detailed clinical information when needed...
  13. pmc Evaluating real-time syndromic surveillance signals from ambulatory care data in four states
    W Katherine Yih
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, 133 Brookline Ave, 6th Floor, Boston, MA 02215, USA
    Public Health Rep 125:111-20. 2010
    ..We evaluated a real-time ambulatory care-based syndromic surveillance system in four metropolitan areas of the United States...
  14. pmc A cohort study of possible risk factors for over-reporting of antihypertensive adherence
    P W Choo
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMC Cardiovasc Disord 1:6. 2001
    ..This study is one of the first to explore possible risk factors for over-reporting of antihypertensive adherence using electronic medication monitoring...
  15. pmc Epidemiology of and surveillance for postpartum infections
    D S Yokoe
    Channing Laboratory, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Emerg Infect Dis 7:837-41. 2001
    ..Use of automated information routinely collected by HMOs and insurers allows efficient identification of postpartum infections not detected by conventional surveillance...
  16. ncbi request reprint Inhaled steroids and the risk of hospitalization for asthma
    J G Donahue
    Channing Laboratory, Boston, MA, USA
    JAMA 277:887-91. 1997
    ..To determine if anti-inflammatory treatment for asthma reduces the risk of asthma hospitalization...
  17. ncbi request reprint Administrative databases provide inaccurate data for surveillance of long-term central venous catheter-associated infections
    Sharon B Wright
    Centers for Disease Control and Prevention Prevention Epicenter of Eastern Massachusetts, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 24:946-9. 2003
    ..Automated medical records and claims data have been used for surveillance of these infections without evaluation of their accuracy or validity...
  18. pmc Using automated pharmacy records to assess the management of tuberculosis
    G S Subramanyan
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Emerg Infect Dis 5:788-91. 1999
    ..Pharmacy records distinguished patients treated in HMOs from those treated elsewhere. For cases treated in HMOs, they provided useful information about appropriateness of prescribed regimens and adherence to therapy...
  19. ncbi request reprint Fever in pediatric primary care: occurrence, management, and outcomes
    J A Finkelstein
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Pediatrics 105:260-6. 2000
    ..To describe the epidemiology, management, and outcomes of children with fever in pediatric primary care practice...
  20. pmc Intraoperative redosing of cefazolin and risk for surgical site infection in cardiac surgery
    G Zanetti
    Brigham and Women s Hospital, Harvard Medical School, and Eastern Massachusetts CDC Prevention Epicenter, Boston, USA
    Emerg Infect Dis 7:828-31. 2001
    ..44, 95% CI 0.23-0.86). Intraoperative redosing of cefazolin was associated with a 16% reduction in the overall risk for surgical site infection after cardiac surgery, including procedures lasting <240 min...
  21. ncbi request reprint Simulation for assessing statistical methods of biologic terrorism surveillance
    Ken P Kleinman
    Harvard Medical School, Harvard Pilgrim Health Care, and CDC Eastern Massachusetts Prevention Epicenter and HMO Research Network Center for Education and Research in Therapeutics, Boston, Massachusetts 02215, USA
    MMWR Morb Mortal Wkly Rep 54:101-8. 2005
    ..In the absence of practical and theoretical results, choosing a particular statistical algorithm can be difficult. One way to evaluate algorithms is through simulation...
  22. pmc Enhanced identification of postoperative infections among outpatients
    Andrew L Miner
    Harvard Medical School, Boston, Massachusetts, USA
    Emerg Infect Dis 10:1931-7. 2004
    ..Claims data may complement other data sources for identification of surgical site infections following breast surgery and cesarean section...
  23. ncbi request reprint Detection of postoperative surgical-site infections: comparison of health plan-based surveillance with hospital-based programs
    Kenneth E Sands
    Centers for Disease Control and Prevention, Eastern Massachusetts Prevention Epicenter, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 24:741-3. 2003
    ..We compared these two methods for identifying SSIs following coronary artery bypass graft (CABG) procedures...
  24. pmc Automated identification of acute hepatitis B using electronic medical record data to facilitate public health surveillance
    Michael Klompas
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, United States of America
    PLoS ONE 3:e2626. 2008
    ..We describe the development and implementation of an algorithm for prospective surveillance of patients with acute hepatitis B using electronic medical record data...
  25. doi request reprint Potential population-based electronic data sources for rapid pandemic influenza vaccine adverse event detection: a survey of health plans
    Kristen M Moore
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 17:1137-41. 2008
    ..Many public and private health plans and payers have such information...
  26. ncbi request reprint Intrapartum antibiotics and neonatal invasive infections caused by organisms other than group B streptococcus
    Anushua Sinha
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Pediatr 142:492-7. 2003
    ..We conducted a nested case-control study to define the association between maternal intrapartum antibiotics and risk of neonatal non-GBS infection...
  27. doi request reprint Active drug safety surveillance: a tool to improve public health
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 17:1175-82. 2008
    ....
  28. ncbi request reprint The projected health benefits of maternal group B streptococcal vaccination in the era of chemoprophylaxis
    Anushua Sinha
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Vaccine 23:3187-95. 2005
    ..Maternal GBS vaccination is predicted to prevent more cases of neonatal GBS disease than current practice and would prevent approximately one in 25 very preterm births...
  29. doi request reprint Early adverse drug event signal detection within population-based health networks using sequential methods: key methodologic considerations
    Jeffrey S Brown
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 18:226-34. 2009
    ..Our objective was to expand our previous signal detection work by investigating the effect on signal detection of alternative study specifications...
  30. pmc Pharmacy data for tuberculosis surveillance and assessment of patient management
    Deborah S Yokoe
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Emerg Infect Dis 10:1426-31. 2004
    ..Pharmacy data can help public health officials to find TB cases and assess their management in populations that receive care in the private sector...
  31. ncbi request reprint Chronic disease score as a predictor of hospitalization
    Kathleen G Putnam
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Epidemiology 13:340-6. 2002
    ..We compared four versions of the score for their ability to predict hospitalization among members of eight health maintenance organizations nationwide...
  32. ncbi request reprint Reduced risk of neonatal respiratory infections among breastfed girls but not boys
    Anushua Sinha
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 112:e303. 2003
    ..We therefore chose respiratory tract infections diagnosed after nursery discharge as representative of neonatal community-acquired infection and studied the impact of breastfeeding on this neonatal infection syndrome...
  33. pmc Enhanced identification of postoperative infections among inpatients
    Deborah S Yokoe
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    Emerg Infect Dis 10:1924-30. 2004
    ..This screening method was efficient, readily standardized, and suitable for most hospitals...
  34. doi request reprint Cluster randomized trials in comparative effectiveness research: randomizing hospitals to test methods for prevention of healthcare-associated infections
    Richard Platt
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Med Care 48:S52-7. 2010
    ..The need for evidence about the effectiveness of therapeutics and other medical practices has triggered new interest in methods for comparative effectiveness research...
  35. ncbi request reprint Multivariate scan statistics for disease surveillance
    Martin Kulldorff
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, 6th Floor, Boston, MA 02215, USA
    Stat Med 26:1824-33. 2007
    ..The strongest signal was generated by a single data set and due to a familial outbreak of pinworm disease. The second and third strongest signals were generated by the combined strength of two of the three data sets...
  36. ncbi request reprint Epidemiology of neonatal infections: experience during and after hospitalization
    Anushua Sinha
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Pediatr Infect Dis J 22:244-51. 2003
    ..We assessed the epidemiology of neonatal infections coming to medical attention among inpatient and outpatient newborn infants within a defined health care maintenance organization (HMO) population...
  37. ncbi request reprint Early detection of adverse drug events within population-based health networks: application of sequential testing methods
    Jeffrey S Brown
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 16:1275-84. 2007
    ....
  38. ncbi request reprint Improving methicillin-resistant Staphylococcus aureus surveillance and reporting in intensive care units
    Susan S Huang
    Brigham and Women s Hospital, Channing Laboratory and Infection Control Department, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
    J Infect Dis 195:330-8. 2007
    ..In addition, many assessments underestimate the incidence of acquisition by including prevalent carriers in the at-risk population...
  39. ncbi request reprint Speed bumps, potholes, and tollbooths on the road to panacea: making best use of data
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Health Aff (Millwood) 26:w153-5. 2007
    ..Realizing databases' potential will require long-term commitment and investment beyond the maintenance of the databases themselves...
