Biju Parekkadan

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis
    Anne L Fletcher
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK
    Sci Transl Med 6:249ra109. 2014
  2. pmc Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells
    Jessica S Elman
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospital for Children, Boston, Massachusetts, United States of America
    PLoS ONE 9:e89882. 2014
  3. pmc Aire controls mesenchymal stem cell-mediated suppression in chronic colitis
    Biju Parekkadan
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, USA
    Mol Ther 20:178-86. 2012
  4. pmc Mesenchymal stem cells as therapeutics
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospital for Children, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Biomed Eng 12:87-117. 2010
  5. pmc Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure
    Hiroshi Yagi
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospitals for Children and Harvard Medical School, Boston, Massachusetts 02114, USA
    Tissue Eng Part A 15:3377-88. 2009
  6. pmc Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1
    Hiroshi Yagi
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, Massachusetts, USA
    Mol Ther 18:1857-64. 2010
  7. pmc Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, Massachusetts 02114, USA
    Gastroenterology 140:966-75. 2011
  8. pmc Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors
    Matthew Li
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Shriners Hospital for Children, Boston, MA, USA
    J Tissue Eng Regen Med 6:369-77. 2012
  9. pmc Mesenchymal stem cells: Mechanisms of immunomodulation and homing
    Hiroshi Yagi
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospitals for Children and Harvard Medical School, Boston, MA, USA
    Cell Transplant 19:667-79. 2010
  10. ncbi request reprint Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
    Daan van Poll
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA, USA
    Hepatology 47:1634-43. 2008

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Lymph node fibroblastic reticular cell transplants show robust therapeutic efficacy in high-mortality murine sepsis
    Anne L Fletcher
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria 3800, Australia School of Immunity and Infection, University of Birmingham, Birmingham B15 2TT, UK
    Sci Transl Med 6:249ra109. 2014
    ..Together, these data describe a new anti-inflammatory cell type and provide preclinical evidence for therapeutic efficacy in severe sepsis that warrants further translational study. ..
  2. pmc Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells
    Jessica S Elman
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospital for Children, Boston, Massachusetts, United States of America
    PLoS ONE 9:e89882. 2014
    ..We assert that a combined consideration of cell delivery strategies and molecular pharmacokinetics can provide a more predictive model for outcomes of MSC transplantation and potentially other transient cell therapeutics. ..
  3. pmc Aire controls mesenchymal stem cell-mediated suppression in chronic colitis
    Biju Parekkadan
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, USA
    Mol Ther 20:178-86. 2012
    ..We propose that Aire represents an early molecular switch imposing a suppressive MSC phenotype via regulation of Eta-1. Monitoring Aire expression in MSCs may thus be a critical parameter for clinical use...
  4. pmc Mesenchymal stem cells as therapeutics
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospital for Children, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Biomed Eng 12:87-117. 2010
    ..By integrating principles of MSC biology, therapy, and engineering, the field is armed to usher in the next generation of stem cell therapeutics...
  5. pmc Long-term superior performance of a stem cell/hepatocyte device for the treatment of acute liver failure
    Hiroshi Yagi
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospitals for Children and Harvard Medical School, Boston, Massachusetts 02114, USA
    Tissue Eng Part A 15:3377-88. 2009
    ..These findings demonstrate the importance of nonparenchymal cells in the cellular composition of LADs, and strongly support the integration of MSCs into hepatocyte-coculture-based LADs as a potential destination therapy for ALF...
  6. pmc Reactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1
    Hiroshi Yagi
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, Massachusetts, USA
    Mol Ther 18:1857-64. 2010
    ..These results suggest that improvements of inflammatory responses in animal models after local transplantation of MSCs are at least, in part, explained by the NFκB-dependent secretion of sTNFR1 by MSCs...
  7. pmc Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, and Shriners Hospitals for Children, Boston, Massachusetts 02114, USA
    Gastroenterology 140:966-75. 2011
    ..We investigated the effects of MSCs in mice with chemically induced colitis and determined the effects of CD11b(+) cells based on the hypothesis that MSCs increase numbers of regulatory T cells...
  8. pmc Phenotypic and functional characterization of human bone marrow stromal cells in hollow-fibre bioreactors
    Matthew Li
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Shriners Hospital for Children, Boston, MA, USA
    J Tissue Eng Regen Med 6:369-77. 2012
    ....
