Bernhard Payer

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint X chromosome dosage compensation: how mammals keep the balance
    Bernhard Payer
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Annu Rev Genet 42:733-72. 2008
  2. pmc X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells
    Bernhard Payer
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    Hum Genet 130:265-80. 2011
  3. pmc Two-step imprinted X inactivation: repeat versus genic silencing in the mouse
    Satoshi H Namekawa
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA, USA
    Mol Cell Biol 30:3187-205. 2010
  4. pmc Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming
    Bernhard Payer
    Howard Hughes Medical Institute, Boston, MA 02114, USA Department of Genetics, Harvard Medical School, Boston, MA 02114, USA Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell 52:805-18. 2013
  5. pmc An ex vivo model for imprinting: mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation
    Jennifer A Erwin
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02214, USA
    Genetics 192:857-68. 2012
  6. pmc Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    Dawang Zhou
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Cell 16:425-38. 2009
  7. pmc Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes
    Montserrat C Anguera
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Stem Cell 11:75-90. 2012

Collaborators

Detail Information

Publications7

  1. doi request reprint X chromosome dosage compensation: how mammals keep the balance
    Bernhard Payer
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Annu Rev Genet 42:733-72. 2008
    ..Here, we review various facets of the ever-expanding field of mammalian dosage compensation and discuss its evolutionary, developmental, and mechanistic components...
  2. pmc X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells
    Bernhard Payer
    Department of Genetics, Harvard Medical School, Boston, MA, USA
    Hum Genet 130:265-80. 2011
    ..Here we summarize recent progress in the study of X-inactivation and X-reactivation during mammalian reproduction and development as well as in pluripotent stem cells...
  3. pmc Two-step imprinted X inactivation: repeat versus genic silencing in the mouse
    Satoshi H Namekawa
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA, USA
    Mol Cell Biol 30:3187-205. 2010
    ..Our model incorporates aspects of the so-called classical, de novo, and preinactivation hypotheses and suggests that Xist RNA functions relatively late during preimplantation mouse development...
  4. pmc Tsix RNA and the germline factor, PRDM14, link X reactivation and stem cell reprogramming
    Bernhard Payer
    Howard Hughes Medical Institute, Boston, MA 02114, USA Department of Genetics, Harvard Medical School, Boston, MA 02114, USA Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Cell 52:805-18. 2013
    ..Thus, our study provides functional and mechanistic links between cellular and X chromosome reprogramming...
  5. pmc An ex vivo model for imprinting: mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivation
    Jennifer A Erwin
    Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02214, USA
    Genetics 192:857-68. 2012
    ..We propose that mutually exclusive binding between Cdx2 and Oct4 in Xist underlies the switch between imprinted and random XCI in the early mouse embryo...
  6. pmc Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene
    Dawang Zhou
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cancer Cell 16:425-38. 2009
    ..Approximately 30% of human HCCs show low Yap1(Ser127) phosphorylation and a majority exhibit loss of cleaved, activated Mst1. Mst1/2 inhibition of Yap1 is an important pathway for tumor suppression in liver relevant to human HCC...
  7. pmc Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes
    Montserrat C Anguera
    Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cell Stem Cell 11:75-90. 2012
    ..We conclude that female hiPSCs may be epigenetically less stable in culture and caution that loss of XIST may result in qualitatively less desirable stem cell lines...