Diego A Pizzagalli

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research
    A Der-Avakian
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Transl Psychiatry 3:e297. 2013
  2. pmc Acute stress selectively reduces reward sensitivity
    Lisa H Berghorst
    Department of Psychology, Harvard University Cambridge, MA, USA Center for Depression, Anxiety and Stress Research, Harvard Medical School, McLean Hospital Belmont, MA, USA
    Front Hum Neurosci 7:133. 2013
  3. pmc Depression, stress, and anhedonia: toward a synthesis and integrated model
    Diego A Pizzagalli
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478 email
    Annu Rev Clin Psychol 10:393-423. 2014
  4. pmc Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis
    Quentin Jm Huys
    Gatsby Computational Neuroscience Unit, UCL, London, UK
    Biol Mood Anxiety Disord 3:12. 2013
  5. pmc Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study
    Elena L Goetz
    Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
    Biol Mood Anxiety Disord 3:3. 2013
  6. pmc Frontocingulate dysfunction in depression: toward biomarkers of treatment response
    Diego A Pizzagalli
    Center for Depression, Anxiety, and Stress Research and Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 36:183-206. 2011
  7. pmc Enhanced negative feedback responses in remitted depression
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Neuroreport 19:1045-8. 2008
  8. pmc Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthood
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Biol Psychiatry 66:206-13. 2009
  9. pmc Spatiotemporal dynamics of error processing dysfunctions in major depressive disorder
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Arch Gen Psychiatry 65:179-88. 2008
  10. pmc Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Hum Brain Mapp 30:1963-76. 2009

Research Grants

  1. Neuroimaging Studies of Reward Processing in Depression
    Diego A Pizzagalli; Fiscal Year: 2010
  2. Neuroimaging Studies of Reward Processing in Depression
    Diego A Pizzagalli; Fiscal Year: 2010

