L J Palmer

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Airway responsiveness in early infancy predicts asthma, lung function, and respiratory symptoms by school age
    L J Palmer
    Department of Paediatrics, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 163:37-42. 2001
  2. ncbi request reprint Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region
    L J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Harvard University, Boston, MA 02115, USA
    Hum Mol Genet 10:891-99. 2001
  3. ncbi request reprint Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families
    L J Palmer
    Genetic Epidemiology Unit, Division of Population Sciences, TVW Telethon Institute for Child Health Research, Perth, Australia
    Eur J Hum Genet 8:853-60. 2000
  4. ncbi request reprint Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children
    L J Palmer
    Department of Paediatrics and Centre for Molecular Immunology and Instrumentation, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 158:1825-30. 1998
  5. ncbi request reprint Asthma, rhinitis, and skin test reactivity to aeroallergens in families of asthmatic subjects in Anqing, China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 163:1108-12. 2001
  6. ncbi request reprint Body mass index and asthma in adults in families of subjects with asthma in Anqing, China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 164:1835-40. 2001
  7. ncbi request reprint Gibbs sampling-based segregation analysis of asthma-associated quantitative traits in a population-based sample of nuclear families
    L J Palmer
    Genetic Epidemiology Unit, Division of Population Sciences, TVW Telethon Institute for Child Health Research, Perth, Western Australia
    Genet Epidemiol 20:356-72. 2001
  8. ncbi request reprint Sensitization to silk and childhood asthma in rural China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 107:E80. 2001
  9. ncbi request reprint Determinants of airway responsiveness to histamine in children
    S W Turner
    School of Pediatrics and Child Health, University of Western Australia, Perth, Australia
    Eur Respir J 25:462-7. 2005
  10. ncbi request reprint The effect of age on the relationship between birth order and immunoglobulin E sensitization
    S W Turner
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    Clin Exp Allergy 35:630-4. 2005

Detail Information

Publications45

  1. ncbi request reprint Airway responsiveness in early infancy predicts asthma, lung function, and respiratory symptoms by school age
    L J Palmer
    Department of Paediatrics, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 163:37-42. 2001
    ..These data suggest that airway responsiveness in early life defines a functional state that is associated with abnormal airway function, lower respiratory symptoms, and the emergence of asthma by 6 yr of age...
  2. ncbi request reprint Meta-analysis for linkage to asthma and atopy in the chromosome 5q31-33 candidate region
    L J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Harvard University, Boston, MA 02115, USA
    Hum Mol Genet 10:891-99. 2001
    ....
  3. ncbi request reprint Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families
    L J Palmer
    Genetic Epidemiology Unit, Division of Population Sciences, TVW Telethon Institute for Child Health Research, Perth, Australia
    Eur J Hum Genet 8:853-60. 2000
    ..Our study suggests that total and specific serum IgE levels, blood eosinophil counts and airways responsiveness to inhaled agonist are appropriate phenotypes for molecular investigations of the genetic susceptibility to asthma...
  4. ncbi request reprint Linkage of chromosome 5q and 11q gene markers to asthma-associated quantitative traits in Australian children
    L J Palmer
    Department of Paediatrics and Centre for Molecular Immunology and Instrumentation, University of Western Australia, Perth, Australia
    Am J Respir Crit Care Med 158:1825-30. 1998
    ..Phenotypes were residualized for age and sex. These data are consistent with the existence of loci regulating asthma-associated quantitative traits in both the 5q31-33 and 11q13 chromosomal regions...
  5. ncbi request reprint Asthma, rhinitis, and skin test reactivity to aeroallergens in families of asthmatic subjects in Anqing, China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 163:1108-12. 2001
    ..Our findings also suggest that allergic rhinitis is far less common among asthmatic subjects in rural China than in asthmatic subjects in industrialized countries with a Western lifestyle...
  6. ncbi request reprint Body mass index and asthma in adults in families of subjects with asthma in Anqing, China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 164:1835-40. 2001
    ..21) (kg/m)(2) = 1.3 to 3.1; 95% CI(30) (vs.) (21) (kg/m)(2) = 1.2 to 4.5). Among adults in families of subjects with asthma living in rural China, both underweight and overweight are associated with an increased risk of asthma...
  7. ncbi request reprint Gibbs sampling-based segregation analysis of asthma-associated quantitative traits in a population-based sample of nuclear families
    L J Palmer
    Genetic Epidemiology Unit, Division of Population Sciences, TVW Telethon Institute for Child Health Research, Perth, Western Australia
    Genet Epidemiol 20:356-72. 2001
    ..These results have implications for gene discovery programs...
  8. ncbi request reprint Sensitization to silk and childhood asthma in rural China
    J C Celedon
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Pediatrics 107:E80. 2001
    ..Because silk products are commonly used in Chinese society, we were interested in examining the relation between sensitization to silk and asthma...
  9. ncbi request reprint Determinants of airway responsiveness to histamine in children
    S W Turner
    School of Pediatrics and Child Health, University of Western Australia, Perth, Australia
    Eur Respir J 25:462-7. 2005
    ..In children with asthma, airway responsiveness may be influenced by the early onset of atopy. The current findings may explain the inconsistent relationship between airway responsiveness and asthma...
  10. ncbi request reprint The effect of age on the relationship between birth order and immunoglobulin E sensitization
    S W Turner
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    Clin Exp Allergy 35:630-4. 2005
    ..An association between birth order and IgE sensitization or allergic diseases has been reported in many studies...
  11. ncbi request reprint Familial aggregation and heritability of adult lung function: results from the Busselton Health Study
    L J Palmer
    Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
    Eur Respir J 17:696-702. 2001
    ..The results of this study were consistent with the existence of important genetic determinants of adult lung function that are independent of asthma or other atopic disease, cigarette smoking, height, age or sex...
  12. doi request reprint The PHF11 gene is not associated with asthma or asthma phenotypes in two independent populations
    J McClenaghan
    Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Nedlands, WA, Australia
    Thorax 64:620-5. 2009
    ..Initial studies have reported strong associations of variants in the plant homeodomain zinc finger protein 11 (PHF11) gene with serum IgE levels, asthma, airway hyper-responsiveness and childhood atopic dermatitis...
  13. ncbi request reprint beta2 adrenoceptor Arg16Gly polymorphism, airway responsiveness, lung function and asthma in infants and children
    S W Turner
    School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
    Clin Exp Allergy 34:1043-8. 2004
    ..We have previously reported a relationship between increased airway responsiveness (AR) in infancy and reduced childhood lung function...
  14. doi request reprint Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm
    L Smallwood
    School of Surgery, University of Western Australia, Fremantle Hospital, Fremantle, WA 6959, Australia
    Eur J Vasc Endovasc Surg 38:169-71. 2009
    ..To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA)...
  15. ncbi request reprint Single region linkage analyses of asthma: description of data sets
    L J Palmer
    Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Genet Epidemiol 21:S9-15. 2001
    ..This paper describes the ascertainment, data collection methods, phenotypic data, and genotypic data available for the single linkage region analyses undertaken for Genetic Analysis Workshop 12...
  16. ncbi request reprint Genetic variance components analysis for binary phenotypes using generalized linear mixed models (GLMMs) and Gibbs sampling
    P R Burton
    Division of Biostatistics and Genetic Epidemiology, TVW Telethon Institute for Child Health Research, Perth, Australia
    Genet Epidemiol 17:118-40. 1999
    ..Using simulated data we show that model parameters seem consistent and appear unbiased in smaller data sets. We illustrate our methods using data from an ongoing cohort study...
  17. ncbi request reprint Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases
    E K Silverman
    Channing Laboratory, Brigham and Women s Hospital, Boston, Mass 02114, USA
    Hum Hered 52:223-32. 2001
    ..We have used the protease inhibitor (PI) type as a genetic marker rather than a disease gene, and we have performed linkage analysis between PI type and serum A1AT level and spirometry-related phenotypes...
  18. doi request reprint The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits
    R J Webster
    Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, B Block, Queen Elizabeth II Medical Centre, Nedlands, WA 6009, Australia
    Diabetologia 52:106-14. 2009
    ..Our aim was to examine the longitudinal associations of four such variants in the apolipoprotein A-V (APOA5), lipoprotein lipase (LPL), and glucokinase (GCK) genes with fasting glucose or lipid levels...
  19. pmc Using single nucleotide polymorphisms as a means to understanding the pathophysiology of asthma
    L J Palmer
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Respir Res 2:102-12. 2001
    ..This paper reviews both current and potential future contributions of SNPs to our understanding of asthma pathophysiology...
  20. ncbi request reprint Linkages and associations to intermediate phenotypes underlying asthma and allergic disease
    L J Palmer
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Allergy Clin Immunol 1:393-8. 2001
    ....
  21. ncbi request reprint The relationship between ACE genotype and risk of severe hypoglycaemia in a large population-based cohort of children and adolescents with type 1 diabetes
    M K Bulsara
    School of Population Health, University of Western Australia, 35 Stirling Highway, Crawley, Nedlands, Perth, WA 6009, Australia
    Diabetologia 50:965-71. 2007
    ..This large prospective cohort study assesses this relationship in a large sample of children and adolescents with type 1 diabetes...
