Kathryn L Penney

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Association of prostate cancer risk variants with gene expression in normal and tumor tissue
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Cancer Epidemiol Biomarkers Prev 24:255-60. 2015
  2. pmc Gleason grade progression is uncommon
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 73:5163-8. 2013
  3. pmc Selenoprotein P genetic variants and mrna expression, circulating selenium, and prostate cancer risk and survival
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Prostate 73:700-5. 2013
  4. pmc TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, USA
    BMC Cancer 7:175. 2007
  5. pmc mRNA expression signature of Gleason grade predicts lethal prostate cancer
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 29:2391-6. 2011
  6. pmc Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 32:853-9. 2011
  7. pmc A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 3:604-10. 2010
  8. pmc Genetic variation in RNASEL associated with prostate cancer risk and progression
    Mara S Meyer
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 31:1597-603. 2010
  9. pmc Modification of the association between obesity and lethal prostate cancer by TMPRSS2:ERG
    Andreas Pettersson
    Affiliations of authors Department of Epidemiology AP, AM, MF, REG, KLP, JRR, EJN, MJS, ELG, LAM and Department of Nutrition MJS, ELG, Harvard School of Public Health, Boston, MA Channing Division of Network Medicine AP, KLP, JRR, MJS, ELG, LAM and Division of Preventive Medicine HDS, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Department of Pathology, Brigham and Women s Hospital, Boston, MA RTL, ECS, ML Center for Molecular Oncologic Pathology RTL, RF, ECS, MF, SF, NEM, ML, Department of Radiation Oncology NEM, Centre for Regenerative Medicine
    J Natl Cancer Inst 105:1881-90. 2013
  10. ncbi request reprint A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk
    Matthew L Freedman
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Cancer Res 65:7516-22. 2005

Detail Information

Publications30

  1. pmc Association of prostate cancer risk variants with gene expression in normal and tumor tissue
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts
    Cancer Epidemiol Biomarkers Prev 24:255-60. 2015
    ..One possibility is that these variants influence gene expression in prostate tissue. We therefore examined the association of prostate cancer risk variants with the expression of genes nearby and genome-wide...
  2. pmc Gleason grade progression is uncommon
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cancer Res 73:5163-8. 2013
    ..This has implications for the understanding of tumor progression and prognosis, and may help patients diagnosed with lower grade disease feel more comfortable choosing active surveillance...
  3. pmc Selenoprotein P genetic variants and mrna expression, circulating selenium, and prostate cancer risk and survival
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Prostate 73:700-5. 2013
    ..We examined the association of SEPP1 single nucleotide polymorphisms (SNPs) with PCa risk and survival, and tested for interactions...
  4. pmc TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study
    David G Cox
    Program in Molecular and Genetic Epidemiology, Epidemiology Department, Harvard School of Public Health, USA
    BMC Cancer 7:175. 2007
    ..Single nucleotide polymorphisms in TGFB1 and a microsatellite in TGFBR1 have been investigated for association with risk of breast cancer, with conflicting results...
  5. pmc mRNA expression signature of Gleason grade predicts lethal prostate cancer
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 29:2391-6. 2011
    ....
  6. pmc Association of KLK3 (PSA) genetic variants with prostate cancer risk and PSA levels
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Carcinogenesis 32:853-9. 2011
    ..Understanding the mechanism by which genetic variation in KLK3 affects prostate cancer risk has important implications for study of the biological role of PSA in prostate tumorigenesis...
  7. pmc A large prospective study of SEP15 genetic variation, interaction with plasma selenium levels, and prostate cancer risk and survival
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Cancer Prev Res (Phila) 3:604-10. 2010
    ..Additionally, the association of selenium with PCa mortality was modified by a variant, suggesting the possibility that some men with PCa may benefit more from selenium than others, depending on their genotype...
  8. pmc Genetic variation in RNASEL associated with prostate cancer risk and progression
    Mara S Meyer
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Carcinogenesis 31:1597-603. 2010
    ..The results of this study support a link between RNASEL and prostate cancer and suggest that the association may be mediated through inflammation. These novel findings warrant replication in future studies...
