DONNA PLATT

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development
    Donna M Platt
    Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, PO Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 163:265-82. 2002
  2. ncbi request reprint Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434
    D M Platt
    Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 293:1017-26. 2000
  3. pmc Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine
    Donna M Platt
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 200:167-76. 2008
  4. ncbi request reprint Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 313:658-67. 2005
  5. pmc Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, One Pine Hill Dr, Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 332:985-95. 2010
  6. ncbi request reprint Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 308:1030-9. 2004
  7. pmc Opioid receptors and the discriminative stimulus effects of ethanol in squirrel monkeys: Mu and delta opioid receptor mechanisms
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Eur J Pharmacol 650:233-9. 2011
  8. ncbi request reprint Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys
    Donna M Platt
    New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, PO Box 9102, MA 01772 9102, Southborough, USA
    Psychopharmacology (Berl) 166:298-305. 2003
  9. ncbi request reprint Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys
    D M Platt
    Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 157:208-16. 2001
  10. ncbi request reprint Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms
    D M Platt
    Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    J Pharmacol Exp Ther 299:760-7. 2001

Detail Information

Publications32

  1. ncbi request reprint Behavioral effects of cocaine and dopaminergic strategies for preclinical medication development
    Donna M Platt
    Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, PO Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 163:265-82. 2002
    ..The functional analysis of behavior in laboratory animals has allowed for the development of strategies identifying candidate medications to treat cocaine addiction...
  2. ncbi request reprint Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434
    D M Platt
    Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 293:1017-26. 2000
    ..The prominent cocaine-antagonist properties and the low incidence of motoric side effects of SKF 83959 may reflect its unique binding profile at D1 as well as nondopaminergic receptors...
  3. pmc Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine
    Donna M Platt
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 200:167-76. 2008
    ..Cocaine addicts use varied amounts of cocaine over long periods of time, and an effective pharmacotherapy would almost certainly require more chronic treatment...
  4. ncbi request reprint Contribution of alpha 1GABAA and alpha 5GABAA receptor subtypes to the discriminative stimulus effects of ethanol in squirrel monkeys
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 313:658-67. 2005
    ..These findings suggest a key role for alpha(5)GABA(A), but not alpha(1)GABA(A), receptor mechanisms in the DS effects of ethanol and the ethanol-like DS effects of benzodiazepine agonists...
  5. pmc Asymmetric generalization and interaction profiles in rhesus monkeys discriminating intravenous cocaine or intravenous heroin from vehicle
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, One Pine Hill Dr, Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 332:985-95. 2010
    ....
  6. ncbi request reprint Opioid partial agonist effects of 3-O-methylnaltrexone in rhesus monkeys
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 308:1030-9. 2004
    ..The results suggest that 3-MNTX functions primarily as a partial agonist at micro-receptors in monkeys and do not support a singular role for M6G receptors in the abuse-related effects of heroin...
  7. pmc Opioid receptors and the discriminative stimulus effects of ethanol in squirrel monkeys: Mu and delta opioid receptor mechanisms
    Donna M Platt
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Eur J Pharmacol 650:233-9. 2011
    ....
  8. ncbi request reprint Suppression of cocaine- and food-maintained behavior by the D2-like receptor partial agonist terguride in squirrel monkeys
    Donna M Platt
    New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, PO Box 9102, MA 01772 9102, Southborough, USA
    Psychopharmacology (Berl) 166:298-305. 2003
    ..The D2-like receptor partial agonist terguride has a profile of behavioral effects in rats that suggests potential benefit as a pharmacotherapy for cocaine addiction...
  9. ncbi request reprint Modulation of cocaine and food self-administration by low- and high-efficacy D1 agonists in squirrel monkeys
    D M Platt
    Harvard Medical School, New England Regional Primate Research Center, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 157:208-16. 2001
    ..Dopamine D1 ligands have been proposed as candidate medications for cocaine abuse. Previous studies have shown that the ability of D1 ligands to modulate the behavioral effects of cocaine may depend on agonist efficacy...
  10. ncbi request reprint Discriminative stimulus effects of intravenous heroin and its metabolites in rhesus monkeys: opioid and dopaminergic mechanisms
