LOUIS ROBERT PASQUALE

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Feasibility of High-Throughput Genome-Wide Genotyping using DNA from Stored Buccal Cell Samples
    Stephanie J Loomis
    Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Biomark Insights 5:49-55. 2010
  2. pmc Reproductive factors and NOS3 variant interactions in primary open-angle glaucoma
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Mol Vis 17:2544-51. 2011
  3. pmc Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States
    Louis R Pasquale
    Department of Ophthalmology, Mass Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 19:1471-81. 2013
  4. pmc CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 155:342-353.e5. 2013
  5. pmc DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    BMC Med Genet 9:5. 2008
  6. doi request reprint Optimizing therapy for newly diagnosed open-angle glaucoma: lessons learned from the Collaborative Initial Glaucoma Treatment Study
    Louis R Pasquale
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 126:125-7. 2008
  7. ncbi request reprint Attributes of female reproductive aging and their relation to primary open-angle glaucoma: a prospective study
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    J Glaucoma 16:598-605. 2007
  8. pmc Anthropometric measures and their relation to incident primary open-angle glaucoma
    Louis R Pasquale
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 117:1521-9. 2010
  9. pmc Female reproductive factors and primary open-angle glaucoma in the Nurses' Health Study
    L R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Brigham and Women s Hospital, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Eye (Lond) 25:633-41. 2011
  10. ncbi request reprint Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in women
    Louis R Pasquale
    Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 113:1081-6. 2006

Research Grants

  1. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2005
  2. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2006
  3. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2007
  4. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2009
  5. Gene-Environment Interactions in Glaucoma
    LOUIS ROBERT PASQUALE; Fiscal Year: 2010
  6. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2009

