Amy E Pasquinelli

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi MicroRNAs: deviants no longer
    Amy E Pasquinelli
    Dept of Molecular Biology, Wellman 8, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114, USA
    Trends Genet 18:171-3. 2002
  2. ncbi Trans-splicing and polyadenylation of let-7 microRNA primary transcripts
    John Bracht
    Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    RNA 10:1586-94. 2004
  3. ncbi Control of developmental timing by micrornas and their targets
    Amy E Pasquinelli
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Cell Dev Biol 18:495-513. 2002
  4. ncbi MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
    Jennifer H Mansfield
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 36:1079-83. 2004
  5. ncbi MicroRNA silencing through RISC recruitment of eIF6
    Thimmaiah P Chendrimada
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 447:823-8. 2007
  6. ncbi The evolving role of microRNAs in animal gene expression
    Katlin B Massirer
    Department of Biology, University of California, San Diego, La Jolla, California 92093-0349, USA
    Bioessays 28:449-52. 2006
  7. ncbi Analysis of the regulation of lin-41 during chick and mouse limb development
    Joseph J Lancman
    Department of Anatomy, University of Wisconsin, Madison, 53706, USA
    Dev Dyn 234:948-60. 2005
  8. ncbi Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
    Shveta Bagga
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    Cell 122:553-63. 2005
  9. ncbi MicroRNAs: a developing story
    Amy E Pasquinelli
    Molecular Biology Section, Division of Biology 0349, Bonner Hall Rm 4118, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Curr Opin Genet Dev 15:200-5. 2005
  10. ncbi Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis
    Arash Bashirullah
    Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East Room 5100, University of Utah, Salt Lake City, UT 84112 5331, USA
    Dev Biol 259:1-8. 2003

Collaborators

  • Clifford J Tabin
  • Michael T McManus
  • GARY B RUVKUN
  • BRIAN DAVID HARFE
  • Hema Bashyam
  • M Q Martindale
  • CARL THUMMEL
  • Shveta Bagga
  • John Bracht
  • Thimmaiah P Chendrimada
  • Trina M Norden-Krichmar
  • Katlin B Massirer
  • Janette Holtz
  • Joseph J Lancman
  • Rachel Eachus
  • Shaun Hunter
  • Jennifer H Mansfield
  • Arash Bashirullah
  • Terry Gaasterland
  • Richard I Gregory
  • Xinjun Ji
  • Ramin Shiekhattar
  • Stephen A Liebhaber
  • David Baillat
  • Kenneth J Finn
  • Alexander Pertsemlidis
  • Nicholas C Caruccio
  • John F Fallon
  • Katlin Massirer
  • Jeoffrey J Schageman
  • John Obenauer
  • Phillip Weeks
  • Jalagani Srineel
  • Aadel Chaudhuri
  • Phillip A Sharp
  • Raphael Farzan-Kashani
  • Robert Nissen
  • Michael Zuker
  • Norbert Perrimon
  • Amy A Kiger

Detail Information

Publications14

  1. ncbi MicroRNAs: deviants no longer
    Amy E Pasquinelli
    Dept of Molecular Biology, Wellman 8, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114, USA
    Trends Genet 18:171-3. 2002
    ..The discovery of miRNAs establishes a new class of regulatory RNAs and highlights the existence of unexpected RNA genes that, although ancient, are not extinct...
  2. ncbi Trans-splicing and polyadenylation of let-7 microRNA primary transcripts
    John Bracht
    Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
    RNA 10:1586-94. 2004
    ..Finally, the observation that let-7 primary transcripts undergo splicing highlights the importance of identifying the sequence of endogenous pri-miRNA substrates recognized by the cellular processing machinery...
  3. ncbi Control of developmental timing by micrornas and their targets
    Amy E Pasquinelli
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Cell Dev Biol 18:495-513. 2002
    ..Instead of inventing new gene functions, even subtle changes in temporal expression of pre-existing control genes can result in speciation by altering the time at which they function...
  4. ncbi MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression
    Jennifer H Mansfield
    Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Genet 36:1079-83. 2004
    ..Furthermore, miR-196a negatively regulates Hoxb8, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox complex...
  5. ncbi MicroRNA silencing through RISC recruitment of eIF6
    Thimmaiah P Chendrimada
    The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
    Nature 447:823-8. 2007
    ..These results uncover an evolutionarily conserved function of the ribosome anti-association factor eIF6 in miRNA-mediated post-transcriptional silencing...
  6. ncbi The evolving role of microRNAs in animal gene expression
    Katlin B Massirer
    Department of Biology, University of California, San Diego, La Jolla, California 92093-0349, USA
    Bioessays 28:449-52. 2006
    ..Thus, the miRNA pathway broadly contributes to the complex gene regulatory networks that shape animal tissue development and identity...
  7. ncbi Analysis of the regulation of lin-41 during chick and mouse limb development
    Joseph J Lancman
    Department of Anatomy, University of Wisconsin, Madison, 53706, USA
    Dev Dyn 234:948-60. 2005
    ..elegans let-7 and lin-4. Finally, we show that these miRNAs and others are expressed in the chick limb consistent with the hypothesis that they regulate chicken Lin-41 activity in vivo...
  8. ncbi Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
    Shveta Bagga
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    Cell 122:553-63. 2005
    ....
  9. ncbi MicroRNAs: a developing story
    Amy E Pasquinelli
    Molecular Biology Section, Division of Biology 0349, Bonner Hall Rm 4118, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
    Curr Opin Genet Dev 15:200-5. 2005
    ..Recent studies of restricted expression patterns and functional roles have implicated specific microRNAs in complex genetic pathways regulating embryogenesis, hematopoiesis, neuronal differentiation and Hox-mediated development...
  10. ncbi Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis
    Arash Bashirullah
    Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East Room 5100, University of Utah, Salt Lake City, UT 84112 5331, USA
    Dev Biol 259:1-8. 2003
    ..We conclude that a common precursor RNA containing both let-7 and miR-125 is induced independently of ecdysone in Drosophila, raising the possibility of a temporal signal that is distinct from the well-characterized ecdysone-EcR pathway...
  11. ncbi Identification and analysis of microRNAs
    Shveta Bagga
    Molecular Biology Section, Division of Biology, University of California, San Diego, La Jolla, CA 92093-0349, USA
    Genet Eng (N Y) 27:1-20. 2006
  12. ncbi Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?
    Amy E Pasquinelli
    Molecular Biology Section, Division of Biology 0368, University of California, San Diego, 9500 Gilman Drive, Bonner Hall, Room 2214, La Jolla, CA 92093 0368, USA
    Evol Dev 5:372-8. 2003
    ..We argue that let-7 is not a bilaterian or triploblast synapomorphy but instead evolved later in metazoan evolution, perhaps in association with complex life history traits...
  13. ncbi Demystifying small RNA pathways
    Amy E Pasquinelli
    Department of Biology, University of California, San Diego, La Jolla, 92093, USA
    Dev Cell 10:419-24. 2006
  14. ncbi Computational prediction and experimental validation of Ciona intestinalis microRNA genes
    Trina M Norden-Krichmar
    Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, MSC 0202, La Jolla, CA 92093 USA
    BMC Genomics 8:445. 2007
    ....