  22. ncbi request reprint Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica
    J C Celedon
    Channing Laboratory Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Clin Exp Allergy 32:387-90. 2002
    ..Single nucleotide polymorphisms (SNPs) in the IL-13 gene have been associated with asthma and total serum IgE level in Caucasian populations...
  23. pmc A polymorphism of the CC16 gene is associated with an increased risk of asthma
    I A Laing
    Department of Paediatrics, University of Western Australia, Children s Hospital Medical Centre, Perth
    J Med Genet 35:463-7. 1998
    ..These associations were independent of age, gender, and tobacco smoke exposure. These data and the known anti-inflammatory role of CC16 in the respiratory tract suggest that alteration to the gene at position 38 may contribute to asthma...
  24. ncbi request reprint Combining multiple phenotypic traits optimally for detecting linkage with sib-pair observations
    X Xu
    Program for Population Genetics, FXB-103, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Genet Epidemiol 21:S479-83. 2001
    ..Q4) studied, our linkage results suggest that major loci affecting Q1 and Q2 localize at or near markers D02G172, D19G032, and D09G122, while loci affecting Q3 and Q4 localize at or near markers D09G122 and D17G051...
  25. ncbi request reprint Gene frequencies of human platelet antigens 1-5 in indigenous Australians in Western Australia
    J A Bennett
    Haematology Department, Western Australian Centre for Pathology and Medical Research PathCentre, Perth, Nedlands, Western Australia 6009, Australia
    Transfus Med 12:199-203. 2002
    ....
  26. ncbi request reprint The immune anti-tumor effects of GM-CSF and B7-1 gene transfection are enhanced by surgical debulking of tumor
    S Mukherjee
    Department of Medicine, University of Western Australia, Perth, Australia
    Cancer Gene Ther 8:580-8. 2001
    ..This has implications for the future design of human gene therapy trials for solid tumors such as MM...
  27. ncbi request reprint The C-480T hepatic lipase polymorphism is associated with HDL-C but not with risk of coronary heart disease
    P A McCaskie
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, Centre for Medical Research, University of Western Australia, Nedlands, Perth, Western Australia
    Clin Genet 70:114-21. 2006
    ..19-0.78, p = 0.008). These findings replicate those of previous studies in three independent populations and suggest that the genetic determinants of CHD are complex and cannot be entirely explained through intermediate phenotypes...
  28. ncbi request reprint Perinatal and childhood origins of cardiovascular disease
    R C Huang
    School of Medicine and Pharmacology, The University of Western Australia UWA M570, Royal Perth Hospital, Perth, Western Australia, Australia
    Int J Obes (Lond) 31:236-44. 2007
    ..We sought to identify early life influences on development of obesity, hypertension and dyslipidemia in children...
  29. ncbi request reprint Cohort profile: The Western Australian Family Connections Genealogical Project
    E J Glasson
    Telethon Institute for Child Health Research, Centre for Child Health Research, The University of Western Australia, Perth, Australia
    Int J Epidemiol 37:30-5. 2008
  30. ncbi request reprint Toll-like receptor 6 gene (TLR6): single-nucleotide polymorphism frequencies and preliminary association with the diagnosis of asthma
    K Tantisira
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Genes Immun 5:343-6. 2004
    ..Although replication of this finding in other, larger samples is needed, variation in TLR6 may have relevance to the pathogenesis of immunologically mediated diseases...
  31. ncbi request reprint Combined analysis of three whole genome linkage scans for Ankylosing Spondylitis
    K W Carter
    Laboratory for Genetic Epidemiology, Western Australian Institute for Medical Research, UWA Centre for Medical Research, University of Western Australia, Nedlands, Western Australia 6009, Australia
    Rheumatology (Oxford) 46:763-71. 2007
    ..One potential solution to these issues is to combine data from multiple studies in a retrospective meta-analysis...
  32. ncbi request reprint Post-disaster service provision following proactive identification of children with emotional distress and depression
    B M McDermott
    Department of Paediatrics, University of Western Australia, Perth, Australia
    Aust N Z J Psychiatry 33:855-63. 1999
    ....
  33. ncbi request reprint MICA, HLA-B haplotypic variation in five population groups of sub-Saharan African ancestry
    W Tian
    Center for Blood Research, Harvard Medical School, Boston, MA, USA
    Genes Immun 4:500-5. 2003
    ..These findings are important from an anthropologic perspective, and will inform future HLA-linked disease association studies in related ethnic groups of African-derived ancestry...
