Dipak Panigrahy

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts, USA
    J Clin Invest 122:178-91. 2012
  2. pmc Cytochrome P450-derived eicosanoids: the neglected pathway in cancer
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital Boston, Boston, MA, USA
    Cancer Metastasis Rev 29:723-35. 2010
  3. pmc EET signaling in cancer
    Dipak Panigrahy
    Vascular Biology Program, Boston Children s Hospital, Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Cancer Metastasis Rev 30:525-40. 2011
  4. pmc PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:985-90. 2008
  5. pmc PPARalpha deficiency in inflammatory cells suppresses tumor growth
    Arja Kaipainen
    Vascular Biology Program, Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e260. 2007
  6. pmc Epoxyeicosanoids promote organ and tissue regeneration
    Dipak Panigrahy
    Vascular Biology Program and Department of Surgery, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:13528-33. 2013
  7. doi request reprint Regulation of inflammation in cancer by eicosanoids
    Emily R Greene
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Prostaglandins Other Lipid Mediat 96:27-36. 2011
  8. ncbi request reprint PPARgamma as a therapeutic target for tumor angiogenesis and metastasis
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital, Department of Surgery, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Biol Ther 4:687-93. 2005
  9. ncbi request reprint Therapeutic potential of thiazolidinediones as anticancer agents
    Dipak Panigrahy
    Children s Hospital, Research Building, Floor 12, Boston, MA, USA
    Expert Opin Investig Drugs 12:1925-37. 2003
  10. doi request reprint Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib
    Carmen M Barnes
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Res 71:168-78. 2012

