Research Topics
| Roger PitmanSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Amygdala, medial prefrontal cortex, and hippocampal function in PTSDLisa M Shin
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
Ann N Y Acad Sci 1071:67-79. 2006..Lastly, the reviewed research suggests diminished volumes, neuronal integrity, and functional integrity of the hippocampus in PTSD. Remaining research questions and related future directions are presented...
An fMRI study of unconditioned responses in post-traumatic stress disorderClas Linnman
Department of Psychiatry, Harvard Medical School and Massachusetts General Hospital, 149 13th Street, Charlestown, MA, USA
Biol Mood Anxiety Disord 1:8. 2011..abstract:..- Psychophysiologic assessment of posttraumatic stress disorder in breast cancer patientsR K Pitman
VA Research Service, Manchester, New Hampshire, USA
Psychosomatics 42:133-40. 2001..Physiologic responses were significantly and positively correlated with CAPS scores. These results provide psychophysiologic support for the proposition that a diagnosis of with a life-threatening illness can cause PTSD... - Combat effects on mental health: the more things change, the more they remain the sameRoger K Pitman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129, USA
Arch Gen Psychiatry 63:127-8. 2006 - Clarifying the origin of biological abnormalities in PTSD through the study of identical twins discordant for combat exposureRoger K Pitman
Massachusetts General Hospital, Room 2616, Bldg 149, 13th St, Charlestown, MA 02129, USA
Ann N Y Acad Sci 1071:242-54. 2006..These results support the conclusion that the latter abnormalities represent antecedent, familial vulnerability factors for developing chronic PTSD upon exposure to a traumatic event... - Commentary: synthesis and perspectivesR K Pitman
Massachusetts General Hospital-East, Charleston, MA 02129, USA
Prog Brain Res 167:249-54. 2008 
Systemic mifepristone blocks reconsolidation of cue-conditioned fear; propranolol prevents this effectRoger K Pitman
Department of Psychiatry, Massachusetts General Hospital, MGH East, 120 Second Avenue, Charlestown, MA 02129, USA
Behav Neurosci 125:632-8. 2011..Concurrent administration of propranolol prevents this effect. Postreactivation mifepristone may be a promising treatment for PTSD, but not necessarily in combination with propranolol...- Conceptually driven pharmacologic approaches to acute traumaRoger K Pitman
Massachusetts General Hospital, Charlestown, MA 02129, USA
CNS Spectr 10:99-106. 2005..One study did not find benzodiazepines effective in preventing PTSD. Selective serotonin reuptake inhibitors, antiepileptics, and alpha2-adrenergic agonists have yet to be tried... - Configural cue performance in identical twins discordant for posttraumatic stress disorder: theoretical implications for the role of hippocampal functionMark W Gilbertson
Manchester VA Medical Center, Manchester, New Hampshire 03104, USA
Biol Psychiatry 62:513-20. 2007..We test the hypothesis that hippocampus-based configural processing deficits are a pre-existing vulnerability factor for unremitting forms of PTSD... - Subtle neurologic compromise as a vulnerability factor for combat-related posttraumatic stress disorder: results of a twin studyTamara V Gurvits
Research Service, Veterans Affairs Medical Center, Manchester, NH, USA
Arch Gen Psychiatry 63:571-6. 2006.... - Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concertMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 62:446-54. 2007..The aim of the present study is to investigate the mediating anatomy of extinction recall in healthy humans... - Intensity dependence of auditory P2 in monozygotic twins discordant for Vietnam combat: associations with posttraumatic stress disorderLinda J Metzger
Research Service, Department of Veterans Affairs VA Medical Center, Manchester, NH 03104, USA
J Rehabil Res Dev 45:437-49. 2008..Inspection of group means suggests that the observed increased P2 intensity dependence is a consequence of PTSD. Our findings further suggest that low serotonergic tone may emerge as one potential consequence of this disorder... - Event-related potentials to auditory stimuli in monozygotic twins discordant for combat: association with PTSDLinda J Metzger
Veterans Affairs Medical Center, Manchester, New Hampshire 03104, USA