  34. ncbi request reprint AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population
    J Hui
    UWA Centre for Medical Research, Western Australian Institute for Medical Research, The University of Western Australia, and Western Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Western Australia
    Clin Exp Allergy 36:728-34. 2006
    ..Background The highly polymorphic non-classical MHC class I polypeptide-related (MIC) genes, MICA and MICB, encode stress inducible glycoproteins, which are expressed on a variety of epithelial cells, including those of the lungs...
  35. ncbi request reprint Cysteinyl leukotriene receptor 1 promoter polymorphism is associated with aspirin-intolerant asthma in males
    S H Kim
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    Clin Exp Allergy 36:433-9. 2006
    ..CysLTR1-selective antagonists have anti-bronchoconstrictive and anti-inflammatory effects in asthma, particularly aspirin-intolerant asthma (AIA)...
  36. ncbi request reprint Family-based association test method: age of onset traits and covariates
    S Horvath
    Department of Human Genetics, UCLA School of Medicine, Gonda Neuroscience and Genetics Research Center, 695 Charles E. Young Drive South, Box 708822, Los Angeles, CA 90095-7088, USA
    Genet Epidemiol 21:S403-8. 2001
    ..We find only weak evidence (p = 0.0002) that marker D06G032 is associated with the affectation status...
  37. ncbi request reprint Polymorphisms in the angiotensinogen gene are associated with carotid intimal-medial thickening in females from a community-based population
    C M Chapman
    Clinical Biochemistry, PathCentre, Locked Bag 2009, 6909, Nedlands, Australia
    Atherosclerosis 159:209-17. 2001
    ..We investigated the association of polymorphisms in the angiotensinogen (AGT) and angiotensin II receptor type 1 (AGTR1) genes with increased intima-media thickness (IMT) and the presence of plaques in carotid arteries...
  38. doi request reprint A genome-wide association scan for asthma in a general Australian population
    J Hui
    Western Australian Institute for Medical Research and UWA Centre for Medical Research, B Block, QEII Medical Centre, The University of Western Australia, Nedlands, WA, 6009, Australia
    Hum Genet 123:297-306. 2008
    ..001). Each region contains a predicted gene that showed strong associations with asthma. Further studies are underway to characterize the novel candidate asthma susceptibility genes identified in this genome-wide study...
  39. ncbi request reprint Polymorphisms of the interleukin-6 gene promoter and abdominal aortic aneurysm
    L Smallwood
    School of Surgery and Pathology, University of Western Australia
    Eur J Vasc Endovasc Surg 35:31-6. 2008
    ..Genetic association studies are one means of trying to clarify the role of specific mediators in the causal pathway. The aim of the present study was to examine the association between variants of the IL-6 gene and AAAs...
  40. ncbi request reprint Pooling data and linkage analysis in the chromosome 5q candidate region for asthma
    K B Jacobs
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Genet Epidemiol 21:S103-8. 2001
    ..This study has provided a clearer understanding of the significance, or lack of significance, of the 5q31-33 region in asthma genetics for the phenotypes studied...
  41. pmc Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm
    L Smallwood
    Schools of Surgery, University of Western Australia, Fremantle, Western Australia
    Br J Surg 95:1239-44. 2008
    ..Increased matrix metalloproteinase (MMP) 9 activity has been implicated in the formation of abdominal aortic aneurysm (AAA). The aim was to explore the association between potentially functional variants of the MMP-9 gene and AAA...
  42. ncbi request reprint Segregation analysis of asthma and respiratory allergy in population-based samples of families
    A H Schnell
    Department of Epidemiology and Biostatistics, Case Western Reserve University, MetroHealth Medical Center, 2500 MetroHealth Dr, Cleveland, OH 44109, USA
    Genet Epidemiol 21:S30-5. 2001
    ..This finding has implications for the meta-analysis of asthma linkage studies...
  43. ncbi request reprint Improved evidence for linkage on 6p and 5p with retrospective pooling of data from three asthma genome screens
    S K Iyengar
    Department of Epidemiology and Biostatistics, Case Western Reserve University, R203A Rammelkamp Building, 2500 MetroHealth Drive, Cleveland, OH 44109, USA
    Genet Epidemiol 21:S130-5. 2001
    ..In conclusion, retrospective analysis of pooled genome scan data is a potentially powerful and useful method to examine both positive and negative evidence for linkage of quantitative and categorical phenotypes across populations...
  44. ncbi request reprint Genome-wide linkage analysis in a general population sample using sigma 2A random effects (SSARs) fitted by Gibbs sampling
    L J Palmer
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio, USA
    Genet Epidemiol 21:S674-9. 2001
    ....