Diego Pizzagalli

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Resting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: a 128-channel EEG study
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hum Brain Mapp 27:185-201. 2006
  2. ncbi Frontal brain asymmetry and reward responsiveness: a source-localization study
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychol Sci 16:805-13. 2005
  3. pmc Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Psychopharmacology (Berl) 196:221-32. 2008
  4. pmc Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    J Psychiatr Res 43:76-87. 2008
  5. pmc Increased perceived stress is associated with blunted hedonic capacity: potential implications for depression research
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Behav Res Ther 45:2742-53. 2007
  6. pmc Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
    Am J Psychiatry 166:702-10. 2009
  7. pmc Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuropsychopharmacology 35:1186-97. 2010
  8. ncbi Spatio-temporal dynamics of brain mechanisms in aversive classical conditioning: high-density event-related potential and brain electrical tomography analyses
    Diego A Pizzagalli
    Department of Psychology, University of Wisconsin Madison, 1202 W Johnson Street, Madison, WI 53706, USA
    Neuropsychologia 41:184-94. 2003
  9. ncbi Functional but not structural subgenual prefrontal cortex abnormalities in melancholia
    D A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Mol Psychiatry 9:325, 393-405. 2004
  10. pmc Toward an objective characterization of an anhedonic phenotype: a signal-detection approach
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, Massachusetts, USA
    Biol Psychiatry 57:319-27. 2005

