Research Topics
Genomes and GenesSpecies | LOUIS ROBERT PASQUALESummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
CDKN2B-AS1 Genotype-Glaucoma Feature Correlations in Primary Open-Angle Glaucoma Patients From the United StatesLouis R Pasquale
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts Channing Division of Network Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts Electronic address
Am J Ophthalmol 155:342-353.e5. 2013....- DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversityBao Jian Fan
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
BMC Med Genet 9:5. 2008.... - Female reproductive factors and primary open-angle glaucoma in the Nurses' Health StudyL R Pasquale
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Brigham and Women s Hospital, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
Eye (Lond) 25:633-41. 2011..The purpose of this study was to explore the relation between age at menarche, parity, and oral contraceptive (OC) use, and primary open-angle glaucoma (POAG)... - Anthropometric measures and their relation to incident primary open-angle glaucomaLouis R Pasquale
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Ophthalmology 117:1521-9. 2010..To assess the relation between anthropometric measures and incident primary open-angle glaucoma (POAG)... - Lifestyle, nutrition, and glaucomaLouis R Pasquale
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
J Glaucoma 18:423-8. 2009..This review also outlines future directions for research into the primary prevention of POAG... 
Optimizing therapy for newly diagnosed open-angle glaucoma: lessons learned from the Collaborative Initial Glaucoma Treatment StudyLouis R Pasquale
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Arch Ophthalmol 126:125-7. 2008- Attributes of female reproductive aging and their relation to primary open-angle glaucoma: a prospective studyLouis R Pasquale
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
J Glaucoma 16:598-605. 2007..We investigated the relation between age at menopause, postmenopausal hormone (PMH) use, and incident primary open-angle glaucoma (POAG)... - Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in womenLouis R Pasquale
Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
Ophthalmology 113:1081-6. 2006..To study the relation between type 2 diabetes mellitus (T2DM) and incident primary open-angle glaucoma (POAG) in women... - The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditionsMarilyn C Cornelis
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
Genet Epidemiol 34:364-72. 2010..By maximizing knowledge obtained through collaborative GWAS incorporating environmental exposure information, GENEVA aims to enhance our understanding of disease etiology, potentially identifying opportunities for intervention... - Caffeine consumption and the risk of primary open-angle glaucoma: a prospective cohort studyJae Hee Kang
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Invest Ophthalmol Vis Sci 49:1924-31. 2008..To investigate whether caffeine, which transiently increases intraocular pressure (IOP) is associated with the risk of primary open-angle glaucoma (POAG)... - Prospective study of cigarette smoking and the risk of primary open-angle glaucomaJae H Kang
Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
Arch Ophthalmol 121:1762-8. 2003..To examine the association between cigarette smoking and incident primary open-angle glaucoma (POAG)... - Prospective study of alcohol consumption and the risk of primary open-angle glaucomaJae H Kang
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Ophthalmic Epidemiol 14:141-7. 2007..Alcohol intake reduces intraocular pressure, a risk factor for primary open-angle glaucoma (POAG). We investigated whether alcohol consumption is associated with a reduced risk of POAG... 
Shunts to divert aqueous humor to distant epithelialized cavities after keratoprosthesis surgeryClaes H Dohlman
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
J Glaucoma 19:111-5. 2010..In this retroactive study of such shunts, the risk of postoperative infection (especially endophthalmitis) has been assessed...- Antioxidant intake and primary open-angle glaucoma: a prospective studyJae H Kang
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Epidemiol 158:337-46. 2003..97 (95% CI: 0.62, 1.52) for vitamin E, and 1.11 (95% CI: 0.82, 1.51) for vitamin A. In conclusion, the authors did not observe any strong associations between antioxidant consumption and the risk of primary open-angle glaucoma... - Dietary fat consumption and primary open-angle glaucomaJae H Kang
Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
Am J Clin Nutr 79:755-64. 2004..Prostaglandin F(2alpha) analogues are effective intraocular-pressure-lowering drugs. Dietary fatty acids affect endogenous prostaglandin F(2alpha) concentrations and may thus influence intraocular pressure... - Surgical management of glaucoma in pseudophakic patientsLillian C Lee
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard University, Boston, MA, USA
Semin Ophthalmol 17:131-7. 2002..The decision to operate and the choice of surgical procedure must be individualized for each patient... - Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone useJae Hee Kang
Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
Invest Ophthalmol Vis Sci 51:971-9. 2010..To evaluate the association between the nitric oxide synthase gene (NOS3) variants and primary open-angle glaucoma (POAG)... - Cystoid macular edema in aphakia and pseudophakia after use of prostaglandin analogsD Lynn Halpern
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
Semin Ophthalmol 17:181-6. 2002..Until our understanding of these issues is more advanced, judicious use of prostaglandin analogs in patients at risk for cystoid macular edema would be prudent... - Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucomaBao Jian Fan
Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
J Glaucoma 19:432-6. 2010..To evaluate the elastin gene (ELN) as a secondary risk factor for pseudoexfoliation syndrome (PXFS) and the associated glaucoma pseudoexfoliation glaucoma (PXFG)... - Hyphema following selective laser trabeculoplastyDouglas J Rhee
Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
Ophthalmic Surg Lasers Imaging 40:493-4. 2009..Her intermittent use of oral nonsteroidal anti-inflammatory medications and chronic topical nonsteroidal anti-inflammatory use may have been a contributing risk factor... - Endophthalmitis after glaucoma drainage implant surgeryJeffrey N Wentzloff
Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, MA 02114, USA
Int Ophthalmol Clin 47:109-15. 2007 - The association of primary open-angle glaucoma with mortality: a meta-analysis of observational studiesMona Akbari
Harvard University School of Public Health, Boston, Massachusetts, USA
Arch Ophthalmol 127:204-10. 2009..To conduct a meta-analysis to estimate the relationship between primary open-angle glaucoma (POAG) and mortality... - Retinal blood flow and nerve fiber layer measurements in early-stage open-angle glaucomaFatmire Berisha
Schepens Retina Associates Foundation, One Autumn Street, Boston, MA 02215, USA
Am J Ophthalmol 146:466-472. 2008.... - Periorbital changes associated with topical bimatoprostTheodoros Filippopoulos
Department of Ophthalmology, Glaucoma Consultation Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
Ophthal Plast Reconstr Surg 24:302-7. 2008..To describe periorbital changes induced by chronic topical therapy with daily bimatoprost 0.03% (Lumigan, Allergan Inc., Irvine, CA, U.S.A.)... - Traumatic hyphemaPrithvi S Sankar
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA
Int Ophthalmol Clin 42:57-68. 2002 - Health care charges for patients with ocular hypertension or primary open-angle glaucomaLouis R Pasquale
Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
Ophthalmology 115:633-638.e4. 2008..To determine the total and condition-related direct health care charges of patients with ocular hypertension (OH) or primary open-angle glaucoma (POAG) and identify factors that affect these charges... - Retinal blood flow response to posture change in glaucoma patients compared with healthy subjectsGilbert T Feke
Schepens Retina Associates Foundation, Boston, Massachusetts 02215, USA
Ophthalmology 115:246-52. 2008..To characterize the retinal vascular autoregulatory response to ocular perfusion pressure (OPP) changes in patients with glaucoma and in healthy control subjects... - Herpes simplex virus: an important etiology for secondary glaucomaRelief Jones
Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, MA 02114, USA
Int Ophthalmol Clin 47:99-107. 2007 - The course of glaucoma during pregnancy: a retrospective case seriesStacey C Brauner
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Arch Ophthalmol 124:1089-94. 2006..CONCLUSIONS: The course of glaucoma during pregnancy is variable, and women must be monitored closely during pregnancy. Medications may be necessary to control IOP and to prevent vision loss during pregnancy... - Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smokingJae Hee Kang
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Arch Ophthalmol 129:773-80. 2011..To evaluate whether an association between risk of any of the factors of hypertension, alcohol intake, and cigarette smoking and the risk of primary open-angle glaucoma (POAG) depended on nitric oxide synthase 3 (NOS3) gene variants... - Glaucomas secondary to intraocular melanomasJason B Wanner
Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
Semin Ophthalmol 21:181-9. 2006..The workup needed for unilateral glaucoma will be covered in detail. Treatment options for secondary glaucomas include topical and oral medications as well as argon laser trabeculoplasty and transscleral cyclophotocoagulation... - Healthcare charges in patients who transition from ocular hypertension to primary open-angle glaucoma based on ophthalmic coding dataLouis R Pasquale
Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
Adv Ther 26:947-58. 2009..The purpose of this research was to assess the impact of transition from ocular hypertension (OHT) to primary open-angle glaucoma (POAG) on healthcare charges... - Argon versus selective laser trabeculoplasty in the treatment of open angle glaucomaJing Cheng Zhao
Progressive Visision Insitute, Eye Care Center, 201 East Laurel Boulevard, Pottsville, PA 17901, USA
Int Ophthalmol Clin 45:97-106. 2005 - Management and prevention of thin, cystic blebsLaura C Fine
Massachusetts Ear and Eye Infirmary, Boston 02114, USA
Int Ophthalmol Clin 44:29-42. 2004 - Lens extraction for angle-closure glaucomaChing Lin Ho
Massachusetts Ear and Eye Infirmary, Boston 02114, USA
Int Ophthalmol Clin 44:213-28. 2004 - Long-term results of Ahmed glaucoma valve implantation for uveitic glaucomaThekla G Papadaki
Massachusetts Eye Research and Surgery Institute, Ocular Immunology and Uveitis Foundation, Harvard Medical School Boston, Massachusetts, USA
Am J Ophthalmol 144:62-69. 2007..To present long-term outcomes of Ahmed glaucoma valve implantation for uveitic glaucoma... - Costs and utilization of end-stage glaucoma patients receiving visual rehabilitation care: a US multisite retrospective studyDavid K Gieser
Wheaton Eye Clinic, Wheaton, IL, USA
J Glaucoma 15:419-25. 2006..Advanced primary open-angle glaucoma has a substantial cost-of-illness, warranting improved management in early stages of disease... - Low intracranial pressure: a tipping point in our understanding of primary open-angle glaucoma?Louis R Pasquale
Ophthalmology 115:761-2. 2008
Research Grants
- Gene-Environment Interactions in GlaucomaLouis Pasquale; Fiscal Year: 2007..The discovery of gene-environment interactions that serve as determinants of POAG could lead to genotype-specific primary prevention strategies for this complex disease. ..
- Gene-Environment Interactions in GlaucomaLOUIS ROBERT PASQUALE; Fiscal Year: 2010..The discovery of the combination of genetic and environment factors that link vascular dysfunction, gender biology and POAG could lead to more effective treatments for this potentially blinding condition. ..
- Gene-Environment Interactions in GlaucomaLouis Pasquale; Fiscal Year: 2009..The discovery of gene-environment interactions that serve as determinants of POAG could lead to genotype-specific primary prevention strategies for this complex disease. ..