Research Topics
Genomes and Genes | Jennifer K PaiSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Polymorphisms in the CC-chemokine receptor-2 (CCR2) and -5 (CCR5) genes and risk of coronary heart disease among US womenJennifer K Pai
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Atherosclerosis 186:132-9. 2006..Genetic variation in CC-chemokine receptor-2 (CCR2) and -5 (CCR5), and their common haplotypes, acting through inflammatory responses, may affect atherosclerosis and risk of coronary heart disease (CHD)...
Complement factor H (Y402H) polymorphism and risk of coronary heart disease in US men and womenJennifer K Pai
Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Kresge 9th Floor, Boston, MA 02115, USA
Eur Heart J 28:1297-303. 2007..We assessed the association between Y402H and risk of CHD in nested case-control studies among two large prospective cohorts of US male health professionals and female nurses...
C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studiesJennifer K Pai
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
PLoS ONE 3:e1395. 2008..However, few studies have comprehensively examined six common single-nucleotide polymorphisms (SNPs) in the CRP gene, haplotypes, and plasma CRP levels with risk of coronary heart disease (CHD)...
Moderate alcohol consumption and lower levels of inflammatory markers in US men and womenJennifer K Pai
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Atherosclerosis 186:113-20. 2006..Moderate alcohol consumption is associated with substantially lower risk of cardiovascular disease (CVD). We assessed the relationship between alcohol intake and inflammatory markers to partially explain this beneficial effect...
Single nucleotide polymorphisms at the adiponectin locus and risk of coronary heart disease in men and womenTobias Pischon
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Obesity (Silver Spring) 15:2051-60. 2007..The objective was to examine the association of 5 common single nucleotide polymorphisms (SNPs) at the adiponectin locus with risk of coronary heart disease (CHD) in men and women...
Inflammatory markers and the risk of coronary heart disease in men and womenJennifer K Pai
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
N Engl J Med 351:2599-610. 2004..Although plasma lipid levels were more strongly associated with an increased risk than were inflammatory markers, the level of C-reactive protein remained a significant contributor to the prediction of coronary heart disease...
CRP gene variation and risk of community-acquired pneumoniaKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Respirology 15:160-4. 2010..Whether this variation influences risk of infection, and hence whether CRP has anti-infective activity in humans, is uncertain...
Paraoxonase 1 polymorphisms and risk of myocardial infarction in women and menKenneth J Mukamal
Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Circ J 73:1302-7. 2009..Previous studies of genetic variants of paraoxonase 1 (PON1) and coronary heart disease (CHD) have been conflicting and the modifying effects of lifestyle factors that affect PON1 activity are uncertain...
Peroxisome proliferator-activated receptor-gamma2 P12A polymorphism and risk of coronary heart disease in US men and womenTobias Pischon
Department of Nutrition and Epidemiology, Harvard School of Public Health, Boston, Mass, USA
Arterioscler Thromb Vasc Biol 25:1654-8. 2005..Studies suggest that the A12 allele is associated with reduced risk of type 2 diabetes; however, data on the risk of coronary heart disease (CHD) are scarce and controversial...
Kidney dysfunction, inflammation, and coronary events: a prospective studyEric L Knight
Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Soc Nephrol 15:1897-903. 2004..These findings warrant further investigation in other populations...
Effects of lymphotoxin-alpha gene and galectin-2 gene polymorphisms on inflammatory biomarkers, cellular adhesion molecules and risk of coronary heart diseaseFolkert W Asselbergs
Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, U S A
Clin Sci (Lond) 112:291-8. 2007..05). However, no overall effect was demonstrated between LTA gene polymorphisms and risk of CHD...
Long-term alcohol consumption in relation to all-cause and cardiovascular mortality among survivors of myocardial infarction: the Health Professionals Follow-up StudyJennifer K Pai
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
Eur Heart J 33:1598-605. 2012..The aim of this study was to examine the association between long-term alcohol consumption, alcohol consumption before and after myocardial infarction (MI), and all-cause and cardiovascular mortality among survivors of MI...
Associations between conventional cardiovascular risk factors and risk of peripheral artery disease in menMichel M Joosten
Division of General Medicine and Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
JAMA 308:1660-7. 2012..Previous studies have examined the associations of individual clinical risk factors with risk of peripheral artery disease (PAD), but the combined effects of these risk factors are largely unknown...
Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart diseaseMajken K Jensen
Department of Nutrition, Harvard School of Public Health, Boston, MA, United States
Atherosclerosis 195:e172-80. 2007..Neither the -17C/G SNP nor the 2 the coding polymorphisms were associated with risk of CHD. The -565C/T and the -191G/C variants were inversely associated with risk of CHD among healthy women, without pronounced effects on plasma lipids...
Stability of novel plasma markers associated with cardiovascular disease: processing within 36 hours of specimen collectionJennifer K Pai
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Clin Chem 48:1781-4. 2002
Thrombospondin-4 Ala387Pro polymorphism is not associated with vascular function and risk of coronary heart disease in US men and womenFolkert W Asselbergs
Thromb Haemost 95:589-90. 2006
