Research Topics
| Duane S PintoSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Cardiac manifestations of Lyme diseaseDuane S Pinto
Harvard Medical School, Department of Internal Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
Med Clin North Am 86:285-96. 2002..Routine therapy and screening of patients with idiopathic dilated cardiomyopathy is of limited utility and should be reserved for patients with clear history of antecedent Lyme disease or tick bite...- Reperfusion strategies for ST-elevation myocardial infarctionSaumil R Shah
Division of Cardiology, Beth Israel Deaconess Medical Center, 350 Longwood Avenue, First Floor, Boston, MA 02115, USA
Curr Cardiol Rep 9:281-8. 2007..The evidence supporting facilitated PCI varies according to the pharmacologic regimen at this time... 
Bivalirudin therapy is associated with improved clinical and economic outcomes in ST-elevation myocardial infarction patients undergoing percutaneous coronary intervention: results from an observational databaseDuane S Pinto
Division of Cardiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Circ Cardiovasc Qual Outcomes 5:52-61. 2012....- Impact of routine angiographic follow-up on the clinical benefits of paclitaxel-eluting stents: results from the TAXUS-IV trialDuane S Pinto
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 48:32-6. 2006.... - Clinical problem-solving. A sailor's heartbreakDuane S Pinto
Division of Cardiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
N Engl J Med 353:934-9. 2005 - A 43-year-old man with angina, elevated troponin, and lateral ST depression: management of acute coronary syndromesDuane S Pinto
Harvard Medical School, and Cardiac Catheterization Laboratory, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
JAMA 303:54-63. 2010..The timing of cardiac catheterization, for whom catheterization is indicated, and the rationale for medication treatment are discussed... - Economic evaluation of bivalirudin with or without glycoprotein IIb/IIIa inhibition versus heparin with routine glycoprotein IIb/IIIa inhibition for early invasive management of acute coronary syndromesDuane S Pinto
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 52:1758-68. 2008..The aim of this study was to determine the economic impact of several anticoagulation strategies for moderate- and high-risk non-ST-segment elevation acute coronary syndrome (NSTE-ACS) patients managed invasively... - Association of impaired thrombolysis in myocardial infarction myocardial perfusion grade with ventricular tachycardia and ventricular fibrillation following fibrinolytic therapy for ST-segment elevation myocardial infarctionC Michael Gibson
TIMI Study Group, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 51:546-51. 2008..The goal of this analysis was to evaluate the association of impaired Thrombolysis In Myocardial Infarction myocardial perfusion grade (TMPG) with sustained ventricular tachycardia (VT) or ventricular fibrillation (VF)... - Intracoronary bolus administration of eptifibatide during percutaneous coronary stenting for non ST elevation myocardial infarction and unstable anginaAlbert J Deibele
Division of Cardiology, Duluth Clinic, Duluth, Minnesota, USA
J Thromb Thrombolysis 22:47-50. 2006..Larger prospective and randomized studies are warranted to further explore the efficacy of this strategy.Intracoronary eptifibatide administration during PCI for UA/NSTEMI is feasible and safe... - Early recurrence of arrhythmia in patients taking amiodarone or class 1C agents for treatment of atrial fibrillation or atrial flutterThomas H Hauser
Cardiovascular Division, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 93:1173-6. 2004..Recurrent arrhythmia was not more common with amiodarone... - Quantitative relationship of stress Tc-99m sestamibi lung uptake with resting Tl-201 lung uptake and with indices of left ventricular dysfunction and coronary artery diseaseGaurav M Patel
Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
J Nucl Cardiol 11:408-13. 2004..001). CONCLUSIONS: Increased stress Tc-99m sestamibi LHR correlates with rest Tl-201 LHR in patients with known or suspected CAD. Stress Tc-99m sestamibi lung uptake is also associated with invasively measured LV filling pressures... - Association of blood glucose with angiographic and clinical outcomes among patients with ST-segment elevation myocardial infarction (from the CLARITY-TIMI-28 study)Duane S Pinto