  9. pmc Mesenchymal stem cells: Mechanisms of immunomodulation and homing
    Hiroshi Yagi
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Shriners Hospitals for Children and Harvard Medical School, Boston, MA, USA
    Cell Transplant 19:667-79. 2010
    ..These aspects of MSC grafts--immunomodulation and homing--are contextualized to understand a reported side effect of MSC therapy, cancer development...
  10. ncbi request reprint Mesenchymal stem cell-derived molecules directly modulate hepatocellular death and regeneration in vitro and in vivo
    Daan van Poll
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and Shriners Hospitals for Children, Boston, MA, USA
    Hepatology 47:1634-43. 2008
    ..Direct antiapoptotic and promitotic effects of MSC-CM on hepatocytes were demonstrated using in vitro assays...
  11. pmc A mesenchymal stem cell potency assay
    Joy Jiao
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Methods Mol Biol 677:221-31. 2011
    ..This assay provides a powerful tool in analyzing the potency of MSC-CM and MSC-Ly, as well as characterizing the interaction between MSC-CM and target cells in the blood...
  12. pmc Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, USA
    PLoS ONE 2:e941. 2007
    ....
  13. pmc Enriched Protein Screening of Human Bone Marrow Mesenchymal Stromal Cell Secretions Reveals MFAP5 and PENK as Novel IL-10 Modulators
    Jack M Milwid
    1 Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA 2 Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Mol Ther 22:999-1007. 2014
    ..Greater than 85% of secreted factors were recaptured that were otherwise undetected by proteomic methods, and remarkable hit rates of 18% in vitro and 9% in vivo were achieved. ..
  14. pmc Implantable microenvironments to attract hematopoietic stem/cancer cells
    Jungwoo Lee
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 109:19638-43. 2012
    ..This implantable construct can serve as a tool enabling the study of hematopoiesis...
  15. pmc Secreted factors from bone marrow stromal cells upregulate IL-10 and reverse acute kidney injury
    Jack M Milwid
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, 51 Blossom Street, Boston, MA 02114, USA Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Stem Cells Int 2012:392050. 2012
    ..In all, these results demonstrate that BMSC-secreted factors are capable of providing support without cell transplantation, and the IL-10 increase seen in BMSC-CM-treated animals correlates with attenuation of severe AKI...
  16. pmc Cell-cell interaction modulates neuroectodermal specification of embryonic stem cells
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, MA, USA
    Neurosci Lett 438:190-5. 2008
    ..Moreover, this study demonstrates the integration of microscale culture techniques to explore the biology of ES cells and gain insight into relevant developmental processes otherwise undefined due to bulk culture methods...
  17. pmc Gap junction inhibition prevents drug-induced liver toxicity and fulminant hepatic failure
    Suraj J Patel
    Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Biotechnol 30:179-83. 2012
    ..These findings indicate that gap junction inhibition could provide a pharmaceutical strategy to limit DILI and improve drug safety...
  18. ncbi request reprint Bone marrow-derived mesenchymal stem cells ameliorate autoimmune enteropathy independently of regulatory T cells
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Stem Cells 26:1913-9. 2008
    ..These data implicate the intestine as a new site of MSC tolerance induction and should motivate additional studies evaluating the use of MSCs as a treatment for autoimmune enteropathies...
  19. ncbi request reprint Microcavity substrates casted from self-assembled microsphere monolayers for spheroid cell culture
    Keyue Shen
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, MA, 02114, USA
    Biomed Microdevices 16:609-15. 2014
    ..The presented technique offers a simple and effective way of forming high-density uniformly-sized spheroids without microfabrication equipment for biological and drug screening applications. ..
  20. pmc Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, 51 Blossom Street, Boston, MA 02114, USA
    Biochem Biophys Res Commun 363:247-52. 2007
    ....
  21. pmc Capture and printing of fixed stromal cell membranes for bioactive display on PDMS surfaces
    Jungwoo Lee
    Department of Surgery, Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, United States
    Langmuir 29:10611-6. 2013
    ..The presented process is applicable to virtually any adherent cell and can broaden the functional display of biomolecules on PDMS for biotechnology applications. ..
  22. ncbi request reprint Osmotic selection of human mesenchymal stem/progenitor cells from umbilical cord blood
    Biju Parekkadan
    Center for Engineering in Medicine and Surgical Services, BioMEMS Resource Center, Harvard Medical School, Massachusetts General Hospital and the Shriners Hospitals for Children, Boston, MA, USA
    Tissue Eng 13:2465-73. 2007
    ..Disruption of filamentous actin polymerization by cytochalasin D sensitized MSCs to osmotic lysis, which suggests a cytoskeletal element involved in osmolytic resistance...