Detail Information

Publications17

  1. pmc Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts, USA
    J Clin Invest 122:178-91. 2012
    ..Thus, our data indicate a central role for EETs in tumorigenesis, offering a mechanistic link between lipid signaling and cancer and emphasizing the critical importance of considering possible effects of EET-modulating drugs on cancer...
  2. pmc Cytochrome P450-derived eicosanoids: the neglected pathway in cancer
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital Boston, Boston, MA, USA
    Cancer Metastasis Rev 29:723-35. 2010
    ..In this review, the emerging role in cancer of cytochrome P450 metabolites, notably 20-HETE and EETs, are discussed...
  3. pmc EET signaling in cancer
    Dipak Panigrahy
    Vascular Biology Program, Boston Children s Hospital, Division of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    Cancer Metastasis Rev 30:525-40. 2011
    ..In this review, the emerging role of EET signaling in angiogenesis, inflammation, and cancer is discussed...
  4. pmc PPARalpha agonist fenofibrate suppresses tumor growth through direct and indirect angiogenesis inhibition
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital, Department of Surgery, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:985-90. 2008
    ..Our results provide a mechanistic rationale for evaluating the clinical benefits of PPARalpha agonists in cancer treatment, alone and in combination with other therapies...
  5. pmc PPARalpha deficiency in inflammatory cells suppresses tumor growth
    Arja Kaipainen
    Vascular Biology Program, Department of Surgery, Children s Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 2:e260. 2007
    ..These findings suggest that the absence of PPARalpha activity renders inflammatory infiltrates tumor suppressive and, thus, may provide a target for inhibiting tumor growth by modulating stromal processes, such as angiogenesis...
  6. pmc Epoxyeicosanoids promote organ and tissue regeneration
    Dipak Panigrahy
    Vascular Biology Program and Department of Surgery, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 110:13528-33. 2013
    ..Thus, our observations indicate a central role for EETs in organ and tissue regeneration and their contribution to tissue homeostasis. ..
  7. doi request reprint Regulation of inflammation in cancer by eicosanoids
    Emily R Greene
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Prostaglandins Other Lipid Mediat 96:27-36. 2011
    ..Eicosanoids may represent a missing link between inflammation and cancer and thus could serve as therapeutic target(s) for inhibiting tumor growth...
  8. ncbi request reprint PPARgamma as a therapeutic target for tumor angiogenesis and metastasis
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital, Department of Surgery, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Biol Ther 4:687-93. 2005
    ..This will be paramount if the potent biological activity of PPARgamma agonists are to be harnessed for cancer therapy...
  9. ncbi request reprint Therapeutic potential of thiazolidinediones as anticancer agents
    Dipak Panigrahy
    Children s Hospital, Research Building, Floor 12, Boston, MA, USA
    Expert Opin Investig Drugs 12:1925-37. 2003
    ..Further studies suggest that TZDs may be effective in prevention of certain cancers and in the treatment of cancer as adjuvant therapy...
  10. doi request reprint Inhibition of neuroblastoma cell proliferation with omega-3 fatty acids and treatment of a murine model of human neuroblastoma using a diet enriched with omega-3 fatty acids in combination with sunitinib
    Carmen M Barnes
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Res 71:168-78. 2012
    ..We investigated the use of dietary omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) in the treatment of neuroblastoma both as a sole agent and in combination with sunitinib, a broad-spectrum tyrosine kinase receptor inhibitor...
  11. pmc PPARgamma ligands inhibit primary tumor growth and metastasis by inhibiting angiogenesis
    Dipak Panigrahy
    Surgical Research Laboratory, Children s Hospital, Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 110:923-32. 2002
    ..These results suggest that PPARgamma ligands may be useful in treating angiogenic diseases such as cancer by inhibiting angiogenesis...
  12. pmc Adipose tissue mass can be regulated through the vasculature
    Maria A Rupnick
    Division of Cardiovascular Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:10730-5. 2002
    ..We conclude that adipose tissue mass is sensitive to angiogenesis inhibitors and can be regulated by its vasculature...
  13. pmc The anti-angiogenic peptide, loop 6, binds insulin-like growth factor-1 receptor
    Cecilia A Fernandez
    Vascular Biology Program, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Biol Chem 285:41886-95. 2010
    ....
  14. ncbi request reprint Mechanisms of oncogenic KIT signal transduction in primary gastrointestinal stromal tumors (GISTs)
    Anette Duensing
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Oncogene 23:3999-4006. 2004
    ....
  15. doi request reprint Specific uptake of (99m)Tc-NC100692, an αvβ3-targeted imaging probe, in subcutaneous and orthotopic tumors
    Jason L J Dearling
    Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Boston Children s Hospital, Boston, MA, USA Harvard Medical School, Boston, MA, USA Electronic address
    Nucl Med Biol 40:788-94. 2013
    ..In an effort to begin to address this limitation, we evaluated the tumor uptake of (99m)Tc-NC100692, a cyclic RGD peptide that binds to αvβ3 with ~1-nM affinity, in an αvβ3-positive tumor model as well as its in vivo specificity...
  16. doi request reprint The growing role of eicosanoids in tissue regeneration, repair, and wound healing
    Brian T Kalish
    Vascular Biology Program, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    Prostaglandins Other Lipid Mediat 104:130-8. 2013
    ..In this review, we describe how this diverse group of molecules is a key regulator of tissue repair and regeneration in multiple organ systems and biologic contexts. ..
  17. pmc Broad spectrum antiangiogenic treatment for ocular neovascular diseases
    Ofra Benny
    Vascular Biology Program and Department of Surgery, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:. 2010
    ..Several unique properties make Lodamin especially beneficial for ophthalmic use. Our results support the concept that broad spectrum antiangiogenic drugs are promising agents for AMD treatment and prevention...

Research Grants1

  1. Control of cancer and metastasis by endothelial-derived epoxyeicosatrienoic acids
    Dipak Panigrahy; Fiscal Year: 2010
    ..Conversely, blocking the EET pathway may offer a new strategy to block tumor blood vessels and, hence, help combat cancer. Thus, novel drugs which block EETs will be tested in preclinical trials to confirm their activity. ..