SHIV SUBRAMANIAM PILLAI

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Rethinking mechanisms of autoimmune pathogenesis
    Shiv Pillai
    Massachusetts General Hospital, Center for Cancer Research, Harvard Medical School, Boston, MA 02129, USA Electronic address
    J Autoimmun 45:97-103. 2013
  2. pmc Siglecs and immune regulation
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Immunol 30:357-92. 2012
  3. doi request reprint The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow-derived B lymphocytes
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 2129, USA
    Immunol Cell Biol 87:16-9. 2009
  4. pmc Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance
    Shiv Pillai
    Cancer Center, Massachusetts General Hospital, Boston MA 02129, USA
    Trends Immunol 30:488-93. 2009
  5. ncbi request reprint Marginal zone B cells
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Immunol 23:161-96. 2005
  6. pmc Birth pangs: the stressful origins of lymphocytes
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 115:224-7. 2005
  7. doi request reprint The follicular versus marginal zone B lymphocyte cell fate decision
    Shiv Pillai
    Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Rev Immunol 9:767-77. 2009
  8. pmc B cells and autoimmunity
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States
    Curr Opin Immunol 23:721-31. 2011
  9. ncbi request reprint Tec kinase pathways in lymphocyte development and transformation
    Shiv Pillai
    Massachusetts General Hospital Cancer Center, Harvard Medical School, 13th Street, Charlestown, Boston, MA 02129, USA
    Biochim Biophys Acta 1602:162-7. 2002
  10. pmc Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
    Ira Surolia
    Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 466:243-7. 2010