    D M Platt
    Harvard Medical School, New England Regional Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    J Pharmacol Exp Ther 299:760-7. 2001
    ..Despite previous speculation that morphine-3-glucuronide lacks significant opioid activity, it substituted fully for heroin in our study, suggesting that it can exhibit prominent mu-agonist effects in vivo...
  11. ncbi request reprint Noradrenergic mechanisms in cocaine-induced reinstatement of drug seeking in squirrel monkeys
    Donna M Platt
    New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 322:894-902. 2007
    ..These findings suggest that NE transporter inhibition and alpha2-adrenoceptor mechanisms play a significant role in cocaine-induced reinstatement of drug seeking that is not secondary to activation of brain stress pathways...
  12. ncbi request reprint Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/alpha1-preferring antagonist beta-CCt in squirrel monkeys
    Donna M Platt
    Harvard Medical School, New England Regional Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 164:151-9. 2002
    ..OBJECTIVES. The purpose of the present study was to investigate the role of GABAA/alpha1 receptors in the sedative and motor-impairing effects of benzodiazepines...
  13. pmc Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes
    Stephanie C Licata
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772 9102, USA
    Neuropharmacology 58:357-64. 2010
    ..These data suggest that efficacy at alpha2, alpha3, and/or alpha5 subunit-containing GABA(A) receptors likely are sufficient for engendering BZ-like discriminative stimulus effects...
  14. ncbi request reprint Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine
    Buyean Lee
    Harvard Medical School, New England Primate Research Center, P O Box 9102, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 312:1232-40. 2005
    ..The contrasting interactions of MPEP and dizocilpine with cocaine imply that glutamate acting through different metabotropic and ionotropic receptors may modulate the behavioral effects of cocaine in qualitatively different ways...
  15. ncbi request reprint Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms
    Glenn R Valdez
    Division of Behavioral Biology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, USA
    J Pharmacol Exp Ther 323:525-33. 2007
    ..The results point to interactions between a subpopulation of kappa opioid receptors and central corticotropin-releasing factor and noradrenergic stress systems in the reinstatement of cocaine seeking induced by kappa agonists...
  16. pmc Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms
    Daniela Ruedi-Bettschen
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 210:169-77. 2010
    ..The mechanisms underlying this effect have not been characterized fully but may have a serotonergic component as kappa agonists also increase the release of serotonin (5-hydroxytryptamine, 5-HT)...
  17. pmc A pharmacogenetic model of naltrexone-induced attenuation of alcohol consumption in rhesus monkeys
    Eric J Vallender
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, Southborough, MA 01772, USA
    Drug Alcohol Depend 109:252-6. 2010
    ..Naltrexone, an antagonist at the receptor, has been used to treat alcoholism in humans and has been reported to show differences in effectiveness depending on genotype...
  18. pmc The dopamine D3 receptor partial agonist CJB 090 inhibits the discriminative stimulus but not the reinforcing or priming effects of cocaine in squirrel monkeys
    Cindy Achat-Mendes
    Division of Neuroscience, New England Primate Research Center, Harvard Medical School, One Pine Hill Dr, P O Box 9102, Southborough, MA 01772, USA
    Psychopharmacology (Berl) 206:73-84. 2009
    ..Dopamine D3 receptor mechanisms have been implicated in the abuse-related behavioral effects of cocaine...
  19. pmc Intravenous self-administration of etonitazene alone and combined with cocaine in rhesus monkeys: comparison with heroin and antagonism by naltrexone and naloxonazine
    Cindy Achat-Mendes
    Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA
    Psychopharmacology (Berl) 204:489-98. 2009
    ....
  20. pmc Dopamine D3 and D2 receptor mechanisms in the abuse-related behavioral effects of cocaine: studies with preferential antagonists in squirrel monkeys
    Cindy Achat-Mendes
    Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772, USA
    J Pharmacol Exp Ther 334:556-65. 2010
    ....
  21. ncbi request reprint Modulation of heroin and cocaine self-administration by dopamine D1- and D2-like receptor agonists in rhesus monkeys
    James K Rowlett
    New England Primate Research Center, Harvard Medical School, Box 9102, One Pine Hill Dr, Southborough, MA 01772 9102, USA
    J Pharmacol Exp Ther 321:1135-43. 2007
    ....
  22. ncbi request reprint Role of the hypothalamic-pituitary-adrenal axis in reinstatement of cocaine-seeking behavior in squirrel monkeys
    Buyean Lee
    New England Regional Primate Research Center, Harvard Medical School, One Pine Hill Drive, Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 168:177-83. 2003
    ..An important physiological system activated by stress is the hypothalamic-pituitary-adrenal (HPA) axis; however, evidence for a role of HPA axis activation in cocaine relapse has been contradictory...