Collaborators

Detail Information

Publications46

  1. pmc Assessment of reward responsiveness in the response bias probabilistic reward task in rats: implications for cross-species translational research
    A Der-Avakian
    Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093 0603, USA
    Transl Psychiatry 3:e297. 2013
    ..Thus, this new procedure in rats, which is conceptually and procedurally analogous to the one used in humans, provides a reverse translational platform to investigate abnormal reward responsiveness across species...
  2. pmc Acute stress selectively reduces reward sensitivity
    Lisa H Berghorst
    Department of Psychology, Harvard University Cambridge, MA, USA Center for Depression, Anxiety and Stress Research, Harvard Medical School, McLean Hospital Belmont, MA, USA
    Front Hum Neurosci 7:133. 2013
    ..While such results highlight the possibility that stress-induced anhedonia might be an important mechanism linking stress to affective disorders, future studies are necessary to confirm this conjecture...
  3. pmc Depression, stress, and anhedonia: toward a synthesis and integrated model
    Diego A Pizzagalli
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478 email
    Annu Rev Clin Psychol 10:393-423. 2014
    ..In the last section, we provide a synthesis of these four literatures, present initial evidence consistent with our model, and discuss directions for future research. ..
  4. pmc Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis
    Quentin Jm Huys
    Gatsby Computational Neuroscience Unit, UCL, London, UK
    Biol Mood Anxiety Disord 3:12. 2013
    ..We attempted to disentangle these factors with respect to anhedonia in the context of stress, Major Depressive Disorder (MDD), Bipolar Disorder (BPD) and a dopaminergic challenge...
  5. pmc Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study
    Elena L Goetz
    Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
    Biol Mood Anxiety Disord 3:3. 2013
    ..abstract:..
  6. pmc Frontocingulate dysfunction in depression: toward biomarkers of treatment response
    Diego A Pizzagalli
    Center for Depression, Anxiety, and Stress Research and Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 36:183-206. 2011
    ..The review ends with a discussion of the limitations of current work and future directions...
  7. pmc Enhanced negative feedback responses in remitted depression
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Neuroreport 19:1045-8. 2008
    ..The present findings suggest that abnormal responses to negative feedback extend to samples at increased risk for depressive episodes in the absence of current symptoms...
  8. pmc Childhood adversity is associated with left basal ganglia dysfunction during reward anticipation in adulthood
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Biol Psychiatry 66:206-13. 2009
    ..In animal models, early adversity is associated with dysfunction in basal ganglia regions involved in reward processing, but this relationship has not been established in humans...
  9. pmc Spatiotemporal dynamics of error processing dysfunctions in major depressive disorder
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Arch Gen Psychiatry 65:179-88. 2008
    ..Depression is characterized by executive dysfunctions and abnormal reactions to errors; however, little is known about the brain mechanisms that underlie these deficits...
  10. pmc Single dose of a dopamine agonist impairs reinforcement learning in humans: evidence from event-related potentials and computational modeling of striatal-cortical function
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Hum Brain Mapp 30:1963-76. 2009
    ..These preliminary findings offer important insights on the role of phasic DA signals on reinforcement learning in humans and provide initial evidence regarding the spatiotemporal dynamics of brain mechanisms underlying these processes...
  11. pmc Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence
    Amy C Janes
    Brain Imaging Center McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 67:722-9. 2010
    ..We hypothesized that functional magnetic resonance imaging (fMRI) reactivity to smoking-related cues, measured before a quit attempt, could identify smokers with heightened relapse vulnerability...
  12. pmc Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
    Am J Psychiatry 166:702-10. 2009
    ....
  13. pmc Neural responses to negative feedback are related to negative emotionality in healthy adults
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Soc Cogn Affect Neurosci 7:794-803. 2012
    ....
  14. pmc Corticotropin-releasing hormone receptor type 1 (CRHR1) genetic variation and stress interact to influence reward learning
    Ryan Bogdan
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 31:13246-54. 2011
    ..Homozygosity for the A allele at rs12938031 may increase risk for psychopathology via stress-induced reward learning deficits...
  15. pmc Neural substrates of attentional bias for smoking-related cues: an FMRI study
    Amy C Janes
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 35:2339-45. 2010
    ..Treatments capable of inhibiting shifts to drug cue-induced memories and internal states may lead to personalized tobacco dependence treatment for smokers with high attentional bias to smoking-related stimuli...
  16. pmc Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    J Psychiatr Res 43:76-87. 2008
    ..The goal of the present study was to test the hypothesis that individuals with major depression are characterized by blunted reward responsiveness, particularly when anhedonic symptoms are prominent...
  17. pmc Variation in TREK1 gene linked to depression-resistant phenotype is associated with potentiated neural responses to rewards in humans