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Am J Cardiol 101:303-7. 2008..IRA patency after fibrinolytic administration is related to admission glucose independent of clopidogrel administration... - Administration of intracoronary eptifibatide during ST-elevation myocardial infarctionDuane S Pinto
Beth Israel Deaconess Medical Center, Division of Cardiology, Boston, Massachusetts, USA
Am J Cardiol 96:1494-7. 2005..Further prospective randomized trials are warranted to evaluate the efficacy and safety of intracoronary eptifibatide... - Benefit of transferring ST-segment-elevation myocardial infarction patients for percutaneous coronary intervention compared with administration of onsite fibrinolytic declines as delays increaseDuane S Pinto
Division of Cardiology, Interventional Section, Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Boston MA 02115, USA
Circulation 124:2512-21. 2011..We hypothesized that delays resulting from transfer would reduce the survival advantage of X-PCI compared with O-FT... - Association of epicardial and tissue-level reperfusion with left ventricular end-diastolic pressures in ST-elevation myocardial infarctionAjay J Kirtane
Department of Medicine, Beth Israel Deaconess Medical Center, USA
J Thromb Thrombolysis 17:177-84. 2004..8, p = 0.02) and 30-day congestive heart failure (OR 4.4, p = 0.02). In STEMI, angiographic indices of incomplete reperfusion are associated with an elevated LVEDP, and elevated LVEDP is associated with adverse clinical outcomes... - Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration ratesAjay J Kirtane
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
J Am Coll Cardiol 45:1781-6. 2005..CONCLUSIONS: Among patients with unstable coronary syndromes and predominantly normal or mildly reduced GFR, an elevated BUN is associated with increased mortality, independent of sCr-based estimates of GFR and other biomarkers... - Hospital delays in reperfusion for ST-elevation myocardial infarction: implications when selecting a reperfusion strategyDuane S Pinto
TIMI Study Group and the Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 185 Pilgrim Rd, Boston, MA 02115, USA
Circulation 114:2019-25. 2006..As indicated in the American College of Cardiology/American Heart Association guidelines, both the hospital-based PPCI-related delay (DB-DN time) and patient characteristics should be considered when a reperfusion strategy is selected... - Comparison of outcomes using sirolimus-eluting stenting in diabetic versus nondiabetic patients with comparison of insulin versus non-insulin therapy in the diabetic patientsRamon Kumar
Department of Medicine, Cardiology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am J Cardiol 100:1187-91. 2007.... 
Cost-effectiveness of sirolimus-eluting stents compared with vascular brachytherapy for the treatment of in-stent restenosisMatthew R Reynolds
Division of Cardiology, Beth Israel Deaconess Medical Center, Boston, MA, USA
Am Heart J 154:1221-7. 2007..Sirolimus-eluting stents (SESs) were recently shown to be superior to vascular brachytherapy for the treatment of restenosis within a bare metal stent. No economic comparison of these alternative strategies has yet been reported...- Association of creatinine and creatinine clearance on presentation in acute myocardial infarction with subsequent mortalityC Michael Gibson
TIMI Study Chairman s Office, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
J Am Coll Cardiol 42:1535-43. 2003..We hypothesized that impaired renal function would also be associated with poorer clinical outcomes among patients with ST-segment elevation myocardial infarction (STEMI) treated with fibrinolysis... - Combination platelet glycoprotein IIb/IIIa receptor and lepirudin administration during percutaneous coronary intervention in patients with heparin-induced thrombocytopeniaDuane S Pinto
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Catheter Cardiovasc Interv 58:65-8. 2003..In selected patients with HIT, the combination of a direct thrombin inhibitor, lepirudin, and abciximab, tirofiban, or eptifibatide appears to be a safe and effective anticoagulation strategy for PCI... - Optimal selection of STEMI treatment strategies in the current era: benefit of transferring STEMI patients for PCI compared with administration of onsite fibrinolytic therapyAnjan K Chakrabarti
