MARY PATTI

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia
    M E Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetologia 48:2236-40. 2005
  2. ncbi Nutrient sensor links obesity with diabetes risk
    Mary-Elizabeth Patti
    Nat Med 10:1049-50. 2004
  3. ncbi Gene expression in the pathophysiology of type 2 diabetes mellitus
    Mary Elizabeth Patti
    Harvard Medical School, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Curr Diab Rep 4:176-81. 2004
  4. ncbi Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology?
    Mary Elizabeth Patti
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Curr Opin Clin Nutr Metab Care 7:383-90. 2004
  5. ncbi Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level
    Jacob Ilany
    Research Division, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:4481-6. 2006
  6. ncbi Hypoglycaemia following gastric bypass surgery--diabetes remission in the extreme?
    M E Patti
    Research Division, Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Diabetologia 53:2276-9. 2010
  7. ncbi Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism
    Mary Elizabeth Patti
    Harvard Medical School, Harvard University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1671-7. 2009
  8. ncbi The role of mitochondria in the pathogenesis of type 2 diabetes
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Endocr Rev 31:364-95. 2010
  9. ncbi Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?
    Mary Elizabeth Patti
    Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 120:2646-8. 2010
  10. ncbi Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003

Research Grants

  1. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2004
  2. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2006

Collaborators

Detail Information

Publications20

  1. ncbi Severe hypoglycaemia post-gastric bypass requiring partial pancreatectomy: evidence for inappropriate insulin secretion and pancreatic islet hyperplasia
    M E Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Diabetologia 48:2236-40. 2005
    ..We investigated three patients with severe postprandial hypoglycaemia and hyperinsulinaemia unresponsive to diet, octreotide and diazoxide with the aim of elucidating the pathological mechanisms involved...
  2. ncbi Nutrient sensor links obesity with diabetes risk
    Mary-Elizabeth Patti
    Nat Med 10:1049-50. 2004
  3. ncbi Gene expression in the pathophysiology of type 2 diabetes mellitus
    Mary Elizabeth Patti
    Harvard Medical School, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Curr Diab Rep 4:176-81. 2004
    ....
  4. ncbi Gene expression in humans with diabetes and prediabetes: what have we learned about diabetes pathophysiology?
    Mary Elizabeth Patti
    Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Curr Opin Clin Nutr Metab Care 7:383-90. 2004
    ..This review will summarize these data and highlight the potential importance of oxidative metabolism in diabetes pathophysiology...
  5. ncbi Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level
    Jacob Ilany
    Research Division, Joslin Diabetes Center and Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 103:4481-6. 2006
    ..These results demonstrate a potential synergistic interaction between increased expression of Rad and high-fat diet in creation of insulin resistance and altered lipid metabolism present in type 2 diabetes...
  6. ncbi Hypoglycaemia following gastric bypass surgery--diabetes remission in the extreme?
    M E Patti
    Research Division, Joslin Diabetes Center and Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Diabetologia 53:2276-9. 2010
    ....
  7. ncbi Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism
    Mary Elizabeth Patti
    Harvard Medical School, Harvard University, Boston, Massachusetts, USA
    Obesity (Silver Spring) 17:1671-7. 2009
    ..57, P = 0.004). Together, our data suggest that altered bile acid levels and composition may contribute to improved glucose and lipid metabolism in patients who have had GB...
  8. ncbi The role of mitochondria in the pathogenesis of type 2 diabetes
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Endocr Rev 31:364-95. 2010
    ....
  9. ncbi Rehashing endocannabinoid antagonists: can we selectively target the periphery to safely treat obesity and type 2 diabetes?
    Mary Elizabeth Patti
    Joslin Diabetes Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 120:2646-8. 2010
    ..However, new data, presented by Tam and colleagues in this issue of the JCI, demonstrate that selective blockade of peripheral cannabinoid receptors may be a novel successful therapeutic approach...
  10. ncbi Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
    Mary Elizabeth Patti
    Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 100:8466-71. 2003
    ..Decreased PGC1 expression may be responsible for decreased expression of NRF-dependent genes, leading to the metabolic disturbances characteristic of insulin resistance and DM...
  11. ncbi Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model
    Josep C Jimenez-Chillaron
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    Diabetes 54:702-11. 2005
    ..5-fold increase in hexokinase activity. Taken together, these data suggest that, at least in mice, primary beta-cell dysfunction may play a significant role in the pathogenesis of LBW-associated type 2 diabetes...
  12. ncbi To catch up or not to catch up: is this the question? Lessons from animal models
    Josep C Jimenez-Chillaron
    Endocrinology Division, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 20115, USA
    Curr Opin Endocrinol Diabetes Obes 14:23-9. 2007
    ....
  13. ncbi Links between thyroid hormone action, oxidative metabolism, and diabetes risk?
    Sarah Crunkhorn
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02115, USA
    Thyroid 18:227-37. 2008
    ....
  14. ncbi Diabetes risk begins in utero
    MELISSA WOO
    Research Division, Joslin Diabetes Center, 1 Joslin Place, Boston, MA 02215, USA
    Cell Metab 8:5-7. 2008
    ..Thus, intrauterine stress can initiate a disturbing epigenetic cascade of progressive transcriptional repression linked to beta cell failure...
  15. ncbi Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice
    Vijay K Yechoor
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 99:10587-92. 2002
    ..These data point to as of yet undefined mechanisms for highly coordinated regulation of gene expression by insulin and potential new targets for therapy of diabetes mellitus...
  16. ncbi Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression
    Matthias Bluher
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:31891-901. 2004
    ..These data suggest an intrinsic heterogeneity of adipocytes with differences in gene expression related to adipocyte size and insulin signaling...
  17. ncbi The emerging genetic architecture of type 2 diabetes
    Alessandro Doria
    Joslin Diabetes Center, One Joslin Place, Harvard Medical School, Boston, MA 02215, USA
    Cell Metab 8:186-200. 2008
    ....
  18. ncbi Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: an in vivo analysis in MIRKO mice
    Vijay K Yechoor
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 101:16525-30. 2004
    ..These distinct pathways of direct and indirect regulation of gene expression provide insights into the complex mechanisms of transcriptional control in diabetes and areas of potential therapeutic targeting...
  19. ncbi Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes
    Daniel O Espinoza
    Research Division, Joslin Diabetes Center, Boston, Massachusetts, USA
    FASEB J 24:1003-14. 2010
    ..Espinoza, D. O., Boros, L. G., Crunkhorn, S., Gami, H., Patti, M.-E. Dual Modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes...
  20. ncbi A thin phenotype is protective for impaired glucose tolerance and related to low birth weight in mice
    Marcelino Hernandez-Valencia
    Endocrine Research Unit, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico
    Arch Med Res 37:813-7. 2006
    ..To determine the efficacy of this approach, we utilized our mouse model of low birth weight related to maternal undernutrition during the third week of pregnancy...

Research Grants6

  1. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2004
    ..These studies should help to define pathophysiology of diabetes and ultimately help to develop more effective and specific methods of prevention and treatment of type 2 diabetes. ..
  2. Gene Expression in Prediabetes: Potential Role of PGC-1
    MARY PATTI; Fiscal Year: 2006
    ..abstract_text> ..