Genomes and Genes
G N Patrick
Affiliation: Harvard University
- p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathwayG N Patrick
Howard Hughes Medical Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 273:24057-64. 1998....
- Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowthL R Zukerberg
Howard Hughes Medical Institute, Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
Neuron 26:633-46. 2000..Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system...
- Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegenerationG N Patrick
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 402:615-22. 1999..These findings indicate that cleavage of p35, followed by accumulation of p25, may be involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases...