Anton Y Peleg

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched case-control study
    Anton Y Peleg
    Infectious Diseases Department, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Clin Infect Dis 44:1307-14. 2007
  2. pmc Acinetobacter baumannii: emergence of a successful pathogen
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
    Clin Microbiol Rev 21:538-82. 2008
  3. pmc Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus
    Anton Y Peleg
    Department of Microbiology, School of Biomedical Sciences, Monash University, Melbourne, Australia
    PLoS ONE 7:e28316. 2012
  4. ncbi request reprint Prophylaxis against pulmonary viral and fungal infections in solid organ transplant recipients
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
    Curr Infect Dis Rep 11:209-15. 2009
  5. pmc Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis St, LMOB Suite GB, Boston, MA 02215, USA
    Antimicrob Agents Chemother 51:2065-9. 2007
  6. ncbi request reprint Optimizing therapy for Acinetobacter baumannii
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Semin Respir Crit Care Med 28:662-71. 2007
  7. pmc Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics
    Anton Y Peleg
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Antimicrob Agents Chemother 53:2605-9. 2009
  8. pmc Utility of peptide nucleic acid fluorescence in situ hybridization for rapid detection of Acinetobacter spp. and Pseudomonas aeruginosa
    A Y Peleg
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Microbiol 47:830-2. 2009
  9. pmc Reduced susceptibility to vancomycin influences pathogenicity in Staphylococcus aureus infection
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02215, USA
    J Infect Dis 199:532-6. 2009
  10. doi request reprint Medically important bacterial-fungal interactions
    Anton Y Peleg
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Rev Microbiol 8:340-9. 2010

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Risk factors, clinical characteristics, and outcome of Nocardia infection in organ transplant recipients: a matched case-control study
    Anton Y Peleg
    Infectious Diseases Department, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Clin Infect Dis 44:1307-14. 2007
    ..Risk factors for Nocardia infection in organ transplant recipients have not been formally assessed in the current era of transplantation...
  2. pmc Acinetobacter baumannii: emergence of a successful pathogen
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
    Clin Microbiol Rev 21:538-82. 2008
    ....
  3. pmc Whole genome characterization of the mechanisms of daptomycin resistance in clinical and laboratory derived isolates of Staphylococcus aureus
    Anton Y Peleg
    Department of Microbiology, School of Biomedical Sciences, Monash University, Melbourne, Australia
    PLoS ONE 7:e28316. 2012
    ..Daptomycin remains one of our last-line anti-staphylococcal agents. This study aims to characterize the genetic evolution to daptomycin resistance in S. aureus...
  4. ncbi request reprint Prophylaxis against pulmonary viral and fungal infections in solid organ transplant recipients
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and Harvard Medical School, 110 Francis Street, LMOB Suite GB, Boston, MA 02215, USA
    Curr Infect Dis Rep 11:209-15. 2009
    ..This article focuses on strategies to prevent pulmonary viral and fungal infections in transplant recipients, with an emphasis on recent evidence that may influence practice guidelines...
  5. pmc Tigecycline Efflux as a Mechanism for Nonsusceptibility in Acinetobacter baumannii
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, 110 Francis St, LMOB Suite GB, Boston, MA 02215, USA
    Antimicrob Agents Chemother 51:2065-9. 2007
    ..These results indicate that an efflux-based mechanism plays a role in reduced tigecycline susceptibility in Acinetobacter...
  6. ncbi request reprint Optimizing therapy for Acinetobacter baumannii
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Semin Respir Crit Care Med 28:662-71. 2007
    ..It is now clear that new antimicrobials with unique mechanisms of action are urgently required to combat the rising trends seen globally with drug-resistant A. baumannii...
  7. pmc Galleria mellonella as a model system to study Acinetobacter baumannii pathogenesis and therapeutics
    Anton Y Peleg
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Antimicrob Agents Chemother 53:2605-9. 2009
    ..G. mellonella is a relatively simple, nonmammalian model system that can be used to facilitate the in vivo study of host-pathogen interactions in A. baumannii and the efficacy of antibacterial agents...
  8. pmc Utility of peptide nucleic acid fluorescence in situ hybridization for rapid detection of Acinetobacter spp. and Pseudomonas aeruginosa
    A Y Peleg
    Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Clin Microbiol 47:830-2. 2009
    ..and 100% and 95%, respectively, for P. aeruginosa. PNA FISH was able to detect both pathogens simultaneously and directly from spiked blood cultures...