Psychophysiology 46:172-8. 2009..Results replicate increased N2 latency and diminished P3b amplitude in PTSD and suggest that diminished P3b amplitude is an acquired condition in PTSD... - Fear extinction in rats: implications for human brain imaging and anxiety disordersMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Bldg 149 13th St, Charlestown, 02129, USA
Biol Psychol 73:61-71. 2006.... - Performance on visuospatial copying tasks in individuals with chronic posttraumatic stress disorderTamara V Gurvits
VA Research Service, 718 Smyth Rd, Manchester, NH 03104, USA
Psychiatry Res 112:263-8. 2002..These findings are consistent with pre-trauma visual-spatial impairment as being among the risk factors for chronic PTSD... - Orbitofrontal thickness, retention of fear extinction, and extraversionScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Neuroreport 16:1909-12. 2005..Path analysis indicates that extinction retention mediates the relationship between the medial orbitofrontal cortex thickness and extraversion, thereby illustrating one path through which brain structure influences personality... - Psychophysiology of post-traumatic stress disorderScott P Orr
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
Psychiatr Clin North Am 25:271-93. 2002..We hope that the broad range of psychophysiologic investigations and findings in PTSD will inspire others to consider possible applications of these methodologies to their own clinical and research endeavors... - Physiologic responses to sudden, loud tones in monozygotic twins discordant for combat exposure: association with posttraumatic stress disorderScott P Orr
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
Arch Gen Psychiatry 60:283-8. 2003..Studying identical twins discordant for traumatic exposure offers an opportunity to resolve these competing origins... - Memory distortion in people reporting abduction by aliensSusan A Clancy
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
J Abnorm Psychol 111:455-61. 2002..The groups did not differ in correct recall or recognition. Hypnotic suggestibility, depressive symptoms, and schizotypic features were significant predictors of false recall and false recognition... - Thickness of ventromedial prefrontal cortex in humans is correlated with extinction memoryMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 102:10706-11. 2005..e., greater extinction memory). These results suggest that the size of the vmPFC might explain individual differences in the ability to modulate fear among humans... - A role for the human dorsal anterior cingulate cortex in fear expressionMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 62:1191-4. 2007..This study examined the role of dACC during fear conditioning in healthy humans with magnetic resonance imaging (MRI)... - Event-related potentials to auditory stimuli in female Vietnam nurse veterans with posttraumatic stress disorderLinda J Metzger
Veterans Affairs Medical Center, Manchester, New Hampshire, USA
Psychophysiology 39:49-63. 2002..Future research is needed to determine whether the opposite ERP abnormalities observed in this PTSD sample reflect gender-, trauma-, or sample-specific findings... - Smaller hippocampal volume predicts pathologic vulnerability to psychological traumaMark W Gilbertson
Research Service, Veterans Administration Medical Center, 718 Smyth Road, Manchester, New Hampshire 03104, USA
Nat Neurosci 5:1242-7. 2002..Furthermore, severe PTSD twin pairs-both the trauma-exposed and unexposed members-had significantly smaller hippocampi than non-PTSD pairs... - Physiologic responses to loud tones in individuals with obsessive-compulsive disorderUlrike Buhlmann
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Psychosom Med 69:166-72. 2007..To determine if individuals with obsessive-compulsive disorder (OCD) are characterized by larger eyeblink and/or autonomic responses to sudden, loud (startling) tones... - Presence and acquired origin of reduced recall for fear extinction in PTSD: results of a twin studyMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States
J Psychiatr Res 42:515-20. 2008..Furthermore, they support the conclusion that this deficit is acquired as a result of combat trauma leading to PTSD, rather than being a predisposing factor to developing PTSD upon the stress of combat... - Selectively reduced regional cortical volumes in post-traumatic stress disorderScott L Rauch
Psychiatric Neuroimaging Research Group, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