  40. ncbi request reprint Risk of acquiring antibiotic-resistant bacteria from prior room occupants
    Susan S Huang
    Departments of Medicine and Infection Control, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 166:1945-51. 2006
    ....
  41. pmc Distributed data processing for public health surveillance
    Ross Lazarus
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    BMC Public Health 6:235. 2006
    ....
  42. ncbi request reprint Impact of routine intensive care unit surveillance cultures and resultant barrier precautions on hospital-wide methicillin-resistant Staphylococcus aureus bacteremia
    Susan S Huang
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Clin Infect Dis 43:971-8. 2006
    ..To our knowledge, the relative impact of these interventions has not previously been ascertained...
  43. pmc Use of automated ambulatory-care encounter records for detection of acute illness clusters, including potential bioterrorism events
    Ross Lazarus
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Emerg Infect Dis 8:753-60. 2002
    ..This system complements emergency room- and hospital-based surveillance by adding the capacity to rapidly identify clusters of illness, including potential bioterrorism events...
  44. pmc Using automated health plan data to assess infection risk from coronary artery bypass surgery
    Richard Platt
    Centers for Disease Control and Prevention Eastern Massachusetts Prevention Epicenter, Boston, USA
    Emerg Infect Dis 8:1433-41. 2002
    ....
  45. ncbi request reprint Computerized prescribing alerts and group academic detailing to reduce the use of potentially inappropriate medications in older people
    Steven R Simon
    HMO Research Network Center for Education and Research in Therapeutics, Harvard Medical School and Harvard Pilgrim Healthcare, Boston, MA 02215, USA
    J Am Geriatr Soc 54:963-8. 2006
    ....
  46. ncbi request reprint Evaluating spatial surveillance: detection of known outbreaks in real data
    Ken Kleinman
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, USA
    Stat Med 25:755-69. 2006
    ..They can be used to assess whether the new system works in that it detects the outbreaks better than chance would suggest and can also determine if the new systems' signals are generated earlier than an extant system...
  47. ncbi request reprint FDA drug prescribing warnings: is the black box half empty or half full?
    Anita K Wagner
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 15:369-86. 2006
    ..The purpose of the present study was to assess the frequency of use of BBW medications in ambulatory care and prescribing compliance with BBW recommendations...
  48. ncbi request reprint A generalized linear mixed models approach for detecting incident clusters of disease in small areas, with an application to biological terrorism
    Ken Kleinman
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, MA 02215 3920, USA
    Am J Epidemiol 159:217-24. 2004
    ..The authors argue that there is great value in using the geographic data...
  49. doi request reprint Automated use of WHONET and SaTScan to detect outbreaks of Shigella spp. using antimicrobial resistance phenotypes
    J Stelling
    Department of Medicine, Brigham and Women s Hospital, WHO Collaborating Centre for Surveillance of Antimicrobial Resistance, Boston, MA 02115, USA
    Epidemiol Infect 138:873-83. 2010
    ..Electronic laboratory-based disease surveillance incorporating statistical cluster detection methods can enhance infectious disease outbreak detection and response...
  50. ncbi request reprint Perioperative antibiotic prophylaxis for herniorrhaphy and breast surgery
    R Platt
    Department of Medicine, Harvard Medical School, Boston, MA
    N Engl J Med 322:153-60. 1990
    ..We conclude that perioperative antibiotic prophylaxis with cefonicid is useful for herniorrhaphy and certain types of breast surgery...
  51. ncbi request reprint Bayesian inference on protective antibody levels using case-control data
    V J Carey
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biometrics 57:135-42. 2001
    ..Frequentist evaluation indicates good coverage probabilities of credibility intervals for antibody-dependent risk, and rules for estimation of the MPAC are illustrated with epidemiological data...
  52. ncbi request reprint Epidemiology of sepsis syndrome in 8 academic medical centers
    K E Sands
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    JAMA 278:234-40. 1997
    ..Sepsis syndrome is a leading cause of mortality in hospitalized patients. However, few studies have described the epidemiology of sepsis syndrome in a hospitalwide population...
  53. pmc Prevalence and duration of postmenopausal hormone replacement therapy use in a managed care organization, 1990-1995
    M T Connelly
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    J Gen Intern Med 15:542-50. 2000
    ..To determine the prevalence and duration of postmenopausal hormone replacement therapy (HRT) use and identify correlates of adherence to therapy...
