Parth Patwari

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Mechanical control of tissue morphogenesis
    Parth Patwari
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Circ Res 103:234-43. 2008
  2. pmc Potent inhibition of cartilage biosynthesis by coincubation with joint capsule through an IL-1-independent pathway
    P Patwari
    Continuum Electromechanics Group, Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Scand J Med Sci Sports 19:528-35. 2009
  3. pmc Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins
    Parth Patwari
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 284:24996-5003. 2009
  4. pmc The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange
    Parth Patwari
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 281:21884-91. 2006
  5. pmc Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage
    Parth Patwari
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
    Biomech Model Mechanobiol 6:83-9. 2007
  6. pmc Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage
    P Patwari
    Massachusetts Institute of Technology, Department of Electrical Engineering, Cambridge, MA 02139, USA
    Osteoarthritis Cartilage 13:269-77. 2005
  7. pmc Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity
    William A Chutkow
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts, USA
    Diabetes 59:1424-34. 2010
  8. ncbi request reprint Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines
    Parth Patwari
    Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Arthritis Rheum 48:1292-301. 2003
  9. ncbi request reprint Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury
    Michael A DiMicco
    Massachusetts Institute of Technology and Children s Hospital, Boston, Massachusetts 02139, USA
    Arthritis Rheum 50:840-8. 2004
  10. ncbi request reprint Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy
    Laurel Ng
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Struct Biol 143:242-57. 2003