Research Grants

Collaborators

Detail Information

Publications41

  1. ncbi Resting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: a 128-channel EEG study
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hum Brain Mapp 27:185-201. 2006
    ..Because rostral ACC regions have been implicated in treatment response in depression, our findings provide initial insight into putative mechanisms fostering treatment response...
  2. ncbi Frontal brain asymmetry and reward responsiveness: a source-localization study
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychol Sci 16:805-13. 2005
    ..8% of the variance in reward bias. These findings not only confirm that frontal EEG asymmetry modulates the propensity to engage in appetitively motivated behavior, but also provide anatomical details about the underlying brain systems...
  3. pmc Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Psychopharmacology (Berl) 196:221-32. 2008
    ..Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes remain largely unexplored in humans...
  4. pmc Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    J Psychiatr Res 43:76-87. 2008
    ..The goal of the present study was to test the hypothesis that individuals with major depression are characterized by blunted reward responsiveness, particularly when anhedonic symptoms are prominent...
  5. pmc Increased perceived stress is associated with blunted hedonic capacity: potential implications for depression research
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Behav Res Ther 45:2742-53. 2007
    ..These findings are consistent with preclinical data highlighting links between stress and anhedonia, and offer promising insights into potential mechanisms linking stress to depression...
  6. pmc Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
    Am J Psychiatry 166:702-10. 2009
    ....
  7. pmc Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuropsychopharmacology 35:1186-97. 2010
    ....
  8. ncbi Spatio-temporal dynamics of brain mechanisms in aversive classical conditioning: high-density event-related potential and brain electrical tomography analyses
    Diego A Pizzagalli
    Department of Psychology, University of Wisconsin Madison, 1202 W Johnson Street, Madison, WI 53706, USA
    Neuropsychologia 41:184-94. 2003
    ....
  9. ncbi Functional but not structural subgenual prefrontal cortex abnormalities in melancholia
    D A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Mol Psychiatry 9:325, 393-405. 2004
    ..Based on preclinical evidence, we suggest that subgenual PFC dysfunction in melancholia may be associated with blunted hedonic response and exaggerated stress responsiveness...
  10. pmc Toward an objective characterization of an anhedonic phenotype: a signal-detection approach
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, Massachusetts, USA
    Biol Psychiatry 57:319-27. 2005
    ..Decreased approach-related behavior and anhedonia (lack of responsiveness to pleasure) are considered cardinal features of depression, but few studies have used laboratory-based measures to objectively characterize these constructs...
  11. pmc Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Hum Brain Mapp 30:1963-76. 2009
    ..These preliminary findings offer important insights on the role of phasic DA signals on reinforcement learning in humans and provide initial evidence regarding the spatiotemporal dynamics of brain mechanisms underlying these processes...
  12. pmc Spatiotemporal dynamics of error processing dysfunctions in major depressive disorder
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Arch Gen Psychiatry 65:179-88. 2008
    ..Depression is characterized by executive dysfunctions and abnormal reactions to errors; however, little is known about the brain mechanisms that underlie these deficits...
  13. pmc Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Biol Psychiatry 64:162-8. 2008
    ..Our goal was to test the hypothesis that BPD is characterized by impairments in adjusting behavior as a function of prior reinforcement history, particularly in the presence of residual anhedonic symptoms...
  14. ncbi Brain electrical tomography in depression: the importance of symptom severity, anxiety, and melancholic features
    Diego A Pizzagalli
    Department of Psychology, University of Wisconsin Madison, 57305 2280, USA
    Biol Psychiatry 52:73-85. 2002
    ....
  15. pmc Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthood
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Biol Psychiatry 66:206-13. 2009
    ..In animal models, early adversity is associated with dysfunction in basal ganglia regions involved in reward processing, but this relationship has not been established in humans...
  16. ncbi Anxiety selectively disrupts visuospatial working memory
    Alexander J Shackman
    Department of Psychology, University of Wisconsin Madison, 59706, USA
    Emotion 6:40-61. 2006
    ..These observations suggest a revision of extant models of how anxiety sculpts cognition and underscore the utility of the desiderata...
  17. pmc Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hum Brain Mapp 31:210-21. 2010
    ..Future studies in depressed samples should evaluate whether variation in neural responses to rewards may contribute to the association between TREK1 and antidepressant response in humans...
  18. ncbi Depression: perspectives from affective neuroscience
    Richard J Davidson
    Laboratory for Affective Neuroscience and W M Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin Madison, Madison, Wisconsin 53705 2280, USA
    Annu Rev Psychol 53:545-74. 2002
    ....
  19. pmc Acute stress reduces reward responsiveness: implications for depression
    Ryan Bogdan
    Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
    Biol Psychiatry 60:1147-54. 2006
    ..Stress, one of the strongest risk factors for depression, has been linked to "anhedonic" behavior and dysfunctional reward-related neural circuitry in preclinical models...
  20. pmc Enhanced negative feedback responses in remitted depression
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Neuroreport 19:1045-8. 2008
    ..The present findings suggest that abnormal responses to negative feedback extend to samples at increased risk for depressive episodes in the absence of current symptoms...
  21. pmc Electrophysiological correlates of spatial orienting towards angry faces: a source localization study
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Neuropsychologia 46:1338-48. 2008
    ..Results suggest that the earliest modulation of spatial attention by face stimuli is manifested in the P1 component, and provide insights about mechanisms underlying attentional orienting toward cues of threat and social disapproval...
  22. pmc Effects of task-relevant incentives on the electrophysiological correlates of error processing in major depressive disorder
    Avram J Holmes
    Harvard University, Cambridge, Massachusetts, USA
    Cogn Affect Behav Neurosci 10:119-28. 2010
    ..The present findings highlight distinct effects of task incentives on electrophysiological components of error processing and are interpreted within current theories of action monitoring and incentive processing in depression...
  23. pmc Effects of early life stress on cognitive and affective function: an integrated review of human literature
    Pia Pechtel
    Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Room 233C, De Marneffe Building, 115 Mill Street, Belmont, MA 02478 9106, USA
    Psychopharmacology (Berl) 214:55-70. 2011