Neuroreport 14:913-6. 2003..These results are consistent with contemporary schemes regarding functional and structural dissection of frontal cortex, and suggest specific regional cortical pathology in PTSD... - The panic attack-posttraumatic stress disorder model: applicability to orthostatic panic among Cambodian refugeesDevon E Hinton
Southeast Asian Clinic, Arbour Counseling Services, Lowell, MA 02114, USA
Cogn Behav Ther 37:101-16. 2008.... - Stress reduction correlates with structural changes in the amygdalaBritta K Hölzel
Massachusetts General Hospital, Charlestown, MA 02129, USA
Soc Cogn Affect Neurosci 5:11-7. 2010.... - PTSD arousal and depression symptoms associated with increased right-sided parietal EEG asymmetryLinda J Metzger
Veterans Affairs Medical Center Research Service, Manchester, NH 03104, USA
J Abnorm Psychol 113:324-9. 2004..These findings underscore the importance of isolating, both theoretically and statistically, emotional subcomponents in studies of regional brain activation... - Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorderMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 66:1075-82. 2009..amygdala, hippocampus, ventromedial prefrontal cortex (vmPFC), and dorsal anterior cingulate cortex (dACC)... - Psychophysiological responding during script-driven imagery in people reporting abduction by space aliensRichard J McNally
Department of Psychology, Harvard University, Cambridge, MA 02138, USA
Psychol Sci 15:493-7. 2004..05). Therefore, belief that one has been traumatized may generate emotional responses similar to those provoked by recollection of trauma (e.g., combat)... - Sleep promotes generalization of extinction of conditioned fearEdward F Pace-Schott
Harvard Medical School, Department of Psychiatry, Center for Sleep and Cognition, Beth Israel Deaconess Medical Center Boston, MA 02215, USA
Sleep 32:19-26. 2009..To examine the effects of sleep on fear conditioning, extinction, extinction recall, and generalization of extinction recall in healthy humans... - Assessment of posttraumatic stress disorder in Cambodian refugees using the Clinician-Administered PTSD Scale: psychometric properties and symptom severityDevon E Hinton
Department of Psychiatry, Massachusetts General Hospital, 15 Parkman Street, WACC 812, Boston, MA 02114, USA
J Trauma Stress 19:405-9. 2006..Those patients who met criteria for current PTSD had significantly higher CAPS total scores (M = 65.3, SD = 18.1) than those who did not meet the criteria (M = 13.9, SD = 16.7)... - Physiologic reactivity to startling tones in female Vietnam nurse veterans with PTSDMargaret A Carson
Department of Nursing, Saint Anselm College, Manchester, NH 03102 1310, USA
J Trauma Stress 20:657-66. 2007..A larger HR response to loud tones is one of the most robust physiologic findings in PTSD and may reflect increased defensive responding... - Pilot study of secondary prevention of posttraumatic stress disorder with propranololRoger K Pitman
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 51:189-92. 2002..04 (all p values one-tailed). CONCLUSIONS: These pilot results suggest that acute, posttrauma propranolol may have a preventive effect on subsequent PTSD... - Context modulation of memory for fear extinction in humansMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Psychophysiology 42:456-64. 2005..This finding demonstrates context dependency of extinction recall in humans... - Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorderMark H Pollack
Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
J Clin Psychiatry 67:394-9. 2006.... - Extinction memory is impaired in schizophreniaDaphne J Holt
Psychiatric Neuroimaging Research Program, Psychiatry Department, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
Biol Psychiatry 65:455-63. 2009..To investigate this possibility, we measured the acquisition and extinction of conditioned fear responses and delayed recall of extinction in schizophrenia and control subjects... - Absence of selected neurological soft signs in Vietnam nurse veterans with post-traumatic stress disorderTamara V Gurvits
VA Medical Center, VA Research Service, 228 Maple Street, Manchester, NH 03103, USA
