G N Patrick

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway
    G N Patrick
    Howard Hughes Medical Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:24057-64. 1998
  2. ncbi request reprint Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
    L R Zukerberg
    Howard Hughes Medical Institute, Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Neuron 26:633-46. 2000
  3. ncbi request reprint Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    G N Patrick
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 402:615-22. 1999

Collaborators

Detail Information

Publications3

  1. ncbi request reprint p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway
    G N Patrick
    Howard Hughes Medical Institute, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 273:24057-64. 1998
    ....
  2. ncbi request reprint Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
    L R Zukerberg
    Howard Hughes Medical Institute, Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Neuron 26:633-46. 2000
    ..Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the developing nervous system...
  3. ncbi request reprint Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
    G N Patrick
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 402:615-22. 1999
    ..These findings indicate that cleavage of p35, followed by accumulation of p25, may be involved in the pathogenesis of cytoskeletal abnormalities and neuronal death in neurodegenerative diseases...