Genomes and Genes
Amy E Pasquinelli
Affiliation: Harvard University
- MicroRNAs: deviants no longerAmy E Pasquinelli
Dept of Molecular Biology, Wellman 8, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114, USA
Trends Genet 18:171-3. 2002..The discovery of miRNAs establishes a new class of regulatory RNAs and highlights the existence of unexpected RNA genes that, although ancient, are not extinct...
- Trans-splicing and polyadenylation of let-7 microRNA primary transcriptsJohn Bracht
Department of Biology, University of California, San Diego, La Jolla, CA 92093, USA
RNA 10:1586-94. 2004..Finally, the observation that let-7 primary transcripts undergo splicing highlights the importance of identifying the sequence of endogenous pri-miRNA substrates recognized by the cellular processing machinery...
- Control of developmental timing by micrornas and their targetsAmy E Pasquinelli
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA
Annu Rev Cell Dev Biol 18:495-513. 2002..Instead of inventing new gene functions, even subtle changes in temporal expression of pre-existing control genes can result in speciation by altering the time at which they function...
- MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expressionJennifer H Mansfield
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Genet 36:1079-83. 2004..Furthermore, miR-196a negatively regulates Hoxb8, indicating that its restricted expression pattern probably reflects a role in the patterning function of the Hox complex...
- MicroRNA silencing through RISC recruitment of eIF6Thimmaiah P Chendrimada
The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA
Nature 447:823-8. 2007..These results uncover an evolutionarily conserved function of the ribosome anti-association factor eIF6 in miRNA-mediated post-transcriptional silencing...
- The evolving role of microRNAs in animal gene expressionKatlin B Massirer
Department of Biology, University of California, San Diego, La Jolla, California 92093-0349, USA
Bioessays 28:449-52. 2006..Thus, the miRNA pathway broadly contributes to the complex gene regulatory networks that shape animal tissue development and identity...
- Analysis of the regulation of lin-41 during chick and mouse limb developmentJoseph J Lancman
Department of Anatomy, University of Wisconsin, Madison, 53706, USA
Dev Dyn 234:948-60. 2005..elegans let-7 and lin-4. Finally, we show that these miRNAs and others are expressed in the chick limb consistent with the hypothesis that they regulate chicken Lin-41 activity in vivo...
- Regulation by let-7 and lin-4 miRNAs results in target mRNA degradationShveta Bagga
Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
Cell 122:553-63. 2005....
- MicroRNAs: a developing storyAmy E Pasquinelli
Molecular Biology Section, Division of Biology 0349, Bonner Hall Rm 4118, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0349, USA
Curr Opin Genet Dev 15:200-5. 2005..Recent studies of restricted expression patterns and functional roles have implicated specific microRNAs in complex genetic pathways regulating embryogenesis, hematopoiesis, neuronal differentiation and Hox-mediated development...
- Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosisArash Bashirullah
Howard Hughes Medical Institute, Department of Human Genetics, 15 North 2030 East Room 5100, University of Utah, Salt Lake City, UT 84112 5331, USA
Dev Biol 259:1-8. 2003..We conclude that a common precursor RNA containing both let-7 and miR-125 is induced independently of ecdysone in Drosophila, raising the possibility of a temporal signal that is distinct from the well-characterized ecdysone-EcR pathway...
- Identification and analysis of microRNAsShveta Bagga
Molecular Biology Section, Division of Biology, University of California, San Diego, La Jolla, CA 92093-0349, USA
Genet Eng (N Y) 27:1-20. 2006
- Expression of the 22 nucleotide let-7 heterochronic RNA throughout the Metazoa: a role in life history evolution?Amy E Pasquinelli
Molecular Biology Section, Division of Biology 0368, University of California, San Diego, 9500 Gilman Drive, Bonner Hall, Room 2214, La Jolla, CA 92093 0368, USA
Evol Dev 5:372-8. 2003..We argue that let-7 is not a bilaterian or triploblast synapomorphy but instead evolved later in metazoan evolution, perhaps in association with complex life history traits...
- Demystifying small RNA pathwaysAmy E Pasquinelli
Department of Biology, University of California, San Diego, La Jolla, 92093, USA
Dev Cell 10:419-24. 2006
- Computational prediction and experimental validation of Ciona intestinalis microRNA genesTrina M Norden-Krichmar
Scripps Institution of Oceanography, University of California, San Diego, 9500 Gilman Drive, MSC 0202, La Jolla, CA 92093 USA
BMC Genomics 8:445. 2007....