Roger Pitman

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
    Lisa M Shin
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Ann N Y Acad Sci 1071:67-79. 2006
  2. pmc The relationship between Hippocampal asymmetry and working memory processing in combat-related PTSD - a monozygotic twin study
    Timothy Hall
    Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia
    Biol Mood Anxiety Disord 2:21. 2012
  3. pmc Predicting post-trauma stress symptoms from pre-trauma psychophysiologic reactivity, personality traits and measures of psychopathology
    Scott P Orr
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Biol Mood Anxiety Disord 2:8. 2012
  4. pmc An fMRI study of unconditioned responses in post-traumatic stress disorder
    Clas Linnman
    Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA
    Biol Mood Anxiety Disord 1:8. 2011
  5. ncbi request reprint Psychophysiologic assessment of posttraumatic stress disorder in breast cancer patients
    R K Pitman
    VA Research Service, Manchester, New Hampshire, USA
    Psychosomatics 42:133-40. 2001
  6. ncbi request reprint Combat effects on mental health: the more things change, the more they remain the same
    Roger K Pitman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Arch Gen Psychiatry 63:127-8. 2006
  7. ncbi request reprint Conceptually driven pharmacologic approaches to acute trauma
    Roger K Pitman
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    CNS Spectr 10:99-106. 2005
  8. ncbi request reprint Commentary: synthesis and perspectives
    R K Pitman
    Massachusetts General Hospital East, Charleston, MA 02129, USA
    Prog Brain Res 167:249-54. 2008
  9. pmc Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure
    Roger K Pitman
    Massachusetts General Hospital, Room 2616, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 1071:242-54. 2006
  10. doi request reprint Systemic mifepristone blocks reconsolidation of cue-conditioned fear; propranolol prevents this effect
    Roger K Pitman
    Department of Psychiatry, Massachusetts General Hospital, MGH East, 120 Second Avenue, Charlestown, MA 02129, USA
    Behav Neurosci 125:632-8. 2011

Research Grants

  1. Prophylaxis of PTSD with Post-Trauma Propranolol
    Roger Pitman; Fiscal Year: 2007
  2. TWIN STUDY OF BIOLOGIC MARKERS FOR PTSD
    Roger Pitman; Fiscal Year: 2006
  3. TWIN STUDY OF BIOLOGIC MARKERS FOR PTSD
    Roger Pitman; Fiscal Year: 2004

Detail Information

Publications64

  1. ncbi request reprint Amygdala, medial prefrontal cortex, and hippocampal function in PTSD
    Lisa M Shin
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Ann N Y Acad Sci 1071:67-79. 2006
    ..Lastly, the reviewed research suggests diminished volumes, neuronal integrity, and functional integrity of the hippocampus in PTSD. Remaining research questions and related future directions are presented...
  2. pmc The relationship between Hippocampal asymmetry and working memory processing in combat-related PTSD - a monozygotic twin study
    Timothy Hall
    Discipline of Psychiatry, School of Medicine, University of Adelaide, Adelaide, Australia
    Biol Mood Anxiety Disord 2:21. 2012
    ..abstract:..
  3. pmc Predicting post-trauma stress symptoms from pre-trauma psychophysiologic reactivity, personality traits and measures of psychopathology
    Scott P Orr
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Biol Mood Anxiety Disord 2:8. 2012
    ..abstract:..
  4. pmc An fMRI study of unconditioned responses in post-traumatic stress disorder
    Clas Linnman
    Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA
    Biol Mood Anxiety Disord 1:8. 2011
    ..abstract:..
  5. ncbi request reprint Psychophysiologic assessment of posttraumatic stress disorder in breast cancer patients
    R K Pitman
    VA Research Service, Manchester, New Hampshire, USA
    Psychosomatics 42:133-40. 2001
    ..Physiologic responses were significantly and positively correlated with CAPS scores. These results provide psychophysiologic support for the proposition that a diagnosis of with a life-threatening illness can cause PTSD...