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hum Brain Mapp 31:210-21. 2010
    ..Future studies in depressed samples should evaluate whether variation in neural responses to rewards may contribute to the association between TREK1 and antidepressant response in humans...
  18. pmc Individual differences in reinforcement learning: behavioral, electrophysiological, and neuroimaging correlates
    Diane L Santesso
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Neuroimage 42:807-16. 2008
    ..Furthermore, these results highlight the importance of the dACC to probabilistic reward learning in humans...
  19. pmc Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuropsychopharmacology 35:1186-97. 2010
    ....
  20. pmc GABA levels in the dorsal anterior cingulate cortex associated with difficulty ignoring smoking-related cues in tobacco-dependent volunteers
    Amy C Janes
    Brain Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 38:1113-20. 2013
    ..This newly discovered relationship between dACC GABA and attentional bias provides evidence for a neurochemical target, which may aid smoking cessation in highly cue-reactive individuals...
  21. pmc Electrophysiological correlates of spatial orienting towards angry faces: a source localization study
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Neuropsychologia 46:1338-48. 2008
    ..Results suggest that the earliest modulation of spatial attention by face stimuli is manifested in the P1 component, and provide insights about mechanisms underlying attentional orienting toward cues of threat and social disapproval...
  22. pmc Response conflict and frontocingulate dysfunction in unmedicated participants with major depression
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuropsychologia 46:2904-13. 2008
    ....
  23. ncbi request reprint Prefrontal oscillations during recall of conditioned and extinguished fear in humans
    Erik M Mueller
    Department of Clinical Psychology, Justus Liebig University Giessen, 35394 Giessen, Germany, and Center For Depression, Anxiety and Stress Research and McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478
    J Neurosci 34:7059-66. 2014
    ..The present work thereby bridges findings from prior rodent electrophysiological research and human neuroimaging studies and indicates that EEG is a valuable tool for future fear extinction research. ..
  24. pmc Perception of a naturalistic stressor interacts with 5-HTTLPR/rs25531 genotype and gender to impact reward responsiveness
    Yuliya Nikolova
    Affective Neuroscience Laboratory, Department of Psychology, Harvard University, Cambridge, MA, USA
    Neuropsychobiology 65:45-54. 2012
    ....
  25. pmc Euthymic patients with bipolar disorder show decreased reward learning in a probabilistic reward task
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Biol Psychiatry 64:162-8. 2008
    ..Our goal was to test the hypothesis that BPD is characterized by impairments in adjusting behavior as a function of prior reinforcement history, particularly in the presence of residual anhedonic symptoms...
  26. ncbi request reprint Frontal brain asymmetry and reward responsiveness: a source-localization study
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychol Sci 16:805-13. 2005
    ..8% of the variance in reward bias. These findings not only confirm that frontal EEG asymmetry modulates the propensity to engage in appetitively motivated behavior, but also provide anatomical details about the underlying brain systems...
  27. pmc Increased perceived stress is associated with blunted hedonic capacity: potential implications for depression research
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Behav Res Ther 45:2742-53. 2007
    ..These findings are consistent with preclinical data highlighting links between stress and anhedonia, and offer promising insights into potential mechanisms linking stress to depression...
  28. ncbi request reprint Anxiety selectively disrupts visuospatial working memory
    Alexander J Shackman
    Department of Psychology, University of Wisconsin Madison, 59706, USA
    Emotion 6:40-61. 2006
    ..These observations suggest a revision of extant models of how anxiety sculpts cognition and underscore the utility of the desiderata...
  29. pmc Dissociation of neural regions associated with anticipatory versus consummatory phases of incentive processing
    Daniel G Dillon
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Psychophysiology 45:36-49. 2008
    ..Although the study features several methodological improvements and helps clarify the neural basis of incentive processing, replications in larger samples are needed...
  30. pmc Asymmetry in resting intracortical activity as a buffer to social threat
    Katrina Koslov
    Department of Psychiatry, University of California, San Francisco, CA 94111, USA
    Psychol Sci 22:641-9. 2011
    ..Our data are the first to show that social context matters when attempting to link individual differences in cortical asymmetry with approach-related cardiovascular and emotional outcomes...
  31. pmc Dissociable recruitment of rostral anterior cingulate and inferior frontal cortex in emotional response inhibition
    Pearl H Chiu
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuroimage 42:988-97. 2008
    ....
  32. pmc Varenicline as a smoking cessation aid in schizophrenia: effects on smoking behavior and reward sensitivity
    Sunny J Dutra
    Department of Psychology, Yale University, P O Box 208205, New Haven, CT 06520, USA
    Psychopharmacology (Berl) 219:25-34. 2012
    ..To maximize treatment efficacy while minimizing risks, it is critical to identify reliable predictors of positive response to varenicline in smokers with schizophrenia...
  33. pmc Effects of early life stress on cognitive and affective function: an integrated review of human literature