  54. pmc Electronic Support for Public Health: validated case finding and reporting for notifiable diseases using electronic medical data
    Ross Lazarus
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    J Am Med Inform Assoc 16:18-24. 2009
    ..Source code for this highly interoperable application is freely available under an approved open-source license at http://esphealth.org...
  55. pmc Health and economic impact of surgical site infections diagnosed after hospital discharge
    Eli N Perencevich
    Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Emerg Infect Dis 9:196-203. 2003
    ..Average total costs during the 8 weeks after discharge were US dollars 5,155 for patients with SSI and US dollars 1,773 for controls (p<0.001)...
  56. ncbi request reprint A cohort study of the incidence of serious acute liver injury in diabetic patients treated with hypoglycemic agents
    K Arnold Chan
    Department of Medicine, Brigham and Women s Hospital, Boston, Mass, USA
    Arch Intern Med 163:728-34. 2003
    ..The incidence of acute liver failure or serious liver injury in diabetic patients is needed to evaluate the safety of hypoglycemic drug therapy...
  57. ncbi request reprint A beneficial side effect of the Medicare drug benefit
    Richard Platt
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, USA
    N Engl J Med 353:2742-3. 2005
  58. ncbi request reprint Improvement of intraoperative antibiotic prophylaxis in prolonged cardiac surgery by automated alerts in the operating room
    Giorgio Zanetti
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, and the CDC Eastern Massachusetts Prevention Epicenter, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 24:13-6. 2003
    ..To assess the impact of an automated intraoperative alert to redose prophylactic antibiotics in prolonged cardiac operations...
  59. ncbi request reprint Improving the assessment of vancomycin-resistant enterococci by routine screening
    Susan S Huang
    Brigham and Women s Hospital, Channing Laboratory and Department of Infection Control, Harvard Medical School, and Harvard Pilgrim Health Care, Boston, MA 02115, USA
    J Infect Dis 195:339-46. 2007
    ..Routine surveillance cultures can substantially improve prevalence and incidence estimates, and assessing the range of improvement across diverse units is important...
  60. pmc Attitudes of healthcare workers in U.S. hospitals regarding smallpox vaccination
    W Katherine Yih
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    BMC Public Health 3:20. 2003
    ..Vaccination is voluntary, and it is unknown what factors drive vaccine acceptance. This study's aims were to estimate the proportion of workers willing to accept vaccination and to identify factors likely to influence their decisions...
  61. pmc Real-time surveillance for tuberculosis using electronic health record data from an ambulatory practice in eastern Massachusetts
    Michael S Calderwood
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Public Health Rep 125:843-50. 2010
    ..We report on the development and validation of a TB detection algorithm for EHR data followed by implementation in a live surveillance and reporting system...
  62. ncbi request reprint Predictive value of clinical diagnostic codes for the CDC case definition of pelvic inflammatory disease (PID): implications for surveillance
    Sylvie Ratelle
    Division of STD Prevention, Massachusetts Department of Public Health, Boston, Massachusetts 02130, USA
    Sex Transm Dis 30:866-70. 2003
    ..Reporting burden can be alleviated with the use of administrative data...
  63. pmc A model-adjusted space-time scan statistic with an application to syndromic surveillance
    K P Kleinman
    Department of Ambulatory Care and Prevention, Harvard Medical School, Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Epidemiol Infect 133:409-19. 2005
    ..The large number of days with clusters renders the census and membership approaches impractical for public health surveillance. The proposed adjustment allows practical surveillance...
  64. ncbi request reprint Reducing antibiotic use in children: a randomized trial in 12 practices
    J A Finkelstein
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA
    Pediatrics 108:1-7. 2001
    ..Setting. Twelve practices affiliated with 2 managed care organizations (MCOs) in eastern Massachusetts and northwest Washington State. Patients. All enrolled children younger than 6 years old...
  65. ncbi request reprint Simplified surveillance for nosocomial bloodstream infections
    D S Yokoe
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Infect Control Hosp Epidemiol 19:657-60. 1998
    ..To compare a surveillance definition of noso comial bloodstream infections requiring only microbiology data to the Centers for Disease Control and Prevention's (CDC) current definition...
