J Manuel Perez
Affiliation: Harvard University
- Dextran-coated gold nanoparticles for the assessment of antimicrobial susceptibilitySudip Nath
NanoScience Technology Center, Burnett School of Biomedical Sciences, and Department of Chemistry, University of Central Florida, 12424 Research Parkway, Orlando, FL 32826, USA
Anal Chem 80:1033-8. 2008....
- Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological mediaJ Manuel Perez
MGH Center for Molecular Imaging Research, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
J Am Chem Soc 125:10192-3. 2003..The applications of this new method span from high-throughput NMR detection of viruses in biological samples to potential MR imaging of viral distribution in vivo...
- Novel nanosensors for rapid analysis of telomerase activityJan Grimm
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 64:639-43. 2004..Together, these studies establish and validate a novel and powerful tool for rapidly sensing telomerase activity and provide the rationale for developing analogous magnetic nanoparticles for in vivo sensing...
- Use of magnetic nanoparticles as nanosensors to probe for molecular interactionsJ Manuel Perez
Center for Molecular Imaging Research, Massachusetts General Hospital, Harvard Medical School, Building 149, 13th Street, 5404, Charlestown, MA 02129, USA
Chembiochem 5:261-4. 2004..These magnetic nanosensors have been designed to detect specific mRNA, proteins, enzymatic activity, and pathogens (e.g., virus) with sensitivity in the low femtomole range (0.5-30 fmol)...
- DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agentsJ Manuel Perez
MGH-Center for Molecular Imaging Research, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
J Am Chem Soc 124:2856-7. 2002..These qualities render the developed nanoparticles and their nanoassemblies as magnetic relaxation switches capable of screening for DNA-cleaving compounds by magnetic resonance methods such as MRI and NMR...
- Polymeric nanoparticle preparation that eradicates tumorsJason R McCarthy
MGH-Harvard Medical School, Center for Molecular Imaging Research, 149 13th Street, Room 5404, Charlestown, MA 02129, USA
Nano Lett 5:2552-6. 2005..Importantly, in vivo experiments show complete eradication of cancers in mouse models. The concept of photosensitizers with selective phototoxicity should have widespread applications in cancer therapy...
- Detection of peroxidase/H2O2-mediated oxidation with enhanced yellow fluorescent proteinAndrew Tsourkas
Center for Molecular Imaging Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
Anal Chem 77:2862-7. 2005..Combined expression of EYFP (quenchable) and ECFP or EGFP (nonquenchable) is expected to allow sensitive monitoring of oxidative stress...
- Magnetic relaxation switches capable of sensing molecular interactionsJ Manuel Perez
Center for Molecular Imaging Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02129
Nat Biotechnol 20:816-20. 2002....
- Synthesis of biocompatible dextran-coated nanoceria with pH-dependent antioxidant propertiesJ Manuel Perez
NanoScience Technology Center, Department of Chemistry, and Burnett School of Biomedical Sciences University of Central Florida 12424 Research Parkway, Suite 400 Orlando, FL 32826, USA
Small 4:552-6. 2008
- One-step, nanoparticle-mediated bacterial detection with magnetic relaxationCharalambos Kaittanis
NanoScience Technology Center, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, Florida 32826, USA
Nano Lett 7:380-3. 2007..The use of the described magnetic nanosensors in the identification and quantification of bacteria in clinical and environmental samples is anticipated...
- Iron oxide nanoparticles: hidden talentJ Manuel Perez
Nat Nanotechnol 2:535-6. 2007