Genomes and Genes
Affiliation: Harvard University
- BACE1 and BACE2 in pathologic and normal human muscleGaetano Vattemi
USC Neuromuscular Center, Department of Neurology, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles 90017 1912, USA
Exp Neurol 179:150-8. 2003..Accordingly, BACE1 and BACE2 participate in normal and abnormal processes of human muscle, suggesting that their functions are broader than previously thought...
- Pathogenic mechanisms in Alzheimer's diseaseLucia Pastorino
Cancer Biology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
Eur J Pharmacol 545:29-38. 2006..This review discusses recent literature on beta- and gamma-secretase, and on those cellular factors, like cholesterol and phosphorylation of APP, that are involved in aging and may affect the function of both beta- and gamma-secretase...
- Alzheimer's disease-related loss of Pin1 function influences the intracellular localization and the processing of AβPPLucia Pastorino
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
J Alzheimers Dis 30:277-97. 2012....
- Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenanceTae Ho Lee
Cancer Biology Program and Biology of Aging Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS 0408, Boston, MA 02215, USA
Nat Cell Biol 11:97-105. 2009..Thus, Pin1 is an essential regulator of TRF1 stability, telomere maintenance and ageing...
- Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer diseaseSuk Ling Ma
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 287:6969-73. 2012..These results uncover a novel role of Pin1 in inhibiting GSK3β kinase activity to reduce APP protein levels, providing a previously unrecognized mechanism by which Pin1 protects against Alzheimer disease...
- Pin1 has opposite effects on wild-type and P301L tau stability and tauopathyJormay Lim
Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 118:1877-89. 2008..Thus, Pin1 has opposite effects on the tauopathy phenotype depending on whether the tau is WT or a P301L mutant, indicating the need for disease-specific therapies for tauopathies...
- Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer diseaseTae Ho Lee
Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
Expert Rev Mol Med 13:e21. 2011....
- The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta productionLucia Pastorino
Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
Nature 440:528-34. 2006..These findings provide new insight into the pathogenesis and treatment of Alzheimer's disease...
- A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's diseaseSuk Ling Ma
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Neurobiol Aging 33:804-13. 2012..These results indicate that regulation of Pin1 by AP4 plays a critical role in determining age at onset of AD and might be a novel therapeutic target to delay the onset of AD...
- Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?Martin Balastik
Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
Biochim Biophys Acta 1772:422-9. 2007..Moreover, in the human AD brain Pin1 is downregulated or inhibited by oxidative modifications and/or genetic changes. These results suggest that Pin1 deregulation may provide a link between formation of tangles and plaques in AD...
- [alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patientsFrancesca Colciaghi
Centre of Excellence on Neurodegenerative Diseases and Department of Pharmacolgical Sciences, University of Milano, School of Pharmacy, Italy
Mol Med 8:67-74. 2002..e., ADAM10) reduced in accessible cells of Alzheimer Disease (AD) patients? 2) Are ADAM10 levels in the peripheral cells of AD patients related to a concomitant decrease in alpha APPs?..
- The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta)Lucia Pastorino
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
Mol Cell Neurosci 19:175-85. 2002..Mutating either the leucines or the serine did not alter the secretion of A(beta). Our data are consistent with a role for the cytoplasmic domain in regulating BACE trafficking and localization...
- ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral modelBarbara Borroni
Department of Neurology, University of Brescia, Piazzale Spediale Civili 1, 25123 Brescia, Italy
Eur Neuropsychopharmacol 12:195-200. 2002..0001). The present study provides evidence that donepezil influences APP metabolism in platelets, and suggests that ApoE genotype might be an important modulating factor for drug responsiveness in AD...