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Curr Opin Cardiol 27:651-4. 2012..This benefit diminishes as PCI-related delay increases. This review examines recent data exploring this relationship, offering insight into possible mechanisms for the time-dependent benefit of PCI... - Platelet glycoprotein IIb/IIIa inhibition with eptifibatide: prolongation of inhibition of aggregation in acute renal failure and reversal with hemodialysisRobert T Sperling
Section of Interventional Cardiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Catheter Cardiovasc Interv 59:459-62. 2003..Acute renal hemodialysis may reverse the inhibitory effect of eptifibatide on platelet aggregation in these patients... - Stent thrombosis after successful sirolimus-eluting stent implantationAllen Jeremias
Section of Interventional Cardiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
Circulation 109:1930-2. 2004..The discontinuation of antiplatelet therapy was strongly associated with the development of ST in this patient population... - Drug eluting stents for ST-elevation myocardial infarction: risk and benefitJason Ryan
Beth Israel Deaconess Medical Center and Harvard Medical School, 1 Deaconess Road, Boston, MA 02215, USA
J Thromb Thrombolysis 24:293-9. 2007..This review with discuss the theoretical risks and benefits of DES for STEMI, the available data regarding their use, and the areas where future studies are needed... - Cost-effectiveness of transcatheter aortic valve replacement compared with surgical aortic valve replacement in high-risk patients with severe aortic stenosis: results of the PARTNER (Placement of Aortic Transcatheter Valves) trial (Cohort A)Matthew R Reynolds
Harvard Clinical Research Institute, Boston, Massachusetts, USA
J Am Coll Cardiol 60:2683-92. 2012..The aim of this study was to evaluate the cost-effectiveness of transcatheter aortic valve replacement (TAVR) compared with surgical aortic valve replacement (AVR) for patients with severe aortic stenosis and high surgical risk... - Association of an activated clotting time < or =250 seconds with adverse event rates after percutaneous coronary intervention using tirofiban and heparin (a TACTICS-TIMI 18 substudy)Duane S Pinto
Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
Am J Cardiol 91:976-8, A4. 2003 - Effects of B-type natriuretic peptide (nesiritide) on coronary epicardial arteries, systemic vasculature and microvesselsGui Fu Wu
Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA, 02215, USA
J Invasive Cardiol 20:76-80. 2008..Ischemic heart disease remains the major underlying cause for congestive heart failure, however, the effects of intravenous and intracoronary nesiritide on coronary circulation have not been adequately studied... - Drug-eluting stents for ST[corrected]-elevation acute myocardial infarction: do we need randomized trials?Jason Ryan
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
Coron Artery Dis 17:667-71. 2006..In this chapter, we discuss the theoretical risks and benefits of drug-eluting stents for ST elevation acute myocardial infarction, the available data regarding their use, and the areas in which future studies are needed... - Zebra or horse?Daniel Tsyvine
Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
Am J Med 120:591-3. 2007 - Door-to-balloon delays with percutaneous coronary intervention in ST-elevation myocardial infarctionDuane S Pinto
Cardiovascular Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Am Heart J 151:S24-9. 2006..Continued efforts, aimed at reducing the time to therapy with PCI and fibrinolysis, are of paramount importance... - Safety and feasibility of a clinical pathway for the outpatient initiation of antiarrhythmic medications in patients with atrial fibrillation or atrial flutterThomas H Hauser
Cardiovascular Division, Department of Medicine, Baker 4, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Am J Cardiol 91:1437-41. 2003..Most adverse events occurred beyond the usual time period for in-hospital monitoring of the initiation of AAMs... - Images in clinical medicine. Prinzmetal's anginaH S Vincent Chen
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
N Engl J Med 349:e1. 2003 - Inhaled nitric oxide as an adjunct to suction thrombectomy for pulmonary embolismSalomao Faintuch
Departments of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue WCC 308, Boston, Massachusetts 02215, USA
