RANDALL T contact PETERSON

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Discovery of therapeutic targets by phenotype-based zebrafish screens
    Randall T Peterson
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA Electronic
    Drug Discov Today Technol 1:49-54. 2004
  2. pmc Identification of a novel retinoid by small molecule screening with zebrafish embryos
    Chetana Sachidanandan
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 3:e1947. 2008
  3. pmc Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure
    Anjali K Nath
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    FASEB J 27:1928-38. 2013
  4. pmc Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
    Gregory D Cuny
    Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women s Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Bioorg Med Chem Lett 18:4388-92. 2008
  5. pmc Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Brief Funct Genomic Proteomic 7:483-90. 2008
  6. pmc Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
    Jason Rihel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 327:348-51. 2010
  7. pmc Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    Paul B Yu
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 4:33-41. 2008
  8. ncbi request reprint Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule
    Ebrahim Shafizadeh
    Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, 621 Charles E Young Drive, South Life Sciences Building, LS4325, Los Angeles, CA 90095, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:245-9. 2004
  9. ncbi request reprint Discovery and use of small molecules for probing biological processes in zebrafish
    Randall T Peterson
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Methods Cell Biol 76:569-91. 2004

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Discovery of therapeutic targets by phenotype-based zebrafish screens
    Randall T Peterson
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA Electronic
    Drug Discov Today Technol 1:49-54. 2004
    ..Can zebrafish screens also be used for unbiased discovery of novel drug targets?: ..
  2. pmc Identification of a novel retinoid by small molecule screening with zebrafish embryos
    Chetana Sachidanandan
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 3:e1947. 2008
    ....
  3. pmc Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure
    Anjali K Nath
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    FASEB J 27:1928-38. 2013
    ....
  4. pmc Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors
    Gregory D Cuny
    Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham and Women s Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA
    Bioorg Med Chem Lett 18:4388-92. 2008
    ..g., plasma t(1/2)=1.6h) following intraperitoneal administration in mice. These studies provide useful molecular probes for examining the in vivo pharmacology of BMP signaling inhibition...
  5. pmc Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish
    David Kokel
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Brief Funct Genomic Proteomic 7:483-90. 2008
    ..Thus, behaviour-based chemical screens in the zebrafish may improve our understanding of neurobiology and accelerate the pace of psychiatric drug discovery...
  6. pmc Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation
    Jason Rihel
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    Science 327:348-51. 2010
    ..These results demonstrate the power of high-throughput behavioral profiling in zebrafish to discover and characterize psychotropic drugs and to dissect the pharmacology of complex behaviors...
  7. pmc Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
    Paul B Yu
    Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 4:33-41. 2008
    ..These findings suggest an essential physiological role for hepatic BMP signaling in iron-hepcidin homeostasis...
  8. ncbi request reprint Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule
    Ebrahim Shafizadeh
    Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, 621 Charles E Young Drive, South Life Sciences Building, LS4325, Los Angeles, CA 90095, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:245-9. 2004
    ..The induced anemia is reversible and treated fish recover in about 4 days. This study shows the feasibility of using zebrafish to screen for small molecules that can modulate the specific process of erythropoiesis...
  9. ncbi request reprint Discovery and use of small molecules for probing biological processes in zebrafish
    Randall T Peterson
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Methods Cell Biol 76:569-91. 2004

Research Grants13

  1. CHEMICAL TOOLS FOR DISSECTION OF BLOOD VESSEL IDENTITY
    Randall Peterson; Fiscal Year: 2005
    ..Moreover, it will establish novel methodologies for phenotype-based chemical screening that complement traditional genetic screens and can be applied broadly to other areas of zebrafish research. ..
  2. BMP inhibitors and the study of disease mechanisms in anemia of inflammation
    RANDALL T contact PETERSON; Fiscal Year: 2010
    ..Recently, chemical compounds that specifically block activation of BMP receptors have been discovered. This research project seeks to optimize and test these BMP receptor blockers for treating Anemia of Inflammation. ..
  3. In Vivo Discovery of Psychotropic Drugs by High-Throughput Behavioral Phenotyping
    Randall T Peterson; Fiscal Year: 2010
    ..This project proposes a bold new approach to nervous system drug discovery based on robotic testing of thousands of potential new drugs for their ability to alter brain function in microscopic zebrafish. ..
  4. In Vivo Discovery of Psychotropic Drugs by High-Throughput Behavioral Phenotyping
    Randall Peterson; Fiscal Year: 2009
    ..This project proposes a bold new approach to nervous system drug discovery based on robotic testing of thousands of potential new drugs for their ability to alter brain function in microscopic zebrafish. ..
  5. BMP inhibitors and the study of disease mechanisms in anemia of inflammation
    Randall Peterson; Fiscal Year: 2009
    ..Recently, chemical compounds that specifically block activation of BMP receptors have been discovered. This research project seeks to optimize and test these BMP receptor blockers for treating Anemia of Inflammation. ..
  6. CHEMICAL TOOLS FOR DISSECTION OF BLOOD VESSEL IDENTITY
    Randall Peterson; Fiscal Year: 2007
    ..Moreover, it will establish novel methodologies for phenotype-based chemical screening that complement traditional genetic screens and can be applied broadly to other areas of zebrafish research. ..
  7. Chemical genetic modifiers of acute myelogenous leukemia
    Randall Peterson; Fiscal Year: 2007
    ..Compounds discovered using these tests will provide important insights into how this cancer progresses and may be useful tools for treating leukemia. ..
  8. CHEMICAL TOOLS FOR DISSECTION OF BLOOD VESSEL IDENTITY
    Randall Peterson; Fiscal Year: 2006
    ..Moreover, it will establish novel methodologies for phenotype-based chemical screening that complement traditional genetic screens and can be applied broadly to other areas of zebrafish research. ..
  9. Chemical genetic modifiers of acute myelogenous leukemia
    Randall Peterson; Fiscal Year: 2006
    ..Compounds discovered using these tests will provide important insights into how this cancer progresses and may be useful tools for treating leukemia. ..
  10. BMP inhibitors and the study of disease mechanisms in anemia of inflammation
    RANDALL T contact PETERSON; Fiscal Year: 2010
    ..Recently, chemical compounds that specifically block activation of BMP receptors have been discovered. This research project seeks to optimize and test these BMP receptor blockers for treating Anemia of Inflammation. ..