  9. pmc Modification of the association between obesity and lethal prostate cancer by TMPRSS2:ERG
    Andreas Pettersson
    Affiliations of authors Department of Epidemiology AP, AM, MF, REG, KLP, JRR, EJN, MJS, ELG, LAM and Department of Nutrition MJS, ELG, Harvard School of Public Health, Boston, MA Channing Division of Network Medicine AP, KLP, JRR, MJS, ELG, LAM and Division of Preventive Medicine HDS, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA Department of Pathology, Brigham and Women s Hospital, Boston, MA RTL, ECS, ML Center for Molecular Oncologic Pathology RTL, RF, ECS, MF, SF, NEM, ML, Department of Radiation Oncology NEM, Centre for Regenerative Medicine
    J Natl Cancer Inst 105:1881-90. 2013
    ..TMPRSS2:ERG is a hormonally regulated gene fusion present in about half of prostate tumors. We investigated whether obesity, which deregulates several hormonal pathways, interacts with TMPRSS2:ERG to impact prostate cancer outcomes...
  10. ncbi request reprint A haplotype-based case-control study of BRCA1 and sporadic breast cancer risk
    Matthew L Freedman
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Cancer Res 65:7516-22. 2005
    ....
  11. pmc Seasonal variation in expression of markers in the vitamin D pathway in prostate tissue
    Mara M Epstein
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Causes Control 23:1359-66. 2012
    ..As serum vitamin D levels vary by season, we sought to determine whether the expression of genes on the vitamin D pathway, assessed in prostate tumor tissue, do the same...
  12. pmc Common genetic variation of the calcium-sensing receptor and lethal prostate cancer risk
    Irene M Shui
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 22:118-26. 2013
    ..We assessed whether (i) common genetic variation in CaSR was associated with PCa risk and (ii) these associations varied by calcium intake or plasma 25-hydroxyvitamin D [25(OH)D] levels...
  13. pmc Genome-wide association study of prostate cancer mortality
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 19:2869-76. 2010
    ..Identifying genetic variants associated with lethal prostate cancer could inform clinical decision making...
  14. pmc Genetic variation in the toll-like receptor 4 and prostate cancer incidence and mortality
    Irene M Shui
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Prostate 72:209-16. 2012
    ..Common genetic variants in the Toll-like receptor 4 (TLR4), which is involved in inflammation and immune response pathways, may be important for prostate cancer...
  15. pmc Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study
    Matthew L Freedman
    Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Hum Genet 76:82-90. 2005
    ..A systematic approach that assesses both coding and noncoding genetic variation in large and diverse patient samples can help clarify hypotheses about association between genetic variants and disease...
  16. pmc Genetic variation across C-reactive protein and risk of prostate cancer
    Sarah C Markt
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts
    Prostate 74:1034-42. 2014
    ..We investigated the role of genetic variation in CRP and prostate cancer, under the hypothesis that variants may alter risk of disease...
  17. pmc Vitamin D receptor protein expression in tumor tissue and prostate cancer progression
    Whitney K Hendrickson
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
    J Clin Oncol 29:2378-85. 2011
    ..How VDR expression in tumor tissue may influence prostate cancer progression has not been evaluated in large studies...
  18. pmc Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study
    Irene M Shui
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02215, USA
    J Natl Cancer Inst 104:690-9. 2012
    ..The association of vitamin D status with prostate cancer is controversial; no association has been observed for overall incidence, but there is a potential link with lethal disease...
  19. pmc Evaluation of 8q24 and 17q risk loci and prostate cancer mortality
    Kathryn L Penney
    Department of Epidemiology, Harvard School of Public Health, Harvard University, Cambridge, Massachusetts, USA
    Clin Cancer Res 15:3223-30. 2009
    ..We investigated whether the 8q24 and 17q risk variants are associated with clinical variables as well as prostate cancer mortality...
  20. pmc Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer
    Preet K Dhillon
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 20:2618-27. 2011
    ..However, the role of genetic variation in the adiponectin (ADIPOQ) and receptor genes (ADIPOR1/R2) in prostate cancer is largely unknown...
  21. pmc Analysis of the 10q11 cancer risk locus implicates MSMB and NCOA4 in human prostate tumorigenesis
    Mark M Pomerantz
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS Genet 6:e1001204. 2010
    ..More broadly, the findings demonstrate that disease risk alleles may influence multiple genes, and associations between genotype and expression may only be observed in the context of specific tissue and disease states...