  9. pmc Reduced susceptibility to vancomycin influences pathogenicity in Staphylococcus aureus infection
    Anton Y Peleg
    Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02215, USA
    J Infect Dis 199:532-6. 2009
    ..These results show that G. mellonella can be effectively used to facilitate the in vivo study of S. aureus virulence and, more specifically, the relationship between antibiotic drug resistance and the pathogenesis of infection...
  10. doi request reprint Medically important bacterial-fungal interactions
    Anton Y Peleg
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Nat Rev Microbiol 8:340-9. 2010
    ..This Review describes the clinical and molecular characteristics of bacterial-fungal interactions that are relevant to human disease...
  11. pmc Serine/threonine phosphatase Stp1 contributes to reduced susceptibility to vancomycin and virulence in Staphylococcus aureus
    David R Cameron
    Department of Microbiology, Monash University, Melbourne, Australia
    J Infect Dis 205:1677-87. 2012
    ..Stp1 provides a new link between vancomycin susceptibility and virulence in S. aureus...
  12. ncbi request reprint Acinetobacter baumannii bloodstream infection while receiving tigecycline: a cautionary report
    Anton Y Peleg
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Antimicrob Chemother 59:128-31. 2007
    ..baumannii occurring in patients receiving tigecycline for other indications. The possible mechanisms of resistance and pharmacokinetic limitations of the drug are addressed...
  13. pmc Phenotypic detection of carbapenem-susceptible metallo-beta-lactamase-producing gram-negative bacilli in the clinical laboratory
    Clare Franklin
    Microbiology Unit, Alfred Pathology Service, Alfred Hospital, Commercial Road, Melbourne, Victoria 3004, Australia
    J Clin Microbiol 44:3139-44. 2006
    ....
  14. pmc Failure of current cefepime breakpoints to predict clinical outcomes of bacteremia caused by gram-negative organisms
    Sunil V Bhat
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Suite 3A Falk Medical Building, 3601 Fifth Avenue, Pittsburgh, PA 15213, USA
    Antimicrob Agents Chemother 51:4390-5. 2007
    ....
  15. pmc The functions of Mediator in Candida albicans support a role in shaping species-specific gene expression
    Nathalie Uwamahoro
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    PLoS Genet 8:e1002613. 2012
    ..cerevisiae and are activators of the ALS genes in C. albicans. This suggests that Mediator subunits regulate adhesion in a distinct manner between these two distantly related fungal species...
  16. pmc Mitochondrial sorting and assembly machinery subunit Sam37 in Candida albicans: insight into the roles of mitochondria in fitness, cell wall integrity, and virulence
    Yue Qu
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Melbourne, Australia
    Eukaryot Cell 11:532-44. 2012
    ..Beyond the relevance to fungal pathogenesis, this work also provides new insight into the mitochondrial and cellular roles of the SAM complex in fungi...
  17. pmc Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans
    Anton Y Peleg
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:14585-90. 2008
    ..elegans and by use of genetic manipulation, provides a whole-animal model system to investigate the complex dynamics of a polymicrobial infection...
  18. ncbi request reprint Opportunistic infections in 547 organ transplant recipients receiving alemtuzumab, a humanized monoclonal CD-52 antibody
    Anton Y Peleg
    Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Clin Infect Dis 44:204-12. 2007
    ..We assessed the risks of infection in, to our knowledge, the largest cohort and broadest range of organ transplant recipients yet reported to have received alemtuzumab...
  19. doi request reprint Carbapenem resistance in Acinetobacter baumannii: laboratory challenges, mechanistic insights and therapeutic strategies
    Iain Abbott
    Department of Infectious Diseases, The Alfred Hospital, Melbourne, Vic, Australia
    Expert Rev Anti Infect Ther 11:395-409. 2013
    ..baumannii make this a truly problematic isolate. Therapeutic options are exceedingly limited, relying on polymyxins in combinations with other antibiotics, with few, if any, new active agents in the pipeline...
  20. pmc The RpoB H₄₈₁Y rifampicin resistance mutation and an active stringent response reduce virulence and increase resistance to innate immune responses in Staphylococcus aureus
    Wei Gao
    Infectious Diseases Department, Austin Centre for Infection Research, University of Melbourne, Australia
    J Infect Dis 207:929-39. 2013
    ..Our study highlights the wider consequences of suboptimal antimicrobial use, where drug resistance and immune escape mechanisms coevolve, thus increasing the likelihood of treatment failure...
  21. ncbi request reprint Emergence of carbapenem resistance in Acinetobacter baumannii recovered from blood cultures in Australia
    Anton Y Peleg
    Infectious Diseases Unit, Alfred Hospital, Melbourne, Victoria, Australia
    Infect Control Hosp Epidemiol 27:759-61. 2006
    ..Selected isolates were of the same clonal type, and no genes encoding carbapenemases were identified...
  22. pmc Interaction of Candida albicans with an intestinal pathogen, Salmonella enterica serovar Typhimurium
    Emmanouil Tampakakis
    Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Eukaryot Cell 8:732-7. 2009
    ..Typhimurium, reduces the viability of the eukaryote, C. albicans. Identifying the molecular mechanisms of this interaction may provide important insights into microbial pathogenesis...
  23. pmc The role of horizontal gene transfer in the dissemination of extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae isolates in an endemic setting
    Yohei Doi
    Division of Infectious Diseases, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Diagn Microbiol Infect Dis 74:34-8. 2012
    ..HGT among clonally distinct strains contributes to the transmission dynamics of these ESBL-producing Gram-negative bacteria and should be considered when evaluating the spread of these pathogens...
  24. doi request reprint Insights into Acinetobacter baumannii pathogenicity
    Gustavo M Cerqueira
    Faculty of Medicine, Nursing and Health Sciences, Department of Microbiology, Monash University, Melbourne, Australia
    IUBMB Life 63:1055-60. 2011
    ..This review focuses on current understanding of A. baumannii pathogenesis and the model systems used to study this interesting organism...
  25. doi request reprint Risk factors and outcome of extended-spectrum β-lactamase-producing Enterobacter cloacae bloodstream infections
    Zubair A Qureshi
    Division of Infectious Diseases, University of Pittsburgh Medical Center, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Int J Antimicrob Agents 37:26-32. 2011
    ..The majority of isolates produced SHV-type ESBL, whereas two isolates produced CTX-M-type ESBL. Initial therapy with a carbapenem appears to be associated with improved clinical outcome in BSI due to ESBL-producing E. cloacae...
  26. pmc Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model
    Read Pukkila-Worley
    Massachusetts General Hospital, Gray Jackson 504, 55 Fruit St, Boston, MA 02114, USA
    Eukaryot Cell 8:1750-8. 2009
    ..elegans, including the recently described CAS5 and ADA2 genes. These studies in a C. elegans-C. albicans infection model provide insights into the virulence mechanisms of an important human pathogen...
  27. pmc The success of acinetobacter species; genetic, metabolic and virulence attributes
    Anton Y Peleg
    Department of Microbiology, Monash University, Melbourne, Victoria, Australia
    PLoS ONE 7:e46984. 2012
    ..The current study provides important insights into the elucidation of differences in clinical relevance among Acinetobacter species...
  28. doi request reprint The interface between antibiotic resistance and virulence in Staphylococcus aureus and its impact upon clinical outcomes
    David R Cameron
    Department of Microbiology, Monash University, Melbourne, Australia
    Clin Infect Dis 53:576-82. 2011
    ....
  29. doi request reprint Treatment of Acinetobacter infections
    Joel Fishbain
    Division of Infectious Diseases, St John Hospital and Medical Center, Detroit, Michigan 48236, USA
    Clin Infect Dis 51:79-84. 2010
    ..We will review the currently available antimicrobial agents and discuss the clinical data supporting the use of the various agents...
  30. pmc Statin therapy and decreased incidence of positive Candida cultures among patients with type 2 diabetes mellitus undergoing gastrointestinal surgery
    Elias K Spanakis
    Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114 2696, USA
    Mayo Clin Proc 85:1073-9. 2010
    ..To assess whether statin therapy decreases the incidence of cultures positive for Candida species among high-risk hospitalized patients with type 2 diabetes mellitus (DM)...
  31. doi request reprint The evolution of vancomycin intermediate Staphylococcus aureus (VISA) and heterogenous-VISA
    Benjamin P Howden
    Austin Centre for Infection Research ACIR, Infectious Diseases Department, Austin Health, Heidelberg, Victoria, Australia Microbiology Department, Austin Health, Heidelberg, Victoria, Australia Department of Microbiology and Immunology, University of Melbourne, Victoria, Australia Department of Microbiology, Monash University, Wellington Rd, Clayton, Victoria, Australia Electronic address
    Infect Genet Evol 21:575-82. 2014
    ..The present review will detail the current understanding of the evolutionary process in the generation of hVISA and VISA, and explore the diverse additional changes that occur in these strains. ..
  32. doi request reprint Population genetics and the evolution of virulence in Staphylococcus aureus
    Kyra Y L Chua
    Department of Microbiology and Immunology, University of Melbourne, Victoria 3052, Australia Austin Centre for Infection Research ACIR, Infectious Diseases Department, Austin Health, Heidelberg, Victoria 3084, Australia Microbiology Department, Austin Health, Heidelberg, Victoria 3084, Australia
    Infect Genet Evol 21:554-62. 2014
    ..The knowledge generated from population genetics has the potential to inform strategies to assist in the prevention or treatment of this highly successful human pathogen. ..
  33. ncbi request reprint Surveillance of infection burden in residential aged care facilities
    Ching Jou Lim
    Centre for Medicine Use and Safety, Monash University, Melbourne, Vic, Australia
    Med J Aust 196:327-31. 2012
    ..To explore the burden of illness associated with infectious syndromes and to measure the associated use of antimicrobials in residential aged care facilities (RACFs)...
  34. ncbi request reprint Dissemination of the metallo-beta-lactamase gene blaIMP-4 among gram-negative pathogens in a clinical setting in Australia
    Anton Y Peleg
    Infectious Diseases and Microbiology Department, The Alfred Hospital, Melbourne, Australia
    Clin Infect Dis 41:1549-56. 2005
    ..We describe the first outbreak in Australia of infection and/or colonization with gram-negative pathogens carrying the MBL gene blaIMP-4...
  35. pmc The benefits of steroids versus steroids plus antivirals for treatment of Bell's palsy: a meta-analysis
    Eudocia C Quant
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    BMJ 339:b3354. 2009
    ..To determine whether steroids plus antivirals provide a better degree of facial muscle recovery in patients with Bell's palsy than steroids alone...
  36. ncbi request reprint Inter-country transfer of Gram-negative organisms carrying the VIM-4 and OXA-58 carbapenem-hydrolysing enzymes
    Anton Y Peleg
    J Antimicrob Chemother 57:794-5. 2006
  37. ncbi request reprint Common infections in diabetes: pathogenesis, management and relationship to glycaemic control
    Anton Y Peleg
    Department of Infectious Diseases, Royal Brisbane and Women s Hospital, Herston, Brisbane, Australia
    Diabetes Metab Res Rev 23:3-13. 2007
    ..Nevertheless, further research is needed to improve our understanding of the role of diabetes and glycaemic control in the pathogenesis and management of community- and hospital-acquired infections...
  38. ncbi request reprint Fatal necrotising pneumonia due to community-acquired methicillin-resistant Staphylococcus aureus (MRSA)
    Anton Y Peleg
    Med J Aust 181:228-9. 2004
  39. ncbi request reprint Emergence of IMP-4 metallo-beta-lactamase in a clinical isolate from Australia
    Anton Y Peleg
    J Antimicrob Chemother 54:699-700. 2004
  40. ncbi request reprint Modifying antibiotic prescribing in primary care
    Anton Y Peleg
    Clin Infect Dis 42:1231-3. 2006
  41. pmc OXA-58 and IMP-4 carbapenem-hydrolyzing beta-lactamases in an Acinetobacter junii blood culture isolate from Australia
    Anton Y Peleg
    Antimicrob Agents Chemother 50:399-400. 2006
  42. ncbi request reprint Epidemiological profile of linezolid-resistant coagulase-negative staphylococci
    Brian A Potoski
    Department of Pharmacy and Therapeutics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Clin Infect Dis 43:165-71. 2006
    ..We investigated the risk factors for and the epidemiological profile of linezolid-resistant coagulase-negative staphylococci...