Research Topics
Genomes and GenesSpecies | Diego PizzagalliSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsivenessDiego A Pizzagalli
Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
Psychopharmacology (Berl) 196:221-32. 2008..Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes remain largely unexplored in humans...
Resting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: a 128-channel EEG studyDiego A Pizzagalli
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Hum Brain Mapp 27:185-201. 2006..Because rostral ACC regions have been implicated in treatment response in depression, our findings provide initial insight into putative mechanisms fostering treatment response...- Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward taskDiego A Pizzagalli
Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
J Psychiatr Res 43:76-87. 2008..The goal of the present study was to test the hypothesis that individuals with major depression are characterized by blunted reward responsiveness, particularly when anhedonic symptoms are prominent... - Increased perceived stress is associated with blunted hedonic capacity: potential implications for depression researchDiego A Pizzagalli
Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
Behav Res Ther 45:2742-53. 2007..These findings are consistent with preclinical data highlighting links between stress and anhedonia, and offer promising insights into potential mechanisms linking stress to depression... - Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorderDiego A Pizzagalli
Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
Am J Psychiatry 166:702-10. 2009.... - Frontal brain asymmetry and reward responsiveness: a source-localization studyDiego A Pizzagalli
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Psychol Sci 16:805-13. 2005..8% of the variance in reward bias. These findings not only confirm that frontal EEG asymmetry modulates the propensity to engage in appetitively motivated behavior, but also provide anatomical details about the underlying brain systems... - Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depressionAvram J Holmes
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Neuropsychopharmacology 35:1186-97. 2010.... - Spatio-temporal dynamics of brain mechanisms in aversive classical conditioning: high-density event-related potential and brain electrical tomography analysesDiego A Pizzagalli
Department of Psychology, University of Wisconsin Madison, 1202 W Johnson Street, Madison, WI 53706, USA
Neuropsychologia 41:184-94. 2003.... - Functional but not structural subgenual prefrontal cortex abnormalities in melancholiaD A Pizzagalli
Department of Psychology, Harvard University, Cambridge, MA, USA
Mol Psychiatry 9:325, 393-405. 2004..Based on preclinical evidence, we suggest that subgenual PFC dysfunction in melancholia may be associated with blunted hedonic response and exaggerated stress responsiveness... - Toward an objective characterization of an anhedonic phenotype: a signal-detection approachDiego A Pizzagalli
Department of Psychology, Harvard University, Cambridge, Massachusetts, USA
Biol Psychiatry 57:319-27. 2005.... - Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical functionDiane L Santesso
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Hum Brain Mapp 30:1963-76. 2009..These preliminary findings offer important insights on the role of phasic DA signals on reinforcement learning in humans and provide initial evidence regarding the spatiotemporal dynamics of brain mechanisms underlying these processes... - Spatiotemporal dynamics of error processing dysfunctions in major depressive disorderAvram J Holmes
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Arch Gen Psychiatry 65:179-88. 2008..Depression is characterized by executive dysfunctions and abnormal reactions to errors; however, little is known about the brain mechanisms that underlie these deficits... - Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward taskDiego A Pizzagalli
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Biol Psychiatry 64:162-8. 2008..Our goal was to test the hypothesis that BPD is characterized by impairments in adjusting behavior as a function of prior reinforcement history, particularly in the presence of residual anhedonic symptoms... - Brain electrical tomography in depression: the importance of symptom severity, anxiety, and melancholic featuresDiego A Pizzagalli
Department of Psychology, University of Wisconsin-Madison, 57305-2280, USA
Biol Psychiatry 52:73-85. 2002.... - Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthoodDaniel G Dillon
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Biol Psychiatry 66:206-13. 2009..In animal models, early adversity is associated with dysfunction in basal ganglia regions involved in reward processing, but this relationship has not been established in humans... - Anxiety selectively disrupts visuospatial working memoryAlexander J Shackman
Department of Psychology, University of Wisconsin-Madison, 59706, USA