  22. ncbi request reprint Transferability of tag SNPs in genetic association studies in multiple populations
    Paul I W de Bakker
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, Massachusetts, 02142, USA
    Nat Genet 38:1298-303. 2006
    ..These results demonstrate that the HapMap DNA samples can be used to select tags for genome-wide association studies in many samples around the world...
  23. pmc Protein expression of PTEN, insulin-like growth factor I receptor (IGF-IR), and lethal prostate cancer: a prospective study
    Ke Zu
    Authors Affiliations Departments of Nutrition, Epidemiology, and Biostatistics, Harvard School of Public Health Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School Department of Radiation Oncology, Dana Farber Cancer Institute Brigham and Women s Hospital Departments of Pathology and Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts Molecular and Transplantation Pathology Laboratory, F Addarii Institute of Oncology, University of Bologna, Bologna, Italy Center of Public Health Sciences, University of Iceland, Reykjavik, Iceland The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia Department of Pathology and Laboratory Medicine and Oncology, University of Calgary, Calgary, Alberta and Departments of Medicine and Oncology, McGill University, Jewish General Hospital, Montreal, Quebec, Canada
    Cancer Epidemiol Biomarkers Prev 22:1984-93. 2013
    ..We investigated the association between PTEN expression and prostate cancer mortality and the potential effect modification by IGF-IR, a direct activator of the phosphoinositide-3-kinase (PI3K) pathway...
  24. pmc Evaluation of the 8q24 prostate cancer risk locus and MYC expression
    Mark M Pomerantz
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Cancer Res 69:5568-74. 2009
    ..These data will help to direct the future study of this risk locus...
  25. ncbi request reprint Common variation in BRCA2 and breast cancer risk: a haplotype-based analysis in the Multiethnic Cohort
    Matthew L Freedman
    The Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Hum Mol Genet 13:2431-41. 2004
    ..However, a significant elevation in risk was observed among approximately 6% of women who carried a specific haplotype pattern and may harbor a susceptibility allele at the BRCA2 locus...
  26. pmc Fatty acid synthase polymorphisms, tumor expression, body mass index, prostate cancer risk, and survival
    Paul L Nguyen
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 28:3958-64. 2010
    ..We examined whether common germline single nucleotide polymorphisms (SNPs) in the FASN gene affect prostate cancer (PCa) risk or PCa-specific mortality and whether these effects vary by body mass index (BMI)...
  27. pmc The TMPRSS2:ERG rearrangement, ERG expression, and prostate cancer outcomes: a cohort study and meta-analysis
    Andreas Pettersson
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Cancer Epidemiol Biomarkers Prev 21:1497-509. 2012
    ..Whether the genomic rearrangement transmembrane protease, serine 2 (TMPRSS2):v-ets erythroblastosis virus E26 oncogene homolog (ERG) has prognostic value in prostate cancer is unclear...
  28. pmc Prostate cancer (PCa) risk variants and risk of fatal PCa in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium
    Irene M Shui
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA Electronic address
    Eur Urol 65:1069-75. 2014
    ..Studies have identified multiple genetic risk loci for PCa incidence, but it is unknown whether they could be used as biomarkers for PCa-specific mortality (PCSM)...
  29. ncbi request reprint Assessing the impact of population stratification on genetic association studies
    Matthew L Freedman
    Department of Medicine and Molecular Biology, Massachusetts General Hospital, Boston, and Program in Medical and Population Genetics, Broad Institute, Cambridge, USA
    Nat Genet 36:388-93. 2004
    ..Our results suggest that modest amounts of stratification can exist even in well designed studies...
  30. pmc Plasma antioxidants, genetic variation in SOD2, CAT, GPX1, GPX4, and prostate cancer survival
    Erin L Van Blarigan
    Authors Affiliations Departments of Epidemiology and Biostatistics, Urology, University of California, San Francisco, California Channing Division of Network Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School Departments of Epidemiology, and Nutrition, Harvard School of Public Health, Boston, Massachusetts and Department of Food Science and Human Nutrition, University of Illinois, Urbana, Illinois
    Cancer Epidemiol Biomarkers Prev 23:1037-46. 2014
    ..Antioxidants may reduce risk of aggressive prostate cancer, and single-nucleotide polymorphisms (SNP) in antioxidant genes may modify this association...