T L Petryshen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology
    Melanie P Leussis
    Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Biol Mood Anxiety Disord 2:18. 2012
  2. pmc Population genetic study of the brain-derived neurotrophic factor (BDNF) gene
    T L Petryshen
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 15:810-5. 2010
  3. ncbi request reprint Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia
    T L Petryshen
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA
    Mol Psychiatry 10:1074-88, 1057. 2005
  4. pmc Genomic survey of prepulse inhibition in mouse chromosome substitution strains
    M P Leussis
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Genes Brain Behav 8:806-16. 2009
  5. ncbi request reprint Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis
    P Sklar
    Department of Psychiatry, Harvard Medical School, and Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Psychiatry 9:213-8. 2004
  6. ncbi request reprint Support for involvement of neuregulin 1 in schizophrenia pathophysiology
    T L Petryshen
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Psychiatry 10:366-74, 328. 2005

Detail Information

Publications6

  1. pmc Ankyrin 3: genetic association with bipolar disorder and relevance to disease pathophysiology
    Melanie P Leussis
    Psychiatric and Neurodevelopmental Genetics Unit, Department of Psychiatry and Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Biol Mood Anxiety Disord 2:18. 2012
    ..This knowledge is expected to lead to a better understanding of the brain abnormalities contributing to BD symptoms, and to potentially identify new targets for treatment and intervention approaches...
  2. pmc Population genetic study of the brain-derived neurotrophic factor (BDNF) gene
    T L Petryshen
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 15:810-5. 2010
    ..These phenomena can have a profound impact on the detection of disease susceptibility genes and must be considered in gene association studies of BDNF...
  3. ncbi request reprint Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia
    T L Petryshen
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA, USA
    Mol Psychiatry 10:1074-88, 1057. 2005
    ..Taken together, these results support the involvement of the chromosome 5q GABAA receptor gene cluster in schizophrenia, and suggest that schizophrenia-associated haplotypes may alter expression of GABA-related genes...
  4. pmc Genomic survey of prepulse inhibition in mouse chromosome substitution strains
    M P Leussis
    Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
    Genes Brain Behav 8:806-16. 2009
    ..Identification of genes that modulate PPI will provide insight into the neural mechanisms underlying sensorimotor gating, as well as the psychopathology of disorders characterized by gating deficits...
  5. ncbi request reprint Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a susceptibility locus for schizophrenia and psychosis
    P Sklar
    Department of Psychiatry, Harvard Medical School, and Psychiatric and Neurodevelopmental Genetics Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Psychiatry 9:213-8. 2004
    ..03, P=0.0012 at D5S820), suggesting that this locus may be responsible for the psychotic symptoms observed in both diseases. Molecular Psychiatry (2004) 9, 213-218. doi:10.1038/sj.mp.4001418 Published online 30 December 2003..
  6. ncbi request reprint Support for involvement of neuregulin 1 in schizophrenia pathophysiology
    T L Petryshen
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Psychiatry 10:366-74, 328. 2005
    ..In summary, our results suggest that haplotypes across NRG1 and multiple NRG1 variants are involved in schizophrenia...