Research Topics
Genomes and GenesSpecies | M A PfefferSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Early versus delayed angiotensin-converting enzyme inhibition therapy in acute myocardial infarction. The healing and early afterload reducing therapy trialM A Pfeffer
Brigham and Women s Hospital, Boston, Mass, USA
Circulation 95:2643-51. 1997..Although ACE inhibitor therapy has been shown to reduce mortality in patients with acute myocardial infarction (MI), the optimal dose and the timing of its initiation have not been determined...- Influence of baseline lipids on effectiveness of pravastatin in the CARE Trial. Cholesterol And Recurrent EventsM A Pfeffer
Department of Medicine, Brigham and Women s Hospital and Harvard School of Public Health, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 33:125-30. 1999..We sought to assess the influence of baseline lipid levels on coronary event rates and the effectiveness of pravastatin therapy in the Cholesterol And Recurrent Events (CARE) study... - Relationship between plasma LDL concentrations during treatment with pravastatin and recurrent coronary events in the Cholesterol and Recurrent Events trialF M Sacks
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
Circulation 97:1446-52. 1998..Although LDL lowering has been shown to reduce recurrent coronary events in patients with coronary heart disease, little direct information is available on the extent of LDL lowering required to achieve this outcome... - Inflammation, pravastatin, and the risk of coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events (CARE) InvestigatorsP M Ridker
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass 02115, USA
Circulation 98:839-44. 1998..We studied whether inflammation after myocardial infarction (MI) is a risk factor for recurrent coronary events and whether randomized treatment with pravastatin reduces that risk... - Recovery of ventricular function after myocardial infarction in the reperfusion era: the healing and early afterload reducing therapy studyS D Solomon
Cardiovascular Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Ann Intern Med 134:451-8. 2001..Nevertheless, recovery of ventricular function occurs in a significant proportion of patients after myocardial infarction, and modern reperfusion strategies have been associated with increased recovery of function... - Sphygmomanometrically determined pulse pressure is a powerful independent predictor of recurrent events after myocardial infarction in patients with impaired left ventricular function. SAVE investigators. Survival and Ventricular EnlargementG F Mitchell
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 96:4254-60. 1997..There is increasing evidence of a link between conduit vessel stiffness and cardiovascular events, although the association has never been tested in a large post-myocardial infarction patient population... - A prospective evaluation of the angiotensin-converting enzyme D/I polymorphism and left ventricular remodeling in the 'Healing and Early Afterload Reducing Therapy' studyR Y L Zee
Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215 1204, USA
Clin Genet 61:21-5. 2002.... - VLDL, apolipoproteins B, CIII, and E, and risk of recurrent coronary events in the Cholesterol and Recurrent Events (CARE) trialF M Sacks
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
Circulation 102:1886-92. 2000..Plasma triglyceride concentration has been an inconsistent independent risk factor for coronary heart disease, perhaps because of the metabolic heterogeneity among VLDL particles, the main carriers of triglycerides in plasma... - Equipotent antihypertensive agents variously affect pulsatile hemodynamics and regression of cardiac hypertrophy in spontaneously hypertensive ratsG F Mitchell
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
Circulation 94:2923-9. 1996..However, the pulsatile component of hemodynamic load has not been evaluated in this model... - Mechanistic lessons from the SAVE Study. Survival and Ventricular EnlargementM A Pfeffer
Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts 02115
Am J Hypertens 7:106S-111S. 1994..These clinical observations point to an important potentially modifiable interface between the renin-angiotensin system and the risk of experiencing a coronary atherosclerotic event.(ABSTRACT TRUNCATED AT 250 WORDS).. - Valsartan in acute myocardial infarction trial (VALIANT): rationale and designM A Pfeffer
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Am Heart J 140:727-50. 2000..The development of angiotensin II receptor blockers offers a new, more specific, and theoretically more complete pharmacologic mode to inhibit the adverse influence of angiotensin II... - The platelet Pl(A2) and angiotensin-converting enzyme (ACE) D allele polymorphisms and the risk of recurrent events after acute myocardial infarctionP F Bray
Department of Medicine, Thrombosis Research Section, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Cardiol 88:347-52. 2001..These data suggest that it would be important to perform a larger study to address the potential role of these genotypes in therapeutic decision making... - Long-term effects of pravastatin on plasma concentration of C-reactive protein. The Cholesterol and Recurrent Events (CARE) InvestigatorsP M Ridker
Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, The Children s Hospital Medical Center, Boston, MA, USA
Circulation 100:230-5. 1999..We evaluated whether long-term therapy with pravastatin, an agent that reduces cardiovascular risk, might alter levels of this inflammatory parameter... - Increased pulse pressure and risk of heart failure in the elderlyC U Chae
Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
JAMA 281:634-9. 1999..Arterial stiffness increases with age. Thus, pulse pressure, an index of arterial stiffening, may predict congestive heart failure (CHF) in the elderly... - The heart and conduit vessels in hypertensionG F Mitchell
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Med Clin North Am 81:1247-71. 1997..This article reviews the adaptation of the heart and vessels to hypertension, the clinical implications of these structural and functional changes, and the effects of therapy on cardiovascular function... - Will more complete inhibition of the RAAS with angiotensin receptor blockade improve survival following myocardial infarction?M A Pfeffer
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
J Renin Angiotensin Aldosterone Syst 1:S41-3. 2000..VALIANT, with its three arms targetting 14,500 patients, is uniquely poised to determine whether the pharmacological advance in the development of ARBs confers additional clinical (survival) value in high risk MI patients... 
Aspirin-triggered resolvin D1 reduces mucosal inflammation and promotes resolution in a murine model of acute lung injuryO Eickmeier
Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Mucosal Immunol 6:256-66. 2013..Taken together, these findings indicate that AT-RvD1 displays potent mucosal protection and promotes catabasis after ALI...- Effects of reperfusion on arrhythmias and death after coronary artery occlusion in the rat: increased electrical stability independent of myocardial salvageC F Opitz
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Coll Cardiol 32:261-7. 1998..This study sought to delineate salvage-dependent from salvage-independent coronary reperfusion in acute myocardial infarction and the effects on spontaneously occurring arrhythmias and arrhythmic death in rats... - Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4A Planagumà
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
Mucosal Immunol 3:270-9. 2010.... - Prevalence and prognostic implications of electrocardiographic left ventricular hypertrophy in heart failure: evidence from the CHARM programmeN M Hawkins
Department of Cardiology, Stobhill Hospital, Balornock Road, Springburn, Glasgow G21 3UW, UK
Heart 93:59-64. 2007..Electrocardiographic left ventricular hypertrophy (ECG LVH) is a powerful independent predictor of cardiovascular morbidity and mortality in hypertension...