Research Grants

Collaborators

Detail Information

Publications27

  1. doi request reprint Rethinking mechanisms of autoimmune pathogenesis
    Shiv Pillai
    Massachusetts General Hospital, Center for Cancer Research, Harvard Medical School, Boston, MA 02129, USA Electronic address
    J Autoimmun 45:97-103. 2013
    ..Another important and evolving area that has been discussed relates to the role of the intestinal microbiome in influencing helper T cell polarization and the development of autoimmunity. ..
  2. pmc Siglecs and immune regulation
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Immunol 30:357-92. 2012
    ..Siglecs modulate immune responses, influencing almost every cell in the immune system, and are of relevance both in health and disease...
  3. doi request reprint The bone marrow perisinusoidal niche for recirculating B cells and the positive selection of bone marrow-derived B lymphocytes
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 2129, USA
    Immunol Cell Biol 87:16-9. 2009
    ..Although immature B cells can mature into follicular B cells in this niche as well as in the spleen, the lineage commitment event that accompanies positive selection of B cells occurs only in the spleen...
  4. pmc Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance
    Shiv Pillai
    Cancer Center, Massachusetts General Hospital, Boston MA 02129, USA
    Trends Immunol 30:488-93. 2009
    ....
  5. ncbi request reprint Marginal zone B cells
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Annu Rev Immunol 23:161-96. 2005
    ..Here, we discuss the functions of these cells in both innate and adaptive immunity. We also attempt to reconcile differing viewpoints regarding the generation and function of marginal zone B cells in rodents and primates...
  6. pmc Birth pangs: the stressful origins of lymphocytes
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 115:224-7. 2005
    ..A study in this issue of the JCI reveals, quite unexpectedly, that IRE1 is also required early in B lymphocyte development for the induction of the machinery that mediates Ig gene rearrangement...
  7. doi request reprint The follicular versus marginal zone B lymphocyte cell fate decision
    Shiv Pillai
    Cancer Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Rev Immunol 9:767-77. 2009
    ..This cell fate decision could provide mechanistic insights that are relevant to other commitment events in lymphocytes...
  8. pmc B cells and autoimmunity
    Shiv Pillai
    Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, United States
    Curr Opin Immunol 23:721-31. 2011
    ..Current information on tolerance checkpoints in B cells, B cell depletion, BAFF blockade, regulatory B cells and clonal ignorance mediated by the SIAE/Siglec pathway will be reviewed...
  9. ncbi request reprint Tec kinase pathways in lymphocyte development and transformation
    Shiv Pillai
    Massachusetts General Hospital Cancer Center, Harvard Medical School, 13th Street, Charlestown, Boston, MA 02129, USA
    Biochim Biophys Acta 1602:162-7. 2002
  10. pmc Functionally defective germline variants of sialic acid acetylesterase in autoimmunity
    Ira Surolia
    Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 466:243-7. 2010
    ..9 in subjects with type I diabetes. Functionally defective SIAE rare and polymorphic variants represent a strong genetic link to susceptibility in relatively common human autoimmune disorders...
  11. pmc B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase
    Annaiah Cariappa
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Exp Med 206:125-38. 2009
    ..These results describe a novel catalytic regulator of B cell signaling and underscore the crucial role of inhibitory signaling in the maintenance of immunological tolerance in the B lineage...
  12. ncbi request reprint Synergism between NF-kappa B1/p50 and Notch2 during the development of marginal zone B lymphocytes
    Stewart T Moran
    Cancer Center, Massachusetts General Hospital, Harvard Medical Scool, 13th Street, Charlestown, MA 02129, USA
    J Immunol 179:195-200. 2007
    ..These studies provide in vivo evidence for a genetic interaction between the Notch and NF-kappaB pathways...
  13. ncbi request reprint Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations
    Stewart T Moran
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Mol Immunol 43:1694-9. 2006
    ..Taken together, these data demonstrate that the loss of this RIP-family kinase does not compromise B lymphocyte development and maintenance, but leaves open the possibility that PKK may have a redundant role in these processes...
  14. ncbi request reprint Antigen-dependent B-cell development
    Annaiah Cariappa
    Massachusetts General Hospital Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    Curr Opin Immunol 14:241-9. 2002
    ..Differences in antigen-receptor signal strength may determine whether B cells assume a marginal zone, follicular or B-1 phenotype...
  15. ncbi request reprint A catalytically inactive form of protein kinase C-associated kinase/receptor interacting protein 4, a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development
    Annaiah Cariappa
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA
    J Immunol 171:1875-80. 2003
    ..These studies suggest that PKK may be required early in B cell development and for BCR-mediated B cell proliferation...
  16. ncbi request reprint Positive selection and lineage commitment during peripheral B-lymphocyte development
    Shiv Pillai
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA
    Immunol Rev 197:206-18. 2004
    ....
  17. ncbi request reprint Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner
    Stewart T Moran
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    J Biol Chem 278:21526-33. 2003
    ..Taken together, these data indicate that PKK may function in both a kinase-dependent as well as a kinase-independent manner to activate NFkappaB...
  18. ncbi request reprint Perisinusoidal B cells in the bone marrow participate in T-independent responses to blood-borne microbes
    Annaiah Cariappa
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA
    Immunity 23:397-407. 2005
    ..The bone marrow represents a unique type of secondary lymphoid organ in which mature B cells are strategically positioned in the path of circulating microbes...
  19. ncbi request reprint Naive recirculating B cells mature simultaneously in the spleen and bone marrow
    Annaiah Cariappa
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Blood 109:2339-45. 2007
    ..These data suggest that newly formed B cells mature into IgD(hi) B cells simultaneously in the spleen and the bone marrow and establish in a stringent manner that humoral immune responses can be initiated in situ in the bone marrow...
  20. pmc Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells
    Lois L Cavanagh
    The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1029-37. 2005
    ..Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell-mediated recall responses in the bone marrow...
  21. pmc NK T cells provide lipid antigen-specific cognate help for B cells
    Elizabeth A Leadbetter
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:8339-44. 2008
    ....
  22. ncbi request reprint Ig knock-in mice producing anti-carbohydrate antibodies: breakthrough of B cells producing low affinity anti-self antibodies
    Lorenzo Benatuil
    Transplantation Research Center, Brigham and Women s Hospital, Children s Hospital Boston and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:3839-48. 2008
    ..We suggest that in these mice, receptor editing functioned to lower the affinity for self-Ag below a threshold that would result in overt pathology, while allowing development of low affinity anti-self Abs...
  23. ncbi request reprint Defective proliferative responses in B lymphocytes and thymocytes that lack neurofibromin
    Tae Jin Kim
    Cancer Center, Massachusetts General Hospital, Building 149, 13th Street, Charlestown Navy Yard, Boston, MA 02129, USA
    Mol Immunol 38:701-8. 2002
    ..Peripheral B cells exhibited circumscribed defects in anti-IgM induced protein tyrosine phosphorylation, which may contribute to the unexpected proliferative defect seen in these cells...
  24. pmc Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice
    Diana M Brainard
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Virol 83:7305-21. 2009
    ....
  25. ncbi request reprint The CD9 tetraspanin is not required for the development of peripheral B cells or for humoral immunity
    Annaiah Cariappa
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02129, USA
    J Immunol 175:2925-30. 2005
    ..These results suggest that CD9 is dispensable for B cell development and humoral immunity, but that this protein may serve as an additional marker for the presumed MZ precursor population of splenic B cells...
  26. pmc A unique B2 B cell subset in the intestine
    Yasuyo Shimomura
    Experimental Pathology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Med 205:1343-55. 2008
    ..These results describe the existence of an alternative pathway of B cell maturation in the periphery that gives rise to a tissue-specific B cell subset...
  27. ncbi request reprint The recirculating B cell pool contains two functionally distinct, long-lived, posttransitional, follicular B cell populations
    Annaiah Cariappa
    Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA
    J Immunol 179:2270-81. 2007
    ..These two follicular populations exhibit differences in basal tyrosine phosphorylation and in BCR-induced proliferation, suggesting that they may represent functionally distinct populations of long-lived recirculating B cells...

