Research Topics
| Mark C PierceSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Advances in optical coherence tomography imaging for dermatologyMark C Pierce
Wellman Center for Photomedicine Harvard Medical School, Massachusetts General Hospital, 50 Blossom Street, Boston, MA 02114, USA
J Invest Dermatol 123:458-63. 2004..In particular, combining the previously described structural and Doppler imaging functions with polarization-sensitive imaging increases the utility of the technique for rapid, non-invasive investigations in the skin...- Birefringence measurements in human skin using polarization-sensitive optical coherence tomographyMark C Pierce
Harvard Medical School, Massachusetts General Hospital, Wellman Center for Photomedicine, 50 Blossom Street Boston, Massachusetts 02114, USA
J Biomed Opt 9:287-91. 2004..Examples of PS-OCT images from skin sites following wound healing and repair are also presented and discussed... - Collagen denaturation can be quantified in burned human skin using polarization-sensitive optical coherence tomographyMark C Pierce
Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Burns 30:511-7. 2004..In conclusion, PS-OCT is capable of imaging and quantifying collagen denaturation in burned human skin, providing a new parameter against which post-injury outcome may be compared... - Comment on "Optical-fiber-based Mueller optical coherence tomography"B Hyle Park
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 7, Boston, Massachusetts 02114, USA
Opt Lett 29:2873-4; discussion 2875-7. 2004..Opt. Lett. 25, 1355 (2000)]... - Imaging the human vocal folds in vivo with optical coherence tomography: a preliminary experienceAdam M Klein
Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
Ann Otol Rhinol Laryngol 115:277-84. 2006..To our knowledge, this study is the first application of PS-OCT for in vivo imaging of the human vocal folds... - Optic axis determination accuracy for fiber-based polarization-sensitive optical coherence tomographyB Hyle Park
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, BAR 7, Boston, Massachusetts 02114, USA
Opt Lett 30:2587-9. 2005..We discuss the accuracy of optic axis determination due to a fundamental limit on the accuracy with which a polarization state can be determined as a function of signal-to-noise ratio... - Spectral domain optical coherence tomography: ultra-high speed, ultra-high resolution ophthalmic imagingTeresa C Chen
Department of Ophthalmology, Harvard Medical School, Boston, Mass, USA
Arch Ophthalmol 123:1715-20. 2005..To introduce a new ophthalmic optical coherence tomography technology that allows unprecedented simultaneous ultra-high speed and ultra-high resolution... - Thickness and birefringence of healthy retinal nerve fiber layer tissue measured with polarization-sensitive optical coherence tomographyBarry Cense
Harvard Medical School and Wellman Center of Photomedicine, Massachusetts General Hospital, Boston, 02114, USA
Invest Ophthalmol Vis Sci 45:2606-12. 2004..The data do not invalidate the clinical value of a phase-retardation measurement, but affect the conversion of phase retardation to RNFL thickness... - Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomographySeemantini K Nadkarni
Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
J Am Coll Cardiol 49:1474-81. 2007..The purpose of this study was to investigate the measurement of collagen and smooth muscle cell (SMC) content in atherosclerotic plaques using polarization-sensitive optical coherence tomography (PSOCT)... - Polarization-sensitive optical coherence tomography of invasive basal cell carcinomaJohn Strasswimmer
Wellman Center of Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, 50 Blossom Street, Boston, Massachusetts 02114, USA
J Biomed Opt 9:292-8. 2004..These results indicate that PS-OCT can identify features that distinguish normal skin from tumor and may have the potential to guide surgeons in the treatment of aggressive skin cancer... - Jones matrix analysis for a polarization-sensitive optical coherence tomography system using fiber-optic componentsB Hyle Park
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Opt Lett 29:2512-4. 2004..The relative importance of diattenuation versus birefringence to angular displacement of Stokes vectors on a Poincaré sphere was quantified... - In vivo birefringence and thickness measurements of the human retinal nerve fiber layer using polarization-sensitive optical coherence tomographyBarry Cense
Wellman Laboratories of Photomedicine, Harvard Medical School and Massachusetts General Hospital, 50 Blossom Street BAR 714, Boston, MA 02114, USA
J Biomed Opt 9:121-5. 2004..A trend in the preliminary measurements shows that the nerve fiber layer located inferior and superior to the optic nerve head is more birefringent than the thinner layer of nerve fiber tissue in the temporal and nasal regions... - Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomographyJohannes F de Boer
Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 724, Boston, Massachusetts 02114, USA
Opt Lett 28:2067-9. 2003..A significant SNR gain of several hundredfold is found for acquisition in the spectral domain. The SNR benefit is demonstrated experimentally in a hybrid time-domain-spectral-domain OCT system... - Imaging the mucosa of the human vocal fold with optical coherence tomographyJames A Burns
Department of Surgery, Harvard Medical School, Boston, MA 02114, USA
Ann Otol Rhinol Laryngol 114:671-6. 2005..We believe that these imaging techniques will have applications in the exploration of solutions to vocal fold scarring and in imaging vocal fold disorders in the clinic and operating room... - Optical contrast agents and imaging systems for detection and diagnosis of cancerMark C Pierce
Department of Bioengineering, Rice University, Houston, TX, USA
Int J Cancer 123:1979-90. 2008..In this article, we review fundamental techniques and recent developments in optical molecular imaging, emphasizing laboratory and clinical systems that aim to visualize the microscopic and macroscopic hallmarks of cancer...