  66. ncbi request reprint Mortality and costs of acute renal failure associated with amphotericin B therapy
    D W Bates
    Division of General Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Clin Infect Dis 32:686-93. 2001
    ..Although residual confounding exists despite adjustment, the increases in resource utilization that we found are large and the associated mortality is high when acute renal failure occurs following amphotericin B therapy...
  67. ncbi request reprint Management of urethritis in health maintenance organization members receiving care at a multispecialty group practice in Massachusetts
    S Ratelle
    Massachusetts Department of Public Health, Boston, USA
    Sex Transm Dis 28:232-5. 2001
    ..Cost containment has led to a concern that health maintenance organization-insured patients presenting with complaints of urethritis may be treated without being tested...
  68. ncbi request reprint Risk of methicillin-resistant Staphylococcus aureus infection after previous infection or colonization
    Susan S Huang
    Channing Laboratory, Brigham and Women s Hospital, Division of Infectious Diseases, Boston, MA 02115, USA
    Clin Infect Dis 36:281-5. 2003
    ..Accurate assessment of the risk of MRSA-associated sequelae requires prolonged follow-up after discharge...
  69. ncbi request reprint Real-time vaccine safety surveillance for the early detection of adverse events
    Tracy A Lieu
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Med Care 45:S89-95. 2007
    ..Sequential testing procedures are needed to detect vaccine or drug safety problems as soon as possible after introduction...
  70. pmc Using electronic medical records to enhance detection and reporting of vaccine adverse events
    Virginia L Hinrichsen
    Dept of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, 133 Brookline Avenue, Boston, MA 02215, USA
    J Am Med Inform Assoc 14:731-5. 2007
    ..By coupling simplified reporting with the initial prompt, clinicians can consider and report a vaccine adverse event electronically in a few moments during the office visit...
  71. ncbi request reprint Gastric and duodenal safety of daily alendronate
    James G Donahue
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Intern Med 162:936-42. 2002
    ..This study was conducted to estimate the excess risk of hospitalizations for gastric or duodenal perforations, ulcers, and bleeding associated with alendronate use...
  72. pmc Developing algorithms for healthcare insurers to systematically monitor surgical site infection rates
    Susan S Huang
    Channing Laboratory, Department of Medicine Brigham and Women s Hospital Boston, MA, USA
    BMC Med Res Methodol 7:20. 2007
    ..We now operationalize this method for use by payers without transfer of protected health information, or any insurer data, to external analytic centers...
  73. ncbi request reprint Community-level predictors of pneumococcal carriage and resistance in young children
    Susan S Huang
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA, USA
    Am J Epidemiol 159:645-54. 2004
    ..5, 95% confidence interval: 1.0, 11.7). The two- to threefold odds of pneumococcal carriage conferred by certain community characteristics suggest that these measures may target communities for interventions to decrease transmission...
  74. ncbi request reprint Potential drug-drug interactions in the outpatient setting
    Jennifer Elston Lafata
    Henry Ford Health System, Detroit, Michigan 48202, Channing Laboratory, Brigham and Women s Hospital, and Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Med Care 44:534-41. 2006
    ..Although medication safety research has tended to focus on inpatients, the safety of drug use among outpatients is also a concern...
  75. doi request reprint Development of an algorithm for surveillance of ventilator-associated pneumonia with electronic data and comparison of algorithm results with clinician diagnoses
    Michael Klompas
    Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 29:31-7. 2008
    ..We sought to improve the efficiency and objectivity of VAP surveillance by adapting the CDC criteria to make them amenable to evaluation with electronic data...
  76. ncbi request reprint Antivirals and antibiotics for influenza in the United States, 1995--2002
    Jeffrey A Linder
    Division of General Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 14:531-6. 2005
    ..To measure the rates of antiviral and antibiotic prescribing for patients diagnosed with influenza in the United States...
  77. pmc Impact of an environmental cleaning intervention on the presence of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci on surfaces in intensive care unit rooms
    Eric R Goodman
    Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Infect Control Hosp Epidemiol 29:593-9. 2008
    ....
  78. ncbi request reprint Prescription drug use in pregnancy
    Susan E Andrade
    Meyers Primary Care Institute Fallon Healthcare System and University of Massachusetts Medical School, 630 Plantation Street, Worcester, MA, USA
    Am J Obstet Gynecol 191:398-407. 2004
    ..The purpose of this study was to provide information on the prevalence of the use of prescription drugs among pregnant women in the United States...