Psychiatry Res 110:81-5. 2002..The increased NSSs observed in the previously studied PTSD samples were not found in the nurses with PTSD. The results fail to support the hypothesis that the stress of a traumatic event and/or resultant PTSD damages the nervous system... - Fear conditioning and extinction: influence of sex and menstrual cycle in healthy humansMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA
Behav Neurosci 120:1196-203. 2006..On Day 2, men and early cycle women expressed greater extinction memory than midcycle women. These data confirm sex differences in conditioned fear acquisition and suggest that midcycle hormones attenuate extinction recall... - Reevaluating the association between emergency department heart rate and the development of posttraumatic stress disorder: A public health approachDouglas F Zatzick
Department of Psychiatry, Harborview Medical Center, University of Washington School of Medicine, Box 359911, HMC, 325 Ninth Avenue, Seattle, WA 98104, USA
Biol Psychiatry 57:91-5. 2005..Other studies suggest no association, however... - Somatic panic-attack equivalents in a community sample of Rwandan widows who survived the 1994 genocideAthanase Hagengimana
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, USA
Psychiatry Res 117:1-9. 2003..Future studies of traumatized non-Western populations should carefully assess not only somatoform disorder but also somatically focused panic attacks... - Probing reward function in posttraumatic stress disorder: expectancy and satisfaction with monetary gains and lossesJames W Hopper
Behavioral Psychopharmacology Research Laboratory, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
J Psychiatr Res 42:802-7. 2008..Posttraumatic stress disorder (PTSD) may be associated with dysfunctional reward processing. The present study assessed for such dysfunction in both the expectancy and outcome phases of reward processing... - Probing reward function in post-traumatic stress disorder with beautiful facial imagesIgor Elman
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Psychiatry Res 135:179-83. 2005..There were no significant group differences in the attractiveness ratings. However, PTSD patients expended less effort to extend the viewing time of the beautiful female faces. These findings suggest a reward deficit in PTSD... - Impaired reproduction of three-dimensional objects by cocaine-dependent subjectsIgor Elman
Department of Psychiatry, McLean Hospital Harvard Medical School, 115 Mill St, Belmont, MA 02478 9106, USA
J Neuropsychiatry Clin Neurosci 20:478-84. 2008..g., parietal lobe damage) and their role in the pathophysiology of cocaine dependence... - A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorderLisa M Shin
Department of Psychology, Tufts University, Medford, Mass, USA
Arch Gen Psychiatry 62:273-81. 2005.... - Prospective evaluation of plasma cortisol in recent trauma survivors with posttraumatic stress disorderOmer Bonne
The Center for Traumatic Stress, Hadassah University Hospital, Jerusalem, Israel
Psychiatry Res 119:171-5. 2003..Survivors with and without PTSD had similar mean levels of cortisol at both time points. Cortisol levels at 6 months negatively correlated with self-reported PTSD symptoms within PTSD subjects... - Persistence and change of PTSD symptomatology--a longitudinal co-twin control analysis of the Vietnam Era Twin RegistryPeter Roy-Byrne
Dept. of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
Soc Psychiatry Psychiatr Epidemiol 39:681-5. 2004..There is no evidence that genetic influences on exposure to combat are shared with those inducing a genetic vulnerability to PTSD. Clinicians need to be aware of the persistent and long-term residual effects of trauma exposure... - Volume of cerebellar vermis in monozygotic twins discordant for combat exposure: lack of relationship to post-traumatic stress disorderJames J Levitt
VA Boston Healthcare System, Clinical Neuroscience Division, Laboratory of Neuroscience, Brockton, MA 02301, USA
Psychiatry Res 148:143-9. 2006..Thus, the results do not support the structural abnormality of cerebellar vermis in combat-related PTSD... - Hippocampal function in posttraumatic stress disorderLisa M Shin
Department of Psychology, Tufts University, 490 Boston Avenue, Medford, MA 02155, USA
Hippocampus 14:292-300. 2004.... - Risk factors and outcome in ambulatory assault victims presenting to the acute emergency department setting: implications for secondary prevention studies in PTSDPeter P Roy-Byrne
Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, University of Washington, Seattle, Washington 98104 2499, USA