J Vasc Interv Radiol 15:1311-5. 2004..The treatment with this inhalable vasodilator was based on the hypothesis that prolonged ischemia had induced microcirculatory vasospasm, persistent after removal of the central clot... - Which antithrombin for whom? Identifying the patient population that benefits most from novel antithrombin agentsDavid A Burke
Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
Curr Cardiol Rep 14:493-501. 2012.... - Sinus versus nonsinus tachycardia in the emergency department: importance of age and heart rateDuane S Pinto
Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
BMC Cardiovasc Disord 3:7. 2003..The emergency department diagnosis of sinus versus nonsinus tachycardia is an important clinical challenge. The objective of this study was to identify subjects with a high prevalence of nonsinus tachycardia... - Current clinical characteristics and economic impact of subacute stent thrombosisMatthew R Reynolds
Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
J Invasive Cardiol 14:364-8. 2002..Conclusions. Despite its low overall frequency, the clinical and economic costs of SAT are substantial. Specific strategies at preventing its occurrence are warranted, particularly in high-risk situations... - Association of time to reperfusion with left ventricular function and heart failure in patients with acute myocardial infarction treated with primary percutaneous coronary intervention: A systematic reviewKashish Goel
Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA The PERFUSE Angiographic Core Laboratories and Data Coordinating Center, Beth Israel Deaconess Medical Center, Boston, MA Department of Internal Medicine, Wayne State University Detroit Medical Center, Detroit, MI
Am Heart J 165:451-67. 2013..We conducted a systematic review to examine the association between time to reperfusion and incident HF and/or left ventricular dysfunction... - Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemiaRobina Matyal
Beth Israel Deaconess Medical Center, Department of Anesthesia and Critical Care, Boston, MA, USA
J Mol Cell Cardiol 53:891-8. 2012..Local infiltration of NPY significantly improved collateral vessel formation, blood flow and myocardial function. We believe activation of NPY receptors may be a potential target therapy for patients with diffuse coronary artery disease... - Increased resting Tl-201 lung-to-heart ratio is associated with invasively determined measures of left ventricular dysfunction, extent of coronary artery disease, and resting myocardial perfusion abnormalitiesGregory P Sanders
Cardiovascular Division, Department of Medicine, and Boston University School of Medicine, Boston, Mass 02215, USA
J Nucl Cardiol 10:140-7. 2003..LHR is also associated with the extent of previously infarcted myocardium and may indicate the presence of 3-vessel/left main CAD... - Lyme carditisAirley E Fish
Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Infect Dis Clin North Am 22:275-88, vi. 2008..Cardiovascular manifestations of Lyme disease were first reported nearly 30 years ago. This article describes Lyme carditis, its epidemiology, pathophysiology, methods of diagnosis, and treatment options... - A novel approach using atherectomy for chronic total occlusion of the brachial artery: a case reportYuri B Pride
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
Vasc Med 12:207-10. 2007..We describe a case of chronic brachial artery ischemia due to atherosclerotic disease treated with the SilverHawk plaque excision system and review the available data regarding its use... - Images in clinical medicine. Ventricular septal rupture after myocardial infarctionDuane S Pinto
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
N Engl J Med 347:1334. 2002 - Differential outcomes after sirolimus-eluting stent implantation: comparing on-label versus off-label patients in the 'real world'Allen Jeremias
Division of Cardiovascular Medicine, Stony Brook University Medical Center, Stony Brook, NY 11794, USA
Coron Artery Dis 19:111-5. 2008..This study examined the performance of SES in a 'real world' setting by comparing the outcomes of trial-eligible versus ineligible patients undergoing percutaneous coronary intervention... - U-shaped relationship of blood glucose with adverse outcomes among patients with ST-segment elevation myocardial infarctionDuane S Pinto
J Am Coll Cardiol 46:178-80. 2005