Diego A Pizzagalli

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Depression, stress, and anhedonia: toward a synthesis and integrated model
    Diego A Pizzagalli
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478 email
    Annu Rev Clin Psychol 10:393-423. 2014
  2. pmc Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis
    Quentin Jm Huys
    Gatsby Computational Neuroscience Unit, UCL, London, UK
    Biol Mood Anxiety Disord 3:12. 2013
  3. pmc Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study
    Elena L Goetz
    Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
    Biol Mood Anxiety Disord 3:3. 2013
  4. pmc Neural responses to negative feedback are related to negative emotionality in healthy adults
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Soc Cogn Affect Neurosci 7:794-803. 2012
  5. pmc Frontocingulate dysfunction in depression: toward biomarkers of treatment response
    Diego A Pizzagalli
    Center for Depression, Anxiety, and Stress Research and Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 36:183-206. 2011
  6. ncbi request reprint Perceived stress and cognitive vulnerability mediate the effects of personality disorder comorbidity on treatment outcome in major depressive disorder: a path analysis study
    Michele Candrian
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:729-37. 2007
  7. pmc Effects of early life stress on cognitive and affective function: an integrated review of human literature
    Pia Pechtel
    Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Room 233C, De Marneffe Building, 115 Mill Street, Belmont, MA 02478 9106, USA
    Psychopharmacology (Berl) 214:55-70. 2011
  8. pmc Neural substrates of attentional bias for smoking-related cues: an FMRI study
    Amy C Janes
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 35:2339-45. 2010
  9. pmc Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence
    Amy C Janes
    Brain Imaging Center McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 67:722-9. 2010
  10. pmc Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuropsychopharmacology 35:1186-97. 2010

Research Grants

  1. Neuroimaging Studies of Reward Processing in Depression
    Diego A Pizzagalli; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. doi request reprint Depression, stress, and anhedonia: toward a synthesis and integrated model
    Diego A Pizzagalli
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478 email
    Annu Rev Clin Psychol 10:393-423. 2014
    ..In the last section, we provide a synthesis of these four literatures, present initial evidence consistent with our model, and discuss directions for future research. ..
  2. pmc Mapping anhedonia onto reinforcement learning: a behavioural meta-analysis
    Quentin Jm Huys
    Gatsby Computational Neuroscience Unit, UCL, London, UK
    Biol Mood Anxiety Disord 3:12. 2013
    ..We attempted to disentangle these factors with respect to anhedonia in the context of stress, Major Depressive Disorder (MDD), Bipolar Disorder (BPD) and a dopaminergic challenge...
  3. pmc Genetic moderation of the association between regulatory focus and reward responsiveness: a proof-of-concept study
    Elena L Goetz
    Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
    Biol Mood Anxiety Disord 3:3. 2013
    ..abstract:..
  4. pmc Neural responses to negative feedback are related to negative emotionality in healthy adults
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, MA, USA
    Soc Cogn Affect Neurosci 7:794-803. 2012
    ....
  5. pmc Frontocingulate dysfunction in depression: toward biomarkers of treatment response
    Diego A Pizzagalli
    Center for Depression, Anxiety, and Stress Research and Neuroimaging Center, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Neuropsychopharmacology 36:183-206. 2011
    ..The review ends with a discussion of the limitations of current work and future directions...
  6. ncbi request reprint Perceived stress and cognitive vulnerability mediate the effects of personality disorder comorbidity on treatment outcome in major depressive disorder: a path analysis study
    Michele Candrian
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 195:729-37. 2007
    ..Depressogenic cognitions might be continuously activated by chronic distress in MDD subjects reporting axis II pathology, leading to stress exacerbation and eventually poorer treatment outcome...
  7. pmc Effects of early life stress on cognitive and affective function: an integrated review of human literature
    Pia Pechtel
    Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Room 233C, De Marneffe Building, 115 Mill Street, Belmont, MA 02478 9106, USA
    Psychopharmacology (Berl) 214:55-70. 2011
    ..Emerging findings from longitudinal studies examining developmental trajectories of the brain in healthy samples may provide a new framework to understand mechanisms underlying ELS sequelae...
  8. pmc Neural substrates of attentional bias for smoking-related cues: an FMRI study
    Amy C Janes
    Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 35:2339-45. 2010
    ..Treatments capable of inhibiting shifts to drug cue-induced memories and internal states may lead to personalized tobacco dependence treatment for smokers with high attentional bias to smoking-related stimuli...
  9. pmc Brain reactivity to smoking cues prior to smoking cessation predicts ability to maintain tobacco abstinence
    Amy C Janes
    Brain Imaging Center McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 67:722-9. 2010
    ..We hypothesized that functional magnetic resonance imaging (fMRI) reactivity to smoking-related cues, measured before a quit attempt, could identify smokers with heightened relapse vulnerability...
  10. pmc Serotonin transporter genotype and action monitoring dysfunction: a possible substrate underlying increased vulnerability to depression
    Avram J Holmes
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Neuropsychopharmacology 35:1186-97. 2010
    ....
  11. pmc Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
    Am J Psychiatry 166:702-10. 2009
    ....
  12. pmc Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    J Psychiatr Res 43:76-87. 2008
    ..The goal of the present study was to test the hypothesis that individuals with major depression are characterized by blunted reward responsiveness, particularly when anhedonic symptoms are prominent...
  13. pmc Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Psychopharmacology (Berl) 196:221-32. 2008
    ..Animal studies have emphasized the role of phasic dopamine (DA) signaling in reward-related learning, but these processes remain largely unexplored in humans...
  14. pmc Increased perceived stress is associated with blunted hedonic capacity: potential implications for depression research
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA
    Behav Res Ther 45:2742-53. 2007
    ..These findings are consistent with preclinical data highlighting links between stress and anhedonia, and offer promising insights into potential mechanisms linking stress to depression...
  15. ncbi request reprint Frontal brain asymmetry and reward responsiveness: a source-localization study
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychol Sci 16:805-13. 2005
    ..8% of the variance in reward bias. These findings not only confirm that frontal EEG asymmetry modulates the propensity to engage in appetitively motivated behavior, but also provide anatomical details about the underlying brain systems...
  16. ncbi request reprint Resting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: a 128-channel EEG study
    Diego A Pizzagalli
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Hum Brain Mapp 27:185-201. 2006
    ..Because rostral ACC regions have been implicated in treatment response in depression, our findings provide initial insight into putative mechanisms fostering treatment response...
  17. ncbi request reprint Spatio-temporal dynamics of brain mechanisms in aversive classical conditioning: high-density event-related potential and brain electrical tomography analyses
    Diego A Pizzagalli
    Department of Psychology, University of Wisconsin Madison, 1202 W Johnson Street, Madison, WI 53706, USA
    Neuropsychologia 41:184-94. 2003
    ....
  18. pmc A single dose of nicotine enhances reward responsiveness in nonsmokers: implications for development of dependence
    Ruth S Barr
    Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Psychiatry 63:1061-5. 2008
    ..Accumulated evidence suggests that nicotine may increase appetitive responding for nondrug incentives in the environment...

Research Grants2

  1. Neuroimaging Studies of Reward Processing in Depression
    Diego A Pizzagalli; Fiscal Year: 2010
    ....