Affiliation: Harvard University
- X chromosome dosage compensation: how mammals keep the balanceBernhard Payer
Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Annu Rev Genet 42:733-72. 2008..Here, we review various facets of the ever-expanding field of mammalian dosage compensation and discuss its evolutionary, developmental, and mechanistic components...
- X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cellsBernhard Payer
Department of Genetics, Harvard Medical School, Boston, MA, USA
Hum Genet 130:265-80. 2011..Here we summarize recent progress in the study of X-inactivation and X-reactivation during mammalian reproduction and development as well as in pluripotent stem cells...
- Two-step imprinted X inactivation: repeat versus genic silencing in the mouseSatoshi H Namekawa
Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Department of Genetics, Harvard Medical School, Boston, MA, USA
Mol Cell Biol 30:3187-205. 2010..Our model incorporates aspects of the so-called classical, de novo, and preinactivation hypotheses and suggests that Xist RNA functions relatively late during preimplantation mouse development...
- An ex vivo model for imprinting: mutually exclusive binding of Cdx2 and Oct4 as a switch for imprinted and random X-inactivationJennifer A Erwin
Howard Hughes Medical Institute, Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02214, USA
Genetics 192:857-68. 2012..We propose that mutually exclusive binding between Cdx2 and Oct4 in Xist underlies the switch between imprinted and random XCI in the early mouse embryo...
- Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogeneDawang Zhou
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Cancer Cell 16:425-38. 2009..Approximately 30% of human HCCs show low Yap1(Ser127) phosphorylation and a majority exhibit loss of cleaved, activated Mst1. Mst1/2 inhibition of Yap1 is an important pathway for tumor suppression in liver relevant to human HCC...
- Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genesMontserrat C Anguera
Howard Hughes Medical Institute, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Cell Stem Cell 11:75-90. 2012..We conclude that female hiPSCs may be epigenetically less stable in culture and caution that loss of XIST may result in qualitatively less desirable stem cell lines...