  6. ncbi request reprint Combat effects on mental health: the more things change, the more they remain the same
    Roger K Pitman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
    Arch Gen Psychiatry 63:127-8. 2006
  7. ncbi request reprint Conceptually driven pharmacologic approaches to acute trauma
    Roger K Pitman
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    CNS Spectr 10:99-106. 2005
    ..One study did not find benzodiazepines effective in preventing PTSD. Selective serotonin reuptake inhibitors, antiepileptics, and alpha2-adrenergic agonists have yet to be tried...
  8. ncbi request reprint Commentary: synthesis and perspectives
    R K Pitman
    Massachusetts General Hospital East, Charleston, MA 02129, USA
    Prog Brain Res 167:249-54. 2008
  9. pmc Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposure
    Roger K Pitman
    Massachusetts General Hospital, Room 2616, Bldg 149, 13th St, Charlestown, MA 02129, USA
    Ann N Y Acad Sci 1071:242-54. 2006
    ..These results support the conclusion that the latter abnormalities represent antecedent, familial vulnerability factors for developing chronic PTSD upon exposure to a traumatic event...
  10. doi request reprint Systemic mifepristone blocks reconsolidation of cue-conditioned fear; propranolol prevents this effect
    Roger K Pitman
    Department of Psychiatry, Massachusetts General Hospital, MGH East, 120 Second Avenue, Charlestown, MA 02129, USA
    Behav Neurosci 125:632-8. 2011
    ..Concurrent administration of propranolol prevents this effect. Postreactivation mifepristone may be a promising treatment for PTSD, but not necessarily in combination with propranolol...
  11. pmc Configural cue performance in identical twins discordant for posttraumatic stress disorder: theoretical implications for the role of hippocampal function
    Mark W Gilbertson
    Manchester VA Medical Center, Manchester, New Hampshire 03104, USA
    Biol Psychiatry 62:513-20. 2007
    ..We test the hypothesis that hippocampus-based configural processing deficits are a pre-existing vulnerability factor for unremitting forms of PTSD...
  12. ncbi request reprint Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 62:446-54. 2007
    ..The aim of the present study is to investigate the mediating anatomy of extinction recall in healthy humans...
  13. ncbi request reprint Subtle neurologic compromise as a vulnerability factor for combat-related posttraumatic stress disorder: results of a twin study
    Tamara V Gurvits
    Research Service, Veterans Affairs Medical Center, Manchester, NH, USA
    Arch Gen Psychiatry 63:571-6. 2006
    ..Previous studies have demonstrated subtle neurologic dysfunction in chronic posttraumatic stress disorder (PTSD) manifest as increased neurologic soft signs (NSSs). The origin of this dysfunction is undetermined...
  14. pmc Intensity dependence of auditory P2 in monozygotic twins discordant for Vietnam combat: associations with posttraumatic stress disorder
    Linda J Metzger
    Research Service, Department of Veterans Affairs VA Medical Center, Manchester, NH 03104, USA
    J Rehabil Res Dev 45:437-49. 2008
    ..Inspection of group means suggests that the observed increased P2 intensity dependence is a consequence of PTSD. Our findings further suggest that low serotonergic tone may emerge as one potential consequence of this disorder...
  15. ncbi request reprint Fear extinction in rats: implications for human brain imaging and anxiety disorders
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Bldg 149 13th St, Charlestown, 02129, USA
    Biol Psychol 73:61-71. 2006
    ....
  16. doi request reprint Event-related potentials to auditory stimuli in monozygotic twins discordant for combat: association with PTSD
    Linda J Metzger
    Veterans Affairs Medical Center, Manchester, New Hampshire 03104, USA
    Psychophysiology 46:172-8. 2009
    ..Results replicate increased N2 latency and diminished P3b amplitude in PTSD and suggest that diminished P3b amplitude is an acquired condition in PTSD...