Depress Anxiety 19:77-84. 2004.... - Cavum septum pellucidum in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorderFlavia S May
Department of Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
Biol Psychiatry 55:656-8. 2004..CONCLUSIONS: The presence of abnormally large cavum septum pellucidum is a familial vulnerability factor for posttraumatic stress disorder... - Neurocognitive function in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorderMark W Gilbertson
Research Service, Manchester VA Medical Center, NH 03104, USA
J Abnorm Psychol 115:484-95. 2006..The results support the notion that specific domains of cognitive function may serve as premorbid risk or protective factors in PTSD... - Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSDLisa M Shin
Department of Psychology, Tufts University, Medford, MA 02155, USA
Arch Gen Psychiatry 61:168-76. 2004..However, the functional relationship between these brain regions in PTSD has not been directly examined... - Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorderKiyoto Kasai
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Biol Psychiatry 63:550-6. 2008..We employed a case-control design in monozygotic twin pairs discordant for combat exposure to address the preexisting versus acquired origin of brain morphometric abnormalities in PTSD... - Effects of beta blockade, PTSD diagnosis, and explicit threat on the extinction and retention of an aversively conditioned responseScott P Orr
Department of Veterans Affairs Medical Center, Research Service 151, 718 Smyth Road, Manchester, NH 03104, United States
Biol Psychol 73:262-71. 2006..This suggests that belief in the presence of a threat is necessary and sufficient for activating a previously established CR... - Effect of post-retrieval propranolol on psychophysiologic responding during subsequent script-driven traumatic imagery in post-traumatic stress disorderAlain Brunet
Department of Psychiatry, McGill University and Douglas Hospital Research Center, Montreal, QC, Canada
J Psychiatr Res 42:503-6. 2008.... - Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part I: HPA axis responsesArieh Y Shalev
Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
Int J Neuropsychopharmacol 11:365-72. 2008..Female subjects had lower ACTH levels than males. PTSD in females was associated with higher levels of ACTH. In unselected cohorts of trauma survivors, PTSD is not preceded by a detectable abnormality of peripheral HPA axis hormones... - Treatment preferences and determinants in victims of sexual and physical assaultPeter Roy-Byrne
Department of Psychiatry and Behavioral Science, University of Washington, Harborview Medical Center, 325 9th Avenue, Box 355911, Seattle, WA 98104-2499, USA
J Nerv Ment Dis 191:161-5. 2003.... - New findings on the neurobiology of posttraumatic stress disorderMatthew J Friedman
National Center for PTSD, Department of Veterans Affairs, White River Junction, VT 05009, USA
J Trauma Stress 20:653-5. 2007 - Dorsal anterior cingulate function in posttraumatic stress disorderLisa M Shin
Department of Psychology, Tufts University, Medford, MA 02155, USA
J Trauma Stress 20:701-12. 2007 - Stress hormones and post-traumatic stress disorder in civilian trauma victims: a longitudinal study. Part II: the adrenergic responseElizabeth J Videlock
Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel
Int J Neuropsychopharmacol 11:373-80. 2008..Peripheral levels of NE, shortly after traumatic events, are poor risk indicators of subsequent PTSD among civilian trauma victims. Simplified biological models may not properly capture the complex aetiology of PTSD...
Research Grants
- Prophylaxis of PTSD with Post-Trauma PropranololRoger Pitman; Fiscal Year: 2007..One and three months following the traumatic event, the patient will undergo psychophysiologic, psychodiagnostic, and psychometric testing for PTSD. ..
- TWIN STUDY OF BIOLOGIC MARKERS FOR PTSDRoger Pitman; Fiscal Year: 2006..Results may also have implications for the prophylactic screening of persons at high risk for the development of PTSD upon exposure to military combat or other severe stressors. ..
- TWIN STUDY OF BIOLOGIC MARKERS FOR PTSDRoger Pitman; Fiscal Year: 2004..Results may also have implications for the screening of persons at high risk for the development of PTSD upon exposure to military combat or other severe stressors. ..