Lizabeth Perkins

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye
    Alysia D Vrailas
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 133:1485-94. 2006
  2. ncbi request reprint The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila
    L A Perkins
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Dev Biol 180:63-81. 1996
  3. ncbi request reprint Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila
    C Ghiglione
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Biol 205:181-93. 1999
  4. pmc Analysis of corkscrew signaling in the Drosophila epidermal growth factor receptor pathway during myogenesis
    M R Johnson Hamlet
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genetics 159:1073-87. 2001
  5. pmc In vivo RNAi: today and tomorrow
    Norbert Perrimon
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cold Spring Harb Perspect Biol 2:a003640. 2010
  6. ncbi request reprint Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin
    J A Lorenzen
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Development 128:1403-14. 2001
  7. ncbi request reprint There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor
    N Perrimon
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 89:13-6. 1997
  8. ncbi request reprint Doublesex surprises
    S Vincent
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 106:399-402. 2001
  9. pmc Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster
    Jian Quan Ni
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02175, USA
    Nat Methods 5:49-51. 2008
  10. pmc Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7
    Scott E Baker
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 162:285-96. 2002

Research Grants

Collaborators

  • Norbert Perrimon
  • Marco Tartaglia
  • T A Bunch
  • DANNY BROWER
  • Daniel R Marenda
  • Alysia D Vrailas
  • James A Lorenzen
  • Jian Quan Ni
  • Brian P James
  • Srinivasan Krishnamoorthy
  • Maureen A Powers
  • Kimihiko Oishi
  • Kevin Moses
  • Gee W Lau
  • Scott E Baker
  • J A Lorenzen
  • M R Johnson Hamlet
  • S Vincent
  • Richard Binari
  • Matthew Booker
  • Michele Markstein
  • C Ghiglione
  • Christians Villalta
  • Barret Pfeiffer
  • Lu Ping Liu
  • Summer E Cook
  • Ursula Weber
  • Aloma B Rodrigues
  • Summer Cook
  • In Kyong Kim
  • Konstantin Gaengel
  • Kenichi Kamiya
  • Bruce D Gelb
  • Leslie Pick
  • Huiwen Ying
  • Marek Mlodzik
  • Jennifer Hewitson
  • Wenzhong Xiao
  • Ronald G Tompkins
  • Laurence G Rahme
  • Boyan C Goumnerov
  • Cynthia L Walendziewicz
  • Shalina Mahajan-Miklos
  • Mark H Ginsberg
  • Alison L Jannuzi
  • Steven W Miller
  • F Denhez
  • S E Baker
  • M B Melnick

Detail Information

Publications14

  1. pmc smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye
    Alysia D Vrailas
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 133:1485-94. 2006
    ..Ectopic expression of Msk overcomes this block and disrupts patterning. Additionally, the MAPK cytoplasmic hold is genetically dependent on the presence of Decapentaplegic (Dpp) and Hedgehog receptors...
  2. ncbi request reprint The nonreceptor protein tyrosine phosphatase corkscrew functions in multiple receptor tyrosine kinase pathways in Drosophila
    L A Perkins
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Dev Biol 180:63-81. 1996
    ..In support of this hypothesis, we demonstrate that SHP-2, a vertebrate PTPase similar to Csw and previously implicated in RTK signaling, encodes the functional vertebrate homologue of Csw...
  3. ncbi request reprint Quantitative variations in the level of MAPK activity control patterning of the embryonic termini in Drosophila
    C Ghiglione
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Biol 205:181-93. 1999
    ..Altogether, our results illustrate how a gradient of MAPK activity controls differential gene expression and, thus, the establishment of various cell fates. We discuss the roles of quantitative mechanisms in defining RTK specificity...
  4. pmc Analysis of corkscrew signaling in the Drosophila epidermal growth factor receptor pathway during myogenesis
    M R Johnson Hamlet
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Genetics 159:1073-87. 2001
    ..This work extends previous studies of Csw during Torso and Sevenless RTK signaling to include an in-depth analysis of the role of Csw in the EGFR signaling pathway...
  5. pmc In vivo RNAi: today and tomorrow
    Norbert Perrimon
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cold Spring Harb Perspect Biol 2:a003640. 2010
    ..Further, we discuss the applications of RNAi technologies to crop improvement, pest control and RNAi therapeutics, thus providing an appreciation of the potential for phenomenal applications of RNAi to agriculture and medicine...
  6. ncbi request reprint Nuclear import of activated D-ERK by DIM-7, an importin family member encoded by the gene moleskin
    J A Lorenzen
    Pediatric Surgical Research Laboratories, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Development 128:1403-14. 2001
    ..Mutations in the Drosophila Importin beta homolog Ketel, also reduce the nuclear localization of activated D-ERK. Together, these data indicate that DIM-7 and Ketel are components of the nuclear import machinery for activated D-ERK...
  7. ncbi request reprint There must be 50 ways to rule the signal: the case of the Drosophila EGF receptor
    N Perrimon
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell 89:13-6. 1997
  8. ncbi request reprint Doublesex surprises
    S Vincent
    Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Cell 106:399-402. 2001
  9. pmc Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster
    Jian Quan Ni
    Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02175, USA
    Nat Methods 5:49-51. 2008
    ..To avoid this problem, we have developed a transgenic RNA interference vector based on the phiC31 site-specific integration method...
  10. pmc Genetic interaction between integrins and moleskin, a gene encoding a Drosophila homolog of importin-7
    Scott E Baker
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 162:285-96. 2002
    ..Genetic tests suggest that the moleskin suppression of wing blisters is not directly related to inhibition of D-ERK nuclear import. These data are discussed with respect to the possible regulation of integrin function by cytoplasmic ERK...
  11. pmc Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7
    Brian P James
    Department of Molecular and Cellular Biology, Center for Insect Science, and Department of Biochemistry and Molecular Biophysics, Arizona Cancer Center, Tucson, AZ 85724, USA
    Mol Biol Cell 18:4190-9. 2007
    ..Moreover, dpERK nuclear import can be restored in DIM-7-deficient cells by Xenopus Importin-7, demonstrating that ERK import is an evolutionarily conserved function of this protein...
  12. ncbi request reprint Transgenic Drosophila models of Noonan syndrome causing PTPN11 gain-of-function mutations
    Kimihiko Oishi
    Departments of Pediatrics and Human Genetics, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1498, New York, NY 10029, USA
    Hum Mol Genet 15:543-53. 2006
    ..In addition, these fly models can be used for sensitized screens to identify novel interacting genes as well as for high-throughput screening of therapeutic compounds for NS and PTPN11-related cancers...
  13. pmc MAP kinase subcellular localization controls both pattern and proliferation in the developing Drosophila wing
    Daniel R Marenda
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Development 133:43-51. 2006
    ....
  14. pmc The Drosophila melanogaster toll pathway participates in resistance to infection by the gram-negative human pathogen Pseudomonas aeruginosa
    Gee W Lau
    Department of Surgery, Harvard Medical School and Massachusetts General Hospital and Shriners Burns Institute, Boston, Massachusetts 02114, USA
    Infect Immun 71:4059-66. 2003
    ..Additionally, our results provide the basis for future studies into interactions between P. aeruginosa virulence factors and components of the Toll signaling pathway, which is functionally conserved between flies and humans...

Research Grants4

  1. Receptor Tyrosine Kinase Regulation of Nuclear Import
    Lizabeth Perkins; Fiscal Year: 2004
    ..g. Csw) directly participate in the process of nuclear import will contribute to a greater understanding of how signaling pathways control cellular growth and differentiation. ..