  23. ncbi request reprint Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys
    Buyean Lee
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772 9102, USA
    Neuropsychopharmacology 29:686-93. 2004
    ....
  24. ncbi request reprint Cocaine-like discriminative stimulus effects of heroin: modulation by selective monoamine transport inhibitors
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, Southborough, Massachusetts 01772 9102, USA
    J Pharmacol Exp Ther 310:342-8. 2004
    ..Unlike the DS effects of cocaine itself, however, the cocaine-like DS effects of heroin do not appear to involve either noradrenergic or serotonergic mechanisms...
  25. ncbi request reprint Selective antagonism of GABAA receptor subtypes: an in vivo approach to exploring the therapeutic and side effects of benzodiazepine-type drugs
    James K Rowlett
    Department of Psychiatry and Division of Behavioral Biology, Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, Southborough, MA 01772, USA
    CNS Spectr 10:40-8. 2005
    ..Altogether, these results indicate that subtype-selective antagonists represent a useful approach to studying receptor mechanisms underlying the behavioral effects of BZ-type drugs...
  26. pmc Different GABAA receptor subtypes mediate the anxiolytic, abuse-related, and motor effects of benzodiazepine-like drugs in primates
    James K Rowlett
    Harvard Medical School, New England Primate Research Center, One Pine Hill Road, Box 9102, Southborough, MA 01772, USA
    Proc Natl Acad Sci U S A 102:915-20. 2005
    ..In contrast, stimulation of alpha1GABAA receptors is sufficient, but not necessary, for mediation of the abuse potential of these drugs...
  27. ncbi request reprint Contribution of GABAA receptor subtypes to the anxiolytic-like, motor, and discriminative stimulus effects of benzodiazepines: studies with the functionally selective ligand SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-
    Stephanie C Licata
    Harvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA
    J Pharmacol Exp Ther 313:1118-25. 2005
    ..Moreover, a compound with reduced efficacy at alpha(1) GABA(A) and/or alpha(5) GABA(A) receptors may lack some of the motor and subjective effects associated with conventional BZs...
  28. pmc Contribution of GABA(A) receptors containing α3 subunits to the therapeutic-related and side effects of benzodiazepine-type drugs in monkeys
    Bradford D Fischer
    Harvard Medical School, New England Primate Research Center, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 215:311-9. 2011
    ..Experimental evidence suggests that the differential behavioral effects of benzodiazepines depend on their relative actions at γ-aminobutyric acid type A (GABA(A)) receptors that contain either an α1, α2, α3, or α5 subunit...
  29. ncbi request reprint Enhanced sucrose pellet consumption induced by benzodiazepine-type drugs in squirrel monkeys: role of GABAA receptor subtypes
    Angela N Duke
    New England Primate Research Center, Harvard Medical School, One Pine Hill Drive, P O Box 9102, Southborough, MA 01772 9102, USA
    Psychopharmacology (Berl) 187:321-30. 2006
    ..Benzodiazepine agonists characteristically increase food intake in humans and non-human subjects, and the underlying mechanisms of this effect are not understood completely...
  30. doi request reprint Intravenous self-administration techniques in monkeys
    Donna M Platt
    New England Primate Research Center Harvard Medical School, Southborough, Massachusetts, USA
    Curr Protoc Neurosci . 2005
    ..These procedures also can be used to study the process of drug reinforcement. This unit describes intravenous drug self-administration in large primates, such as rhesus macaques, and smaller primates, such as squirrel monkeys...
  31. ncbi request reprint Attenuation of relapse to cocaine seeking by dopamine D1 receptor agonists and antagonists in non-human primates
    Taline V Khroyan
    SRI International, Center for Health Sciences, 333 Ravenswood Ave, Menlo Park, CA 94025, USA
    Psychopharmacology (Berl) 168:124-31. 2003
    ..The mechanisms by which these different classes of D(1) receptor drugs produce these similar effects on cocaine seeking are unknown...
  32. ncbi request reprint Understanding how the brain perceives alcohol: neurobiological basis of ethanol discrimination
    Clyde W Hodge
    Department of Psychiatry and Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 5679, USA
    Alcohol Clin Exp Res 30:203-13. 2006
    ....

Research Grants7

  1. GABAa receptor subtype mechanisms in nonhuman primate models of alcohol abuse
    DONNA PLATT; Fiscal Year: 2007
    ....
  2. Opioid Receptor Polymorphisms and Nonhuman Primate Models of Alcohol Abuse
    DONNA PLATT; Fiscal Year: 2009
    ..Ultimately, our results should allow for a more informed selection of anti-alcohol medication that is tailored to an individual's likelihood of positive treatment response. ..
  3. GABAa receptor subtype mechanisms in nonhuman primate models of alcohol abuse
    Donna M Platt; Fiscal Year: 2010
    ....
  4. Opioid Receptor Polymorphisms and Nonhuman Primate Models of Alcohol Abuse
    Donna M Platt; Fiscal Year: 2010
    ..Ultimately, our results should allow for a more informed selection of anti-alcohol medication that is tailored to an individual's likelihood of positive treatment response. ..