Collaborators

Detail Information

Publications41

  1. pmc Feasibility of High-Throughput Genome-Wide Genotyping using DNA from Stored Buccal Cell Samples
    Stephanie J Loomis
    Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Biomark Insights 5:49-55. 2010
    ..7 ng/ul, discordant genotyping calls did not cluster in any particular chromosome. Buccal cell-derived DNA represents a viable alternative to blood DNA for genotyping on a high-density platform...
  2. pmc Reproductive factors and NOS3 variant interactions in primary open-angle glaucoma
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, MA, USA
    Mol Vis 17:2544-51. 2011
    ..To investigate whether associations with the nitric oxide synthase gene (NOS3) variants and risk of primary open-angle glaucoma (POAG) depend onĀ female reproductive factors...
  3. pmc Estrogen pathway polymorphisms in relation to primary open angle glaucoma: an analysis accounting for gender from the United States
    Louis R Pasquale
    Department of Ophthalmology, Mass Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Mol Vis 19:1471-81. 2013
    ..We assessed the association between an estrogen metabolism single nucleotide polymorphism (SNP) panel in relation to primary open angle glaucoma (POAG), accounting for gender...
  4. pmc CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 155:342-353.e5. 2013
    ....
  5. pmc DNA sequence variants in the LOXL1 gene are associated with pseudoexfoliation glaucoma in a U.S. clinic-based population with broad ethnic diversity
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    BMC Med Genet 9:5. 2008
    ....
  6. doi request reprint Optimizing therapy for newly diagnosed open-angle glaucoma: lessons learned from the Collaborative Initial Glaucoma Treatment Study
    Louis R Pasquale
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Arch Ophthalmol 126:125-7. 2008
  7. ncbi request reprint Attributes of female reproductive aging and their relation to primary open-angle glaucoma: a prospective study
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    J Glaucoma 16:598-605. 2007
    ..We investigated the relation between age at menopause, postmenopausal hormone (PMH) use, and incident primary open-angle glaucoma (POAG)...
  8. pmc Anthropometric measures and their relation to incident primary open-angle glaucoma
    Louis R Pasquale
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 117:1521-9. 2010
    ..To assess the relation between anthropometric measures and incident primary open-angle glaucoma (POAG)...
  9. pmc Female reproductive factors and primary open-angle glaucoma in the Nurses' Health Study
    L R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Brigham and Women s Hospital, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Eye (Lond) 25:633-41. 2011
    ..The purpose of this study was to explore the relation between age at menarche, parity, and oral contraceptive (OC) use, and primary open-angle glaucoma (POAG)...
  10. ncbi request reprint Prospective study of type 2 diabetes mellitus and risk of primary open-angle glaucoma in women
    Louis R Pasquale
    Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ophthalmology 113:1081-6. 2006
    ..To study the relation between type 2 diabetes mellitus (T2DM) and incident primary open-angle glaucoma (POAG) in women...
  11. pmc Lifestyle, nutrition, and glaucoma
    Louis R Pasquale
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Glaucoma 18:423-8. 2009
    ..This review also outlines future directions for research into the primary prevention of POAG...
  12. ncbi request reprint Dietary fat consumption and primary open-angle glaucoma
    Jae H Kang
    Department of Epidemiology, Harvard School of Public Health, Channing Laboratory, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Clin Nutr 79:755-64. 2004
    ..Prostaglandin F(2alpha) analogues are effective intraocular-pressure-lowering drugs. Dietary fatty acids affect endogenous prostaglandin F(2alpha) concentrations and may thus influence intraocular pressure...
  13. pmc Caffeine consumption and the risk of primary open-angle glaucoma: a prospective cohort study
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
    Invest Ophthalmol Vis Sci 49:1924-31. 2008
    ..To investigate whether caffeine, which transiently increases intraocular pressure (IOP) is associated with the risk of primary open-angle glaucoma (POAG)...
  14. ncbi request reprint Prospective study of cigarette smoking and the risk of primary open-angle glaucoma
    Jae H Kang
    Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arch Ophthalmol 121:1762-8. 2003
    ..To examine the association between cigarette smoking and incident primary open-angle glaucoma (POAG)...
  15. ncbi request reprint Antioxidant intake and primary open-angle glaucoma: a prospective study
    Jae H Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Epidemiol 158:337-46. 2003
    ..97 (95% CI: 0.62, 1.52) for vitamin E, and 1.11 (95% CI: 0.82, 1.51) for vitamin A. In conclusion, the authors did not observe any strong associations between antioxidant consumption and the risk of primary open-angle glaucoma...