  17. ncbi request reprint Performance on visuospatial copying tasks in individuals with chronic posttraumatic stress disorder
    Tamara V Gurvits
    VA Research Service, 718 Smyth Rd, Manchester, NH 03104, USA
    Psychiatry Res 112:263-8. 2002
    ..These findings are consistent with pre-trauma visual-spatial impairment as being among the risk factors for chronic PTSD...
  18. pmc Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memory
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 102:10706-11. 2005
    ..e., greater extinction memory). These results suggest that the size of the vmPFC might explain individual differences in the ability to modulate fear among humans...
  19. ncbi request reprint Orbitofrontal thickness, retention of fear extinction, and extraversion
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Neuroreport 16:1909-12. 2005
    ..Path analysis indicates that extinction retention mediates the relationship between the medial orbitofrontal cortex thickness and extraversion, thereby illustrating one path through which brain structure influences personality...
  20. ncbi request reprint Psychophysiology of post-traumatic stress disorder
    Scott P Orr
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Psychiatr Clin North Am 25:271-93. 2002
    ..We hope that the broad range of psychophysiologic investigations and findings in PTSD will inspire others to consider possible applications of these methodologies to their own clinical and research endeavors...
  21. ncbi request reprint Assessment of posttraumatic stress disorder in Cambodian refugees using the Clinician-Administered PTSD Scale: psychometric properties and symptom severity
    Devon E Hinton
    Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
    J Trauma Stress 19:405-9. 2006
    ..Those patients who met criteria for current PTSD had significantly higher CAPS total scores (M = 65.3, SD = 18.1) than those who did not meet the criteria (M = 13.9, SD = 16.7)...
  22. ncbi request reprint Physiologic responses to loud tones in individuals with obsessive-compulsive disorder
    Ulrike Buhlmann
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Psychosom Med 69:166-72. 2007
    ..To determine if individuals with obsessive-compulsive disorder (OCD) are characterized by larger eyeblink and/or autonomic responses to sudden, loud (startling) tones...
  23. ncbi request reprint A role for the human dorsal anterior cingulate cortex in fear expression
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 62:1191-4. 2007
    ..This study examined the role of dACC during fear conditioning in healthy humans with magnetic resonance imaging (MRI)...
  24. ncbi request reprint Physiologic responses to sudden, loud tones in monozygotic twins discordant for combat exposure: association with posttraumatic stress disorder
    Scott P Orr
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Arch Gen Psychiatry 60:283-8. 2003
    ..Studying identical twins discordant for traumatic exposure offers an opportunity to resolve these competing origins...
  25. pmc The panic attack-posttraumatic stress disorder model: applicability to orthostatic panic among Cambodian refugees
    Devon E Hinton
    Southeast Asian Clinic, Arbour Counseling Services, Lowell, MA 02114, USA
    Cogn Behav Ther 37:101-16. 2008
    ....
  26. ncbi request reprint PTSD arousal and depression symptoms associated with increased right-sided parietal EEG asymmetry
    Linda J Metzger
    Veterans Affairs Medical Center Research Service, Manchester, NH 03104, USA
    J Abnorm Psychol 113:324-9. 2004
    ..These findings underscore the importance of isolating, both theoretically and statistically, emotional subcomponents in studies of regional brain activation...
  27. ncbi request reprint Selectively reduced regional cortical volumes in post-traumatic stress disorder
    Scott L Rauch
    Psychiatric Neuroimaging Research Group, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroreport 14:913-6. 2003
    ..These results are consistent with contemporary schemes regarding functional and structural dissection of frontal cortex, and suggest specific regional cortical pathology in PTSD...
  28. pmc Stress reduction correlates with structural changes in the amygdala
    Britta K Hölzel
    Massachusetts General Hospital, Charlestown, MA 02129, USA
    Soc Cogn Affect Neurosci 5:11-7. 2010
    ....
  29. pmc Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 66:1075-82. 2009
    ..amygdala, hippocampus, ventromedial prefrontal cortex (vmPFC), and dorsal anterior cingulate cortex (dACC)...
  30. pmc Sleep promotes generalization of extinction of conditioned fear
    Edward F Pace-Schott
    Harvard Medical School, Department of Psychiatry, Center for Sleep and Cognition, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
    Sleep 32:19-26. 2009
    ..To examine the effects of sleep on fear conditioning, extinction, extinction recall, and generalization of extinction recall in healthy humans...
  31. ncbi request reprint Psychophysiological responding during script-driven imagery in people reporting abduction by space aliens
    Richard J McNally
    Department of Psychology, Harvard University, Cambridge, MA 02138, USA
    Psychol Sci 15:493-7. 2004
    ..05). Therefore, belief that one has been traumatized may generate emotional responses similar to those provoked by recollection of trauma (e.g., combat)...
  32. pmc Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin study
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States
    J Psychiatr Res 42:515-20. 2008
    ..Furthermore, they support the conclusion that this deficit is acquired as a result of combat trauma leading to PTSD, rather than being a predisposing factor to developing PTSD upon the stress of combat...
  33. pmc Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma
    Mark W Gilbertson
    Research Service, Veterans Administration Medical Center, 718 Smyth Road, Manchester, New Hampshire 03104, USA
    Nat Neurosci 5:1242-7. 2002
    ..Furthermore, severe PTSD twin pairs-both the trauma-exposed and unexposed members-had significantly smaller hippocampi than non-PTSD pairs...
  34. ncbi request reprint Event-related potentials to auditory stimuli in female Vietnam nurse veterans with posttraumatic stress disorder
    Linda J Metzger
    Veterans Affairs Medical Center, Manchester, New Hampshire, USA
    Psychophysiology 39:49-63. 2002
    ..Future research is needed to determine whether the opposite ERP abnormalities observed in this PTSD sample reflect gender-, trauma-, or sample-specific findings...
  35. ncbi request reprint Memory distortion in people reporting abduction by aliens
    Susan A Clancy
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Abnorm Psychol 111:455-61. 2002
    ..The groups did not differ in correct recall or recognition. Hypnotic suggestibility, depressive symptoms, and schizotypic features were significant predictors of false recall and false recognition...
  36. ncbi request reprint Physiologic reactivity to startling tones in female Vietnam nurse veterans with PTSD
    Margaret A Carson
    Department of Nursing, Saint Anselm College, Manchester, NH 03102 1310, USA
    J Trauma Stress 20:657-66. 2007
    ..A larger HR response to loud tones is one of the most robust physiologic findings in PTSD and may reflect increased defensive responding...
  37. ncbi request reprint Pilot study of secondary prevention of posttraumatic stress disorder with propranolol
    Roger K Pitman
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 51:189-92. 2002
    ..This pilot study addressed this hypothesis...
  38. ncbi request reprint Context modulation of memory for fear extinction in humans
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Psychophysiology 42:456-64. 2005
    ..This finding demonstrates context dependency of extinction recall in humans...
  39. ncbi request reprint Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  40. ncbi request reprint Reevaluating the association between emergency department heart rate and the development of posttraumatic stress disorder: A public health approach
    Douglas F Zatzick
    Department of Psychiatry, Harborview Medical Center, University of Washington School of Medicine, Box 359911, HMC, 325 Ninth Avenue, Seattle, WA 98104, USA
    Biol Psychiatry 57:91-5. 2005
    ..Other studies suggest no association, however...
  41. pmc Somatic panic-attack equivalents in a community sample of Rwandan widows who survived the 1994 genocide
    Athanase Hagengimana
    Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
    Psychiatry Res 117:1-9. 2003
    ..Future studies of traumatized non-Western populations should carefully assess not only somatoform disorder but also somatically focused panic attacks...
  42. pmc Extinction memory is impaired in schizophrenia
    Daphne J Holt
    Psychiatric Neuroimaging Research Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Biol Psychiatry 65:455-63. 2009
    ..To investigate this possibility, we measured the acquisition and extinction of conditioned fear responses and delayed recall of extinction in schizophrenia and control subjects...
