G N Patrick

Summary

Affiliation: Harvard University

Country: USA

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway
G N Patrick
Howard Hughes Medical Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 273:24057-64. 1998
Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
L R Zukerberg
Howard Hughes Medical Institute, Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
Neuron 26:633-46. 2000
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
G N Patrick
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 402:615-22. 1999

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway
G N Patrick
Howard Hughes Medical Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 273:24057-64. 1998
....
Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
L R Zukerberg
Howard Hughes Medical Institute, Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
Neuron 26:633-46. 2000
..Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system...
Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
G N Patrick
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 402:615-22. 1999
..These findings indicate that cleavage of p35, followed by accumulation of p25, may be involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases...