Genomes and Genes
Affiliation: Harvard University
- Deletion of a conserved regulatory element in the Drosophila Adh gene leads to increased alcohol dehydrogenase activity but also delays developmentJ Parsch
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138, USA
Genetics 156:219-27. 2000..These results demonstrate a negative fitness effect associated with Adh overexpression. This provides a mechanism whereby natural selection can discriminate between alternative pathways of increasing enzymatic activity...
- Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroupJ Parsch
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 02138 2020, USA
Mol Biol Evol 18:801-11. 2001..These results are consistent with previous studies that have detected an increased rate of evolution in genes with reproductive function...
- Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulansJ Parsch
Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts 01238 2020, USA
Genetics 159:647-57. 2001..melanogaster sequence, indicating that it was the ancestral form. These results suggest that the derived haplotype has risen to high worldwide frequency relatively recently, most likely as a result of natural selection...
- Molecular evolution of the metallothionein gene Mtn in the melanogaster species group: results from Drosophila ananassaeW Stephan
Department of Zoology, University of Maryland, College Park 20742
Genetics 138:135-43. 1994..pseudoobscura Mtn allele, suggesting that the short intron is the ancestral form and that the transition from the short to the long intron occurred within the melanogaster species group.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Site-directed mutations reveal long-range compensatory interactions in the Adh gene of Drosophila melanogasterJ Parsch
Department of Zoology, University of Maryland, College Park 20742, USA
Proc Natl Acad Sci U S A 94:928-33. 1997..However, our results do not fit the classical compensatory substitution model because the second mutation by itself (in the 3' UTR) did not show a measurable reduction in gene expression...
- A highly conserved sequence in the 3'-untranslated region of the drosophila Adh gene plays a functional role in Adh expressionJ Parsch
Molecular and Cell Biology Program, University of Maryland, College Park, Maryland 20742, USA
Genetics 151:667-74. 1999..The selective difference between these two sequence changes, which have similar effects on ADH activity, may be explained by different metabolic costs associated with the increase in activity...
- RNA secondary structure and compensatory evolutionY Chen
Department of Biology, University of Rochester, NY 14627, USA
Genes Genet Syst 74:271-86. 1999..These experiments analyze long-range compensatory interactions between the 5' and 3' ends of Adh mRNA, the different constraints on secondary structures in introns and exons, and the possible role of secondary structures in RNA splicing...
- Long-range base pairing in Drosophila and human mRNA sequencesJ Parsch
Molecular and Cell Biology Program, University of Maryland, College Park, USA
Mol Biol Evol 15:820-6. 1998..The human pairings appear to be stronger and localized to more specific regions near the ends of the mRNA sequence than those of Drosophila...
- Comparative sequence analysis and patterns of covariation in RNA secondary structuresJ Parsch
Department of Biology, University of Rochester, Rochester, New York 14627 0211, USA
Genetics 154:909-21. 2000..This result is in qualitative agreement with Kimura's model of compensatory fitness interactions, which assumes that mutations occurring in RNA helices are individually deleterious but become neutral in appropriate combinations...