  43. ncbi request reprint Absence of selected neurological soft signs in Vietnam nurse veterans with post-traumatic stress disorder
    Tamara V Gurvits
    VA Medical Center, VA Research Service, 228 Maple Street, Manchester, NH 03103, USA
    Psychiatry Res 110:81-5. 2002
    ..The increased NSSs observed in the previously studied PTSD samples were not found in the nurses with PTSD. The results fail to support the hypothesis that the stress of a traumatic event and/or resultant PTSD damages the nervous system...
  44. ncbi request reprint Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humans
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Behav Neurosci 120:1196-203. 2006
    ..On Day 2, men and early cycle women expressed greater extinction memory than midcycle women. These data confirm sex differences in conditioned fear acquisition and suggest that midcycle hormones attenuate extinction recall...
  45. pmc Probing reward function in posttraumatic stress disorder: expectancy and satisfaction with monetary gains and losses
    James W Hopper
    Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
    J Psychiatr Res 42:802-7. 2008
    ..Posttraumatic stress disorder (PTSD) may be associated with dysfunctional reward processing. The present study assessed for such dysfunction in both the expectancy and outcome phases of reward processing...
  46. ncbi request reprint Probing reward function in post-traumatic stress disorder with beautiful facial images
    Igor Elman
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Psychiatry Res 135:179-83. 2005
    ..There were no significant group differences in the attractiveness ratings. However, PTSD patients expended less effort to extend the viewing time of the beautiful female faces. These findings suggest a reward deficit in PTSD...
  47. doi request reprint Impaired reproduction of three-dimensional objects by cocaine-dependent subjects
    Igor Elman
    Department of Psychiatry, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
    J Neuropsychiatry Clin Neurosci 20:478-84. 2008
    ..g., parietal lobe damage) and their role in the pathophysiology of cocaine dependence...
  48. pmc Cavum septum pellucidum in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder
    Flavia S May
    Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Biol Psychiatry 55:656-8. 2004
    ..Abnormally large cavum septum pellucidum has been reported in posttraumatic stress disorder; however, the origin of this association is uncertain...
  49. ncbi request reprint Risk factors and outcome in ambulatory assault victims presenting to the acute emergency department setting: implications for secondary prevention studies in PTSD
    Peter P Roy-Byrne
    Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, University of Washington, Seattle, Washington 98104 2499, USA
    Depress Anxiety 19:77-84. 2004
    ....
  50. ncbi request reprint Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    Arch Gen Psychiatry 61:168-76. 2004
    ..However, the functional relationship between these brain regions in PTSD has not been directly examined...
  51. ncbi request reprint Hippocampal function in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
    Hippocampus 14:292-300. 2004
    ....
  52. ncbi request reprint Prospective evaluation of plasma cortisol in recent trauma survivors with posttraumatic stress disorder
    Omer Bonne
    The Center for Traumatic Stress, Hadassah University Hospital, Jerusalem, Israel
    Psychiatry Res 119:171-5. 2003
    ..Survivors with and without PTSD had similar mean levels of cortisol at both time points. Cortisol levels at 6 months negatively correlated with self-reported PTSD symptoms within PTSD subjects...
  53. ncbi request reprint Persistence and change of PTSD symptomatology--a longitudinal co-twin control analysis of the Vietnam Era Twin Registry
    Peter Roy-Byrne
    Dept of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    Soc Psychiatry Psychiatr Epidemiol 39:681-5. 2004
    ..The purpose of this study is to examine the changes in the combat exposure-PTSD relationship over an additional decade of time...
  54. pmc Volume of cerebellar vermis in monozygotic twins discordant for combat exposure: lack of relationship to post-traumatic stress disorder
    James J Levitt
    VA Boston Healthcare System, Clinical Neuroscience Division, Laboratory of Neuroscience, Brockton, MA 02301, USA
    Psychiatry Res 148:143-9. 2006
    ..Thus, the results do not support the structural abnormality of cerebellar vermis in combat-related PTSD...