    Pia Pechtel
    Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Room 233C, De Marneffe Building, 115 Mill Street, Belmont, MA 02478 9106, USA
    Psychopharmacology (Berl) 214:55-70. 2011
    ..Emerging findings from longitudinal studies examining developmental trajectories of the brain in healthy samples may provide a new framework to understand mechanisms underlying ELS sequelae...
  34. pmc Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Psychopharmacology (Berl) 196:221-32. 2008
    ..Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes remain largely unexplored in humans...
  35. pmc A single dose of nicotine enhances reward responsiveness in nonsmokers: implications for development of dependence
    Ruth S Barr
    Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 63:1061-5. 2008
    ..Accumulated evidence suggests that nicotine may increase appetitive responding for nondrug incentives in the environment...
  36. ncbi request reprint Perceived stress and cognitive vulnerability mediate the effects of personality disorder comorbidity on treatment outcome in major depressive disorder: a path analysis study
    Michele Candrian
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:729-37. 2007
    ..Depressogenic cognitions might be continuously activated by chronic distress in MDD subjects reporting axis II pathology, leading to stress exacerbation and eventually poorer treatment outcome...
  37. pmc Neurogenetics of depression: a focus on reward processing and stress sensitivity
    Ryan Bogdan
    BRAIN Laboratory, Department of Psychology, Washington University in St Louis, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Neurobiol Dis 52:12-23. 2013
    ..We conclude by highlighting challenges facing intermediate phenotype research and future development that will be required to propel this pivotal research into new directions...
  38. pmc Behavioral and electrophysiological correlates of training-induced cognitive control improvements
    Alexander J Millner
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Neuroimage 63:742-53. 2012
    ..Overall, results suggest that a brief training can improve cognitive control, specifically the ability to inhibit task-irrelevant information...
  39. ncbi request reprint Spatio-temporal dynamics of brain mechanisms in aversive classical conditioning: high-density event-related potential and brain electrical tomography analyses
    Diego A Pizzagalli
    Department of Psychology, University of Wisconsin Madison, 1202 W Johnson Street, Madison, WI 53706, USA
    Neuropsychologia 41:184-94. 2003
    ....
  40. pmc Delay discounting and future-directed thinking in anhedonic individuals
    Karolina M Lempert
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    J Behav Ther Exp Psychiatry 41:258-64. 2010
    ..The current findings provide preliminary evidence indicating that anhedonic individuals make less myopic decisions about their future, possibly due to their decreased responsiveness to immediate rewards...
  41. ncbi request reprint The worried mind: autonomic and prefrontal activation during worrying
    Stefan G Hofmann
    Boston University, Department of Psychology, Boston, MA 02215 2002, USA
    Emotion 5:464-75. 2005
    ..Trait public speaking anxiety was positively correlated with left frontal activity during worrying. These results support the notion that worrying is a unique emotional state that is different from fearful anticipation...
  42. pmc Task feedback effects on conflict monitoring and executive control: relationship to subclinical measures of depression
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Emotion 7:68-76. 2007
    ..These findings suggest that subclinical depression is associated with impairments in behavioral adjustments after internal (perceived failure) and external feedback about deficient task performance...
  43. pmc Acute stress reduces reward responsiveness: implications for depression
    Ryan Bogdan
    Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
    Biol Psychiatry 60:1147-54. 2006
    ..Stress, one of the strongest risk factors for depression, has been linked to "anhedonic" behavior and dysfunctional reward-related neural circuitry in preclinical models...
  44. pmc Peril and pleasure: an rdoc-inspired examination of threat responses and reward processing in anxiety and depression
    Daniel G Dillon
    Center for Depression, Anxiety and Stress Research, McLean Hospital, Harvard Medical School, Boston, Massachusetts
    Depress Anxiety 31:233-49. 2014
    ..In addition to its basic scientific value, a better understanding of interactions between the neural systems that mediate threat and reward responses may offer relief from the burdensome condition of anxious depression. ..
  45. pmc Disrupted reinforcement learning and maladaptive behavior in women with a history of childhood sexual abuse: a high-density event-related potential study
    Pia Pechtel
    Center for Depression, Anxiety and Stress Research, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    JAMA Psychiatry 70:499-507. 2013
    ..Despite the epidemiological data available, the mechanisms underlying these maladaptive outcomes remain poorly understood...
  46. ncbi request reprint Resting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: a 128-channel EEG study
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hum Brain Mapp 27:185-201. 2006
    ..Because rostral ACC regions have been implicated in treatment response in depression, our findings provide initial insight into putative mechanisms fostering treatment response...

Research Grants2

  1. Neuroimaging Studies of Reward Processing in Depression
    Diego A Pizzagalli; Fiscal Year: 2010
    ....
  2. Neuroimaging Studies of Reward Processing in Depression
    Diego A Pizzagalli; Fiscal Year: 2010
    ....