Emotion 6:40-61. 2006..These observations suggest a revision of extant models of how anxiety sculpts cognition and underscore the utility of the desiderata... - Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humansDaniel G Dillon
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Hum Brain Mapp 31:210-21. 2010..Future studies in depressed samples should evaluate whether variation in neural responses to rewards may contribute to the association between TREK1 and antidepressant response in humans... - Depression: perspectives from affective neuroscienceRichard J Davidson
Laboratory for Affective Neuroscience and W M Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin Madison, Madison, Wisconsin 53705 2280, USA
Annu Rev Psychol 53:545-74. 2002.... - Acute stress reduces reward responsiveness: implications for depressionRyan Bogdan
Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
Biol Psychiatry 60:1147-54. 2006..Stress-induced hedonic deficit is a promising candidate mechanism linking stressful experiences to depression... - Enhanced negative feedback responses in remitted depressionDiane L Santesso
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Neuroreport 19:1045-8. 2008..The present findings suggest that abnormal responses to negative feedback extend to samples at increased risk for depressive episodes in the absence of current symptoms... - Electrophysiological correlates of spatial orienting towards angry faces: a source localization studyDiane L Santesso
Department of Psychology, Harvard University, Cambridge, MA, USA
Neuropsychologia 46:1338-48. 2008..Results suggest that the earliest modulation of spatial attention by face stimuli is manifested in the P1 component, and provide insights about mechanisms underlying attentional orienting toward cues of threat and social disapproval... - Effects of task-relevant incentives on the electrophysiological correlates of error processing in major depressive disorderAvram J Holmes
Harvard University, Cambridge, Massachusetts, USA
Cogn Affect Behav Neurosci 10:119-28. 2010..The present findings highlight distinct effects of task incentives on electrophysiological components of error processing and are interpreted within current theories of action monitoring and incentive processing in depression... - Effects of early life stress on cognitive and affective function: an integrated review of human literaturePia Pechtel
Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Room 233C, De Marneffe Building, 115 Mill Street, Belmont, MA 02478 9106, USA
Psychopharmacology (Berl) 214:55-70. 2011..Emerging findings from longitudinal studies examining developmental trajectories of the brain in healthy samples may provide a new framework to understand mechanisms underlying ELS sequelae... - Neural substrates of attentional bias for smoking-related cues: an FMRI studyAmy C Janes
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 35:2339-45. 2010..Treatments capable of inhibiting shifts to drug cue-induced memories and internal states may lead to personalized tobacco dependence treatment for smokers with high attentional bias to smoking-related stimuli... - Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinenceAmy C Janes
Brain Imaging Center McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
Biol Psychiatry 67:722-9. 2010..We hypothesized that functional magnetic resonance imaging (fMRI) reactivity to smoking-related cues, measured before a quit attempt, could identify smokers with heightened relapse vulnerability... - Dissociation of neural regions associated with anticipatory versus consummatory phases of incentive processingDaniel G Dillon
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Psychophysiology 45:36-49. 2008..Although the study features several methodological improvements and helps clarify the neural basis of incentive processing, replications in larger samples are needed... - Frontocingulate dysfunction in depression: toward biomarkers of treatment responseDiego A Pizzagalli
Center for Depression, Anxiety, and Stress Research and Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Neuropsychopharmacology 36:183-206. 2011..The review ends with a discussion of the limitations of current work and future directions... - Response conflict and frontocingulate dysfunction in unmedicated participants with major depressionAvram J Holmes
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Neuropsychologia 46:2904-13. 2008.... - Dissociable recruitment of rostral anterior cingulate and inferior frontal cortex in emotional response inhibitionPearl H Chiu
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Neuroimage 42:988-97. 2008.... - Implicit depression and hopelessness in remitted depressed individualsTiffany M Meites
Harvard University, Psychology Department, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