Research Grants29

  1. Studies on peripheral B lymphocyte development
    Shiv Pillai; Fiscal Year: 2009
    ..Insights obtained may be of importance in leukemias and in autoimmune diseases like lupus. ..
  2. Mutations in the SIAE Gene and Susceptibility to Autoimmune Diseases
    SHIV SUBRAMANIAM PILLAI; Fiscal Year: 2010
    ..The actual oligomeric structure of the enzyme will be determined and the possibility that mutations function in a dominant negative manner will be examined in cell line based studies. ..
  3. Molecular identification of a sialyl 9-O-acetyl transferase
    Shiv Pillai; Fiscal Year: 2007
    ..The gene that codes for an enzyme that controls the strength of the immune response will be studied. This gene may be an important target for the treatment of lupus and other related diseases. ..
  4. The role of PKK in NFkappa B activation
    Shiv Pillai; Fiscal Year: 2007
    ..PKK represents a novel enzyme that may be critical in pathways that are important in cancer, inflammation, cell survival, and differentiation. ..
  5. Studies on peripheral B lymphocyte development
    Shiv Pillai; Fiscal Year: 2009
    ..Insights obtained may be of importance in leukemias and in autoimmune diseases like lupus. ..
  6. Inducing neutralizing antibodies to HIV by inhibiting SIAE
    SHIV SUBRAMANIAM PILLAI; Fiscal Year: 2010
    ..A novel strategy for HIV vaccination is proposed, that may permit the induction of protective neutralizing antibodies. ..
  7. MEMBRANE IMMUNOGLOBULIN ASSEMBLY AND FUNCTION
    Shiv Pillai; Fiscal Year: 2002
    ..Since the majority of human lymphomas develop form activated B-cells, these signaling mechanisms are likely to be of direct relevance for a significant proportion of human cancers. ..
  8. Marginal zone B lymphocytes and blood borne pathogens
    Shiv Pillai; Fiscal Year: 2004
    ..Finally we will attempt to determine whether antigen-specific MZ B cells, as opposed to follicuar B cells, can readily capture and present blood borne antigens, and thus activate na'fve T cells. ..
  9. Studies on human peripheral B lymphocytes
    Shiv Pillai; Fiscal Year: 2005
    ....