  79. ncbi request reprint Incidence of outpatient visits and hospitalizations related to influenza in infants and young children
    Megan A O'Brien
    Center for Child Health Care Studies, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    Pediatrics 113:585-93. 2004
    ....
  80. ncbi request reprint Relationship of pulmonary artery catheter use to mortality and resource utilization in patients with severe sepsis
    D Tony Yu
    Division of General Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Crit Care Med 31:2734-41. 2003
    ..To examine the relationship of pulmonary artery catheter (PAC) use to patient outcomes, including mortality rate and resource utilization, in patients with severe sepsis in eight academic medical centers...
  81. pmc Clinical consequences and cost of limiting use of vancomycin for perioperative prophylaxis: example of coronary artery bypass surgery
    G Zanetti
    Channing Laboratory, Brigham and Women s Hospital, and Eastern Massachusetts CDC Prevention Epicenter, Boston, USA
    Emerg Infect Dis 7:820-7. 2001
    ..Data on vancomycin's impact on resistance are needed to quantify the trade-off between individual patients' improved clinical outcomes and lower costs and the future long-term consequences to society...
  82. doi request reprint Comparative-effectiveness research in distributed health data networks
    S Toh
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA
    Clin Pharmacol Ther 90:883-7. 2011
    ..A scalable network architecture supports a wide range of CER activities and meets the data infrastructure needs envisioned by the Federal Coordinating Council for Comparative Effectiveness Research...
  83. pmc Preoperative drug dispensing as predictor of surgical site infection
    K S Kaye
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Emerg Infect Dis 7:57-65. 2001
    ..The chronic disease score improved prediction of infection by the NNIS risk index and augmented the ASA score for risk adjustment...
  84. ncbi request reprint Derivation of adherence metrics from electronic dosing records
    P W Choo
    Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA
    J Clin Epidemiol 54:619-26. 2001
    ..Metrics that are more sensitive to timing variability may thus be preferable when timing as well as quantity of dosing are of interest...
  85. ncbi request reprint Comparing drug effectiveness at health plans: the ethics of cluster randomized trials
    James E Sabin
    Harvard Medical School, USA
    Hastings Cent Rep 38:39-48. 2008
    ..CRTs have not been widely used, in good part because of concerns about whether patients must give informed consent to participate in them. A better understanding of how CRTs fit into clinical practice resolves the concerns...
  86. doi request reprint Distributed health data networks: a practical and preferred approach to multi-institutional evaluations of comparative effectiveness, safety, and quality of care
    Jeffrey S Brown
    Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA 02215, USA
    Med Care 48:S45-51. 2010
    ....
  87. pmc Severe sepsis: variation in resource and therapeutic modality use among academic centers
    D Tony Yu
    Brigham and Women s Hospital, Partners HealthCare System, Wellesley, Massachusetts, USA
    Crit Care 7:R24-34. 2003
    ..The objective of the present study was to assess intercenter variation in resource and therapeutic modality use in patients with severe sepsis...
  88. ncbi request reprint Effect of increased cost-sharing on oral hypoglycemic use in five managed care organizations: how much is too much?
    Douglas W Roblin
    Research Department, Kaiser Permanente, Atlanta, Georgia 30305, and the Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts, USA
    Med Care 43:951-9. 2005
    ..For patients with a chronic disease, increased cost-sharing for medications may lead to unintended consequences, including reduced use of medications essential for control of their disease...
  89. doi request reprint A distributed research network model for post-marketing safety studies: the Meningococcal Vaccine Study
    Priscilla Velentgas
    Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, MA 02215, USA
    Pharmacoepidemiol Drug Saf 17:1226-34. 2008
    ..Implementation has addressed several issues relevant to creation of a large scale post-marketing drug safety surveillance system envisioned by the FDA's Sentinel Initiative...
  90. ncbi request reprint Reduction in antibiotic use among US children, 1996-2000
    Jonathan A Finkelstein
    HMO Research Network Centers for Education and Research on Therapeutics Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA
    Pediatrics 112:620-7. 2003
    ..The Centers for Disease Control and Prevention, in collaboration with other national and state level organizations, have actively promoted more judicious prescribing for children...