Research Grants

Collaborators

Detail Information

Publications22

  1. pmc Mechanical control of tissue morphogenesis
    Parth Patwari
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Circ Res 103:234-43. 2008
    ..Insights into the mechanisms linking mechanical forces to cell and tissue differentiation pathways are important for understanding many congenital diseases and for developing regenerative medicine strategies...
  2. pmc Potent inhibition of cartilage biosynthesis by coincubation with joint capsule through an IL-1-independent pathway
    P Patwari
    Continuum Electromechanics Group, Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Scand J Med Sci Sports 19:528-35. 2009
    ..These results suggest that joint capsule tissue from a normal knee joint can release an uncharacterized cytokine that potently inhibits cartilage biosynthetic activity by an IL-1- and TNF-independent pathway...
  3. pmc Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins
    Parth Patwari
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 284:24996-5003. 2009
    ..These data demonstrate that Txnip regulates cellular metabolism independent of its binding to thioredoxin and reveal the arrestin domains as crucial structural elements in metabolic functions of alpha-arrestin proteins...
  4. pmc The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange
    Parth Patwari
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 281:21884-91. 2006
    ..These data suggest that Txnip is a target of reduced thioredoxin and provide insight into the potential role of Txnip as a redox-sensitive signaling protein...
  5. pmc Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage
    Parth Patwari
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
    Biomech Model Mechanobiol 6:83-9. 2007
    ..However, we observed further evidence for differences in the response of knee and ankle cartilages to injury...
  6. pmc Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage
    P Patwari
    Massachusetts Institute of Technology, Department of Electrical Engineering, Cambridge, MA 02139, USA
    Osteoarthritis Cartilage 13:269-77. 2005
    ....
  7. pmc Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity
    William A Chutkow
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts, USA
    Diabetes 59:1424-34. 2010
    ..Here, we tested the hypothesis that Txnip-null (knockout) mice are protected from insulin resistance induced by a high-fat diet...
  8. ncbi request reprint Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines
    Parth Patwari
    Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Arthritis Rheum 48:1292-301. 2003
    ..We undertook this study to measure aspects of proteoglycan (PG) degradation after in vitro injurious mechanical compression, including up-regulation of enzymatic degradative expression and cytokine-stimulated degradation...
  9. ncbi request reprint Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury
    Michael A DiMicco
    Massachusetts Institute of Technology and Children s Hospital, Boston, Massachusetts 02139, USA
    Arthritis Rheum 50:840-8. 2004
    ....
  10. ncbi request reprint Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy
    Laurel Ng
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Struct Biol 143:242-57. 2003
    ....
  11. pmc Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate
    Rachel E Miller
    Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Arthritis Rheum 62:3686-94. 2010
    ..This study was undertaken to examine the mechanism by which HB-IGF-1 is retained in cartilage and to test whether HB-IGF-1 provides sustained growth factor delivery to cartilage in vivo and to human cartilage explants...
  12. ncbi request reprint Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production
    William A Chutkow
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA
    J Biol Chem 283:2397-406. 2008
    ..While available thioredoxin is not changed in Txnip-null mice, the effects of Txnip on glucose homeostasis are abolished by a single cysteine mutation that inhibits binding to thioredoxin...
  13. pmc The arrestin domain-containing 3 protein regulates body mass and energy expenditure
    Parth Patwari
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 14:671-83. 2011
    ..These results demonstrate that ARRDC3 is a gender-sensitive regulator of obesity and energy expenditure and reveal a surprising diversity for arrestin family protein functions...
  14. ncbi request reprint Mannosamine inhibits aggrecanase-mediated changes in the physical properties and biochemical composition of articular cartilage
    P Patwari
    Continuum Electromechanics Laboratory, Center for Biomedical Engineering, Department of EECS, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Arch Biochem Biophys 374:79-85. 2000
    ....
  15. ncbi request reprint Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress
    Samuel Lee
    Harvard Department of Stem Cell and Regenerative Biology, Harvard Stem Cell Institute Harvard Medical School Brigham and Women s Hospital, Cambridge, MA, USA The Cardiovascular Division, Department of Medicine, Harvard Medical School Brigham and Women s Hospital, Cambridge, MA, USA Department III of Internal Medicine, University Hospital of Cologne, Cologne, Germany
    EMBO Mol Med 6:732-43. 2014
    ..Our results reveal Txnip as a novel direct regulator of PDI activity and a feedback mechanism of UPR signaling to decrease ER stress. ..
  16. pmc An expanded family of arrestins regulate metabolism
    Parth Patwari
    Harvard Stem Cell Institute and the Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, MA 02139, USA
    Trends Endocrinol Metab 23:216-22. 2012
    ..Here we discuss recent evidence suggesting potential common themes for all arrestins, including physiological roles for classical arrestins in metabolism and the functions of α-arrestins in receptor signaling and endocytosis...
  17. pmc Engineering insulin-like growth factor-1 for local delivery
    Tomotake Tokunou
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 22:1886-93. 2008
    ..These data show that the strategy of engineering a "long-distance" growth factor like IGF-1 for local delivery may be useful for tissue repair and minimizing systemic effects...
  18. pmc Thioredoxins, mitochondria, and hypertension
    Parth Patwari
    Partners Research Facility, 65 Landsdowne St, Rm 280, Cambridge, MA 02139, USA
    Am J Pathol 170:805-8. 2007
    ....
  19. pmc Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage
    P Patwari
    Continuum Electromechanics Lab, Center for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Osteoarthritis Cartilage 12:245-52. 2004
    ..For comparison, the TUNEL assay was also performed...
  20. ncbi request reprint Targeted delivery to cartilage is critical for in vivo efficacy of insulin-like growth factor 1 in a rat model of osteoarthritis
    Francesco S Loffredo
    Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts
    Arthritis Rheumatol 66:1247-55. 2014
    ..The aim of this study was to test whether targeted delivery to cartilage by fusion with a heparin-binding domain would be sufficient to prolong the in vivo function of the insulin-like growth factor 1 (IGF-1)...
  21. ncbi request reprint Molecular basis of osteoarthritis: biomechanical aspects
    A Kerin
    MIT Center for Biomedical Engineering, Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell Mol Life Sci 59:27-35. 2002
    ....
  22. ncbi request reprint Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression
    Bodo Kurz
    Anatomisches Institut der Christian Albrechts Universität, Kiel, Kiel, Germany
    Arthritis Rheum 50:123-30. 2004
    ..To study the influence of tissue maturation and antioxidants on apoptosis in bovine articular cartilage induced by injurious compression...

Research Grants2

  1. Regulation of Redox State by Txnip in Vascular Disease
    Parth Patwari; Fiscal Year: 2007
    ..This proposal will study a system the cells normally use to control oxidative stress and test whether this system could cause the death of cells in diabetes due to the high glucose levels in the blood. (End of Abstract) ..