Lucia Pastorino

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint BACE1 and BACE2 in pathologic and normal human muscle
    Gaetano Vattemi
    USC Neuromuscular Center, Department of Neurology, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles 90017 1912, USA
    Exp Neurol 179:150-8. 2003
  2. ncbi request reprint Pathogenic mechanisms in Alzheimer's disease
    Lucia Pastorino
    Cancer Biology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Eur J Pharmacol 545:29-38. 2006
  3. doi request reprint Alzheimer's disease-related loss of Pin1 function influences the intracellular localization and the processing of AβPP
    Lucia Pastorino
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Alzheimers Dis 30:277-97. 2012
  4. pmc Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance
    Tae Ho Lee
    Cancer Biology Program and Biology of Aging Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS 0408, Boston, MA 02215, USA
    Nat Cell Biol 11:97-105. 2009
  5. pmc Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease
    Suk Ling Ma
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 287:6969-73. 2012
  6. pmc Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy
    Jormay Lim
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1877-89. 2008
  7. doi request reprint Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease
    Tae Ho Lee
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Expert Rev Mol Med 13:e21. 2011
  8. ncbi request reprint The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production
    Lucia Pastorino
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 440:528-34. 2006
  9. pmc A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease
    Suk Ling Ma
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neurobiol Aging 33:804-13. 2012
  10. pmc Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?
    Martin Balastik
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Biochim Biophys Acta 1772:422-9. 2007

Research Grants

Collaborators

Detail Information

Publications13

  1. ncbi request reprint BACE1 and BACE2 in pathologic and normal human muscle
    Gaetano Vattemi
    USC Neuromuscular Center, Department of Neurology, University of Southern California Keck School of Medicine, Good Samaritan Hospital, Los Angeles 90017 1912, USA
    Exp Neurol 179:150-8. 2003
    ..Accordingly, BACE1 and BACE2 participate in normal and abnormal processes of human muscle, suggesting that their functions are broader than previously thought...
  2. ncbi request reprint Pathogenic mechanisms in Alzheimer's disease
    Lucia Pastorino
    Cancer Biology Program, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Eur J Pharmacol 545:29-38. 2006
    ..This review discusses recent literature on beta- and gamma-secretase, and on those cellular factors, like cholesterol and phosphorylation of APP, that are involved in aging and may affect the function of both beta- and gamma-secretase...
  3. doi request reprint Alzheimer's disease-related loss of Pin1 function influences the intracellular localization and the processing of AβPP
    Lucia Pastorino
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Alzheimers Dis 30:277-97. 2012
    ....
  4. pmc Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance
    Tae Ho Lee
    Cancer Biology Program and Biology of Aging Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, CLS 0408, Boston, MA 02215, USA
    Nat Cell Biol 11:97-105. 2009
    ..Thus, Pin1 is an essential regulator of TRF1 stability, telomere maintenance and ageing...
  5. pmc Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease
    Suk Ling Ma
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 287:6969-73. 2012
    ..These results uncover a novel role of Pin1 in inhibiting GSK3β kinase activity to reduce APP protein levels, providing a previously unrecognized mechanism by which Pin1 protects against Alzheimer disease...
  6. pmc Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy
    Jormay Lim
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:1877-89. 2008
    ..Thus, Pin1 has opposite effects on the tauopathy phenotype depending on whether the tau is WT or a P301L mutant, indicating the need for disease-specific therapies for tauopathies...
  7. doi request reprint Peptidyl-prolyl cis-trans isomerase Pin1 in ageing, cancer and Alzheimer disease
    Tae Ho Lee
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Expert Rev Mol Med 13:e21. 2011
    ....
  8. ncbi request reprint The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production
    Lucia Pastorino
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 440:528-34. 2006
    ..These findings provide new insight into the pathogenesis and treatment of Alzheimer's disease...
  9. pmc A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimer's disease
    Suk Ling Ma
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Neurobiol Aging 33:804-13. 2012
    ..These results indicate that regulation of Pin1 by AP4 plays a critical role in determining age at onset of AD and might be a novel therapeutic target to delay the onset of AD...
  10. pmc Pin1 in Alzheimer's disease: multiple substrates, one regulatory mechanism?
    Martin Balastik
    Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Biochim Biophys Acta 1772:422-9. 2007
    ..Moreover, in the human AD brain Pin1 is downregulated or inhibited by oxidative modifications and/or genetic changes. These results suggest that Pin1 deregulation may provide a link between formation of tangles and plaques in AD...
  11. pmc [alpha]-Secretase ADAM10 as well as [alpha]APPs is reduced in platelets and CSF of Alzheimer disease patients
    Francesca Colciaghi
    Centre of Excellence on Neurodegenerative Diseases and Department of Pharmacolgical Sciences, University of Milano, School of Pharmacy, Italy
    Mol Med 8:67-74. 2002
    ..e., ADAM10) reduced in accessible cells of Alzheimer Disease (AD) patients? 2) Are ADAM10 levels in the peripheral cells of AD patients related to a concomitant decrease in alpha APPs?..
  12. ncbi request reprint The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta)
    Lucia Pastorino
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Neurosci 19:175-85. 2002
    ..Mutating either the leucines or the serine did not alter the secretion of A(beta). Our data are consistent with a role for the cytoplasmic domain in regulating BACE trafficking and localization...
  13. ncbi request reprint ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model
    Barbara Borroni
    Department of Neurology, University of Brescia, Piazzale Spediale Civili 1, 25123 Brescia, Italy
    Eur Neuropsychopharmacol 12:195-200. 2002
    ..0001). The present study provides evidence that donepezil influences APP metabolism in platelets, and suggests that ApoE genotype might be an important modulating factor for drug responsiveness in AD...

Research Grants2

  1. Role of Pin1 in APP processing and beta-amyloid pathology
    Lucia Pastorino; Fiscal Year: 2007
    ..Lu are ideal conditions for the candidate to be trained in the fields of interest and to learn the skills necessary to complete her background and develop into an independent investigator. ..