Teodor G Paunescu

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis
    Teodor G Paunescu
    Program in Membrane Biology Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 287:C149-62. 2004
  2. pmc V-ATPase expression in the mouse olfactory epithelium
    Teodor G Paunescu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 295:C923-30. 2008
  3. ncbi request reprint Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice
    Teodor G Paunescu
    Div of Nephrology, Massachusetts General Hospital, 185 Cambridge St, CPZN 8150, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 293:F1915-26. 2007
  4. ncbi request reprint Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells
    Teodor G Paunescu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 294:F130-8. 2008
  5. pmc cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells
    Teodor G Paunescu
    MGH Center for Systems Biology, Program in Membrane Biology, and Division of Nephrology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Renal Physiol 298:F643-54. 2010
  6. ncbi request reprint Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit
    Nicolas Da Silva
    Massachusetts General Hospital, Harvard Medical School, Program in Membrane Biology, Nephrology Div, 185 Cambridge St, CPZN 8150, Boston, MA 02114 2790, USA
    Am J Physiol Cell Physiol 293:C199-210. 2007
  7. pmc Altered V-ATPase expression in renal intercalated cells isolated from B1 subunit-deficient mice by fluorescence-activated cell sorting
    Luca Vedovelli
    Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospitaland Harvard Medical School, Boston, Massachusetts, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 304:F522-32. 2013
  8. pmc Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory function
    Teodor G Paunescu
    MGH Center for Systems Biology, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e45395. 2012
  9. pmc Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells
    Teodor G Paunescu
    Program in Membrane Biology Division of Nephrology, Massachusetts General Hospital, Simches Research Center, 185 Cambridge St, CPZN8150, Boston, MA 02114
    Am J Physiol Renal Physiol 305:F1783-95. 2013
  10. pmc Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis
    Jeremy W Roy
    Center for Systems Biology Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts and
    Am J Physiol Cell Physiol 305:C436-46. 2013

Research Grants

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Expression of the 56-kDa B2 subunit isoform of the vacuolar H(+)-ATPase in proton-secreting cells of the kidney and epididymis
    Teodor G Paunescu
    Program in Membrane Biology Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Am J Physiol Cell Physiol 287:C149-62. 2004
    ..These findings indicate that in addition to its role in the acidification of intracellular organelles, the B2 isoform could also contribute to transepithelial proton secretion and the maintenance of acid-base homeostasis...
  2. pmc V-ATPase expression in the mouse olfactory epithelium
    Teodor G Paunescu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital, Massachusetts 02114, USA
    Am J Physiol Cell Physiol 295:C923-30. 2008
    ..These findings suggest that V-ATPase may be involved in proton secretion in the OE and, as such, may be important for the pH homeostasis of the neuroepithelial mucous layer and/or for signal transduction in CO(2) detection...
  3. ncbi request reprint Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice
    Teodor G Paunescu
    Div of Nephrology, Massachusetts General Hospital, 185 Cambridge St, CPZN 8150, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 293:F1915-26. 2007
    ..However, our results show no increase in cell surface V-ATPase activity in response to metabolic acidosis in ICs from these animals, consistent with their inability to appropriately acidify their urine under these conditions...
  4. ncbi request reprint Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells
    Teodor G Paunescu
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 294:F130-8. 2008
    ..This suggests that these enzymes have a close association and could be part of a protein complex that is involved in regulating renal distal proton secretion...
  5. pmc cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells
    Teodor G Paunescu
    MGH Center for Systems Biology, Program in Membrane Biology, and Division of Nephrology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Physiol Renal Physiol 298:F643-54. 2010
    ....
  6. ncbi request reprint Relocalization of the V-ATPase B2 subunit to the apical membrane of epididymal clear cells of mice deficient in the B1 subunit
    Nicolas Da Silva
    Massachusetts General Hospital, Harvard Medical School, Program in Membrane Biology, Nephrology Div, 185 Cambridge St, CPZN 8150, Boston, MA 02114 2790, USA
    Am J Physiol Cell Physiol 293:C199-210. 2007
    ..This relocation compensates for the absence of functional B1 and maintains the luminal pH in an acidic range that is compatible with fertility...
  7. pmc Altered V-ATPase expression in renal intercalated cells isolated from B1 subunit-deficient mice by fluorescence-activated cell sorting
    Luca Vedovelli
    Center for Systems Biology, Program in Membrane Biology, Division of Nephrology, Massachusetts General Hospitaland Harvard Medical School, Boston, Massachusetts, Boston, MA 02114, USA
    Am J Physiol Renal Physiol 304:F522-32. 2013
    ..We conclude that under baseline conditions B2 upregulation compensates for the lack of B1 and is sufficient to maintain basal acid-base homeostasis, even when other V-ATPase subunits are downregulated...
  8. pmc Loss of the V-ATPase B1 subunit isoform expressed in non-neuronal cells of the mouse olfactory epithelium impairs olfactory function
    Teodor G Paunescu
    MGH Center for Systems Biology, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 7:e45395. 2012
    ..We conclude that V-ATPase-mediated H(+) secretion in the olfactory epithelium is required for optimal olfactory function...
  9. pmc Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells
    Teodor G Paunescu
    Program in Membrane Biology Division of Nephrology, Massachusetts General Hospital, Simches Research Center, 185 Cambridge St, CPZN8150, Boston, MA 02114
    Am J Physiol Renal Physiol 305:F1783-95. 2013
    ..Importantly, the absence of apical caveolae indicates that while Cavs may have an as yet undetermined role in vasopressin-regulated signaling processes, this is probably unrelated to AQP2 internalization by caveolae. ..
  10. pmc Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis
    Jeremy W Roy
    Center for Systems Biology Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts and
    Am J Physiol Cell Physiol 305:C436-46. 2013
    ..This study, therefore, identifies aldosterone as an active member of the RAAS for the regulation of luminal acidification in the proximal epididymis. ..
  11. pmc Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking
    Dennis Brown
    Center for Systems Biology, Program in Membrane Biology Nephrology Division, Massachusetts General Hospital, Boston, MA 02114, USA
    J Exp Biol 212:1762-72. 2009
    ..Recent information about these pH-sensing mechanisms, which include the role of the V-ATPase itself as a pH sensor and the soluble adenylyl cyclase as a bicarbonate sensor, will be addressed in this review...
  12. pmc New insights into the dynamic regulation of water and acid-base balance by renal epithelial cells
    Dennis Brown
    MGH Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Simches Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Physiol Cell Physiol 302:C1421-33. 2012
    ..This review summarizes recent advances in our understanding of these fundamental processes...
  13. doi request reprint Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease
    Kevin C Miranda
    Division of Nephrology, Center for Systems Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 78:191-9. 2010
    ..Our study provides an experimental strategy for the routine isolation and use of urinary microvesicles as a novel and non-invasive source of nucleic acids to further renal disease biomarker discovery...
  14. pmc High resolution helium ion scanning microscopy of the rat kidney
    William L Rice
    Center for Systems Biology, Program in Membrane Biology and Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 8:e57051. 2013
    ..Its use in future studies should allow the study of fine cellular details and provide significant advances in our understanding of cell surface structures and membrane organization...
  15. ncbi request reprint V-ATPase B1-subunit promoter drives expression of EGFP in intercalated cells of kidney, clear cells of epididymis and airway cells of lung in transgenic mice
    R Lance Miller
    Dept of Pediatrics, Univ of Utah, 30 N 1900 East, Salt Lake City, UT 84132 2204, USA
    Am J Physiol Cell Physiol 288:C1134-44. 2005
    ....
  16. pmc The B1-subunit of the H(+) ATPase is required for maximal urinary acidification
    Karin E Finberg
    Departments of Genetics, Cellular and Molecular Physiology, Surgery, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:13616-21. 2005
    ....

Research Grants2

  1. Regulation of V-ATPase-mediated Renal Proton Secretion
    TEODOR PAUNESCU; Fiscal Year: 2007
    ....