Genomes and Genes
Affiliation: Harvard University
- PPARalpha deficiency in inflammatory cells suppresses tumor growthArja Kaipainen
Vascular Biology Program, Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 2:e260. 2007..These findings suggest that the absence of PPARalpha activity renders inflammatory infiltrates tumor suppressive and, thus, may provide a target for inhibiting tumor growth by modulating stromal processes, such as angiogenesis...
- Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in miceDipak Panigrahy
Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts, USA
J Clin Invest 122:178-91. 2012..Thus, our data indicate a central role for EETs in tumorigenesis, offering a mechanistic link between lipid signaling and cancer and emphasizing the critical importance of considering possible effects of EET-modulating drugs on cancer...
- EET signaling in cancerDipak Panigrahy
Vascular Biology Program, Boston Children s Hospital, Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Cancer Metastasis Rev 30:525-40. 2011..In this review, the emerging role of EET signaling in angiogenesis, inflammation, and cancer is discussed...
- Cytochrome P450-derived eicosanoids: the neglected pathway in cancerDipak Panigrahy
Vascular Biology Program, Children s Hospital Boston, Boston, MA, USA
Cancer Metastasis Rev 29:723-35. 2010..In this review, the emerging role in cancer of cytochrome P450 metabolites, notably 20-HETE and EETs, are discussed...
- PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibitionDipak Panigrahy
Vascular Biology Program, Children s Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 105:985-90. 2008..Our results provide a mechanistic rationale for evaluating the clinical benefits of PPARalpha agonists in cancer treatment, alone and in combination with other therapies...
- Epoxyeicosanoids promote organ and tissue regenerationDipak Panigrahy
Vascular Biology Program and Department of Surgery, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 110:13528-33. 2013..Thus, our observations indicate a central role for EETs in organ and tissue regeneration and their contribution to tissue homeostasis. ..
- PPARgamma as a therapeutic target for tumor angiogenesis and metastasisDipak Panigrahy
Vascular Biology Program, Children s Hospital, Department of Surgery, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Biol Ther 4:687-93. 2005..This will be paramount if the potent biological activity of PPARgamma agonists are to be harnessed for cancer therapy...
- Therapeutic potential of thiazolidinediones as anticancer agentsDipak Panigrahy
Children s Hospital, Research Building, Floor 12, Boston, MA, USA
Expert Opin Investig Drugs 12:1925-37. 2003..Further studies suggest that TZDs may be effective in prevention of certain cancers and in the treatment of cancer as adjuvant therapy...
- PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesisDipak Panigrahy
Surgical Research Laboratory, Children s Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 110:923-32. 2002..These results suggest that PPARgamma ligands may be useful in treating angiogenic diseases such as cancer by inhibiting angiogenesis...
- Regulation of inflammation in cancer by eicosanoidsEmily R Greene
Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
Prostaglandins Other Lipid Mediat 96:27-36. 2011..Eicosanoids may represent a missing link between inflammation and cancer and thus could serve as therapeutic target(s) for inhibiting tumor growth...
- Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progressionTadanori Mammoto
Vascular Biology Program, Department of Surgery, Boston Children s Hospital and Harvard Medical School, Boston, Massachusetts
Am J Pathol 183:1293-305. 2013..These findings suggest that tumor microenvironment controlled by collagen structure is important in tumor angiogenesis and brain tumor progression...
- Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinibCarmen M Barnes
Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Pediatr Res 71:168-78. 2012..We investigated the use of dietary omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) in the treatment of neuroblastoma both as a sole agent and in combination with sunitinib, a broad-spectrum tyrosine kinase receptor inhibitor...
- Cytochrome P450 2C8 ω3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief reportZhuo Shao
From the Department of Ophthalmology, Boston Children s Hospital Z S, Z F, J S J, C Hatton, A J, C Hurst, L E, Z C, D P, Y G, D X, K T, H B, J C, L E H S and Department of Pathology, Beth Israel Deaconess Medical Center D P, Harvard Medical School, Boston, MA University Eye Hospital Freiburg, Freiburg, Germany A S Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, NC M L E, F L, D C Z Department of Ophthalmology, Hopital Maisonneuve Rosemont, University of Montreal, Montreal, Quebec, Canada P S and Department of Ophthalmology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden A H
Arterioscler Thromb Vasc Biol 34:581-6. 2014..The effect of these enzymes and their metabolites on neovascularization is unknown...
- The growing role of eicosanoids in tissue regeneration, repair, and wound healingBrian T Kalish
Vascular Biology Program, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
Prostaglandins Other Lipid Mediat 104:130-8. 2013..In this review, we describe how this diverse group of molecules is a key regulator of tissue repair and regeneration in multiple organ systems and biologic contexts. ..
- Broad spectrum antiangiogenic treatment for ocular neovascular diseasesOfra Benny
Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
PLoS ONE 5:. 2010..Several unique properties make Lodamin especially beneficial for ophthalmic use. Our results support the concept that broad spectrum antiangiogenic drugs are promising agents for AMD treatment and prevention...
- The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptorCecilia A Fernandez
Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
J Biol Chem 285:41886-95. 2010....
- Regulation of soluble neuropilin 1, an endogenous angiogenesis inhibitor, in liver development and regenerationDipak Panigrahy
1Vascular Biology Program, Boston Children s Hospital 2Department of Surgery, Harvard Medical School 3Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA, United States 4Department of Surgery, Klinikum Grosshadern, LMU Munich, Munich, Germany 5Department of Ophthalmology, Harvard Medical School 6Department of Pathology, Harvard Medical School 7Schepens Eye Research Institute, Massachusetts Eye and Ear, Boston, MA, United States
Pathology 46:416-23. 2014....
- SOCS3 is an endogenous inhibitor of pathologic angiogenesisAndreas Stahl
Department of Ophthalmology, Harvard Medical School, Boston Children s Hospital, Boston, MA 02115, USA
Blood 120:2925-9. 2012..These results identify SOCS3 as a pivotal endogenous feedback inhibitor of pathologic angiogenesis and a potential therapeutic target acting at the converging crossroads of growth factor- and cytokine-induced vessel growth...
- Tumor-associated endothelial cells with cytogenetic abnormalitiesKyoko Hida
Vascular Biology Program, Department of Surgery, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 64:8249-55. 2004..FISH analysis of tumor sections also showed endothelial cell aneuploidy. We conclude that tumor endothelial cells can acquire cytogenetic abnormalities while in the tumor microenvironment...
- Adipose tissue mass can be regulated through the vasculatureMaria A Rupnick
Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 99:10730-5. 2002..We conclude that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature...
- Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)Anette Duensing
Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
Oncogene 23:3999-4006. 2004....
- Specific uptake of 99mTc-NC100692, an αvβ3-targeted imaging probe, in subcutaneous and orthotopic tumorsJason L J Dearling
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children s Hospital, Boston, MA 02115, USA
Nucl Med Biol 40:788-94. 2013..In an effort to begin to address this limitation, we evaluated the tumor uptake of (99m)Tc-NC100692, a cyclic RGD peptide that binds to αvβ3 with ~1-nM affinity, in an αvβ3-positive tumor model as well as its in vivo specificity...
- Control of cancer and metastasis by endothelial-derived epoxyeicosatrienoic acidsDipak Panigrahy; Fiscal Year: 2010..Conversely, blocking the EET pathway may offer a new strategy to block tumor blood vessels and, hence, help combat cancer. Thus, novel drugs which block EETs will be tested in preclinical trials to confirm their activity. ..