Behav Res Ther 46:1078-84. 2008..Results extend prior IAT research by documenting the presence of a reduced tendency to associate the self with happiness in a sample at increased risk for depression... - Task feedback effects on conflict monitoring and executive control: relationship to subclinical measures of depressionAvram J Holmes
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Emotion 7:68-76. 2007..These findings suggest that subclinical depression is associated with impairments in behavioral adjustments after internal (perceived failure) and external feedback about deficient task performance... - Coupling of theta activity and glucose metabolism in the human rostral anterior cingulate cortex: an EEG/PET study of normal and depressed subjectsDiego A Pizzagalli
Department of Psychology, Harvard University, Cambridge, Massachusetts, USA
Psychophysiology 40:939-49. 2003..The results reveal a link between theta and cerebral metabolism in the ACC as well as disruption of functional connectivity within frontocingulate pathways in depression... - Delay discounting and future-directed thinking in anhedonic individualsKarolina M Lempert
Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
J Behav Ther Exp Psychiatry 41:258-64. 2010..The current findings provide preliminary evidence indicating that anhedonic individuals make less myopic decisions about their future, possibly due to their decreased responsiveness to immediate rewards... - The worried mind: autonomic and prefrontal activation during worryingStefan G Hofmann
Boston University, Department of Psychology, Boston, MA 02215 2002, USA
Emotion 5:464-75. 2005..Trait public speaking anxiety was positively correlated with left frontal activity during worrying. These results support the notion that worrying is a unique emotional state that is different from fearful anticipation... - Individual differences in reinforcement learning: behavioral, electrophysiological, and neuroimaging correlatesDiane L Santesso
Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
Neuroimage 42:807-16. 2008..Furthermore, these results highlight the importance of the dACC to probabilistic reward learning in humans... - Functional coupling of simultaneous electrical and metabolic activity in the human brainTerrence R Oakes
W M Keck Laboratory for Functional Brain Imaging and Behavior, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
Hum Brain Mapp 21:257-70. 2004..This method will be useful in the future when it is applied to functional imaging methods with faster time resolution, such as short half-life PET blood flow tracers and functional magnetic resonance imaging... - Effects of electrode density and electrolyte spreading in dense array electroencephalographic recordingLawrence L Greischar
Department of Psychology, University of Wisconsin-Madison, Brogden Hall, Room 371, 1202 West Johnson Street, Madison, WI 53706, USA
Clin Neurophysiol 115:710-20. 2004..Interpolation using spherical splines offers a method for correcting the potentials measured at these electrodes... - When 'go' and 'nogo' are equally frequent: ERP components and cortical tomographyAureliu Lavric
School of Psychology, University of Exeter, Washington Singer Laboratories, Perry Road, Exeter EX4 4QG, England
Eur J Neurosci 20:2483-8. 2004..Because a growing body of evidence implicates these brain regions in inhibitory processes, we conclude that N2 does, at least in part, reflect inhibition... - A single dose of nicotine enhances reward responsiveness in nonsmokers: implications for development of dependenceRuth S Barr
Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 63:1061-5. 2008..Accumulated evidence suggests that nicotine may increase appetitive responding for nondrug incentives in the environment... - Perceived stress and cognitive vulnerability mediate the effects of personality disorder comorbidity on treatment outcome in major depressive disorder: a path analysis studyMichele Candrian
Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Nerv Ment Dis 195:729-37. 2007..Depressogenic cognitions might be continuously activated by chronic distress in MDD subjects reporting axis II pathology, leading to stress exacerbation and eventually poorer treatment outcome... - Frontal brain asymmetry in restrained eatersJaime R Silva
Psychobiology Department, Complutense University, Madrid, Spain
J Abnorm Psychol 111:676-81. 2002..Furthermore, relative right frontal activity was associated with greater self-reported restraint. Right-sided prefrontal asymmetry may thus represent a diathesis associated with increased vulnerability toward restrained eating...
Research Grants
- Neuroimaging Studies of Reward Processing in DepressionDiego Pizzagalli; Fiscal Year: 2007..Overall, the integration of techniques with high temporal (ERP) and spatial (fMRI) resolution will enhance understanding of the functional neuroanatomy of depression. ..
- The effects of SAMe on reward circuitry in depressionDiego Pizzagalli; Fiscal Year: 2007..A better understanding of the mechanisms of actions of SAMe should, in turn, provide a foundation for future clinical trials. ..