    ..Emerging findings from longitudinal studies examining developmental trajectories of the brain in healthy samples may provide a new framework to understand mechanisms underlying ELS sequelae...
  24. pmc Neural substrates of attentional bias for smoking-related cues: an FMRI study
    Amy C Janes
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 35:2339-45. 2010
    ..Treatments capable of inhibiting shifts to drug cue-induced memories and internal states may lead to personalized tobacco dependence treatment for smokers with high attentional bias to smoking-related stimuli...
  25. pmc Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence
    Amy C Janes
    Brain Imaging Center McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 67:722-9. 2010
    ..We hypothesized that functional magnetic resonance imaging (fMRI) reactivity to smoking-related cues, measured before a quit attempt, could identify smokers with heightened relapse vulnerability...
  26. pmc Dissociation of neural regions associated with anticipatory versus consummatory phases of incentive processing
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Psychophysiology 45:36-49. 2008
    ..Although the study features several methodological improvements and helps clarify the neural basis of incentive processing, replications in larger samples are needed...
  27. pmc Frontocingulate dysfunction in depression: toward biomarkers of treatment response
    Diego A Pizzagalli
    Center for Depression, Anxiety, and Stress Research and Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 36:183-206. 2011
    ..The review ends with a discussion of the limitations of current work and future directions...
  28. pmc Response conflict and frontocingulate dysfunction in unmedicated participants with major depression
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuropsychologia 46:2904-13. 2008
    ....
  29. pmc Dissociable recruitment of rostral anterior cingulate and inferior frontal cortex in emotional response inhibition
    Pearl H Chiu
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuroimage 42:988-97. 2008
    ....
  30. pmc Implicit depression and hopelessness in remitted depressed individuals
    Tiffany M Meites
    Harvard University, Psychology Department, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Behav Res Ther 46:1078-84. 2008
    ..Results extend prior IAT research by documenting the presence of a reduced tendency to associate the self with happiness in a sample at increased risk for depression...
  31. pmc Task feedback effects on conflict monitoring and executive control: relationship to subclinical measures of depression
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Emotion 7:68-76. 2007
    ..These findings suggest that subclinical depression is associated with impairments in behavioral adjustments after internal (perceived failure) and external feedback about deficient task performance...
  32. ncbi Coupling of theta activity and glucose metabolism in the human rostral anterior cingulate cortex: an EEG/PET study of normal and depressed subjects
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, Massachusetts, USA
    Psychophysiology 40:939-49. 2003
    ..The results reveal a link between theta and cerebral metabolism in the ACC as well as disruption of functional connectivity within frontocingulate pathways in depression...
  33. pmc Delay discounting and future-directed thinking in anhedonic individuals
    Karolina M Lempert
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    J Behav Ther Exp Psychiatry 41:258-64. 2010
    ..The current findings provide preliminary evidence indicating that anhedonic individuals make less myopic decisions about their future, possibly due to their decreased responsiveness to immediate rewards...
  34. ncbi The worried mind: autonomic and prefrontal activation during worrying
    Stefan G Hofmann
    Boston University, Department of Psychology, Boston, MA 02215 2002, USA
    Emotion 5:464-75. 2005
    ..Trait public speaking anxiety was positively correlated with left frontal activity during worrying. These results support the notion that worrying is a unique emotional state that is different from fearful anticipation...
  35. pmc Individual differences in reinforcement learning: behavioral, electrophysiological, and neuroimaging correlates
    Diane L Santesso
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Neuroimage 42:807-16. 2008
    ..Furthermore, these results highlight the importance of the dACC to probabilistic reward learning in humans...
  36. ncbi Functional coupling of simultaneous electrical and metabolic activity in the human brain
    Terrence R Oakes
    W M Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    Hum Brain Mapp 21:257-70. 2004
    ..This method will be useful in the future when it is applied to functional imaging methods with faster time resolution, such as short half-life PET blood flow tracers and functional magnetic resonance imaging...
  37. ncbi Effects of electrode density and electrolyte spreading in dense array electroencephalographic recording
    Lawrence L Greischar
    Department of Psychology, University of Wisconsin Madison, Brogden Hall, Room 371, 1202 West Johnson Street, Madison, WI 53706, USA
    Clin Neurophysiol 115:710-20. 2004
    ..Power differences as a function of electrode density and electrolyte spreading were examined and a method for correcting these differences was tested...
  38. ncbi When 'go' and 'nogo' are equally frequent: ERP components and cortical tomography
    Aureliu Lavric
    School of Psychology, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, England
    Eur J Neurosci 20:2483-8. 2004
    ..Because a growing body of evidence implicates these brain regions in inhibitory processes, we conclude that N2 does, at least in part, reflect inhibition...
  39. pmc A single dose of nicotine enhances reward responsiveness in nonsmokers: implications for development of dependence
    Ruth S Barr
    Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 63:1061-5. 2008
    ..Accumulated evidence suggests that nicotine may increase appetitive responding for nondrug incentives in the environment...
  40. ncbi Perceived stress and cognitive vulnerability mediate the effects of personality disorder comorbidity on treatment outcome in major depressive disorder: a path analysis study
    Michele Candrian
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:729-37. 2007
    ..Depressogenic cognitions might be continuously activated by chronic distress in MDD subjects reporting axis II pathology, leading to stress exacerbation and eventually poorer treatment outcome...
  41. ncbi Frontal brain asymmetry in restrained eaters
    Jaime R Silva
    Psychobiology Department, Complutense University, Madrid, Spain
    J Abnorm Psychol 111:676-81. 2002
    ..Furthermore, relative right frontal activity was associated with greater self-reported restraint. Right-sided prefrontal asymmetry may thus represent a diathesis associated with increased vulnerability toward restrained eating...

Research Grants7

  1. Neuroimaging Studies of Reward Processing in Depression
    Diego Pizzagalli; Fiscal Year: 2007
    ..Overall, the integration of techniques with high temporal (ERP) and spatial (fMRI) resolution will enhance understanding of the functional neuroanatomy of depression. ..
  2. The effects of SAMe on reward circuitry in depression
    Diego Pizzagalli; Fiscal Year: 2007
    ..A better understanding of the mechanisms of actions of SAMe should, in turn, provide a foundation for future clinical trials. ..