  55. ncbi request reprint Neurocognitive function in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder
    Mark W Gilbertson
    Research Service, Manchester VA Medical Center, NH 03104, USA
    J Abnorm Psychol 115:484-95. 2006
    ..The results support the notion that specific domains of cognitive function may serve as premorbid risk or protective factors in PTSD...
  56. ncbi request reprint Effects of beta blockade, PTSD diagnosis, and explicit threat on the extinction and retention of an aversively conditioned response
    Scott P Orr
    Department of Veterans Affairs Medical Center, Research Service 151, 718 Smyth Road, Manchester, NH 03104, United States
    Biol Psychol 73:262-71. 2006
    ..This suggests that belief in the presence of a threat is necessary and sufficient for activating a previously established CR...
  57. ncbi request reprint Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorder
    Alain Brunet
    Department of Psychiatry, McGill University and Douglas Hospital Research Center, Montreal, QC, Canada
    J Psychiatr Res 42:503-6. 2008
    ....
  58. pmc Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorder
    Kiyoto Kasai
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biol Psychiatry 63:550-6. 2008
    ..We employed a case-control design in monozygotic twin pairs discordant for combat exposure to address the preexisting versus acquired origin of brain morphometric abnormalities in PTSD...
  59. ncbi request reprint A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, Mass, USA
    Arch Gen Psychiatry 62:273-81. 2005
    ..Previous functional neuroimaging studies have demonstrated exaggerated amygdala responses and diminished medial prefrontal cortex responses during the symptomatic state in posttraumatic stress disorder (PTSD)...
  60. ncbi request reprint Dorsal anterior cingulate function in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    J Trauma Stress 20:701-12. 2007
  61. ncbi request reprint New findings on the neurobiology of posttraumatic stress disorder
    Matthew J Friedman
    National Center for PTSD, Department of Veterans Affairs, White River Junction, VT 05009, USA
    J Trauma Stress 20:653-5. 2007
  62. ncbi request reprint Treatment preferences and determinants in victims of sexual and physical assault
    Peter Roy-Byrne
    Department of Psychiatry and Behavioral Science, University of Washington, Harborview Medical Center, 325 9th Avenue, Box 355911, Seattle, WA 98104 2499, USA
    J Nerv Ment Dis 191:161-5. 2003
    ....
  63. ncbi request reprint Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part I: HPA axis responses
    Arieh Y Shalev
    Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 11:365-72. 2008
    ..Female subjects had lower ACTH levels than males. PTSD in females was associated with higher levels of ACTH. In unselected cohorts of trauma survivors, PTSD is not preceded by a detectable abnormality of peripheral HPA axis hormones...
  64. ncbi request reprint Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part II: the adrenergic response
    Elizabeth J Videlock
    Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
    Int J Neuropsychopharmacol 11:373-80. 2008
    ..Peripheral levels of NE, shortly after traumatic events, are poor risk indicators of subsequent PTSD among civilian trauma victims. Simplified biological models may not properly capture the complex aetiology of PTSD...

Research Grants11

  1. Prophylaxis of PTSD with Post-Trauma Propranolol
    Roger Pitman; Fiscal Year: 2007
    ..One and three months following the traumatic event, the patient will undergo psychophysiologic, psychodiagnostic, and psychometric testing for PTSD. ..
  2. TWIN STUDY OF BIOLOGIC MARKERS FOR PTSD
    Roger Pitman; Fiscal Year: 2006
    ..Results may also have implications for the prophylactic screening of persons at high risk for the development of PTSD upon exposure to military combat or other severe stressors. ..
  3. TWIN STUDY OF BIOLOGIC MARKERS FOR PTSD
    Roger Pitman; Fiscal Year: 2004
    ..Results may also have implications for the screening of persons at high risk for the development of PTSD upon exposure to military combat or other severe stressors. ..