Marcus G Pezzolesi

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Family-based association analysis confirms the role of the chromosome 9q21.32 locus in the susceptibility of diabetic nephropathy
    Marcus G Pezzolesi
    Research Division, Joslin Diabetes Center, Boston, MA, USA
    PLoS ONE 8:e60301. 2013
  2. pmc The genetic risk of kidney disease in type 2 diabetes
    Marcus G Pezzolesi
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Med Clin North Am 97:91-107. 2013
  3. pmc Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy
    Marcus G Pezzolesi
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:2698-702. 2009
  4. pmc Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes
    Masahiko Kure
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Mol Genet Metab 103:60-5. 2011
  5. pmc An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes
    Marcus G Pezzolesi
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Kidney Int 80:105-11. 2011
  6. pmc Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes
    Marcus G Pezzolesi
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:1403-10. 2009
  7. pmc The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end-stage renal disease
    Jan Skupien
    Research and Clinic Divisions, Joslin Diabetes Center, Boston, MA, USA
    Kidney Int 82:589-97. 2012
  8. ncbi request reprint Examination of candidate chromosomal regions for type 2 diabetes reveals a susceptibility locus on human chromosome 8p23.1
    Marcus G Pezzolesi
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 53:486-91. 2004
  9. pmc High-density single nucleotide polymorphism genome-wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: discordant sibpair approach
    John J Rogus
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 57:2519-26. 2008
  10. pmc Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection
    Marcus G Pezzolesi
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Semin Nephrol 30:126-40. 2010

Collaborators

Detail Information

Publications11

  1. pmc Family-based association analysis confirms the role of the chromosome 9q21.32 locus in the susceptibility of diabetic nephropathy
    Marcus G Pezzolesi
    Research Division, Joslin Diabetes Center, Boston, MA, USA
    PLoS ONE 8:e60301. 2013
    ..192]) and in analyses expanded to include all relatives (P = 0.019 [adjusted P = 0.114]). These data increase support that SNPs identified in the GoKinD collections on chromosome 9q21.32 are true diabetic nephropathy susceptibility loci...
  2. pmc The genetic risk of kidney disease in type 2 diabetes
    Marcus G Pezzolesi
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Med Clin North Am 97:91-107. 2013
    ..To be successful, the ascertainment and comprehensive study of families with multiple affected members is critical...
  3. pmc Confirmation of genetic associations at ELMO1 in the GoKinD collection supports its role as a susceptibility gene in diabetic nephropathy
    Marcus G Pezzolesi
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:2698-702. 2009
    ....
  4. pmc Genetic variation in the matrix metalloproteinase genes and diabetic nephropathy in type 1 diabetes
    Masahiko Kure
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, MA, USA
    Mol Genet Metab 103:60-5. 2011
    ..51; 95% CI=0.37-0.71, P=6.2×10(-5)). Taken together, our study suggests that genetic variations within the MMP-3/MMP-12 locus influence susceptibility of DN in type 1 diabetes...
  5. pmc An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes
    Marcus G Pezzolesi
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Kidney Int 80:105-11. 2011
    ..4 (near the CARS gene) and 13q33.3 (within an intergenic region between MYO16 and IRS2) are susceptibility loci of kidney disease common to both type 1 and 2 diabetes...
  6. pmc Genome-wide association scan for diabetic nephropathy susceptibility genes in type 1 diabetes
    Marcus G Pezzolesi
    Research Division, Joslin Diabetes Center, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 58:1403-10. 2009
    ..To search for genes that contribute to diabetic nephropathy, a genome-wide association scan was implemented on the Genetics of Kidneys in Diabetes collection...
  7. pmc The early decline in renal function in patients with type 1 diabetes and proteinuria predicts the risk of end-stage renal disease
    Jan Skupien
    Research and Clinic Divisions, Joslin Diabetes Center, Boston, MA, USA
    Kidney Int 82:589-97. 2012
    ..Thus, the early slope of eGFR decline in patients with type 1 diabetes and proteinuria can be used to predict the risk of ESRD...
  8. ncbi request reprint Examination of candidate chromosomal regions for type 2 diabetes reveals a susceptibility locus on human chromosome 8p23.1
    Marcus G Pezzolesi
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 53:486-91. 2004
    ..Although we were able to replicate linkage in our pedigrees on chromosome 2p, we did not find evidence of linkage for regions on 1q, 2q, 3q, 5q, 9q, or 10q...
  9. pmc High-density single nucleotide polymorphism genome-wide linkage scan for susceptibility genes for diabetic nephropathy in type 1 diabetes: discordant sibpair approach
    John J Rogus
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 57:2519-26. 2008
    ..Epidemiological and family studies have demonstrated that susceptibility genes play an important role in the etiology of diabetic nephropathy, defined as persistent proteinuria or end-stage renal disease (ESRD) in type 1 diabetes...
  10. pmc Insights to the genetics of diabetic nephropathy through a genome-wide association study of the GoKinD collection
    Marcus G Pezzolesi
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Semin Nephrol 30:126-40. 2010
    ..Collectively, genome-wide association and genome-wide imputation data from the GoKinD collection will serve as a springboard for future investigations into the genetic basis of DN in type 1 diabetes...
  11. ncbi request reprint A method for developing high-density SNP maps and its application at the type 1 angiotensin II receptor (AGTR1) locus
    Anthony Antonellis
    Section on Genetics and Epidemiology, Joslin Diabetes Center, Boston, Massachusetts, 02215, USA
    Genomics 79:326-32. 2002
    ..Using this technique, we efficiently validated and genotyped 18 polymorphisms spanning the 60.5-kb AGTR1 locus. Our panel of polymorphisms has an average spacing of 3.2 kb and an average minor allele frequency of 24%...