Research Topics
| Thomas PfeifferSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Temporal patterns of genes in scientific publicationsThomas Pfeiffer
Program for Evolutionary Dynamics, Harvard University, One Brattle Square, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 104:12052-6. 2007..We identify interactions between yeast genes from PubMed and show that the frequency differences of genes in publications lead to a biased picture of the resulting interaction network...
Quantifying selective reporting and the Proteus phenomenon for multiple datasets with similar biasThomas Pfeiffer
Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America
PLoS ONE 6:e18362. 2011..Our approach captures and corrects for complex dynamic patterns of bias, and thereby helps generating conclusions from published results that are more robust against the presence of different coexisting types of selective reporting...
Prediction markets and their potential role in biomedical research--a reviewThomas Pfeiffer
Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA
Biosystems 102:71-6. 2010..Moreover, some potential practical problems of prediction market application in science are discussed, and solutions are outlined...
Large-scale assessment of the effect of popularity on the reliability of researchThomas Pfeiffer
Program for Evolutionary Dynamic, Harvard University, Cambridge, MA, USA
PLoS ONE 4:e5996. 2009..We therefore argue that for increasing the reliability of research it is essential to assess the negative effects of popularity and develop approaches to diminish these effects...
Decision-making in research tasks with sequential testingThomas Pfeiffer
Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America
PLoS ONE 4:e4607. 2009..These findings raise concerns about the reliability of research. However, they are based on a very simple scenario of scientific research, where single tests are used to evaluate independent hypotheses...
Digital cows grazing on digital groundsThomas Pfeiffer
Program for Evolutionary Dynamics, Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Curr Biol 16:R946-9. 2006..Adding together the component partial utilities, the rational herdsman concludes that the only sensible course for him to pursue is to add another animal to the herd. And another; and another.....
The value of reputationThomas Pfeiffer
Program for Evolutionary Dynamics, FAS, Harvard University, Cambridge MA 02138, USA
J R Soc Interface 9:2791-7. 2012..Moreover, we show that the more valuable a good reputation is in the PD, the higher the price at which it is traded in the market. Our findings have important implications for the use of reputation systems in practice...
Systematic differences in impact across publication tracks at PNASDavid G Rand
Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, United States of America
PLoS ONE 4:e8092. 2009..This analysis explores the consequences of differences in editor and referee selection, while controlling for the prestige of the journal in which the papers appear...
Dynamic remodeling of in-group bias during the 2008 presidential electionDavid G Rand
Program for Evolutionary Dynamics, Harvard University, Cambridge, MA 02138, USA
Proc Natl Acad Sci U S A 106:6187-91. 2009..The change in salient group identity we describe here likely contributed to the victory of Barack Obama in the 2008 presidential election...
Evolution of cooperation by generalized reciprocityThomas Pfeiffer
Behavioural Ecology, University of Berne, Hinterkappelen, Switzerland
Proc Biol Sci 272:1115-20. 2005..It is sufficient for an individual to base their decision of whether or not to cooperate on the outcome of their last encounter--even if it was with a different partner...
Evolution of cross-feeding in microbial populationsThomas Pfeiffer
Ecology and Evolution, Eidgenossische Technische Hochschule Zurich, Switzerland
Am Nat 163:E126-35. 2004....
Game-theoretical approaches to studying the evolution of biochemical systemsThomas Pfeiffer
Computational Laboratory, ETH Zurich, CH-8092 Zurich, Switzerland
Trends Biochem Sci 30:20-5. 2005..We therefore argue that it is a promising approach to studying the evolution of biochemical systems. Indeed, recent studies have applied evolutionary game theory to key issues in the evolution of energy metabolism...
Optimizing time and resource allocation trade-offs for investment into morphological and behavioral defenseUlrich K Steiner
Institute of Zoology, University of Zurich, CH 8057 Zurich, Switzerland
Am Nat 169:118-29. 2007..In the presence of time constraints, the model shows peak investment into morphological and behavioral defense at intermediate resource levels...
Climate change: all in the gameThomas Pfeiffer
Nature 441:583-4. 2006
Is maximization of molar yield in metabolic networks favoured by evolution?Stefan Schuster
Section of Bioinformatics, Faculty of Biology and Pharmaceutics, Friedrich Schiller University Jena, Ernst Abbe Platz 2, D 07743 Jena, Germany
J Theor Biol 252:497-504. 2008..Together with arguments based on evolutionary game theory, this leads us to the conclusion that maximization of molar yield is by no means a universal principle...
Experimental tests for an evolutionary trade-off between growth rate and yield in E. coliMaja Novak
Institute of Integrative Biology, Eldgenossische Technische Hochschule Zurich, 8092 Zurich, Switzerland
Am Nat 168:242-51. 2006..The observation of a trade-off within, but not between, populations suggests that the populations evolved different genetic solutions for growth in the selective environment, which in turn led to different physiological constraints...
An evolutionary scenario for the transition to undifferentiated multicellularityThomas Pfeiffer
Department of Environmental Sciences, ETH Zurich, CH-8092 Zurich, Switzerland
Proc Natl Acad Sci U S A 100:1095-8. 2003..Following the evolution of simple cell clusters, further benefits could have arisen from the exchange of resources between cells of a cluster...