  16. doi request reprint Shunts to divert aqueous humor to distant epithelialized cavities after keratoprosthesis surgery
    Claes H Dohlman
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    J Glaucoma 19:111-5. 2010
    ..In this retroactive study of such shunts, the risk of postoperative infection (especially endophthalmitis) has been assessed...
  17. ncbi request reprint Prospective study of alcohol consumption and the risk of primary open-angle glaucoma
    Jae H Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Ophthalmic Epidemiol 14:141-7. 2007
    ..Alcohol intake reduces intraocular pressure, a risk factor for primary open-angle glaucoma (POAG). We investigated whether alcohol consumption is associated with a reduced risk of POAG...
  18. pmc The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions
    Marilyn C Cornelis
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115
    Genet Epidemiol 34:364-72. 2010
    ..By maximizing knowledge obtained through collaborative GWAS incorporating environmental exposure information, GENEVA aims to enhance our understanding of disease etiology, potentially identifying opportunities for intervention...
  19. pmc Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 51:971-9. 2010
    ..To evaluate the association between the nitric oxide synthase gene (NOS3) variants and primary open-angle glaucoma (POAG)...
  20. ncbi request reprint Surgical management of glaucoma in pseudophakic patients
    Lillian C Lee
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard University, Boston, MA, USA
    Semin Ophthalmol 17:131-7. 2002
    ..The decision to operate and the choice of surgical procedure must be individualized for each patient...
  21. doi request reprint Lack of association of polymorphisms in elastin with pseudoexfoliation syndrome and glaucoma
    Bao Jian Fan
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Glaucoma 19:432-6. 2010
    ..To evaluate the elastin gene (ELN) as a secondary risk factor for pseudoexfoliation syndrome (PXFS) and the associated glaucoma pseudoexfoliation glaucoma (PXFG)...
  22. ncbi request reprint Endophthalmitis after glaucoma drainage implant surgery
    Jeffrey N Wentzloff
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, MA 02114, USA
    Int Ophthalmol Clin 47:109-15. 2007
  23. doi request reprint Hyphema following selective laser trabeculoplasty
    Douglas J Rhee
    Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Ophthalmic Surg Lasers Imaging 40:493-4. 2009
    ..Her intermittent use of oral nonsteroidal anti-inflammatory medications and chronic topical nonsteroidal anti-inflammatory use may have been a contributing risk factor...
  24. ncbi request reprint Cystoid macular edema in aphakia and pseudophakia after use of prostaglandin analogs
    D Lynn Halpern
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Semin Ophthalmol 17:181-6. 2002
    ..Until our understanding of these issues is more advanced, judicious use of prostaglandin analogs in patients at risk for cystoid macular edema would be prudent...
  25. ncbi request reprint The course of glaucoma during pregnancy: a retrospective case series
    Stacey C Brauner
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Arch Ophthalmol 124:1089-94. 2006
    ..To better understand the course of glaucoma during pregnancy in women with preexisting disease...
  26. doi request reprint The association of primary open-angle glaucoma with mortality: a meta-analysis of observational studies
    Mona Akbari
    Harvard University School of Public Health, Boston, Massachusetts, USA
    Arch Ophthalmol 127:204-10. 2009
    ..To conduct a meta-analysis to estimate the relationship between primary open-angle glaucoma (POAG) and mortality...
  27. ncbi request reprint Traumatic hyphema
    Prithvi S Sankar
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, 02114, USA
    Int Ophthalmol Clin 42:57-68. 2002
  28. ncbi request reprint Herpes simplex virus: an important etiology for secondary glaucoma
    Relief Jones
    Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Boston, MA 02114, USA
    Int Ophthalmol Clin 47:99-107. 2007
  29. ncbi request reprint Retinal blood flow response to posture change in glaucoma patients compared with healthy subjects
    Gilbert T Feke
    Schepens Retina Associates Foundation, Boston, Massachusetts 02215, USA
    Ophthalmology 115:246-52. 2008
    ..To characterize the retinal vascular autoregulatory response to ocular perfusion pressure (OPP) changes in patients with glaucoma and in healthy control subjects...
  30. ncbi request reprint Health care charges for patients with ocular hypertension or primary open-angle glaucoma
    Louis R Pasquale
    Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Ophthalmology 115:633-638.e4. 2008
    ..To determine the total and condition-related direct health care charges of patients with ocular hypertension (OH) or primary open-angle glaucoma (POAG) and identify factors that affect these charges...
  31. doi request reprint Periorbital changes associated with topical bimatoprost
    Theodoros Filippopoulos
    Department of Ophthalmology, Glaucoma Consultation Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthal Plast Reconstr Surg 24:302-7. 2008
    ..To describe periorbital changes induced by chronic topical therapy with daily bimatoprost 0.03% (Lumigan, Allergan Inc., Irvine, CA, U.S.A.)...
  32. doi request reprint Retinal blood flow and nerve fiber layer measurements in early-stage open-angle glaucoma
    Fatmire Berisha
    Schepens Retina Associates Foundation, One Autumn Street, Boston, MA 02215, USA
    Am J Ophthalmol 146:466-472. 2008
    ....
  33. pmc Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with hypertension, alcohol intake, and cigarette smoking
    Jae Hee Kang
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arch Ophthalmol 129:773-80. 2011
    ..To evaluate whether an association between risk of any of the factors of hypertension, alcohol intake, and cigarette smoking and the risk of primary open-angle glaucoma (POAG) depended on nitric oxide synthase 3 (NOS3) gene variants...
  34. ncbi request reprint Glaucomas secondary to intraocular melanomas
    Jason B Wanner
    Glaucoma Service, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA
    Semin Ophthalmol 21:181-9. 2006
    ..The workup needed for unilateral glaucoma will be covered in detail. Treatment options for secondary glaucomas include topical and oral medications as well as argon laser trabeculoplasty and transscleral cyclophotocoagulation...
  35. doi request reprint Healthcare charges in patients who transition from ocular hypertension to primary open-angle glaucoma based on ophthalmic coding data
    Louis R Pasquale
    Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Adv Ther 26:947-58. 2009
    ..The purpose of this research was to assess the impact of transition from ocular hypertension (OHT) to primary open-angle glaucoma (POAG) on healthcare charges...
  36. ncbi request reprint Argon versus selective laser trabeculoplasty in the treatment of open angle glaucoma
    Jing Cheng Zhao
    Progressive Visision Insitute, Eye Care Center, 201 East Laurel Boulevard, Pottsville, PA 17901, USA
    Int Ophthalmol Clin 45:97-106. 2005
  37. ncbi request reprint Costs and utilization of end-stage glaucoma patients receiving visual rehabilitation care: a US multisite retrospective study
    David K Gieser
    Wheaton Eye Clinic, Wheaton, IL, USA
    J Glaucoma 15:419-25. 2006
    ..Glaucoma is a prevalent ophthalmologic disease and leading cause of blindness. A retrospective analysis was conducted to evaluate resources and costs for end-stage glaucoma patients receiving visual rehabilitation care (VRC)...
  38. ncbi request reprint Low intracranial pressure: a tipping point in our understanding of primary open-angle glaucoma?
    Louis R Pasquale
    Ophthalmology 115:761-2. 2008
  39. ncbi request reprint Management and prevention of thin, cystic blebs
    Laura C Fine
    Massachusetts Ear and Eye Infirmary, Boston 02114, USA
    Int Ophthalmol Clin 44:29-42. 2004
  40. ncbi request reprint Lens extraction for angle-closure glaucoma
    Ching Lin Ho
    Massachusetts Ear and Eye Infirmary, Boston 02114, USA
    Int Ophthalmol Clin 44:213-28. 2004
  41. ncbi request reprint Long-term results of Ahmed glaucoma valve implantation for uveitic glaucoma
    Thekla G Papadaki
    Massachusetts Eye Research and Surgery Institute, Ocular Immunology and Uveitis Foundation, Harvard Medical School Boston, Massachusetts, USA
    Am J Ophthalmol 144:62-69. 2007
    ..To present long-term outcomes of Ahmed glaucoma valve implantation for uveitic glaucoma...

Research Grants8

  1. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2005
    ..The discovery of gene-environment interactions that serve as determinants of POAG could lead to genotype-specific primary prevention strategies for this complex disease. ..
  2. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2006
    ..The discovery of gene-environment interactions that serve as determinants of POAG could lead to genotype-specific primary prevention strategies for this complex disease. ..
  3. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2007
    ..The discovery of gene-environment interactions that serve as determinants of POAG could lead to genotype-specific primary prevention strategies for this complex disease. ..
  4. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2009
    ..The discovery of gene-environment interactions that serve as determinants of POAG could lead to genotype-specific primary prevention strategies for this complex disease. ..
  5. Gene-Environment Interactions in Glaucoma
    LOUIS ROBERT PASQUALE; Fiscal Year: 2010
    ..The discovery of the combination of genetic and environment factors that link vascular dysfunction, gender biology and POAG could lead to more effective treatments for this potentially blinding condition. ..
  6. Gene-Environment Interactions in Glaucoma
    Louis Pasquale; Fiscal Year: 2009
    ..The discovery of gene-environment interactions that serve as determinants of POAG could lead to genotype-specific primary prevention strategies for this complex disease. ..