  91. ncbi request reprint Resource utilization among patients with sepsis syndrome
    David W Bates
    Division of General Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Infect Control Hosp Epidemiol 24:62-70. 2003
    ..To assess the resource utilization associated with sepsis syndrome in academic medical centers...
  92. ncbi request reprint Infection control practices to reduce airborne bacteria during total knee replacement: a hospital survey in four states
    Andrew L Miner
    Department of Ambulatory Care and Prevention and Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Infect Control Hosp Epidemiol 26:910-5. 2005
    ..To describe the use of laminar airflow, body exhaust, and ultraviolet lights during total knee replacement (TKR) in four U.S. states...
  93. ncbi request reprint Male sexual dysfunction associated with antiretroviral therapy
    Amy E Colson
    Channing Laboratory, Brigham and Women s Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Acquir Immune Defic Syndr 30:27-32. 2002
    ..69; 95% CI, 0.84-3.37; p =.14), nelfinavir (HR, 1.53; 95% CI, 0.66-3.54; p =.32) and saquinavir (HR, 1.25; 95% CI, 0.53-2.96; p =.60). We conclude that PIs, especially ritonavir, appear to increase the risk of sexual dysfunction...
  94. ncbi request reprint Frequency of high-risk use of QT-prolonging medications
    Nancy M Allen LaPointe
    Duke Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA
    Pharmacoepidemiol Drug Saf 15:361-8. 2006
    ..Concurrent use of more than one QT-prolonging drug or a QT-prolonging drug with a drug that alters its pharmacokinetic profile is an important risk factor for adverse outcomes...
  95. ncbi request reprint Supplementary table: epidemiology of neonatal infections: experience during and after hospitalization
    Anushua Sinha
    Pediatr Infect Dis J 22:E1-5. 2003
  96. ncbi request reprint Use of prescription medications with a potential for fetal harm among pregnant women
    Susan E Andrade
    Meyers Primary Care Institute University of Massachusetts Medical School, the Fallon Foundation, and Fallon Community Health Plan, Worcester, MA 01605, USA
    Pharmacoepidemiol Drug Saf 15:546-54. 2006
    ..To estimate the prevalence of use of prescription drugs with a potential for fetal harm among pregnant women in the United States...
  97. ncbi request reprint Antibiotic prophylaxis for cardiac surgery: does the past predict the future?
    Giorgio Zanetti
    Clin Infect Dis 38:1364-6. 2004
  98. ncbi request reprint Estimation of the period prevalence of inflammatory bowel disease among nine health plans using computerized diagnoses and outpatient pharmacy dispensings
    Lisa J Herrinton
    Division of Research, Kaiser Permanente Northern California, Oakland, CA 94612, USA
    Inflamm Bowel Dis 13:451-61. 2007
    ..There are few contemporary estimates of prevalence rates for inflammatory bowel disease (IBD) in diverse North American communities...
  99. pmc Simulated anthrax attacks and syndromic surveillance
    James D Nordin
    HealthPartners Research Foundation, Minneapolis, Minnesota 55440 1524, USA
    Emerg Infect Dis 11:1394-8. 2005
    ..Timeliness and completeness of detection of events varied by rate of infection. First detection of events ranged from days 3 to 6. Similar modeling may be possible with other surveillance systems and should be a part of their evaluation...
  100. ncbi request reprint Liver and thyroid monitoring in ambulatory patients prescribed amiodarone in 10 HMOs
    Marsha A Raebel
    Kaiser Permanente Colorado Clinical Research Unit, P O Box 378066, Denver, CO 80237 8066, USA
    J Manag Care Pharm 12:656-64. 2006
    ..Amiodarone can cause liver and thyroid toxicity, but little is known about compliance with laboratory tests to evaluate liver and thyroid function among ambulatory patients who are dispensed amiodarone...
  101. ncbi request reprint Validation of diagnoses of peptic ulcers and bleeding from administrative databases: a multi-health maintenance organization study
    Susan E Andrade
    Meyers Primary Care Institute Fallon Healthcare System and University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Clin Epidemiol 55:310-3. 2002
    ..This study, using data from a large number of health plans located in different geographical regions, underscores the importance of evaluating the accuracy of the diagnoses from automated health plan databases...